Causal effects of metabolites on malignant neoplasm of bone and articular cartilage: a mendelian randomization study DOI Creative Commons

Yongwei Du,

Xilin Xiao,

Fuping Liu

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Objective Previous research has demonstrated that metabolites play a significant role in modulating disease phenotypes; nevertheless, the causal association between and malignant malignancies of bones joint cartilage (MNBAC)has not been fully elucidated. Methods This study used two-sample Mendelian randomization (MR) to explore correlation 1,400 MNBAC. Data from recent genome-wide studies (GWAS) involving 8,299 individuals were summarized. The GWAS summary data for acquired IEU Open database, while those MNBAC contributed by Finnish Consortium. We employed eight distinct MR methodologies: simple mode, maximum likelihood estimator, robust adjusted profile score, MR-Egger, weighted median, MR-PRESSO inverse variance scrutinize engendered each gene Consequently, we evaluated outliers, horizontal pleiotropy, heterogeneity, impact single nucleotide polymorphisms (SNPs), adherence normal distribution assumption analysis. Results Our findings suggested plausible causative relationship N-Formylmethionine (FMet) levels, lignoceroylcarnitine (C24) observed nearly FMet levels within cohort ( P = 0.024, odds ratio (OR) 3.22; 95% CI [1.16–8.92]). Moreover, ascertained link C24 0.0009; OR 0.420; 95%CI [0.25–0.70]). These results indicate potential FMet, level Conclusion occurrence may be causally related metabolites. might unveil new possibilities investigating early detection treatment

Language: Английский

A large-scale causal analysis of gut microbiota and delirium: A Mendelian randomization study DOI Creative Commons
Hui Yu,

Xianjie Wan,

Mingyi Yang

et al.

Journal of Affective Disorders, Journal Year: 2023, Volume and Issue: 329, P. 64 - 71

Published: Feb. 25, 2023

Several studies have linked gut microbiota to human brain activity. This study used Mendelian randomization (MR) investigate the causal relationship between microbes and delirium.MR was select SNPs from large-scale GWAS summary data on 211 taxa delirium. Inverse variance weighting (IVW), weighted median, MR-Egger methods were for statistical analyses. Outliers assessed using leave-one-out method. To avoid horizontal pleiotropy, we performed MR-PRESSO intercept tests. Cochran's Q I2 values IVW assess heterogeneity.IVW suggested that genetic prediction of family Desulfovibrionaceae (1.784 (1.267-2.512), P = 0.001), order Desulfovibrionales (1.501 (1.058-2.128), 0.023), genus Candidatus Soleaferrea (1.322 (1.052-1.659), 0.016) increased risk delirium, but Oxalobacteraceae (0.841 (0.722-0.981), 0.027), genera Holdemania (0.766 (0.620-0.946), 0.013), Ruminococcus gnavus (0.806 (0.661-0.982), 0.033), Eggerthella (0.815 (0.667-0.997), 0.047) reduced delirium.(1) Limited sample size, (2) inability interactions, (3) limited European populations.Our results suggest presence microbial Desulfovibrionaceae, Desulfovibrionales, whereas family, Holdemania, gnavus, decreased However, potential probiotic interventions in prevention perioperative delirium should be emphasized.

Language: Английский

Citations

48
Targeting the Gut–Eye Axis: An Emerging Strategy to Face Ocular Diseases DOI Open Access
Lucrezia Irene Maria Campagnoli, Angelica Varesi, Annalisa Barbieri

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(17), P. 13338 - 13338

Published: Aug. 28, 2023

The human microbiota refers to a large variety of microorganisms (bacteria, viruses, and fungi) that live in different body sites, including the gut, oral cavity, skin, eyes. In particular, presence an ocular surface with crucial role maintaining homeostasis by preventing colonization from pathogen species has been recently demonstrated. Moreover, recent studies underline potential association between gut (GM) health. this respect, some evidence supports existence gut-eye axis involved pathogenesis several diseases, age-related macular degeneration, uveitis, diabetic retinopathy, dry eye, glaucoma. Therefore, understanding link GM these disorders might be useful for development new therapeutic approaches, such as probiotics, prebiotics, symbiotics, or faecal transplantation through which could modulated, thus allowing better management diseases.

Language: Английский

Citations

29
The causal links between gut microbiota and COVID‐19: A Mendelian randomization study DOI
Jukun Song, Yadong Wu,

Xinhai Yin

et al.

Journal of Medical Virology, Journal Year: 2023, Volume and Issue: 95(5)

Published: May 1, 2023

Several studies have shown a possible correlation between gut microbiota and COVID-19. However, the cause-and-effect relationship two has not been investigated. We conducted two-sample Mendelian randomization study (MR) using publicly available GWAS data. Inverse variance weighted (IVW) analysis was main MR technique supplemented with other sensitivity analyses. Forty-two bacterial genera were associated COVID-19 susceptibility, hospitalization, severity in IVW method. Among these microbiota, five (genus unknowngenus [id.1000005472], family unknownfamily [id.1000005471], genus Tyzzerella3, order MollicutesRF9.id.11579, phylum Actinobacteria) significantly hospitalization severity. Three (class Negativicutes, Selenomonadales, class while Negativicutes Selenomonadales) severity, susceptibility. Sensitivity did detect any heterogeneity horizontal pleiotropy. Our findings demonstrated that several microorganisms causally linked to COVID-19, improved our understanding of pathology.

