Hybrid Biomimetic Membrane Coated Particles-Mediated Bacterial Ferroptosis for Acute MRSA Pneumonia

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11692 - 11712

Published: June 13, 2023

Acute methicillin resistant Staphylococcus aureus (MRSA) pneumonia is one of the most frequently seen lung infection diseases with high morbidity and mortality. It urgent to explore an efficient antibacterial strategy owing increase drug resistance, virulence, pathogenicity MRSA. was found that Fe3O4 can induce ferroptosis in MRSA, but its effect inhibited by glutathione (GSH) a certain extent, while cinnamaldehyde (CA) enhance consuming GSH. As bacterial quorum sensing (QS) inhibitor, CA suppress QS system further exert antibiofilm effects. Here, we developed Fe3O4-based inducer promote interrupt QS, destroy biofilm, thus effectively treat acute MRSA pneumonia. We used sodium alginate (SA) wrap form particles, then coated surface hybrid biomimetic membrane composed erythrocyte platelet obtain targeted particles (mFe-CA). Under ultrasonic (US) stimulation, mFe-CA efficiently release CA, thereby synergically inducing death characteristics ferroptosis, including mass ROS production, lipid peroxidation, GSH depletion, respiratory chain suppression. Furthermore, + US inhibit system, remove biofilms, reduce strain virulence. In mouse model pneumonia, treatment markedly advanced survival rate mice, reduced load lungs, alleviated inflammatory damage, there no obvious toxicity. This study proposes substitute which may provide foreground for overcoming microbial resistance fighting biofilm-associated infections also provides target theoretical basis clinical

Language: Английский

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Triggers for the onset and recurrence of psoriasis: a review and update

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 12, 2024

Abstract Psoriasis is an immune-mediated inflammatory skin disease, involving a complex interplay between genetic and environmental factors. Previous studies have demonstrated that factors play major role in the pathogenesis of psoriasis. However, non-genetic are also necessary to trigger onset recurrence psoriasis genetically predisposed individuals, which include infections, microbiota dysbiosis gut, dysregulated lipid metabolism, sex hormones, mental illness. can be induced by other triggers, such as trauma, unhealthy lifestyles, medications. Understanding how these triggers provides insights into pathogenesis, well better clinical administration. In this review, we summarize for update current evidence on underlying mechanism elicit disease.

Language: Английский

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Polystyrene microplastics induce pulmonary fibrosis by promoting alveolar epithelial cell ferroptosis through cGAS/STING signaling

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 277, P. 116357 - 116357

Published: April 26, 2024

Polystyrene microplastics (PS-MPs) are new types of environmental pollutant that have garnered significant attention in recent years since they were found to cause damage the human respiratory system when inhaled. The pulmonary fibrosis is one serious consequences PS-MPs inhalation. However, impact and underlying mechanisms on not clear. In this study, we studied potential lung toxicity PS-MPs-developed by long-term intranasal inhalation PS-MPs. results showed after exposing PS-MPs, lungs model mouse had different levels fibrosis. Meanwhile, resulted a markedly decrease glutathione (GSH), an increase malondialdehyde (MDA), iron overload tissue mice alveolar epithelial cells (AECs). These findings suggested occurrence PS-MP-induced ferroptosis. Inhibitor ferroptosis (Fer-1) alleviated PS-MPs-induced Mechanically, triggered cell promoted development via activating cGAS/STING signaling pathway. Inhibition with G150/H151 attenuated exposure. Together, these data provided novel mechanistic insights therapeutic paradigm.

Language: Английский

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Sodium aescinate-induced hepatotoxicity via ATF4/GSH/GPX4 axis-mediated ferroptosis

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 7, 2025

Sodium aescinate (SA), a natural plant extract with various bioactivities, is widely used to treat oedema and inflammation in clinics. However, adverse events, including liver injury, kidney phlebitis, have been reported patients SA recent years. In this study, we BALB/c mice L02 cells evaluate the role of ferroptosis SA-induced injury. significantly increased AST, ALT, MDA Fe2+, decreased GSH levels, induced pathological changes vivo. also reduced viability LDH release, intracellular cysteine reduction, depletion, iron accumulation, ROS production, lipid peroxidation, indicating that causes ferroptosis. addition, inhibited transcriptional activity activating transcription factor 4 (ATF4) subsequently expression downstream genes xCT (solute carrier family 7a member 11, SLC7A11) Cystathionine gamma-lyase (CTH) which play vital roles biosynthesis. Interestingly, cytotoxic effects were effectively attenuated by ATF4 overexpression, while they aggravated silencing. These results revealed triggers hepatocyte inhibiting ATF4, an oxidative imbalance.

Language: Английский

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Advances in Ferroptosis Research: A Comprehensive Review of Mechanism Exploration, Drug Development, and Disease Treatment

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 334 - 334

Published: Feb. 26, 2025

In recent years, ferroptosis, as an emerging modality of programmed cell death, has captured significant attention within the scientific community. This comprehensive review meticulously canvasses pertinent literature past few spanning multiple facets. It delves into intricate mechanisms underpinning tracks evolution its inducers and inhibitors, dissects roles in a diverse array diseases, well resultant therapeutic implications. A profound exploration is conducted functional ferroptosis-related molecules, intracellular pathways, metabolic cascades, signaling transduction routes. Novel ferroptosis inhibitors are introduced detail, covering their design blueprints, synthetic methodologies, bioactivity profiles. Moreover, exhaustive account provided regarding involvement malignancies, neurodegenerative disorders, cardiovascular ailments, other pathologies. By highlighting pivotal status potential regimens various this aspires to furnish thorough reference framework for future investigations clinical translations domain.

