Review: Microbial Therapeutics for Liver Disease DOI Open Access
Cyriac Abby Philips, Philip Augustine

JOURNAL OF GASTROINTESTINAL INFECTIONS, Journal Year: 2023, Volume and Issue: 13(01), P. 001 - 016

Published: Jan. 1, 2023

Abstract The human gut contains many microorganisms, including bacteria, fungi, viruses, and archaea. Patients with liver disorders have altered intestinal flora disrupted barriers. role of the microbiota in pathophysiology is apparent from preclinical models clinical studies. High-quality studies showed that people acute or chronic various etiologies, such as non–alcohol- alcohol-related disease, hepatitis virus infection, cholestatic cirrhosis related complications, less diverse associated perturbed microbial functional metabolism. In this review, we discuss unique therapeutic strategies for diseases involve manipulating using methods. We provide a summary most recent information on untargeted methods treating illnesses, probiotics, prebiotics, postbiotics, fecal transplantation, precision microbiome-centered treatments (e.g., engineered microbes). Recent research suggests altering ways might slow onset disease lessen complications. Growing evidence antimicrobial therapy rifaximin can beneficially alter microbiome to reduce hepatic encephalopathy, portal hypertension, systemic inflammation decompensated cirrhosis. At same time, healthy donor stool transplant improves transplant-free survival severe alcohol-associated hepatitis, prevents reduces incident intercurrent infections multidrug resistance

Language: Английский

Glucans and applications in drug delivery DOI

Hewei Lin,

R Han,

Wei Wu

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121904 - 121904

Published: Feb. 2, 2024

Language: Английский

Citations

16
Microbial underdogs: exploring the significance of low-abundance commensals in host-microbe interactions DOI Creative Commons
Geongoo Han, Shipra Vaishnava

Experimental & Molecular Medicine, Journal Year: 2023, Volume and Issue: 55(12), P. 2498 - 2507

Published: Dec. 1, 2023

Our understanding of host-microbe interactions has broadened through numerous studies over the past decades. However, most investigations primarily focus on dominant members within ecosystems while neglecting low-abundance microorganisms. Moreover, laboratory animals usually do not have microorganisms beyond bacteria. The phenotypes observed in animals, including immune system, displayed notable discrepancies when compared to real-world observations due diverse microbial community natural environments. Interestingly, recent unveiled beneficial roles played by Despite their rarity, these keystone taxa play a pivotal role shaping composition and fulfilling specific functions host. Consequently, become imperative unravel true commensalism. In this review, we provide comprehensive overview important findings how commensal microorganisms, bacteria, fungi, archaea, protozoa, interact with host contribute phenotypes, emphasis system. Indeed, vital development host's influence disease status, key communities niches. Understanding microbes is will lead better relationships.

Language: Английский

Citations

20
Harnessing the potential of probiotics in the treatment of alcoholic liver disorders DOI Creative Commons
Garima Mishra, Pradeep Singh, Mulugeta Molla

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 9, 2023

In the current scenario, prolonged consumption of alcohol across globe is upsurging an appreciable number patients with risk alcohol-associated liver diseases. According to recent report, gut-liver axis crucial in progression alcohol-induced diseases, including steatosis, steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Despite several factors associated alcoholic complexity gut microflora its great interaction have become a fascinating area for researchers due high exposure free radicals, bacterial endotoxins, lipopolysaccharides, inflammatory markers, etc. Undoubtedly, microbiota imbalance stimulates dysbiosis, disrupts intestinal barrier function, trigger immune as well responses which further aggravate hepatic injury. Since currently available drugs mitigate disorders significant side effects, hence, probiotics been widely researched alleviate diseases improve health. A broad range probiotic bacteria like Lactobacillus , Bifidobacteria Escherichia coli Sacchromyces Lactococcus are used reduce or halt Several underlying mechanisms, alteration microbiome, modulation function response, reduction level translocation, implicated through can effectively suppress occurrence disorders. This review addresses therapeutic applications treatment Novel insights into mechanisms by prevent also elaborated.

Language: Английский

Citations

15
Fingerprint profiling for quality evaluation and the related biological activity analysis of polysaccharides from Liuweizhiji Gegen-Sangshen beverage DOI Creative Commons

Shulin Wei,

Mingxing Li, Long Zhao

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: July 8, 2024

Introduction Liuweizhiji Gegen-Sangshen beverage (LGS) is popular in China, which has been used for alleviating alcohol-mediated discomfort and preventing alcoholic liver disease (ALD). This consisted of six herbal components that are known as functional foods fruits. LGS rich polysaccharides, however, the activity quality evaluation LGS-derived polysaccharides remain unexplored. The purpose this study thus to establish a comprehensive control methodology assessment (LGSP) further explore anti-oxidant, anti-inflammatory well prebiotic effect LGSP. Methods LGSP was extracted, followed by analysis molecular weight distribution, monosaccharide content structural characterization via integrating application high-performance size exclusion chromatography (HPSEC), 1-phenyl-3-methyl-5-pyrazolone-HPLC (PMP-HPLC), fourier transform infrared spectroscopy (FT-IR) nuclear magnetic resonance (NMR) techniques. anti-oxidation determined DPPH, ABTS, hydroxyl radical scavenging capacity total antioxidant capacity. anti-inflammation were assessed on RAW 264.7 cells. growth Lactobacillus, Bifidobacterium bifidum adolescentis evaluated. Results results demonstrated had two distribution peaks, with average weights (6.569 ± 0.12) × 10 4 Da (4.641 0.30) Da. composed 8 monosaccharides, galacturonic acid, glucose rhamnose galactose representing highest molar ratios. Homogalacturonic acid (HG) type rhamnosegalacturonic glycans I (RG-I) α-1,4-glucan present concentration 17.94 0.28 mg/mL. Furthermore, fingerprint combined composition quantification batches there high similarity among batches. Notably, exhibited anti-oxidant inhibited expressions pro-inflammatory factors (TNF-α IL-6) LPS-stimulated In addition, remarkably promoted proliferation probiotics adolescentis, showing good activity. Discussion would be help gain understanding structure–activity relationship LGSP, provide reference bioactive facilitate development unique health products future.