Language: Английский

Citations

25
Gut microbiota and chronic obstructive pulmonary disease: a Mendelian randomization study DOI Creative Commons
Yi Wei, Xuechao Lu, Chao Liu

et al.

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: June 19, 2023

Background A growing number of studies implies a strong association between gut microbiota and chronic obstructive pulmonary disease (COPD). However, the causal impact COPD remains unclear. As result, we used two-sample Mendelian randomization (MR) method to investigate connection in this study. Methods The largest available genome-wide study (GWAS) was obtained from MiBioGen consortium. Summary-level dataset for were FinnGen main analysis determining link inverse variance weighted (IVW). Subsequently, pleiotropy heterogeneity tests performed determine reliability results. Results IVW identified 9 bacterial taxa nominally associated with risk COPD. Class Actinobacteria ( p = 0.020), genus Allisonella 0.024), Coprococcus2 0.002) Oscillospira 0.018) protective against In addition, order Desulfovibrionales 0.011), family Desulfovibrionaceae 0.039), Peptococcaceae Victivallaceae 0.012) Marvinbryantia 0.017) higher No or found. Conclusion According findings MR analysis, relationship exists certain New insights into mechanisms mediated by are provided.

Language: Английский

Citations

24
Causal effect between gut microbiota and pancreatic cancer: a two-sample Mendelian randomization study DOI Creative Commons

Zhichen Jiang,

Yiping Mou,

Hui‐Ju Wang

et al.

BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)

Published: Nov. 10, 2023

Gut microbiota (GM) comprises a vast and diverse community of microorganisms, recent studies have highlighted the crucial regulatory roles various GM their secreted metabolites in pancreatic cancer (PC). However, causal relationship between PC has yet to be confirmed.In present study, we used two-sample Mendelian randomization (MR) analysis investigate effect PC, with genome-wide association study (GWAS) from MiBioGen consortium as an exposure factor GWAS data FinnGen outcome factor. Inverse variance weighted (IVW) was primary method for this study.At genus level, observed that Senegalimassilia (OR: 0.635, 95% CI: 0.403-0.998, P = 0.049) exhibited protective against while Odoribacter (OR:1.899, 95%CI:1.157-3.116, 0.011), Ruminiclostridium 9(OR:1.976,95%CI:1.128-3.461, 0.017), Ruminococcaceae (UCG011)(OR:1.433, 95%CI:1.072-1.916, 0.015), Streptococcus(OR:1.712, 95%CI:1.071-1.736, 0.025) were identified causative factors PC. Additionally, sensitivity analysis, Cochran's Q test, pleiotropy residual sum outlier (MR-PRESSO), MR-Egger regression indicated no heterogeneity, horizontal pleiotropy, or reverse causality PC.Our establishes specific which may provide new insights into potential pathogenic mechanisms assignment effective therapeutic strategies.

Language: Английский

Citations

23
Christensenella minuta, a new candidate next-generation probiotic: current evidence and future trajectories DOI Creative Commons
Olga Ignatyeva,

Darya Tolyneva,

A. A. Kovalyov

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 11, 2024

As the field of probiotic research continues to expand, new beneficial strains are being discovered. The

Language: Английский

Citations

13
Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study DOI Creative Commons
Chenglin Ye, Zhiqiang Li, Chun Ye

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 370 - 370

Published: Feb. 11, 2024

Recent observational studies revealed an association between gut microbiota and aging, but whether are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate causal biological age acceleration using largest available GWAS summary data from MiBioGen consortium on acceleration. further conducted sensitivity analysis MR-PRESSO, MR-Egger regression, Cochran Q test, reverse MR analysis. Streptococcus (IVW, β = 0.16, p 0.0001) was Bioage Eubacterium (rectale group) 0.20, 0.0190), Sellimonas 0.06, 0.019), Lachnospira −0.18, 0.01) were suggestive of associations acceleration, latter being protective. Actinomyces 0.26, 0.0083), Butyricimonas 0.21, 0.0184), Lachnospiraceae (FCS020 0.24, 0.0194) Phenoage This study found that Further randomized controlled trials needed its role in process.

