Cutting-edge approaches for targeted drug delivery in breast cancer: beyond conventional therapies

Nanoscale Advances, Journal Year: 2024, Volume and Issue: 6(9), P. 2270 - 2286

Published: Jan. 1, 2024

Breast cancer is a global health challenge with staggering statistics underscoring its pervasive impact. The burden of this disease measured in terms prevalence and the challenges it poses to healthcare systems, necessitating closer look at epidemiology Current breast treatments, including surgery, chemotherapy, radiation therapy, targeted therapies, have made significant strides improving patient outcomes. However, they are not without limitations, often leading adverse effects development drug resistance. This comprehensive review delves into complex landscape cancer, incidence, current treatment modalities, inherent limitations existing therapeutic approaches. It also sheds light on promising role nanotechnology, encompassing both inorganic organic nanoparticles equipped ability selectively deliver agents tumor sites, battle against cancer. addresses emerging their associated challenges, future prospects delivery management.

Language: Английский

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Nanostructured Drug Delivery Systems in Immunotherapy: An Updated Overview of Nanotechnology-Based Therapeutic Innovations

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(19), P. 8948 - 8948

Published: Oct. 4, 2024

Using nanostructured drug delivery systems has attracted increasing interest in immunotherapeutic approaches. The intrinsic immunomodulatory properties and versatility of nanoparticles used as carriers were consistently reported to augment treatment efficiency nanoscaled materials increase accumulation at the desired site, enhance cell internalization, improve therapeutic outcomes. Thus, numerous studies have exploited potential use vehicles delivering different cargo a promising alternative for treating conditions like cancer, autoimmune diseases, infectious allergic immune disorders. In this context, paper presents solid basis innovations, highlighting their advantages improving strategies, reviewing clinical applications, discussing existing challenges ways overcome them.

Language: Английский

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Research progress of sorafenib drug delivery system in the treatment of hepatocellular carcinoma: An update

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 177, P. 117118 - 117118

Published: July 14, 2024

Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors in contemporary era, representing a significant global health concern. Early HCC patients have mild symptoms or are asymptomatic, which promotes onset and progression disease. Moreover, advanced insensitive to chemotherapy, making traditional clinical treatment unable block cancer development. Sorafenib (SFB) first-line targeted drug for with anti-angiogenesis anti-tumor cell proliferation effects. However, efficacy SFB constrained by its off-target distribution, rapid metabolism, multi-drug resistance. In recent years, nanoparticles based on variety materials been demonstrated enhance targeting therapeutic against HCC. Concurrently, advent joint delivery systems has furnished crucial empirical evidence reversing This review will summarize application nanotechnology field over past five years. It focus research progress combined multiple modalities treatment.

Language: Английский

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Bacterial outer membrane vesicles-clothed nanoparticles delivered by live macrophages for potentiating antitumor photoimmunotherapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 499, P. 156420 - 156420

Published: Oct. 5, 2024

Language: Английский

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Injecting hope: the potential of intratumoral immunotherapy for locally advanced and metastatic cancer

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 9, 2025

Despite enormous progress, advanced cancers are still one of the most serious medical problems in current society. Although various agents and therapeutic strategies with anticancer activity known used, they often fail to achieve satisfactory long-term patient outcomes survival. Recently, immunotherapy has shown success patients by harnessing important interactions between immune system cancer. However, many these therapies lead frequent side effects when administered systemically, prompting treatment modifications or discontinuation or, severe cases, fatalities. New approaches like intratumoral immunotherapy, characterized reduced effects, cost, systemic toxicity, offer promising prospects for future applications clinical oncology. In context locally metastatic cancer, combining diverse immunotherapeutic other targeting multiple cancer hallmarks appears crucial. Such combination hold promise improving survival promoting a sustained response. This review aims provide overview approaches, specifically focusing on administration drugs cancers. It also explores integration modalities maximize Additionally, summarizes recent advances discusses novel outlining directions field.

Language: Английский

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Evaluating the Drug Delivery Capacity of 3D Coordination Polymer for Anticancer Drugs

Chemistry - An Asian Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract We synthesized {[Cd 2 (dTMP) (4,4'‐azpy) (H O) ] ⋅ 3(O)} n a novel three‐dimensional metal nucleotide coordination polymer (CP‐1). An assessment of the CP‐1 binding affinity for anticancer drugs was conducted using molecular dynamic simulations. The virtual screening results depict that has lot potential encapsulating anthracycline drug doxorubicin (DOX). It hasn′t yet been investigated how to accomplish high loading capacity, efficiency, and controlled release DOX in dTMP‐based 3D polymers. Utilizing as model our system drug‐loading vehicle, we used UV‐visible circular dichroism titrations examine effects its encapsulation release. mechanism through pH‐responsive behavior by adjusting pH value 8, 7, 6, 5. indicate robust at which facilitates on porous polymer. However, maximum cumulative 87.11 % observed higher correlation coefficient (R ) obtained 5 with Higuchi equation. indicated released primarily diffusion mechanism. polymer‘s ability encapsulate while also permitting possible controlled‐release is confirmed combined insights from experimental findings, energy graphs, RMSD analysis, radius gyration (Rg) data MD

