Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7042 - 7042
Published: June 27, 2024
Respiratory viruses constitute a significant cause of illness and death worldwide. virus-associated injuries include oxidative stress, ferroptosis, inflammation, pyroptosis, apoptosis, fibrosis, autoimmunity, vascular injury. Several studies have demonstrated the involvement nuclear factor erythroid 2-related 2 (Nrf2) in pathophysiology viral infection associated complications. It has thus emerged as pivotal player cellular defense mechanisms against such damage. Here, we discuss impact Nrf2 activation on airway induced by respiratory viruses, including coronaviruses, rhinoviruses, syncytial viruses. The inhibition or deregulation pathway induces tissue damage presence infections. In contrast, demonstrates protection organ injuries. Clinical trials involving agonists are needed to define effect therapeutics tissues organs damaged
Language: Английский
Citations
4
Pathogens, Journal Year: 2023, Volume and Issue: 13(1), P. 39 - 39
Published: Dec. 31, 2023
In humans, acute and chronic respiratory infections caused by viruses are associated with considerable morbidity mortality. Respiratory infect airway epithelial cells induce oxidative stress, yet the exact pathogenesis remains unclear. Oxidative stress activates transcription factor NRF2, which plays a key role in alleviating redox-induced cellular injury. The transcriptional activation of NRF2 has been reported to affect both viral replication inflammation pathways. There is complex bidirectional crosstalk between virus pathway because directly or indirectly regulates expression, can reversely hamper spread across tissues. this review, we discuss regulation main viruses, including coronaviruses, influenza syncytial (RSV), rhinoviruses. We also summarize scientific evidence regarding effects known agonists that be utilized alter pathway.
Language: Английский
Citations
9
Published: March 4, 2024
Abstract: The potential advantages of plant-based interventions in decreasing the incidence and lessening severity mortality COVID-19 are yet to be widely acknowledged. Nevertheless, recent investigations propose that these could effective. Our publication (part one) features an interventional study which we incorporated foods provided supplementation 3470 elderly patients with multiple comorbidities. We pay close attention precise selection food items, application appropriate processing methods, provision nourishing meals our patients. outcome was highly successful as achieved a zero rate, none experienced worsening conditions or required hospitalization. This second paper presents theoretical framework on mechanisms through supplement can mitigate disease mortality. However, only very recently have experts validated hypotheses. measures methods used address ongoing SARS-CoV-2 pandemic supplements effective may help prevent manage future pandemics.
Language: Английский
Citations
3
ACS Omega, Journal Year: 2024, Volume and Issue: 9(13), P. 15535 - 15546
Published: March 22, 2024
Genome-scale metabolic models (GEMs) are promising computational tools that contribute to elucidating host-virus interactions at the system level and developing therapeutic strategies against viral infection. In this study, effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on liver metabolism was investigated using integrated GEMs human hepatocytes SARS-CoV-2. They were generated for uninfected infected transcriptome data. Reporter metabolite analysis resulted in significant transcriptional changes around several metabolites involved xenobiotics, drugs, arachidonic acid, leukotriene metabolisms due SARS-CoV-2 Flux balance minimization adjustment approaches unraveled possible virus-induced hepatocellular reprogramming fatty glycerophospholipid, sphingolipid cholesterol, folate metabolisms, bile acid biosynthesis, carnitine shuttle among others. Reaction knockout provided critical reactions glycolysis, oxidative phosphorylation, purine metabolism, reactive oxygen species detoxification subsystems. Computational also showed administration dopamine, glucosamine, D-xylose, cysteine, (
Language: Английский
Citations
3
Acta Tropica, Journal Year: 2024, Volume and Issue: 255, P. 107201 - 107201
Published: April 9, 2024
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8715 - 8715
Published: Aug. 9, 2024
In 2024, over 775 million cases of COVID-19 were recorded, including approximately 7 deaths, indicating its widespread and dangerous nature. The disease is caused by the SARS-CoV-2 virus, which can manifest a wide spectrum symptoms, from mild infection to respiratory failure even death. Neurological such as headaches, confusion, impaired consciousness, have also been reported in some patients. These observations suggest potential invade central nervous system induce neuroinflammation during infection. This review specifically explores relationship between selected neurological diseases multiple sclerosis (MS), ischemic stroke (IS), Alzheimer's (AD). It has observed that virus increases production cytokines whose action cause destruction myelin sheaths nerve cells. Subsequently, body may synthesize autoantibodies attack cells, resulting damage brain's anatomical elements, potentially contributing onset sclerosis. Additionally, exacerbates inflammation, worsening clinical condition individuals already suffering MS. Moreover, secretion pro-inflammatory lead an escalation blood clot formation, result thrombosis, obstructing flow brain precipitating stroke. AD characterized intense inflammation heightened oxidative stress, both are exacerbated demonstrates enhanced cell entry presence ACE2 receptor, elevated ApoE ε4 allele. Consequently, worsens progresses more rapidly, increasing mortality rate among above information underscores numerous connections diseases.