Language: Английский

Citations

11
Causal relationship between gut microbiota and diabetic nephropathy: a two-sample Mendelian randomization study DOI Creative Commons
Shuxiang Yan, Hua Wang,

Baiyu Feng

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 8, 2024

Objective Emerging evidence has provided compelling linking gut microbiota (GM) and diabetic nephropathy (DN) via the “gut-kidney” axis. But causal relationship between them hasn’t been clarified yet. We perform a Two-Sample Mendelian randomization (MR) analysis to reveal connection with GM development of DN, type 1 diabetes (T1DN), 2 (T2DN), mellitus (T1DM), (T2DM). Methods used summary data from MiBioGen on 211 taxa in 18340 participants. Generalized MR methods were conducted estimate their causality risk T1DN, T2DN, T1DM T2DM FinnGen. To ensure reliability findings, comprehensive set sensitivity analyses confirm resilience consistency results. Results It was showed that Class Verrucomicrobiae [odds ratio (OR) =1.5651, 95%CI:1.1810-2.0742, P FDR=0.0018], Order Verrucomicrobiales (OR=1.5651, 95%CI: 1.1810-2.0742, FDR=0.0018) Family Verrucomicrobiaceae (OR=1.3956, 95%CI:1.0336-1.8844, FDR=0.0296) had significant DN. Our found associations including Verrucomimicrobiae (OR=1.8227, 95% CI: 1.2414-2.6763, PFDR=0.0139), 1.8227-2.6764, PFDR=0.0024), Rhodospirillales (OR=1.8226, 1.2412-2.6763, PFDR=0.0026), Verrucomicroniaceae PFDR=0.0083). The Eubacteriumprotogenes (OR=0.4076, 0.2415-0.6882, PFDR=0.0021) exhibited protection against T1DN. Sensitivity confirmed there no heterogeneity pleiotropy. Conclusions At gene prediction level, we identified specific is causally linked DN both patients. Moreover, distinct microbial changes T1DN differed those seen offering valuable insights into signatures associated subtype nephropathy.

Language: Английский

Citations

11
Investigating the causal impact of gut microbiota on trigeminal neuralgia: a bidirectional Mendelian randomization study DOI Creative Commons
Chuan Zeng, Chaolong Zhang, Yingmin Jia

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 27, 2025

The etiology and pathogenesis of trigeminal neuralgia remain unclear. This study examines the connection between gut microbiota using Mendelian randomization analysis to provide insights into disorder's origin propose potential therapies based on our findings. We used data from MiBioGen consortium (13,266 participants) for IEU OpenGWAS project (800 cases, 195,047 controls) neuralgia. checked heterogeneity horizontal pleiotropy inverse variance weighting method as main approach causal link bacteria neuralgia, MR-Egger, simple mode, weighted median, mode supplementary methods, with a sensitivity test leave-one-out analysis. If bacteria-trigeminal was found, we conducted reverse confirmation. According final results, these groups include Butyricimonas (Genus, id = 945, p-value 0.007, OR 1.742, 95% CI: 1.165-2.604), unknowngenus 1000005479, 0.005, 1.774, 1.187-2.651) Bacteroidales (Family, were causally associated No significant results according In study, identified specific linked To comprehensively understand their impact mechanisms, additional randomized trials are necessary.

Language: Английский

Citations

1
Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study DOI Creative Commons

Yan Xue,

Linzhu Zhang,

Yajun Chen

et al.

Frontiers in Medicine, Journal Year: 2023, Volume and Issue: 10

Published: June 22, 2023

Accumulating evidence suggests that alterations in gut microbiota composition and diversity are associated with Atopic dermatitis (AD). But until now, the causal association between them has been unclear.We employed a two-sample Mendelian Randomization (MR) study to estimate potential causality of on AD risk. The summary statistics related were obtained from large-scale genome-wide genotype 16S fecal microbiome dataset 18,340 individuals (24 cohorts) analyzed by MiBioGen Consortium, comprising 211 microbiota. data also derived strictly defined collected FinnGen biobank analysis, which included 218,467 European ancestors (5,321 patients 213,146 controls). inverse variance weighted method (IVW), median (WME), MR-Egger used determine changes pathogenic bacterial taxa, followed sensitivity analysis including horizontal pleiotropy Cochran's Q test, leave-one-out assess reliability results. In addition, MR Steiger's test was suppositional relationship exposure outcome.A total 2,289 SNPs (p < 1 × 10-5) included, 5 taxa 17 characteristics (1 phylum, 3 classes, order, 4 families, 8 genera), after excluding IVs linkage disequilibrium (LD). Combining results IVW models, there 6 biological (2 genera) intestinal flora positively risk 7 2 family, negatively associated. showed Tenericutes, Mollicutes, Clostridia, Bifidobacteriaceae, Bifidobacteriales, Bifidobacterium, Christensenellaceae R group correlated AD, while Clostridiaceae 1, Bacteroidaceae, Bacteroides, Anaerotruncus, unknown genus, Lachnospiraceae UCG001 opposite trend. And robust. above but not vice versa.The present genetically abundance risk, thus only providing support for microecological therapy laying groundwork further exploration mechanisms contributes pathogenesis AD.

Language: Английский

Citations

22