Modulatory effect of camel milk on intestinal microbiota of mice with non-alcoholic fatty liver disease DOI Creative Commons
Shiqi Hao, Liang Ming, Yafei Li

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Dec. 1, 2022

Non-alcoholic fatty liver disease (NAFLD) is a common metabolic of life, usually caused by unhealthy diet and lifestyle. Compared to normal individuals, the structure intestinal flora NAFLD patients altered accordingly. This study investigates effect camel milk on regulation in mice with high-fat diet-induced NAFLD. model was established feeding C57BL/6J for 12 weeks, meanwhile (3.0 g/kg/d), cow silymarin (200 mg/kg/d) were administered gavage, respectively. Food intake changes physiological indexes observed recorded. The 16S rRNA gene V3-V4 region sequenced diversity function predicted colon contents from different group. results showed that enhanced glucolipid metabolism downregulate levels blood glucose triglyceride (TG) serum, reduced lipid accumulation level TG improved tissue ( p < 0.05). Meanwhile, had positive modulatory mice, increasing relative abundance beneficial bacteria decreasing harmful similar effect. At genus level, increased Bacteroides , norank_f_ Muribaculaceae Alloprevotella decreased Dubosiella Coriobacteriaceae_UCG-002 Camel also Carbohydrate metabolism, Amino acid Energy Metabolism cofactors vitamins Lipid thus reducing degree hepatic maintaining liver. In conclusion, can improve enhance substance energy which has alleviating improving flora.

Language: Английский

Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role of Antioxidant Flavonoids DOI Creative Commons
Un Ju Jung

Antioxidants, Journal Year: 2023, Volume and Issue: 12(5), P. 1063 - 1063

Published: May 8, 2023

Sarcopenic obesity, which refers to concurrent sarcopenia and is characterized by decreased muscle mass, strength, performance along with abnormally excessive fat mass. obesity has received considerable attention as a major health threat in older people. However, it recently become problem the general population. risk factor for metabolic syndrome other complications such osteoarthritis, osteoporosis, liver disease, lung renal mental disease functional disability. The pathogenesis of sarcopenic multifactorial complicated, caused insulin resistance, inflammation, hormonal changes, physical activity, poor diet aging. Oxidative stress core mechanism underlying obesity. Some evidence indicates protective role antioxidant flavonoids although precise mechanisms remain unclear. This review summarizes characteristics pathophysiology focuses on oxidative potential benefits have also been discussed.

Language: Английский

Citations

16
In vitro digestive and fermentation characterization of Polygonatum cyrtonema polysaccharide and its effects on human gut microbiota DOI Creative Commons
Wendi Chen,

Meiqi Dong,

Lijuan Wang

et al.

LWT, Journal Year: 2024, Volume and Issue: 203, P. 116346 - 116346

Published: June 14, 2024

Polygonatum cyrtonema polysaccharide (PCP) was subjected to simulated gastrointestinal digestion, followed by in vitro fermentation using human gut microbiota organisms. The results indicated that PCP did not degrade under salivary conditions; however, a certain increase reducing sugars and monosaccharides, slight reduction the molecular weight of tract were observed, suggesting partial degradation PCP. During fermentation, large proportion degraded fecal samples from both healthy obese people. utilization resulted generation abundant short-chain fatty acids (SCFAs), leading environmental pH stimulation proliferation beneficial bacteria, such as Collinsella Dialister, while impeding growth detrimental bacteria like Flavonifractor. individuals exhibited greater efficiency utilizing compared individuals. PICRUSt prediction analysis regulation mainly linked carbohydrate, amino acid, energy, lipid metabolic pathways. These suggested may promote host health modulating exhibiting potential prebiotic properties.

Language: Английский

Citations

5
Pharmacokinetic, Metabolism, and Metabolomic Strategies Provide Deep Insight Into the Underlying Mechanism of Ginkgo biloba Flavonoids in the Treatment of Cardiovascular Disease DOI Creative Commons
Yi Tao,

Fei Zhu,

Meiling Pan

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: March 23, 2022

, known as the "living fossil," has a long history of being used botanical drug for treating cardiovascular diseases and content flavonoids high 24%. More than 110 different kinds their derivatives have been separated from

Language: Английский

Citations

22
Gut microbiota mediates ambient PM2.5 exposure-induced abnormal glucose metabolism via short-chain fatty acids DOI Creative Commons

Wenpu Shao,

Bin Pan, Zhouzhou Li

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 135096 - 135096

Published: July 2, 2024

PM

Language: Английский

Citations

4
Chrysanthemum extract mitigates high-fat diet-induced inflammation, intestinal barrier damage and gut microbiota disorder DOI
Yu-Hai Yuan, Yu Zhang, Chun‐Li Hu

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

An effective intervention for obesity without side effects is needed.

