A Review on Plants and Microorganisms Mediated Synthesis of Silver Nanoparticles, Role of Plants Metabolites and Applications

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(2), P. 674 - 674

Published: Jan. 7, 2022

Silver nanoparticles are one of the most extensively studied nanomaterials due to their high stability and low chemical reactivity in comparison other metals. They commonly synthesized using toxic reducing agents which reduce metal ions into uncharged nanoparticles. However, last few decades, several efforts were made develop green synthesis methods avoid use hazardous materials. The natural biomolecules found plants such as proteins/enzymes, amino acids, polysaccharides, alkaloids, alcoholic compounds, vitamins responsible for formation silver is an eco-friendly approach, should be further explored potential different synthesize In present review we describe plants, bacteria, fungi role plant metabolites process. Moreover, also describes some applications aspects antimicrobial, biomedicine, mosquito control, environment wastewater treatment, agricultural, food safety, packaging.

Language: Английский

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Green Synthesis of Gold Nanoparticles Using Plant Extracts as Beneficial Prospect for Cancer Theranostics

Molecules, Journal Year: 2021, Volume and Issue: 26(21), P. 6389 - 6389

Published: Oct. 22, 2021

Gold nanoparticles (AuNPs) have been widely explored and are well-known for their medical applications. Chemical physical synthesis methods a way to make AuNPs. In any case, the hunt other more ecologically friendly cost-effective large-scale technologies, such as environmentally biological processes known green synthesis, has gaining interest by worldwide researchers. The international focus on nanotechnology research resulted in various nanomaterials being used physiologically acceptable Several advantages over conventional chemical (simple, one-step approach synthesize, cost-effectiveness, energy efficiency, biocompatibility) drawn scientists’ attention exploring of AuNPs exploiting plants’ secondary metabolites. Biogenic approaches, mainly plant-based metal nanoparticles, chosen ideal strategy due environmental vivo safety, well ease synthesis. this review, we reviewed use synthesized treatment cancer utilizing phytochemicals found plant extracts. This article reviews producing AuNPs, characterization discusses physiochemical properties. study also recent breakthroughs achievements using different mechanisms action, reactive oxygen species (ROS), mediated mitochondrial dysfunction caspase activation, leading apoptosis, etc., anticancer cytotoxic effects. Understanding underlying therapeutic efficacy will aid developing personalized medicines treatments potential strategy.

Language: Английский

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Green Metallic Nanoparticles: Biosynthesis to Applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2022, Volume and Issue: 10

Published: April 6, 2022

Current advancements in nanotechnology and nanoscience have resulted new nanomaterials, which may pose health environmental risks. Furthermore, several researchers are working to optimize ecologically friendly procedures for creating metal oxide nanoparticles. The primary goal is decrease the adverse effects of synthetic processes, their accompanying chemicals, resulting complexes. Utilizing various biomaterials nanoparticle preparation a beneficial approach green nanotechnology. using biological qualities nature through variety activities an excellent way achieve this goal. Algae, plants, bacteria, fungus been employed make energy-efficient, low-cost, nontoxic metallic nanoparticles last few decades. Despite advantages chemistry-based synthesis over traditional methods as discussed article, there some unresolved issues such particle size shape consistency, reproducibility process, understanding mechanisms involved producing via entities. Consequently, need further research analyze comprehend real synthesis-dependent processes. This currently untapped hot topic that required more investment properly leverage manufacturing living review covers synthesizing utilization scientific world.

Language: Английский

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Green Synthesis of Silver Nanoparticles Using Diospyros malabarica Fruit Extract and Assessments of Their Antimicrobial, Anticancer and Catalytic Reduction of 4-Nitrophenol (4-NP)

Nanomaterials, Journal Year: 2021, Volume and Issue: 11(8), P. 1999 - 1999

Published: Aug. 4, 2021

The green synthesis of silver nanoparticles (AgNPs) has currently been gaining wide applications in the medical field nanomedicine. Green is one most effective procedures for production AgNPs. Diospyros malabarica tree grown throughout India reported to have antioxidant and various therapeutic applications. In context this, we investigated fruit potential forming AgNPs analyzed its antibacterial anticancer activity. We developed a rapid, single-step, cost-effective eco-friendly method using aqueous extract at room temperature. began form just after reaction was initiated. formation characterization were confirmed by UV-Vis spectrophotometry, XRD, FTIR, DLS, Zeta potential, FESEM, EDX, TEM photoluminescence (PL) methods. average size AgNPs, accordance with results, found be 17.4 nm. activity against pathogenic microorganism strains Staphylococcus aureus Escherichia coli well diffusion inhibit growth bacteria an zone inhibition (8.4 ± 0.3 mm 12.1 0.5 mm) (6.1 0.7 13.1 500 1000 µg/mL concentrations respectively. effect MTT assay U87-MG (human primary glioblastoma) cell line. IC50 value 58.63 5.74 μg/mL. results showed that synthesized exhibited significant antimicrobial potency. addition, nitrophenols, which are regarded as priority pollutants United States Environmental Protection Agency (USEPA), can also catalytically reduced less toxic aminophenols utilizing As model reaction, employed catalyst reduction 4-nitrophenol 4-aminophenol, intermediate numerous analgesics antipyretic drugs. Thus, study expected help immensely pharmaceutical industries developing drugs and/or drug, cosmetic food industries.