Language: Английский

Citations

4
Alcohol Drinking Patterns and Laboratory Indices of Health: Does Type of Alcohol Preferred Make a Difference? DOI Open Access
Onni Niemelä, Mauri Aalto,

Aini Bloigu

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(21), P. 4529 - 4529

Published: Oct. 27, 2022

Although excessive alcohol consumption is a highly prevalent public health problem the data on associations between and outcomes in individuals preferring different types of alcoholic beverages has remained unclear. We examined relationships amounts patterns drinking with laboratory indices liver function, lipid status inflammation national population-based survey (FINRISK). Data status, drinking, preferred, body weight, smoking, coffee physical activity were recorded from 22,432 subjects (10,626 men, 11,806 women), age range 25-74 years. The participants divided to subgroups based regular intake (abstainers, moderate heavy drinkers), (binge or regular) type beverage preferred (wine, beer, cider long drink, hard liquor mixed). Regular was found be more typical wine drinkers whereas beer often binge-type cigarette smokers. Alcohol use all forms associated increased frequencies abnormalities markers even at rather low levels consumption. highest rates occurred, however, liquor. These results demonstrate that adverse consequences occur average especially who engage binge those Further emphasis should placed such policies aimed preventing alcohol-induced outcomes.

Language: Английский

Citations

18
Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases DOI Creative Commons

Chenchen Bi,

Wenwen Han, Jingru Yu

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(5), P. e15609 - e15609

Published: April 20, 2023

Liver diseases are a spectrum of that include hepatic steatosis, nonalcoholic fatty liver disease, hepatitis, fibrosis, cirrhosis, and cancer. These not only severely decrease the quality life for patients, but also cause financial burden. Although apigenin (APG) has recently become primary treatment injuries (LIADs), there been no systematic review its use. To existing literature put forward novel strategies future APG research on LIADs. A search was conducted in PubMed, Science Direct, Research Gate, Web Science, VIP, Wanfang, CNKI, 809 articles were obtained. After applying inclusion exclusion criteria, 135 included. is promising treating LIADs via various mechanisms arising from anti-inflammation, anti-proliferation, anti-infection, anti-oxidation, anti-cancer properties. This summarizes evidence supporting use as provides an insight into intestinal microbiota, which may have important implications clinical

Language: Английский

Citations

10
Structural characterization of the polysaccharides from Atractylodes chinensis (DC.) Koidz. and the protective effection against alcohol-induced intestinal injury in rats DOI

Jin Sun,

Yuxin Jiang, Bo Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136641 - 136641

Published: Oct. 18, 2024

Language: Английский

Citations

3
The gastrointestinal mycobiome in inflammation and cancer: unraveling fungal dysbiosis, pathogenesis, and therapeutic potential DOI

Neelakanta Sarvashiva Kiran,

Ankita Chatterjee,

Chandrashekar Yashaswini

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 5, 2025

Language: Английский

Citations

0
Advancements in the Alcohol-Associated Liver Disease Model DOI Creative Commons
Lin Zhu, Hai-Di Li, Jiejie Xu

et al.

Biomolecules, Journal Year: 2022, Volume and Issue: 12(8), P. 1035 - 1035

Published: July 27, 2022

Alcohol-associated liver disease (ALD) is an intricate that results in a broad spectrum of damage. The presentation ALD can include simple steatosis, steatohepatitis, fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC). Effective prevention treatment strategies are urgently required for patients. In previous decades, numerous rodent models were established to investigate the mechanisms alcohol-associated explore therapeutic targets. This review provides summary latest developments models, including those involve EtOH administration, which will help us understand characteristics causes at different stages. addition, we discuss pathogenesis summarize existing vitro models. We analyse pros cons these their translational relevance insights have been gained regarding alcoholic injury.

Language: Английский

Citations

15
Oenothein B ameliorates hepatic injury in alcoholic liver disease mice by improving oxidative stress and inflammation and modulating the gut microbiota DOI Creative Commons
Lu Xu, Wei Li, Shu‐Yi Chen

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 12, 2022

Introduction Alcoholic liver disease (ALD) is a global health problem for which there no current food and drug administration (FDA)-approved therapy. Oenothein B (OEB) macrocyclic dimer ellagic tannin that possesses abundant biological activities including antioxidant, anti-inflammation, antitumor, immunomodulatory, antimicrobial properties. Materials methods In this study, the hepatoprotective effect of OEB against ALD was investigated in vivo vitro . Results We found treatment dramatically reduced alcohol-induced hepatic injury, as evidenced by decreased levels aminotransferases inflammatory biomarkers increased antioxidant capacity OEB-treated groups. Discussion alleviated oxidative stress upregulating Keap1/Nrf2 signaling pathway inhibited inflammation downregulating TLR4/NF-κB pathway. Additionally, positively improved intestinal microbial dysbiosis modulating structure composition gut microbiota. Interestingly, we observed increasement short-chain fatty acid (SCFA) producers ( Muribaculaceae ) decreasement Gram-negative bacteria Akkermansia groups, may contribute to inhibition via gut-liver axis. summary, our findings indicate promising therapeutic strategy preventing treating ALD.

Language: Английский

Citations

14