Cancers,
Journal Year:
2024,
Volume and Issue:
17(1), P. 90 - 90
Published: Dec. 30, 2024
Dysbiosis
in
the
gut
microbiota
plays
a
significant
role
GI
cancer
development
by
influencing
immune
function
and
disrupting
metabolic
functions.
can
drive
carcinogenesis
through
pathways
like
dysregulation
release
of
carcinogenic
metabolites,
altered
metabolism,
genetic
instability,
pro-inflammatory
signalling,
contributing
to
initiation
progression.
Helicobacter
pylori
infection
genotoxins
released
from
dysbiosis,
lifestyle
dietary
habits
are
other
factors
that
contribute
development.
Emerging
diagnostic
therapeutic
approaches
show
promise
colorectal
treatment,
including
multitarget
faecal
immunochemical
test
(mtFIT),
standard
FIT,
transplantation
(FMT)
combined
with
PD-1
inhibitors.
We
used
search
engine
databases
PubMed,
Scopus,
Web
Science.
This
review
discusses
dysbiosis
onset
explores
strategies
such
as
FMT,
probiotics,
prebiotics
enhance
response
improve
therapy
outcomes.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 11, 2024
The
cascade
of
metastasis
in
tumor
cells,
exhibiting
organ-specific
tendencies,
may
occur
at
numerous
phases
the
disease
and
progress
under
intense
evolutionary
pressures.
Organ-specific
relies
on
formation
pre-metastatic
niche
(PMN),
with
diverse
cell
types
complex
interactions
contributing
to
this
concept,
adding
a
new
dimension
traditional
cascade.
Prior
metastatic
dissemination,
as
orchestrators
PMN
formation,
primary
tumor-derived
extracellular
vesicles
prepare
fertile
microenvironment
for
settlement
colonization
circulating
cells
distant
secondary
sites,
significantly
impacting
cancer
progression
outcomes.
Obviously,
solely
intervening
sites
passively
after
macrometastasis
is
often
insufficient.
Early
prediction
holistic,
macro-level
control
represent
future
directions
therapy.
This
review
emphasizes
dynamic
intricate
systematic
alterations
that
progresses,
illustrates
immunological
landscape
creation,
deepens
understanding
treatment
modalities
pertinent
metastasis,
thereby
identifying
some
prognostic
predictive
biomarkers
favorable
early
predict
occurrence
design
appropriate
combinations.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2929 - 2929
Published: March 2, 2024
Over
the
past
decade,
research
has
prominently
established
neutrophils
as
key
contributors
to
intricate
landscape
of
tumor
immune
biology.
As
polymorphonuclear
granulocytes
within
innate
system,
play
a
pivotal
and
abundant
role,
constituting
approximately
∼70%
all
peripheral
leukocytes
in
humans
∼10–20%
mice.
This
substantial
presence
positions
them
frontline
defense
against
potential
threats.
Equipped
with
diverse
array
mechanisms,
including
reactive
oxygen
species
(ROS)
generation,
degranulation,
phagocytosis,
formation
neutrophil
extracellular
traps
(NETs),
undeniably
serve
indispensable
components
system.
While
these
functions
enable
interact
adaptive
cells
such
T,
B,
NK
cells,
influencing
their
functions,
they
also
engage
dynamic
interactions
rapidly
dividing
cells.
Consequently,
are
emerging
crucial
regulators
both
pro-
anti-tumor
immunity.
comprehensive
review
delves
into
recent
illuminate
multifaceted
roles
neutrophils.
It
explores
microenvironment,
shedding
light
on
heterogeneity
impact
recruitment,
progression,
modulation.
Additionally,
underscores
anti-tumoral
capabilities.
Finally,
it
provides
valuable
insights
clinical
therapies
targeting
neutrophils,
presenting
promising
approach
leveraging
immunity
for
enhanced
cancer
treatment.
SummaryThe
intestinal
barrier
serves
as
a
boundary
between
the
mucosal
immune
system
in
lamina
propria
and
external
environment
of
lumen,
which
contains
diverse
array
microorganisms
ingested
environmental
factors,
including
pathogens,
food
antigens,
toxins,
other
foreign
substances.
This
has
central
role
regulating
controlled
interaction
luminal
factors
system.
Disruptions
epithelial
cells,
serve
physical
barrier,
or
antimicrobial
peptides
mucins
they
produce,
act
chemical
can
lead
to
leaky
gut.
In
this
state,
wall
is
unable
efficiently
separate
flora
contents
from
The
subsequent
activation
an
important
pathogenesis
inflammatory
bowel
disease,
well
metabolic
dysfunction-associated
steatohepatitis,
primary
sclerosing
cholangitis,
colorectal
cancer.
Dysregulated
integrity
also
been
described
patients
with
chronic
diseases
outside
gastrointestinal
tract,
rheumatoid
arthritis
neurodegenerative
disorders.
Mechanistic
studies
dysfunction
have
revealed
that
local
systemic
circulation
activated
cells
cytokines
secrete,
extracellular
vesicles,
promote
proinflammatory
processes
within
tract.
Review,
we
summarise
these
findings
highlight
several
new
therapeutic
concepts
currently
being
developed
attempt
control
via
direct
indirect
modulation
function.
Journal of Clinical Medicine,
Journal Year:
2024,
Volume and Issue:
13(2), P. 420 - 420
Published: Jan. 12, 2024
The
gut
microbiota’s
influence
on
human
tumorigenesis
is
a
burning
topic
in
medical
research.
