Cited by The sharp edge of immunosuppressive treatments: infections

Surveying haemoperfusion impact on COVID-19 from machine learning using Shapley values DOI

Behzad Einollahi, Mohammad Javanbakht, Mehrdad Ebrahimi

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(4), P. 2285 - 2294

Published: May 19, 2024

Language: Английский

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Evaluation of the effect of therapeutic plasma exchange on serum cytokine levels in pediatric intensive care unit DOI

Selen Ceren Çakmak, Hazal Ceren Tuğrul, Dilan Akgün Ünlü

et al.

Therapeutic Apheresis and Dialysis, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 4, 2025

Abstract Introduction Therapeutic plasma exchange (TPE) is crucial for saving lives when used appropriately. This study aimed to assess TPE's impact on tumor necrosis factor‐like weak inducer of apoptosis (TWEAK) protein and IL‐6 levels in critically ill pediatric patients. Methods Conducted between May 2022 December 2022, the observed intensive care unit (PICU) patients undergoing TPE, recording demographics, lab results, TWEAK, pre‐ post‐procedure. Results Of 41 patients, 53.7% were male, 51.2% had underlying conditions, 39% showed sepsis symptoms. significantly rose post‐TPE ( p : 0.006), while TWEAK dropped 0.030). Positive correlations found interleukin‐6 (IL‐6) pre‐TPE ventilation duration, ferritin <0.05), organ failure indicators, D‐Dimer <0.05). Prognosis no significant difference IL‐6/TWEAK >0.05). Conclusion Serum can indicate disease severity inflammation level, but may not predict prognosis accurately. Clinical Trial Registration Our has clinical registration number B.10.1.TKH.4.34.H.GP.0.01/154 University Health Sciences Ümraniye Training Research Hospital.

Language: Английский

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Macrophage Activation Syndrome in Viral Sepsis DOI

Despoina Papageorgiou,

Charalambos Gogos,

Karolina Akinosoglou

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(7), P. 1004 - 1004

Published: June 22, 2024

Macrophage activation syndrome (MAS) is a life-threatening systemic hyperinflammatory triggered by various infections, particularly viral autoimmune disorders, and malignancy. The condition characterized an increased production of proinflammatory cytokines resulting in cytokine storm has been associated with poor clinical outcomes. During the COVID-19 pandemic, patients severe manifestations developed features similar to those MAS, although these characteristics remained well defined within lung. Additionally, other infections including EBV, herpes family viruses, hepatitis influenza, HIV, hemorrhagic fevers can be complicated MAS. diagnosis management remain challenging due lack consensus on specific guidelines, especially among adult population. Currently, therapeutic options primarily rely medications that are typically used treat primary hemophagocytic lymphohistiocytosis, such as corticosteroids etoposide. In addition, cytokine-targeted therapies present promising treatment options. objective this review discuss emergence MAS context including, but not limited to, its occurrence COVID-19.

Language: Английский

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Tim-3 pathway dysregulation and targeting in sepsis-induced immunosuppression DOI

Jialiu Luo, Cong Zhang, Deng Chen

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 18, 2024

Sepsis is a major medical problem which causes millions of deaths worldwide every year. The host immune response in sepsis characterized by acute inflammation and simultaneous state immunosuppression. In the later stage sepsis, immunosuppression crucial factor that increases susceptibility septic patients to secondary infection mortality. It T cell exhaustion, excessive production anti-inflammatory cytokines, hyperproliferation suppressor cells aberrant expression checkpoint molecules. immunoglobulin mucin domain 3 (Tim-3), an molecule, found on surface various cells, including macrophages, NK NKT cells. There are four different ligands for Tim-3, accumulating evidence indicates Tim-3 its play role regulating dysfunction during sepsis. Anti-Tim-3 antibodies have been applied field cancer immunotherapy achieved positive therapeutic effects some clinical trials. However, efficacy blockade still controversial animal models These challenges highlight need deeper understanding signaling This review examines comprehensive effect development sepsis-induced blockade.

Language: Английский

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Clinical features of macrophage activation syndrome in adult dermatomyositis: A single‐center retrospective case‐control study DOI

Dingxian Zhu, Shuni Ying, Changyi Yang

et al.

Immunity Inflammation and Disease, Journal Year: 2024, Volume and Issue: 12(1)

Published: Jan. 1, 2024

Little is known about the features of macrophage activation syndrome (MAS) in dermatomyositis, especially association between rapidly progressive interstitial lung disease (RP-ILD) and MAS.

Language: Английский

Citations

Macrophage activation syndrome in Sepsis: from pathogenesis to clinical management DOI

Shunyao Chen,

Cong Zhang, Jialiu Luo

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(12), P. 2179 - 2197

Published: Oct. 15, 2024

Language: Английский

Citations

The sharp edge of immunosuppressive treatments: infections DOI

Aybegüm Özşahin, Tuba İlgar, Sudem Mahmutoğlu Çolak

et al.

TURKISH JOURNAL OF MEDICAL SCIENCES, Journal Year: 2024, Volume and Issue: 54(4), P. 752 - 760

Published: Aug. 23, 2024

Different side effects, including infections, are encountered in patients receiving anticytokines used for the treatment of severe coronavirus disease 2019 (COVID-19). The aim this study was to evaluate infections and effects these that develop patient group.

Language: Английский

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