Effects of Physical Exercise on Neurofilament Light Chain and Glial Fibrillary Acidic Protein Level in Patients with Multiple Sclerosis: A Systematic Review and Bayesian Network Meta-Analysis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 839 - 839

Published: Jan. 27, 2025

Background: The prognosis of people with multiple sclerosis (MS) has improved substantially in recent decades due to advances diagnosis and treatment. Due the unpredictable course heterogenous treatment response MS, there is a clear need for biomarkers that reflect disease activity clinical follow-up these patients. We conducted systematic review Bayesian network meta-analysis aim analyzing effects physical exercise on neurofilaments (NfL) glial fibrillary acidic protein (GFAP) levels patients MS. Methods: A was following Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines, starting PICO (patient/population, intervention, comparison, outcome) question: what are (with independence type) NfL and/or GFAP MS compared other interventions or no intervention whatsoever? systematically comprehensive literature search from January March 2024 identify original studies answered question, using main data sources. quality included assessed Quality Index Downs & Black. For followed randomized controlled trial (RCT) design, methodological each paper Physiotherapy Evidence Database (PEDro) Scale. Risk bias also explored by two independent reviewers. Finally, all articles were classified according evidence grades recommendation established Oxford Center Evidence-Based Medicine. continuous outcome measures enough comparisons greater than equal good PEDro scale, (NMA) applied. statistical analyses performed R (version 4.1.3, Core Team 2023) “BUGSnet” “gemtc” packages. NMA can be used obtain posterior probability distribution relative effects, which allows us quantify uncertainty parameter estimates rank treatments network. Results: Eight this six NMA, they appraised quality. characteristics studies, types training described protocols, quality, risk bias, studied outlined. Qualitative synthesis, different modalities selection final model assessment, ranking shown. Conclusions: Our findings indicated moderate-intensity more likely reduce concentration high-intensity exercise, and, turn, low-intensity exercise. However, inconclusive.

Language: Английский

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Proteomic analysis reveals candidate molecules to mediate cortical pathology and identify possible biomarkers in an animal model of multiple sclerosis

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 13, 2025

Introduction Multiple Sclerosis (MS) is a complex neurodegenerative disease marked by recurring inflammatory episodes, demyelination, axonal damage, and subsequent loss of function. MS presents wide range clinical courses, with the progressive forms leading to irreversible neurological disability. Cortical demyelinating lesions are central pathology these forms, gaining critical importance in recent decades due their strong correlation physical disability cognitive decline. Despite this, underlying mechanisms driving cortical lesion formation remain poorly understood, no specific treatments currently available. A significant challenge lies lack animal models that accurately mirror key characteristics lesions. Methods We developed focal model replicates many features lesions, including impairment. This study focuses on conducting proteomic analyses both cerebrospinal fluid (CSF) from animals, aiming identify proteins biomarkers could be validated patients. Results Proteomic differences between frontal cortex tissue CSF were observed when comparing experimental animals controls. Among identified proteins, some have been previously described patients models, while others represent novel discoveries. Notably, we two S100A8 orosomucoid-1, highly expressed regions. Conclusions These findings suggest prognostic molecules this facilitate discovery new or relevant MS, particularly mainly characterized disease.

Language: Английский

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Thalamic nuclei volume partially mediates the effects of aerobic capacity on fatigue in people with multiple sclerosis

Journal of Neurology, Journal Year: 2024, Volume and Issue: 271(6), P. 3378 - 3388

Published: March 20, 2024

Language: Английский

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From progression to progress: The future of multiple sclerosis

Journal of Central Nervous System Disease, Journal Year: 2024, Volume and Issue: 16

Published: May 6, 2024

Significant advances have been made in the diagnosis and treatment of multiple sclerosis recent years yet challenges remain. The current classification MS phenotypes according to disease activity progression, for example, does not adequately reflect underlying pathophysiological mechanisms that may be acting an individual with at different time points. Thus, there is a need clinicians transition management approach based on drive disability MS. A Canadian expert panel convened January 2023 discuss priorities clinical discovery scientific exploration would help advance field. Five key areas focus included: identifying mechanism-based system; developing biomarkers (imaging, fluid, digital) identify pathologic processes; implementing data-driven integrate genetic/environmental risk factors, findings, imaging biomarker data, patient-reported outcomes better characterize many factors associated progression; utilizing precision-based strategies target potentially preventing through Epstein-Barr virus (EBV) vaccination, counselling about environmental (e.g. obesity, exercise, vitamin D/sun exposure, smoking) other measures. Many tools needed meet these needs are currently available. Further work required validate emerging tailor patients. hope more complete view individual’s pathobiology will enable usher era truly personalized medicine, which informed decisions throughout course achieve long-term outcomes.