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11267 - 11267
Published: Oct. 19, 2024
Discovered in late 2019, the SARS-CoV-2 coronavirus has caused largest pandemic of 21st century, claiming more than seven million lives. In most cases, COVID-19 disease by virus is relatively mild and affects only upper respiratory tract; it often manifests itself with fever, chills, cough, sore throat, but also less-common symptoms. patients do not require hospitalization, fully recover. However, some infection leads to development a severe form COVID-19, which characterized life-threatening complications affecting lungs, other organs systems. particular, various forms thrombotic are common among COVID-19. The mechanisms for remain unclear. Accumulated data indicate that pathogenesis based on disruptions functioning innate immune key role primary response viral assigned two These pattern recognition receptors, primarily members toll-like receptor (TLR) family, complement system. Both systems first engage fight against launch whole range aimed at its rapid elimination. Normally, their joint activity destruction pathogen recovery. these can cause an excessive inflammatory dangerous body. turn, inflammation entails activation damage vascular endothelium, as well hypercoagulable state observed seriously ill Activation endothelium hypercoagulation lead thrombosis and, result, tissues. Immune-mediated termed "immunothrombosis". this review, we discuss detail features immunothrombosis associated potential underlying mechanisms.
Language: Английский
Citations
3
Microorganisms, Journal Year: 2024, Volume and Issue: 12(12), P. 2526 - 2526
Published: Dec. 7, 2024
Viral respiratory infections (VRIs) are a leading cause of morbidity and mortality worldwide, making them significant public health concern. During infection, viruses, including Influenza virus, SARS-CoV-2, syncytial virus (RSV), trigger an antiviral immune response, specifically boosting the inflammatory response that plays critical role in their pathogenesis. The induced by viruses can be double-edged sword since it initially to protective/reparative from virus-induced injuries. Still, also detrimental host cells tissues. However, mechanisms differentiate complex crosstalk between favorable responses harmful poorly understood. This review explores interplay viral pathogens mainly focusing on inflammation pathogenesis VRIs. We discuss how both contain exacerbate progression infections, highlighting potential therapeutic targets emerging drugs for modulating aberrant during
Language: Английский
Citations
3
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 22, 2025
Abstract Hydrogen sulfide (H 2 S) is an endogenous gasotransmitter with cardioprotective and antiviral effects. In this work, new cysteine-selective nucleoside-H S-donor hybrid molecules were prepared by conjugating nucleoside biomolecules a thiol-activatable dithioacetyl group. 5′-Dithioacetate derivatives synthesized from the canonical nucleosides (uridine, adenosine, cytidine, guanosine thymidine), putative 5′-thio metabolites also produced uridine adenosine. According to our measurements made H S-specific sensor, dithioacetates are moderately fast S donors, derivative showed fastest kinetics adenosine slowest. The antioxidant activity of 5′-thionucleosides significantly higher than that trolox, but lower ascorbic acid, while intact have no remarkable effect. human Calu cells, moderate anti-SARS-CoV-2 effect which was confirmed virus yield reduction assay. Dithioacetyl-adenosine its metabolite similar acute cardiac effects as however, it noteworthy both modified adenosines increased left ventricular ejection fraction or stroke volume, not observed native
Language: Английский
Citations
0
Journal of Virology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 28, 2025
ABSTRACT Porcine reproductive and respiratory syndrome virus (PRRSV) infections often trigger oxidative stress cytokine storms, resulting in significant tissue damage that causes fatalities piglets issues sows. However, it is still unknown how regulated by viral host factors response to PRRSV infection. Here, we found induced cellular triggering the production of reactive oxygen species inhibiting expression antioxidant enzymes. Although Nrf2 an important redox regulator initiates downstream genes, can impair Nrf2/HO-1 pathway. The overexpression showed a anti-PRRSV effect, promoted proliferation PRRSV. Further analysis positively type I interferons interferon-stimulated which may contribute its effect. By screening PRRSV-encoded protein, nsp5 protein degrade at level. Mechanistically, promotes Nrf2-Keap1 binding affinity p62-mediated Keap1 sequestration increasing expression. Subsequently, this increased Keap1-mediated degradation ubiquitination through K48-linked polyubiquitin. Furthermore, residues Tyr146 Arg147 are crucial for activation Thus, our findings uncover novel mechanism disrupts defense system highlight role pathway against IMPORTANCE Oxidative stress-induced imbalance pathogenic infections. genes serve as main pathways stress. context porcine infection remains unclear. In study, demonstrated decreased signaling triggered strong enhanced Keap1-dependent ubiquitination, thereby weakening resistance antagonizing antiviral activity Nrf2. Our study further revealed new evades innate immunity disturbing homeostasis, providing target developing drugs.
Language: Английский
Citations
0