Flavonols and Flavones as Potential anti-Inflammatory, Antioxidant, and Antibacterial Compounds

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 21

Published: Sept. 6, 2022

Plant preparations have been used to treat various diseases and discussed for centuries. Research has advanced discover identify the plant components with beneficial effects reveal their underlying mechanisms. Flavonoids are phytoconstituents anti-inflammatory, antimutagenic, anticarcinogenic, antimicrobial properties. Herein, we listed contextualized aspects of protective flavonols quercetin, isoquercetin, kaempferol, myricetin flavones luteolin, apigenin, 3',4'-dihydroxyflavone, baicalein, scutellarein, lucenin-2, vicenin-2, diosmetin, nobiletin, tangeretin, 5-O-methyl-scutellarein. We presented structural characteristics subclasses, importance, occurrence, food sources. The bioactive compounds present in our diet, such as fruits vegetables, may affect health disease state. Therefore, role these inflammation, oxidative mechanisms, bacterial metabolism; moreover, synergism antibiotics better outcomes. Indiscriminate use allows emergence multidrug-resistant strains; thus, be adjuvant treatment infectious caused by resistant opportunistic bacteria via direct indirect also focused on reported mechanisms intracellular targets flavones, which support therapeutic inflammatory diseases.

Language: Английский

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The protection of luteolin against diabetic cardiomyopathy in rats is related to reversing JNK-suppressed autophagy

Food & Function, Journal Year: 2023, Volume and Issue: 14(6), P. 2740 - 2749

Published: Jan. 1, 2023

Luteolin improves cardiac function and myocardial remodeling with down-regulation of JNK/c-Jun/miR-221 pathway-inhibited autophagy in the diabetic heart, suggesting that luteolin's inhibition DCM is associated reversing JNK-suppressed autophagy.

Language: Английский

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Medicinal Plant Extracts against Cardiometabolic Risk Factors Associated with Obesity: Molecular Mechanisms and Therapeutic Targets

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 967 - 967

Published: July 21, 2024

Obesity has increasingly become a worldwide epidemic, as demonstrated by epidemiological and clinical studies. may lead to the development of broad spectrum cardiovascular diseases (CVDs), such coronary heart disease, hypertension, failure, cerebrovascular atrial fibrillation, ventricular arrhythmias, sudden cardiac death. In addition there are other cardiometabolic risk factors (CRFs) visceral adiposity, dyslipidemia, insulin resistance, diabetes, elevated levels fibrinogen C-reactive protein, others, all which increase CVD events. The mechanisms involved between obesity mainly include oxidative stress, inflammation, adipokine dysregulation, cause maladaptive structural functional alterations heart, particularly left-ventricular remodeling diastolic dysfunction. Natural products plants provide diversity nutrients different bioactive compounds, including phenolics, flavonoids, terpenoids, carotenoids, anthocyanins, vitamins, minerals, fibers, possess wide range biological activities antihypertensive, antilipidemic, antidiabetic, activities, thus conferring benefits. this review, we discuss main therapeutic interventions using extracts from herbs in preclinical trials with protective properties targeting CRFs. Molecular targets herb plant for prevention treatment CRFs also reviewed.

Language: Английский

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The Mechanistic Perspective of Bilobetin Protective Effects against Cisplatin-Induced Testicular Toxicity: Role of Nrf-2/Keap-1 Signaling, Inflammation, and Apoptosis

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1134 - 1134

Published: May 13, 2022

Cisplatin (CP) is a productive anti-tumor used to treat numerous tumors. However, multiple toxicities discourage prolonged use, especially toxicity on the reproductive system. This experiment was mapped out determine potential therapeutic impact of Bilobetin CP-induced testicular damage. Herein, isolated from Cycas thouarsii leaves R. Br ethyl acetate fractions for first time. A single dose CP (7 mg/kg, IP) evoke third day. Rats were classified into five groups; Normal control, 12 Untreated CP, and treated with (6 respectively) orally daily ten days. treatment ameliorated injury. In addition, it boosted serum testosterone levels considerably restored relative weight. Nevertheless, apoptosis biomarkers such as P53, Cytochrome-C, caspase-3 decreased significantly. Additionally, enhanced testes’ antioxidant status via activation Nrf-2, inhibition Keap-1, significant elevation SOD activity in addition reduction lipid peroxidation. Histopathologically, preserved architecture improved immunostaining Ki67 substantially, showing evidence regeneration. Bilobetin’s beneficial effects damage are associated effects, lowered apoptotic signals, restoration regenerative capability. may be combination protocols mitigate

Language: Английский

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Ginkgo biloba extract protects against depression-like behavior in mice through regulating gut microbial bile acid metabolism

Chinese Journal of Natural Medicines, Journal Year: 2023, Volume and Issue: 21(10), P. 745 - 758

Published: Oct. 1, 2023

Language: Английский

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The efficacy and safety of Ginkgo biloba L. leaves extract combined with ACEI/ARB on diabetic kidney disease: a systematic review and meta-analysis of 41 randomized controlled trials