Language: Английский

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Spotlight on pro-inflammatory chemokines: regulators of cellular communication in cognitive impairment

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 1, 2024

Cognitive impairment is a decline in people's ability to think, learn, and remember, so forth. global health challenge that affects the quality of life thousands people. The condition covers wide range from mild cognitive severe dementia, which includes Alzheimer's disease (AD) Parkinson's (PD), among others. While etiology diverse, role chemokines increasingly evident, especially presence chronic inflammation neuroinflammation. Although inflammatory have been linked impairment, usually multifactorial. Researchers are exploring other mediators dysfunction trying develop therapeutic strategies mitigate their effects. pathogenesis disorders very complex, underlying causative mechanisms not clarified, treatment always one challenges field medicine. Therefore, its has important socioeconomic value. Chemokines growing family structurally functionally related small (8-10 kDa) proteins, there evidence pro-inflammatory associated with many neurobiological processes may be relevant neurological beyond classical chemotactic function play crucial progression disorders. In this paper, we review roles regulatory (CCL2, CCL3, CCL4, CCL5, CCL11, CCL20, CXCL8) impairment. We also discuss intrinsic relationship between two, hoping provide some valuable references for

Language: Английский

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Th1/Th2 cytokines in early peripheral blood of patients with multiple injuries and its predictive value for SIRS: A bioinformatic analysis

SLAS TECHNOLOGY, Journal Year: 2024, Volume and Issue: 29(4), P. 100150 - 100150

Published: May 23, 2024

This study aims to evaluate the changes in helper T lymphocyte (Th)1/Th2 factor levels peripheral blood of patients with severe multiple injuries and their prognostic value for nosocomial infection using bioinformatic analysis. The experimental group consisted 180 numerous admitted our hospital between January 2021 June 2023, 80 healthy volunteers serving as controls. Th1 cytokines (interleukin-2 interferon-γ) Th2 (IL-4 IL-10) were evaluated 48 hours after admission enzyme-linked immunosorbent assays. was separated into two groups: those systemic inflammatory response syndrome (SIRS) without SIRS, cytokine analysis SIRS incidence. Furthermore, examined trauma various body locations within group. A receiver operating characteristic (ROC) curve performed determine predictive Th1/Th2 had lower IL-2 IFN-γ compared control group, but greater IL-4 IL-10. There no significant variations across groups. Patients IL-10 SIRS. Combined have a better than individual alone. In conclusion, individuals change from profiles, which most evident combined substantial incidence this patient cohort.

Language: Английский

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Impact of Physical Activity on Cellular Metabolism Across Both Neurodegenerative and General Neurological Conditions: A Narrative Review

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 1940 - 1940

Published: Nov. 22, 2024

Background: Regular physical activity plays a crucial role in modulating cellular metabolism and mitigating the progression of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Multiple Sclerosis. Objective: The objective this review is to evaluate molecular mechanisms by which exercise influences metabolism, with focus on its potential therapeutic intervention for neurological disorders. Methods: A comprehensive literature was conducted using peer-reviewed scientific articles, period between 2015 2024, analyze effects mitochondrial function, oxidative stress, metabolic health. Results: findings indicate that promotes biogenesis, enhances phosphorylation, reduces reactive oxygen species, contributing improved energy production resilience. These adaptations are associated delayed disease reduced symptoms patients conditions. Additionally, integrating nutritional strategies may further enhance outcomes addressing disturbances comprehensively. Conclusions: This concludes personalized protocols should be developed optimize benefits diseases, while future research biomarker development individualized treatment approaches. highlight importance non-pharmacological interventions managing diseases.

Language: Английский

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Brain-Immune interactions: Implication for Cognitive impairments in Alzheimer's Disease and autoimmune disorders

Journal of Leukocyte Biology, Journal Year: 2024, Volume and Issue: unknown

Published: June 13, 2024

Progressive memory loss and cognitive dysfunction, encompassing deficits in learning, memory, problem-solving, spatial reasoning, verbal expression are characteristics of Alzheimer's disease related dementia (ADRD). A wealth studies has described multiple roles the immune system development or exacerbation dementia. Individuals with autoimmune disorders can also develop a phenomenon termed Together, these findings underscore pivotal role neuroimmune axis both ADRD The dynamic interplay between adaptive innate immunity, outside brain, significantly affects etiology progression conditions. Multidisciplinary research shows that dysfunction arises from bidirectional relationship nervous systems, though specific mechanisms drive impairments not fully understood. Intriguingly, this reciprocal regulation occurs at levels, where neuronal signals modulate responses, system-related processes influence viability function. In review, we consider implications responses various explore their effects on brain We discuss diverse cellular molecular cross talk as they may shed light potential triggers peripheral inflammation, effect integrity blood-brain barrier (BBB) Additionally, assess challenges possibilities associated developing immune-based therapies for treatment decline.

Language: Английский

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The interaction between exercise and neurofilament light chain in multiple sclerosis: a systematic review and meta-analysis

Multiple Sclerosis and Related Disorders, Journal Year: 2024, Volume and Issue: 90, P. 105809 - 105809

Published: Aug. 6, 2024

Language: Английский

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Impact of Lifestyle Interventions on Multiple Sclerosis: Focus on Adipose Tissue

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3100 - 3100

Published: Sept. 14, 2024

Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by demyelination in the central nervous system (CNS), affecting individuals globally. The pathological mechanisms underlying MS remain unclear, but current evidence suggests that inflammation and immune dysfunction play critical role pathogenesis of disease. Adipose tissue (AT) dynamic multifunctional organ involved various diseases, including MS, due to its endocrine function secretion adipokines, which can influence responses. Physical activity represents an efficacious non-pharmacological strategy for management spectrum conditions not only improves inflammatory functions also directly affects status AT. Additionally, exploration nutritional supplementation important field research aimed at enhancing clinical symptoms closely tied regulation metabolic responses, adipokine secretion. This review, therefore, aims elucidate intricate relationship between lifestyle providing overview latest published data about involvement AT main such as adiponectin, leptin, tumor necrosis factor α (TNFα) MS. Furthermore, we explore whether physical dietary could serve useful strategies improve quality life patients.

Language: Английский

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