Language: Английский

Citations

0
Effects of N-Carbamylglutamate supplementation on cecal morphology, microbiota composition, and short-chain fatty acids contents of broiler breeder roosters DOI Creative Commons
Na Liu, Zhe Zhang,

Jiehui Zhang

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

The objective of this study was to assess the effects N-Carbamylglutamate (NCG) supplementation on cecal morphology, microbiota composition, and short-chain fatty acids (SCFAs) contents in broiler breeder roosters. A total 72 11-week-old Zhuanghe Dagu roosters with a similar initial body weight (1.53 ± 0.06 kg) were randomly allocated into two groups. Each group had 3 replicates 12 birds per replicate. experimental period lasted 42 days. All underwent same production practices, except for dietary conditions. It found that an increase muscularis thickness villi epithelium thickness. NCG have regulatory composition microbiota. Additionally, observed content butyric acid cecum fed NCG-containing control diet compared those basal diet. Spearman correlation analysis showed variation closely related as well improvement cecum. positively correlated In conclusion, findings indicate can influence production.

Language: Английский

Citations

0
Research Progress on Hypoglycemic Effects and Molecular Mechanisms of Flavonoids: A Review DOI Creative Commons
Mengyi Liu, Chunlong Liu,

Puba Zhaxi

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 378 - 378

Published: March 22, 2025

As a prevalent metabolic disorder, the increasing incidence of diabetes imposes significant burden on global healthcare. Flavonoids in natural phytochemical products exhibit notable hypoglycemic properties, making them potential alternatives for treatment. This article summarizes properties flavonoid subcategories studied recent years, including flavones, isoflavones, flavonols, flavanols, and others. The relevant targets signal pathways, such as α-amylase, α-glucosidase, insulin receptor substrate (IRS)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT), PKR-like endoplasmic reticulum (PERK)/eukaryotic initiation factor 2α (eIF2α)/activation transcription 4 (ATF4)/C/EBP homologous protein (CHOP), etc., are also elaborated. Additionally, flavonoids have been demonstrated to modulate gut microbiota its metabolites. Through aforementioned mechanisms, mainly suppress carbohydrate metabolism gluconeogenesis; facilitate glucose uptake, glycogenesis, secretion; mitigate resistance, oxidative stress, inflammation, etc. Notably, several studies indicated that certain displayed synergistic effects. In conclusion, this provides comprehensive review effects investigated aiming offer theoretical insights their further exploration.

Language: Английский

Citations

0
Advances in Leaf Plant Bioactive Compounds: Modulation of Chronic Inflammation Related to Obesity DOI Open Access
Jorge Gomes Lopes Barros, Ana S. Abraão, Irene Gouvinhas

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3358 - 3358

Published: April 3, 2025

Over the years, there has been a tendency for an increase in global obesity. The World Health Organization's (WHO) 2024 report states that 2019, more than one billion people were obese, and this condition was responsible five million deaths, being obesity is prevalent among adults compared to adolescents children. Obesity chronic disease characterized by alterations adipose tissue. When excessive food consumed energy expenditure low, tissue undergoes hypertrophy hyperplasia. This process activates B cells induces transition of anti-inflammatory M2-like macrophages into pro-inflammatory M1-like macrophages. cells, acting as inflammatory mediators, stimulate CD8+ T promote macrophage infiltration tissues. triggers inflammation, increases oxidative stress, ultimately leads cellular death. During cytokines occurs along with decrease cytokines. By contrast, stress related reactive oxygen species (ROS), oxidation biomolecules, antioxidants. mechanism can be mitigated through several healthy lifestyle changes, primarily including regular physical activity eating. These factors help reduce mediators ROS, lowering inflammation stress. Therefore, review article focuses on studying bioactive compounds present edible leaves Annona cherimola Mill., Ipomoea batata (L.) Poir., Colocasia esculenta Schott, Eriobotrya japonica, Cymbopogon citratus, Psidium guajava (L.), Smallanthus sonchifolius evaluate their effects mechanisms involved

Language: Английский

Citations

0
Apigenin-loaded nanoparticles for obesity intervention through immunomodulation and adipocyte browning DOI
Neda Mohaghegh,

A. Iyer,

Ethan Wang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113670 - 113670

Published: April 1, 2025

Language: Английский

Citations

0
The Obesity–Epigenetics–Microbiome Axis: Strategies for Therapeutic Intervention DOI Open Access
Shabnam Nohesara, Hamid M. Abdolmaleky,

Ahmad Pirani

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1564 - 1564

Published: May 1, 2025

Obesity (OB) has become a serious health issue owing to its ever-increasing prevalence over the past few decades due contribution severe metabolic and inflammatory disorders such as cardiovascular disease, type 2 diabetes, cancer. The unbalanced energy metabolism in OB is associated with substantial epigenetic changes mediated by gut microbiome (GM) structure composition alterations. Remarkably, experimental evidence also indicates that OB-induced modifications adipocytes can lead cellular “memory” alterations, predisposing individuals weight regain after caloric restriction subsequently inducing pathways liver. Various environmental factors, especially diet, play key roles progression or prevention of OB-related modulating GM affecting mechanisms. Here, we will first focus on role aberrations development OB. Then, discuss association between abnormal alterations interplays epigenome Finally, review promising strategies, including prebiotics, probiotics, methyl-rich polyphenols, herbal foods for and/or treatment via their metabolites influencing epigenome.

Language: Английский

Citations

0