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

Diabetic kidney disease (DKD) has become the leading cause of end-stage renal in world. However, current conventional approaches have not yet achieved satisfactory efficacy. As one most influential products botanical medicine, Ginkgo biloba L. leaves extract (GBE) demonstrates various pharmacological effects on DKD and is gradually used as an adjunctive therapy for this disease. A comprehensive analysis necessary to evaluate efficacy safety GBE adjuvant treatment DKD. This meta-analysis aimed a supplementary renin-angiotensin-aldosterone system inhibitors patients, providing reference subsequent research clinical practice. study been registered PROSPERO CRD42023455792. Ten databases were searched from their inception 21 July 2023. Randomized controlled trials about included. Review Manager 5.4 Stata 16.0 employed conduct analysis. Heterogeneity was assessed through χ2 test I2 test, effect model chosen accordingly. Meta-regression subgroup performed investigate sources heterogeneity influence different factor levels The publication bias evaluated with funnel plot Egger's evidence quality by Grading Recommendations Assessment, Development Evaluation (GRADE) method. total 41 studies 3,269 patients finally enrolled study. None included reported whether or cardiovascular progression events occurred. Compared angiotensin-converting enzyme inhibitor (ACEI)/angiotensin II receptor blocker (ARB) alone, combination more beneficial improving urinary albumin excretion rate (UAER) [mean difference (MD) = -22.99 μg/min, 95% confidence interval (CI): -27.66 -18.31, p < 0.01], serum creatinine (SCr) [MD -8.30 μmol/L, CI: -11.55 -5.05, blood urea nitrogen (BUN) -0.77 mmol/L, -1.04 -0.49, 24-hour protein (24hUTP) -0.28 g/d, -0.35 -0.22, cystatin C (Cys-C) -0.30 mg/L, -0.43 -0.17, cholesterol (TC) -0.69 -1.01 -0.38, triglyceride (TG) -0.40 -0.56 -0.23, low-density lipoprotein (LDL-C) -0.97 -1.28 -0.65, fasting glucose (FBG) -0.54 -0.05, 0.02], hematocrit -4.58%, -5.25 -3.90, 0.01] fibrinogen -0.80 g/L, -1.12 -0.47, 0.01]. No significant improvement found 2-hour postprandial (2hPG), glycated hemoglobin (HbA1c), diastolic pressure (DBP) systolic (SBP). detected adverse events. Combining ACEI/ARB may improve UAER, SCr, BUN, 24hUTP, Cys-C, TC, TG, LDL-C, patients. It also seems oxidative stress inflammation but minimal impact pressure. Combined generally tolerated, monitoring remains essential during its use. More long-term high-quality in-depth molecular are still provide stronger regarding benefits https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=455792, identifier

Language: Английский

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Development and application of a Ginkgo biloba L. callus-derived protoplast transient expression system for exploring the roles of GbMYB11 and GbbHLH3 in flavonoid metabolism

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 226, P. 120716 - 120716

Published: Feb. 20, 2025

Language: Английский

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Pharmacological and Therapeutic Innovation to Mitigate Radiation-Induced Cognitive Decline (RICD) in Brain Tumor Patients

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217700 - 217700

Published: April 1, 2025

Language: Английский

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Molecular docking screening, dynamics simulations, ADMET, and semi-synthesis prediction of flavones and flavonols from the COCONUT database as potent bifunctional neuraminidase inhibitors

Pharmacia, Journal Year: 2024, Volume and Issue: 71, P. 1 - 10

Published: Jan. 3, 2024

Finding new neuraminidase (N) inhibitors to improve anti-influenza treatment is necessary because of the high mutation rates N protein. Over 3,000 flavones/flavonols and their synthesized products from COCONUT database were performed in silico docking screening with N1-H274Y-oseltamivir protein (PDB ID: 3CL0). Several derivatives containing nitrogen heterocyclic groups or aromatic rings showed higher anti-neuraminidase potential than that laninamivir. Especially, linker between flavone aglycone group created interactions triad arginine residues Arg118-Arg292-Arg371, which suggested these compounds could become bifunctional against influenza virus strains at sialic acid binding site adjacent 430-cavity position through binding. ADMET indicators synthesis design strategy most suitable compound, ethyl 4-{2-[(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy]acetyl}piperazine-1-carboxylate, also successfully predicted it be a concerned candidate for further wet-lab synthesis, vivo clinical study.

Language: Английский

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Medicinal Plant Extracts Against Cardiometabolic Risk Factors Associated with Obesity: Molecular Mechanisms and Therapeutic Targets

Published: July 2, 2024

Obesity has increasingly become a worldwide epidemic, as demonstrated by epidemiological and clinical studies. may lead to development of broad spectrum cardiovascular diseases (CVDs), such coronary heart disease (CHD), hypertension, failure (HF), cerebrovascular disease, atrial fibrillation (AF), ventricular arrhythmias, sudden cardiac death (SCD). In addition there are other cardiometabolic risk factors (CRFs) visceral adiposity, dyslipidemia, insulin resistance, diabetes, elevated levels fibrinogen, C-reactive protein others, all which increase the CVD events. Mechanisms involved between obesity mainly include oxidative stress, inflammation, adipokines dysregulation, cause maladaptive structural functional alterations heart, particularly left (LV) remodeling diastolic dysfunction. Natural products plants, provide diversity nutrients different bioactive compounds, including phenolics, flavonoids, terpenoids, carotenoids, anthocyanins, vitamins, minerals, fibers, possess wide range biological activities antihypertensive, antilipidemic, antidiabetic, activities, thus conferring benefits. this review, we discussed main therapeutic interventions using extracts from herbs plants in preclinical trials with protective properties targeting CRFs. Molecular mechanisms targets for prevention treatment CRFs also reviewed.

Language: Английский

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