Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

Cell Host & Microbe, Journal Year: 2019, Volume and Issue: 25(2), P. 219 - 232

Published: Feb. 1, 2019

Language: Английский

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Phage Therapy in the Postantibiotic Era

Clinical Microbiology Reviews, Journal Year: 2019, Volume and Issue: 32(2)

Published: Jan. 15, 2019

Antibiotic resistance is arguably the biggest current threat to global health. An increasing number of infections are becoming harder or almost impossible treat, carrying high morbidity, mortality, and financial cost. The therapeutic use bacteriophages, viruses that infect kill bacteria, well suited be part multidimensional strategies combat antibiotic resistance. Although phage therapy was first implemented a century ago, it brought standstill after successful introduction antibiotics. Now, with rise resistance, experiencing well-deserved rebirth. Among admittedly vast literature recently published on this topic, review aims provide forward-looking perspective its role in modern society. We cover key points crisis then explain biological evolutionary principles support phages, their interaction immune system, comparison therapy. By going through up-to-date reports and, whenever possible, human clinical trials, we examine versatility discuss conventional approaches as novel strategies, including phage-antibiotic combinations, phage-derived enzymes, exploitation mechanisms, bioengineering. Finally, benefits beyond perspective, opportunities for scientific outreach effective education, interdisciplinary collaboration, cultural economic growth, even innovative social media, making case more than just an alternative

Language: Английский

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Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

Viruses, Journal Year: 2018, Volume and Issue: 10(7), P. 351 - 351

Published: June 30, 2018

Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising alternative to conventional antibiotics. Indeed, resistance antibiotics has become major public health problem after decades extensive usage. However, one main questions regarding phage therapy possible rapid emergence phage-resistant bacterial variants, which could impede favourable treatment outcomes. Experimental data shown variants occurred in up 80% studies targeting intestinal milieu and 50% using sepsis models. Phage-resistant have also been observed human studies, described three out four clinical trials recorded resistance. On other hand, recent animal suggest mutations confer phage-resistance may result fitness costs resistant bacterium, which, turn, benefit host. Thus, should not be underestimated efforts made develop methodologies for monitoring preventing it. Moreover, understanding taking advantage resistance-induced pathogens potentially avenue.

Language: Английский

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Interactions between bacterial and phage communities in natural environments

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 20(1), P. 49 - 62

Published: Aug. 9, 2021

Language: Английский

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Current challenges and future opportunities of phage therapy

FEMS Microbiology Reviews, Journal Year: 2020, Volume and Issue: 44(6), P. 684 - 700

Published: May 29, 2020

Antibiotic resistance is a major public health challenge worldwide, whose implications for global might be devastating if novel antibacterial strategies are not quickly developed. As natural predators of bacteria, (bacterio)phages may play an essential role in escaping such dreadful future. The rising problem antibiotic has revived the interest phage therapy and important developments have been achieved over last years. But where do we stand today what can expect from future? This question set to answer this review. Here, scour outcomes human clinical trials case reports, address barriers that way using phages settings. We particularly potential hinder discuss future avenues explore full capacity therapy.

Language: Английский

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Mechanisms and clinical importance of bacteriophage resistance

FEMS Microbiology Reviews, Journal Year: 2021, Volume and Issue: 46(1)

Published: Sept. 15, 2021

Abstract We are in the midst of a golden age uncovering defense systems against bacteriophages. Apart from fundamental interest these systems, and revolutionary applications that have been derived them (e.g. CRISPR-Cas9 restriction endonucleases), it is unknown how contribute to resistance formation bacteriophages clinical settings. Bacteriophages now being reconsidered as therapeutic agents bacterial infections due emergence multidrug resistance. However, bacteriophage through other means could hinder development successful phage-based therapies. Here, we review current state field defense, highlight relevance for potential use suggest new directions research.

Language: Английский

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Food Safety through Natural Antimicrobials

Antibiotics, Journal Year: 2019, Volume and Issue: 8(4), P. 208 - 208

Published: Oct. 31, 2019

Microbial pathogens are the cause of many foodborne diseases after ingestion contaminated food. Several preservation methods have been developed to assure microbial food safety, as well nutritional values and sensory characteristics However, demand for natural antimicrobial agents is increasing due consumers’ concern on health issues. Moreover, use antibiotics leading multidrug resistant microorganisms reinforcing focus researchers industry antimicrobials. Natural compounds from plants, animals, bacteria, viruses, algae mushrooms covered. Finally, new perspectives in field interest innovations reviewed. These approaches should be useful controlling bacterial pathogens; furthermore, shelf-life would extended.

Language: Английский

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Bacteriophages and its applications: an overview

Folia Microbiologica, Journal Year: 2016, Volume and Issue: 62(1), P. 17 - 55

Published: Oct. 8, 2016

Language: Английский

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Fitness Trade-Offs Resulting from Bacteriophage Resistance Potentiate Synergistic Antibacterial Strategies

Infection and Immunity, Journal Year: 2020, Volume and Issue: 88(7)

Published: Feb. 24, 2020

Bacteria that cause life-threatening infections in humans are becoming increasingly difficult to treat. In some instances, this is due intrinsic and acquired antibiotic resistance, indicating new therapeutic approaches needed combat bacterial pathogens. There renewed interest utilizing viruses of bacteria known as bacteriophages (phages) potential antibacterial therapeutics. However, critics suggest similar antibiotics, the development phage-resistant will halt clinical phage therapy.

Language: Английский

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Novel antimicrobial agents for combating antibiotic-resistant bacteria

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 187, P. 114378 - 114378

Published: June 4, 2022

Language: Английский

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