Language: Английский

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A detailed overview of quercetin: implications for cell death and liver fibrosis mechanisms

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 23, 2024

Background Quercetin, a widespread polyphenolic flavonoid, is known for its extensive health benefits and commonly found in the plant kingdom. The natural occurrence extraction methods of quercetin are crucial due to bioactive potential. Purpose This review aims comprehensively cover sources quercetin, methods, bioavailability, pharmacokinetics, role various cell death pathways liver fibrosis. Methods A comprehensive literature search was performed across several electronic databases, including PubMed, Embase, CNKI, Wanfang database, ClinicalTrials.gov, up 10 February 2024. terms employed were “quercetin”, “natural quercetin”, “quercetin methods”, “bioavailability “pharmacokinetics “cell pathways”, “apoptosis”, “autophagy”, “pyroptosis”, “necroptosis”, “ferroptosis”, “cuproptosis”, “liver fibrosis”, “hepatic stellate cells”. These keywords interconnected using AND/OR as necessary. focused on studies that detailed bioavailability pharmacokinetics different pathways, effects Results details quercetin’s involvement apoptosis, autophagy, pyroptosis, necroptosis, ferroptosis, cuproptosis, with particular attention regulatory influence apoptosis autophagy. It dissects mechanisms through which affects these types dosages. Moreover, paper delves into fibrosis, interactions hepatic cells, modulation pertinent signaling cascades. Additionally, it articulates from physical organic chemistry standpoint uniqueness structure potential specific actions liver. Conclusion provides analysis suggesting significant modulating mitigating underscoring therapeutic

Language: Английский

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Camellia Tea Saponin Ameliorates 5–Fluorouracil-Induced Damage of HaCaT Cells by Regulating Ferroptosis and Inflammation

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 764 - 764

Published: Feb. 21, 2025

Background/Objective: Ferroptosis is an iron-dependent form of programmed cell death characterized by lipid peroxidation products (LPOs). A chemotherapeutic drug, 5–fluorouracil (5–FU), can induce epithelial mucositis and favor drug synergism with erastin in ferroptosis. Camellia tea saponin extract (TS) known to exert antioxidative properties. This study aims delineate the protective role TS mitigating 5–FU-induced ferroptosis inflammation human keratinocytes. Methods: HaCaT cells were induced 5–FU erastin, treated different doses, their viability was then determined. Levels cellular reactive oxygen species (ROS), LPOs, labile iron pool (LIP), glutathione (GSH), peroxidase 4 (GPX–4) activity, as well IL–6, IL–1β, TNF–α levels, wound healing properties assessed. Results: per se (at up 25 µg/mL) not toxic but unable restore baseline levels. The compound significantly diminished increases ROS, LIP, while restoring GSH content GPX–4 activity. Additionally, it suppressed cytokine production a concentration–dependent manner. Moreover, exerted wound-healing effects against skin injuries damage dose dependently. Conclusions: insights this work have identified biochemical mechanisms using protect keratinocyte inflammation. highlights promising adjunctive potential mitigation management chemotherapy-induced mucositis.

Language: Английский

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Role of ferroptosis in pregnancy related diseases and its therapeutic potential

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: March 8, 2023

Ferroptosis is a form of regulated cell death characterized by iron overload, overwhelming lipid peroxidation, and disruption antioxidant systems. Emerging evidence suggests that ferroptosis associated with pregnancy related diseases, such as spontaneous abortion, pre-eclampsia, gestational diabetes mellitus, intrahepatic cholestasis pregnancy, preterm birth. According to these findings, inhibiting might be potential option treat diseases. This review summarizes the mechanisms advances ferroptosis, pathogenic role in diseases medicines for its treatment.

Language: Английский

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Multi-Omics Approach to Improved Diagnosis and Treatment of Atopic Dermatitis and Psoriasis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1042 - 1042

Published: Jan. 15, 2024

Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated inflammatory diseases (IMIDs). The prevalence IMIDs is increasing in industrialized societies, influenced by both environmental changes a genetic predisposition. However, exact immune factors driving these chronic, progressive are not fully understood. By using multi-omics techniques IMIDs, it expected to advance understanding skin biology, uncover underlying mechanisms conditions, potentially devise precise personalized approaches diagnosis treatment. We provide narrative review current knowledge genomics, epigenomics, proteomics psoriasis. A literature search was performed for articles published until 30 November 2023. Although there still much uncover, recent evidence has already provided valuable insights, such as proteomic profiles that permit differentiating psoriasis from mycosis fungoides β-defensin 2 correlation PASI its drop due secukinumab first injection, among others.

Language: Английский

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Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies

Toxics, Journal Year: 2023, Volume and Issue: 11(12), P. 1011 - 1011

Published: Dec. 10, 2023

Radiation-induced intestinal injury (RIII) is one of the most common complications caused by radiotherapy for pelvic and abdominal tumors it seriously affects quality life patients. However, treatment acute RIII essentially symptomatic nutritional support an ideal means prevention lacking. Researchers have conducted studies at cellular animal levels found that some chemical or biological agents good therapeutic effects on may be used as potential candidates clinical treatment. This article reviews mechanism strategies based experiments to provide new ideas diagnosis in settings.

Language: Английский

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