Language: Английский

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Comprehensive Methodology for Evaluating the Drug Loading of Iron Oxide Nanoparticles Using Combined Magnetometry and Mössbauer Spectroscopy

Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 676 - 676

Published: Feb. 4, 2025

A methodology for the quantitative estimation of drug loading iron oxide-based magnetic nanoparticles by corroborating magnetometry and Mössbauer spectroscopy investigations is reported. The proposed exemplified in case two series nanoparticles, namely Fe3O4 covered with citric acid molecules further functionalized doxorubicin, L-Cysteine doxorubicin. general idea to probe real structure core via low-temperature correct spontaneous magnetization core. It subsequently uses ratio between that reliable nondestructive evaluation nanoparticle organic molecules. Although magnetite-based it can be successfully considered a large class medicine-loaded Fe-containing where 57Fe applied.

Language: Английский

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A comprehensive review on the latest advances of dimeric anticancer prodrugs

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 20, 2025

The advancement of targeted drug delivery systems has opened up a wide array opportunities in cancer therapy, leading to the exploration various strategies. Among these, use prodrugs stands out as particularly promising approach treatment, aimed at enhancing selectivity and effectiveness cytotoxic agents. In last few years, there been considerable progress area dimeric-based therapy. advantages presented by have significantly improved efficiency delivering anticancer drugs, characterized high loading capacity, advantageous pharmacokinetics, release that responds tumor stimuli. With respect importance dimerization field prodrug development, herein we review latest reports covering research dimeric prodrugs. We categorized article according reported also spent great deal attention on different types used linkers methods dissociation into free monomeric drugs. Readers will easily be able compare between using same drugs with or well cell lines studies.

Language: Английский

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Drug Delivery System for Cancer Immunotherapy: Potential Roles, Challenge and Recent Advances

Technology in Cancer Research & Treatment, Journal Year: 2025, Volume and Issue: 24

Published: April 1, 2025

Immunotherapy has emerged as a pivotal advancement in oncological therapeutics, representing paradigm shift from conventional treatment modalities including surgery, radiotherapy, and chemotherapy. This innovative approach demonstrates considerable clinical potential through its capacity to enhance systemic anti-tumor responses via active or passive immunomodulation. Compared traditional therapies, immunotherapy offers distinct advantages such broad applicability, rapid therapeutic onset, reduced adverse effects. However, critical challenges persist implementation, particularly concerning safety efficacy optimization. Current limitations, drug off-target effects biological delivery barriers, frequently result suboptimal outcomes severe complications autoimmune disorders nonspecific inflammation. Recently advancements systems (DDS) present transformative solutions these challenges. Sophisticated DDS platforms enable precise spatiotemporal of tumor antigens, immunotherapeutic agents, immunostimulatory molecules, thereby achieving targeted modulation diverse immune cell populations. technological innovation not only enhances but also significantly mitigates reactions, while facilitating synergistic combinations with cancer treatments. In this review, we outline the application new major malignancies (including limited melanoma, non-small lung cancer, hormone receptor-positive breast hepatocellular carcinoma). We further propose evidence-based optimization strategies for next-generation platforms, aiming bridge gap between preclinical development implementation immunotherapy.

Language: Английский

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Robust anti-tumor immunity through the integration of targeted lipid nanoparticle-based mRNA nanovaccines with PD-1/PD-L1 blockade

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101136 - 101136

Published: June 22, 2024

Tumor mRNA vaccines present a personalized approach in cancer immunotherapy, encoding distinct tumor antigens to evoke robust immune responses and offering the potential against emerging variants. Despite this, clinical advancement of has been hampered by their limited delivery capacity inefficient activation antigen-presenting cells (APCs). Herein, we employed microfluidics technology engineer mannose-modified lipid-based nanovaccines for specifically targeting APCs. The encapsulation process efficiently entrapped cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) agonist along with antigens. targeted (TNVs) exhibited narrow particle size distribution, ensuring consistent efficient delivery. These TNVs significantly enhanced gene expression mRNA, facilitating antigen presentation activation. When compared non-targeted nanovaccines, outperformed terms Furthermore, combination anti-PD-L1 antibodies elicited synergistic anti-tumor effect. This was attributed antibodies' ability overcome suppression cells. Our findings suggest that treatment most memory results indicate integrating checkpoint inhibitors or other immunostimulatory agents may be crucial enhancing response.

Language: Английский

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