Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104545 - 104545
Published: Oct. 1, 2024
Language: Английский
Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(8), P. 569 - 589
Published: June 5, 2024
Language: Английский
Citations
50
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 16, 2024
Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.
Language: Английский
Citations
14
Progress in Lipid Research, Journal Year: 2024, Volume and Issue: 95, P. 101291 - 101291
Published: July 1, 2024
Language: Английский
Citations
13
Al-Salam Journal for Medical Science, Journal Year: 2024, Volume and Issue: 3(1), P. 45 - 54
Published: Jan. 13, 2024
Prostate cancer is one of the most common malignancies and seriously affects public health. Recently, contemporary microbiome research has found hints that urinary microflora may at least to some extent impact prostate formation treatment outcomes. A comprehensive review This article attempts provide a brief summary integration current knowledge about involvement in development by microbiota, diagnostic capabilities, as well therapeutic opportunities.It examines different microbial spheres inside residents genitourinary system their relevance tumorigenic microenvironments. The looks signatures linked cancer, tries identify potential biological markers for diagnosis disease or patient stratification according risk levels, predictors outcome. Secondly, effect urine microbiota upon response how design novel interventions also form key topics this study.After existing literature recent new studies, illuminate intricate interrelationships between cancer. It hoped effort will insight on future directions research, clinical applications even possibilities precision-medicine paradigms care.
Language: Английский
Citations
11
International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(5)
Published: March 27, 2024
Fungi inhabit different anatomic sites in the human body. Advances omics analyses of host‑microbiome interactions have tremendously improved our understanding effects fungi on health and diseases such as tumors. Due to significant enrichment specific patients with malignant tumors, associations between cancer attracted an increasing attention recent years. Indeed, type‑specific fungal profiles been found tumor tissues. Importantly, also influence tumorigenesis through multiple factors, host immunity bioactive metabolites. Microbiome interactions, factors genetic epigenetic could be involved tissues and/or conversion from a commensal fungus pathogenic fungus. Exploration bacterial microbiome may enable them target for diagnosis treatment. In present review, cancer, mechanisms by which cause were discussed. addition, possible that can lead fungi, well potential therapeutic preventive strategies tumors based intratumoral summarized.
Language: Английский
Citations
11
iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893
Published: May 3, 2024
Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.
Language: Английский
Citations
9
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(38)
Published: July 26, 2024
Abstract In recent years, advancements in microbial sequencing technology have sparked an increasing interest the bacteria residing within solid tumors and its distribution functions various tumors. Intratumoral critically modulate tumor oncogenesis development through DNA damage induction, chronic inflammation, epigenetic alterations, metabolic immune regulation, while also influencing cancer treatment efficacy by affecting drug metabolism. response to these discoveries, a variety of anti‐cancer therapies targeting microorganisms emerged. These approaches encompass oncolytic therapy utilizing tumor‐associated bacteria, design biomaterials based on intratumoral use bacterial components for delivery systems, comprehensive strategies aimed at eradication tumor‐promoting bacteria. Herein, this review article summarizes patterns different tumors, examines their impact evaluates current therapeutic centered Furthermore, challenges prospects developing drugs that target communities are explored, promising new directions treatment.
Language: Английский
Citations
9
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 203, P. 104480 - 104480
Published: Aug. 22, 2024
Gastrointestinal (GI) cancer continues to pose a significant global health challenge. Recent advances in our understanding of the complex relationship between host and gut microbiota have shed light on critical role metabolic interactions pathogenesis progression GI cancer. In this study, we examined how interact with influence signalling pathways that impact formation tumours. Additionally, investigated potential therapeutic approach manipulating for use clinical settings. Revealing molecular exchanges facilitates deeper underlying mechanisms drive development. Metabolic hold promise identification microbial signatures or associated specific stages Hence, study provides strategies diagnosis, treatment management cancers improve patient outcomes.
Language: Английский
Citations
4
Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2776 - 2776
Published: Dec. 6, 2024
The gut microbiota plays a crucial role in modulating anticancer immunity, significantly impacting the effectiveness of various cancer therapies, including immunotherapy, chemotherapy, and radiotherapy. Its impact on development is complex; certain bacteria, like
Language: Английский
Citations
4
European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177343 - 177343
Published: Feb. 1, 2025
Language: Английский
Citations
0