With
the
new
ontological
perspective,
which
considers
body
and
its
pathophysiological
processes
as
result
of
interaction
between
own
eukaryotic
cells
prokaryotic
microorganisms
living
different
niches,
great
interest
has
arisen
role
microbiota
carcinogenesis.
Indeed,
dysbiosis
currently
recognized
cancer-promoting
condition,
multiple
molecular
mechanisms
have
been
described
by
may
drive
tumor
development,
especially
colorectal
cancer
(CRC).
Metastatic
power
undoubtedly
one
most
fearsome
features
neoplastic
tissues.
Therefore,
understanding
underlying
utmost
importance
to
improve
patients’
prognosis.
liver
frequent
target
CRC
metastasis,
evidence
reveals
that
yield
an
effect
diffusion
liver,
thus
defining
intriguing
facet
so-called
“gut-liver
axis”.
In
this
review,
we
aim
summarize
recent
data
about
promoting
or
preventing
hepatic
metastasis
from
CRC,
highlighting
some
potential
future
therapeutic
targets.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(3), P. 368 - 368
Published: Jan. 23, 2025
Fusobacterium
nucleatum,
a
gram-negative
anaerobic
bacterium,
has
emerged
as
significant
player
in
colorectal
cancer
(CRC)
pathogenesis.
The
bacterium
causes
persistent
inflammatory
reaction
the
mucosa
by
stimulating
release
of
pro-inflammatory
cytokines
like
IL-1β,
IL-6,
and
TNF-α,
creating
an
environment
conducive
to
progression.
F.
nucleatum
binds
penetrates
epithelial
cells
through
adhesins
such
FadA,
impairing
cell
junctions
encouraging
epithelial-to-mesenchymal
transition
(EMT),
which
is
associated
with
advancement.
Additionally,
modulates
host
immune
system,
suppressing
activity
conditions
favorable
for
tumor
growth.
Its
interactions
gut
microbiome
contribute
dysbiosis,
further
influencing
carcinogenic
pathways.
Evidence
indicates
that
can
inflict
DNA
damage
either
directly
via
reactive
oxygen
species
or
indirectly
environment.
it
triggers
oncogenic
pathways,
especially
Wnt/β-catenin
signaling
pathway,
promotes
growth
longevity.
Moreover,
alters
microenvironment,
impacting
behavior,
metastasis,
therapeutic
responses.
purpose
this
review
elucidate
molecular
mechanisms
contributes
CRC.
Understanding
these
crucial
development
targeted
therapies
diagnostic
strategies
CRC
nucleatum.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 27, 2025
To
observe
the
inhibitory
effect
and
potential
mechanism
of
Yiqi
Huayu
Jiedu
Decoction
(YHJD)
on
liver
metastasis
colorectal
cancer
(CRC).
We
compared
changes
weight
index
before
after
YHJD
treatment
in
CRC
mouse
models.
HE
staining
was
employed
to
pathological
tissue
sections.
Flow
cytometry
used
analyze
number
marker
neutrophils
treated
with
YHJD.
Transcriptomics,
proteomics,
multiplex
cytokine
array
analyses
were
conducted
further
verify
role
CXCL1.
Differential
gene
analysis
performed
explore
by
which
inhibits
CRC.
Animal
studies
demonstrated
that
reduces
metastases.
results
revealed
promotes
N1
liver.
Combining
multi-omics
multiple
arrays,
we
observed
a
significant
increase
expression
CXCL1
plasma.
GO
KEGG
enrichment
indicated
may
regulate
chemotaxis
inhibit
participating
regulation
cell
adhesion
molecule
binding,
protein
metabolic
pathways.
upregulating
CXCL1,
thereby
promoting
neutrophil
towards
liver,
concurrently
raising
markers.
Journal of Translational Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: March 17, 2025
The
liver
is
the
most
commonly
metastasized
organ
in
colorectal
cancer
(CRC),
and
distant
metastasis
primary
cause
of
mortality
from
CRC.
In
recent
years,
researchers
have
discovered
that
tumor
cells
create
a
"pre-metastatic
niche
(PMN)"
favorable
to
before
reaching
metastatic
location.
This
review
discusses
many
processes
mechanisms
lead
PMN
formation
CRC,
including
gut
microbiota,
stem
cell
stimulation,
immunocyte
interactions,
induction
extracellular
vesicles
carry
important
information.
It
examines
research
methods
diagnostic
therapeutic
approaches
for
treating
CRC
with
PMN.
crucial
significance
also
highlighted.
Frontiers in Bioscience-Landmark,
Journal Year:
2024,
Volume and Issue:
29(4), P. 152 - 152
Published: April 18, 2024
Metastasis
remains
a
leading
cause
of
mortality
for
patients
with
solid
tumors.
An
expanding
body
literature
suggests
interplay
between
the
host,
gut,
and
tumoral
microbiomes
may
play
role
in
cancer
initiation
distant
dissemination.
These
associations
have
been
particularly
well-studied
colorectal
cancer,
where
gut
dysbiosis
an
endotoxin-induced
inflammatory
milieu
foster
premalignant
polyp
formation,
setting
stage
carcinogenesis.
Subsequent
violation
vascular
barrier
enables
dissemination
bacterial
agents
to
sites
such
as
liver,
they
contribute
establishment
pre-metastatic
niches,
which
promote
tumor
cell
extravasation
metastatic
outgrowth.
Intriguingly,
breakdown
this
has
shown
be
aided
by
presence
bacteria.
The
similar
species,
including
