Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 562 - 562

Published: Jan. 31, 2025

Akkermansia muciniphila is a bacterium commonly found in the human gastrointestinal tract that has received considerable interest as potential probiotic for improvement of gut health and overall metabolic function. A. enriched mucus layer intestinal lining, where it degrades mucin plays significant role barrier maintenance immune regulation. A higher abundance been observed healthy individuals relative to those with disorders, multiple benefits, including improved glucose management, reduced body fat, inflammation have linked muciniphila. Current research on primarily relies mouse models, limited interventional studies available. While these animal offer valuable insights into roles disease, further clinical investigations humans are needed fully understand its impact. Here, we explore current scope therapeutic agent improve while also emphasizing need optimize techniques this organism.

Language: Английский

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TGR5 Activation by Dietary Bioactives and Related Improvement in Mitochondrial Function for Alleviating Diabetes and Associated Complications

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Takeda G protein-coupled receptor 5 (TGR5), also known as bile acid 1 (GPBAR1), is a cell surface involved in key physiological processes, including glucose homeostasis and energy metabolism. Recent research has focused on the role of TGR5 activation preventing or treating diabetes while highlighting its potential impact progression diabetic complications. Functional foods edible plants have emerged valuable sources natural compounds that can activate TGR5, offering therapeutic benefits for management. Despite growing interest, studies by dietary bioactive remain scattered. This Review aims to provide comprehensive analysis how bioactives act agents managing It explores mechanisms through both direct agonistic effects indirect pathways via modulation gut microbiota

Language: Английский

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Bibliometric analysis of research trends and prospective directions of Akkermansia muciniphila from 2010 to 2024

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Akkermansia muciniphila (A. muciniphila) is an emerging probiotic with potential impact on human health, and there a growing interest in this area, but overall analysis of research trends lacking. This study conducted detailed bibliometric visualization A. to examine the current status, hotspots, trends, aiming inform future directions. utilized Web Science database search from 2010 2024. Bibliometric was using CiteSpace VOSviewer software generate yearly publication contributions by countries, institutions, distinguished researchers, as well key themes influential researches. aimed visualize explore literature over past 15 years, guiding researches identifying gaps field intestinal flora muciniphila. We searched total 4,423 related publications. Wei Chen, Willem de Vos Patrice D. Cani are primary contributors 's research. The top contributing countries institutions China, United States, South Korea, Spain, Italy, centers such Chinese Academy Sciences, Zhejiang University, University Copenhagen, Helsinki being main contributors. Current hotspots focus molecular biology muciniphila, its role barrier maintenance, immune response, for regulating treating digestive metabolic diseases, cancer, fatty liver disease, inflammatory bowel etc., through bile acid metabolism, extracellular vesicles, insulin resistance. Our synthesizes various disease areas suggests enhancing collaboration among authors advance muciniphila-related clinical basic research, efficacy variety diseases effects commonly used medications fill field, provide valid evidence development novel supplement.

Language: Английский

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The Role of Beneficial Microbiota in COVID-19: Insights from Key Bacterial Genera

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1029 - 1029

Published: April 29, 2025

The COVID-19 pandemic has highlighted the need for a comprehensive understanding of factors influencing disease severity and progression. Emerging research indicates that human microbiota, particularly beneficial bacteria, significantly impacts immune responses health outcomes in patients. While existing studies provide general insights into relationship between microbiota probiotics with COVID-19, they often lack detailed exploration how specific bacterial taxa might be used as adjunctive treatments. This review aims to address this gap by focusing on ten key genera discussing their roles evaluating potential prevention treatment. covers impact these microbes health, population alterations patients, interactions other viral infections. Among microbes, several exhibit distinct patterns abundance highlighting infection dynamics. In populations Akkermansia, Ruminococcus, Roseburia are consistently reduced, while those Faecalibacterium show significant decline more severe cases. Bacteroides presents varying effects depending species involved. Alterations Blautia Lachnospiraceae associated increased inflammation severity. Likewise, depletion Lachnospira Coprococcus populations, both linked anti-inflammatory effects, may exacerbate symptom Oscillospira, though less studied, is connected overall could have implications synthesizes current highlight importance maintaining healthy alleviate contribute development novel therapeutic strategies involving modulation.

Language: Английский

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Short- and Long-Term Effects of Different Antibiotics on the Gut Microbiota and Cytokines Level in Mice

Infection and Drug Resistance, Journal Year: 2022, Volume and Issue: Volume 15, P. 6785 - 6797

Published: Nov. 1, 2022

Antibiotics are the first line of treatment for infectious diseases. However, their overuse can increase spread drug-resistant bacteria. The present study analyzed impact different types antibiotics on gut microbiome and cytokines level mice.A total five groups 8-week-old male BALB/c mice (n = 35) were treated with piperacillin-tazobactam (TZP), ceftriaxone (CRO), tigecycline (TGC), levofloxacin (LEV) or normal saline (Ctrl), respectively, up to 4 weeks. Fecal samples by bacterial 16S rRNA gene sequencing identification. Blood used determination 23 serum using multiplex immunoassay.Exposure was shown affect weight gain mice. Significant changes in composition caused TZP, CRO TGC included decreased abundance Bacteroidetes (p < 0.01), Muribaculaceae 0.01) Lachnospiraceae increased Proteobacteria 0.05), Enterobacteriaceae (including Klebsiella Enterobacter) Enterococcaceae Enterococcus) 0.01). After 4-week treatment, LEV had significantly lower concentrations several cytokines. Correlation analysis top 30 genera showed that Enterococcus strongly positively correlated tumor necrosis factor-α (TNF-α), interleukins (IL) IL-12p70 IL-1β. Desulfovibrio, Candidatus Saccharimonas, norank_f__norank_o__Clostridia_UCG-014, Lactobacillus, Roseburia negatively these cytokines.This demonstrates effects various intestinal microflora immune status Compared TGC, minimal microbiota. In addition long-term intervention lead a decrease cytokine levels, which may depend microflora, antibiotic duration treatment.