Language: Английский

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Current Overview of Metal Nanoparticles’ Synthesis, Characterization, and Biomedical Applications, with a Focus on Silver and Gold Nanoparticles

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(10), P. 1410 - 1410

Published: Oct. 4, 2023

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements manufacturing, characterization, biomedical utilization metal NPs, with primary focus on silver gold NPs. Their potential as effective anticancer, anti-inflammatory, antimicrobial agents, drug delivery systems, imaging agents diagnosis treatment variety disorders is reviewed. Moreover, translation therapeutic settings, issue inclusion clinical trials, are assessed light over 30 investigations concentrate administering either or NPs conditions ranging from nosocomial infections different types cancers. paper aims not only examine biocompatibility nanomaterials but also emphasize challenges may limit safe integration into healthcare practices. More than 100 nanomedicines currently market, which justifies ongoing study use medicine. Overall, present review highlight innovative therapeutics field biomedicine, citing some relevant current applications.

Language: Английский

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Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance

Microorganisms, Journal Year: 2022, Volume and Issue: 10(2), P. 303 - 303

Published: Jan. 27, 2022

A biofilm is a community of stable microorganisms encapsulated in an extracellular matrix produced by themselves. Many types that are found on living hosts or the environment can form biofilms. These include pathogenic bacteria serve as reservoir for persistent infections, and culpable leading to broad spectrum chronic illnesses emergence antibiotic resistance making them difficult be treated. The absence biofilm-targeting antibiotics drug discovery pipeline indicates unmet opportunity designing new inhibitors antimicrobial agents using various strategies targeting distinct stages formation. available control formation enzymes proteins specific microorganism those involved adhesion pathways resistant This review primarily focuses recent advances responsible identifying myriad antibiofilm their mechanism inhibition, including polymeric substance synthesis inhibitors, quorum sensing efflux pump cyclic diguanylate inhibitors. Furthermore, we present structure-activity relationships (SAR) these agents, recently discovered nature-derived bioactive scaffolds, synthetic small molecules, peptides, compounds isolated from fungi, non-proteinogenic amino acids antibiotics. We hope fuel interest focus research efforts development uniquely complex, physical chemical heterogeneous biofilms through multipronged approach combinatorial therapeutics more effective management across diseases.

Language: Английский

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Zinc oxide nanoparticles prepared through microbial mediated synthesis for therapeutic applications: a possible alternative for plants

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 5, 2023

Zinc oxide nanoparticles (ZnO-NPs) synthesized through biogenic methods have gained significant attention due to their unique properties and potential applications in various biological fields. Unlike chemical physical approaches that may lead environmental pollution, synthesis offers a greener alternative, minimizing hazardous impacts. During synthesis, metabolites present the biotic sources (like plants microbes) serve as bio-reductants bio-stabilizers. Among sources, microbes emerged promising option for ZnO-NPs numerous advantages, such being environmentally friendly, non-toxic, biodegradable, biocompatible. Various like bacteria, actinomycetes, fungi, yeast can be employed synthesize ZnO-NPs. The occur either intracellularly, within microbial cells, or extracellularly, using proteins, enzymes, other biomolecules secreted by microbes. main key advantage of is manipulating reaction conditions optimize preferred shape size This control over process allows tailoring NPs specific fields, including medicine, agriculture, remediation, more. Some include drug delivery systems, antibacterial agents, bioimaging, biosensors, nano-fertilizers improved crop growth. While green benefits, it essential assess toxicological effects, critical aspect requires thorough investigation ensure safe use applications. Overall, presented review highlights mechanism exploration while emphasizing importance studying effects viable friendly strategy.

Language: Английский

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Bio-inspired Synthesis of Metal and Metal Oxide Nanoparticles: The Key Role of Phytochemicals

Journal of Cluster Science, Journal Year: 2022, Volume and Issue: 34(2), P. 665 - 704

Published: May 20, 2022

Language: Английский

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Amylases: Biofilm Inducer or Biofilm Inhibitor?

Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11

Published: April 27, 2021

Biofilm is a syntrophic association of sessile groups microbial cells that adhere to biotic and abiotic surfaces with the help pili extracellular polymeric substances (EPS). EPSs also prevent penetration antimicrobials/antibiotics into cells. Hence, methods agents avoid or remove biofilms are urgently needed. Enzymes play important roles in removal biofilm natural environments may be promising for this purpose. As major component EPS polysaccharide, amylase has inhibited by preventing adherence cells, thus making suitable antimicrobial agent. On other hand, salivary binds amylase-binding protein plaque-forming Streptococci initiates formation biofilm. This review investigates contradictory actions microbe-associated genes amylases, emphasis on their structural functional characteristics.

Language: Английский

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Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Antibiotics, Journal Year: 2022, Volume and Issue: 11(6), P. 708 - 708

Published: May 25, 2022

Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 100 nanometers appeared recently antibacterial agents, which are also known “nanoantibiotics”. Nanomaterials been shown exert greater effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants restorative matters prevent bacterial harm vaccinations control infections examples nanoparticle applications in biomedical sectors. The unique nanostructures, nanocrystals nanostructured materials, is an exciting step alternative efforts manage microorganisms because these materials provide disrupted effects, including better biocompatibility, opposed minor molecular systems, short-term functions poisonous. Although mechanism action nanoparticles (NPs) unknown, scientific suggestions include oxidative-reductive phenomenon, reactive ionic metals, oxygen species (ROS). Many synchronized gene transformations same cell essential resistance emerge; thus, cells find it difficult build nanoparticles. Therefore, nanomaterials considered advanced solution tools fields science allied health science. current review emphasizes importance various nanosized agents based their size, nature, etc.

Language: Английский

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