Language: Английский

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Gut microbiota diversity of hospitalized older adult patients with and without antibiotic-associated diarrhea

Aging Clinical and Experimental Research, Journal Year: 2023, Volume and Issue: 35(7), P. 1541 - 1555

Published: May 30, 2023

Language: Английский

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Effects of hemicellulose on intestinal mucosal barrier integrity, gut microbiota, and metabolomics in a mouse model of type 2 diabetes mellitus

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 6, 2023

Background and objective Impaired gut barrier contributes to the progression of type 2 diabetes mellitus (T2DM), microbiota metabolome play an important role in it. Hemicellulose, a potential prebiotics, how its supplementation impacted glucose level, impaired barrier, T2DM remained unclear. Methods In this study, some mice were arranged randomly into four groups: db/db fed by compositionally defined diet (CDD), CDD with 10% 20% hemicellulose supplementation, control CDD. Body weight fasting blood levels monitored weekly. The was evaluated. Fresh stool samples analyzed using metagenomic sequencing liquid chromatography-mass spectrometry detect changes. Systemic colonic inflammation Results Better glycemic control, restoration lowered systemic observed 10 or hemicellulose. showed significant differences beta diversity among groups. Fifteen genera differential relative abundances 59 significantly different metabolites found. group, eliminated redundant Faecalibaculum Enterorhabdus . increased succinate ursodeoxycholic acid (UDCA) after treatment negatively correlated Bifidobacterium, Erysipelatoclostridium , addition, reduced expressions TLR2/4 TNF-α mice. Conclusion Hemicellulose may serve as therapeutic intervention for improving intestinal mucosal integrity, modulating composition, altering metabolic profile.

Language: Английский

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Strategies for applying probiotics in the antibiotic management ofClostridioides difficileinfection

Food & Function, Journal Year: 2023, Volume and Issue: 14(19), P. 8711 - 8733

Published: Jan. 1, 2023

The vital role of probiotics in the food field has been widely recognized, and at same time, are gradually exhibiting surprising effects nutraceuticals, especially regulating gut inflammation nutritional environment. As a dietary supplement clinical nutrition, coadministration with antibiotics model applied to prevent intestinal infections caused by Clostridioides difficile. However, mechanism behind this "bacteria-drug combination" remains unclear. In particular, selection specific probiotic strains, order or antibiotics, time interval key issues that need be further explored clarified. Here, we focus on mentioned above give reasonable opinions, mainly including: (1) safer more effective when they intervene after have used; (2) choice between should based metabolism host, differences baseline ecological environment host's intestine, host immune level; addition, regime also take into account factors such as antibiotic sensitivity dosage probiotics; (3) encapsulating probiotics, combining prebiotics, developing next-generation (NGPs) postbiotic formulations, can provide reference for type model, targeted guidance application supplements management C. difficile infection.

Language: Английский

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Akkermansia muciniphila in infectious disease: A new target for this next-generation probiotic?

Science Progress, Journal Year: 2024, Volume and Issue: 107(1)

Published: Jan. 1, 2024

The common gastrointestinal commensal Akkermansia muciniphila is a mucin-degrading bacterium that greatly reduced in individuals consuming high-fat diet. Increasing evidence from variety of clinical and pre-clinical studies suggests oral supplementation with can improve metabolic health moderate systemic inflammation. We others have demonstrated role for administration protection against infectious disease the outcome sepsis. Very recent indicated molecular mechanisms by which A. may interact host to influence immune-regulation control microbial pathogenesis. Here we consider demonstrate efficacy this potential next-generation probiotic animal models Salmonella Typhimurium, Listeria monocytogenes Clostridioides difficile as well influenza virus phlebovirus. local immune responses are discussed.

Language: Английский

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Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: April 4, 2024

Clostridioides difficile infection (CDI), as well its etiology and pathogenesis, have been extensively investigated. However, the absence of suitable CDI animal models that reflect symptoms associated gut microbiome changes in humans has limited research progress this field. Thus, we aimed to investigate whether Mongolian gerbils, which present a range human pathological conditions, can used studies on CDI. Methods: In study, infected gerbils two existing model animals, mice hamsters, with hypervirulent ribotype 027 C. strain, comparatively analyzed their composition via 16S rRNA gene sequencing. The results obtained showed colonized gastrointestinal tracts three rodents, after challenge, C57BL/6J did not manifest intestines no significant changes. hamsters explosive intestinal bleeding inflammation presented diarrhea increased infiltration inflammatory cells, mucus secretion, epithelial cell shedding tissue. Further, analysis revealed differences respect flora abundance diversity. Specifically, Firmicutes/Bacteroidetes ratio decreased for mice, but significantly hamsters. Furthermore, Proteobacteria all models, especially while Verrucomicrobia only gerbils. Our also indicated relative abundances Lactobacillaceae Akkermansia were primarily responsible observed response challenge. Based responses concluded first time gerbil could be an Additionally, taxa identified study may biomarkers further improve understanding regarding CDI-related diseases.

Language: Английский

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