International Journal of Pharmaceutical Sciences and Research,
Journal Year:
2023,
Volume and Issue:
14(9)
Published: Sept. 1, 2023
Parkinson's
disease
(PD)
is
the
second
most
prevalent
type
of
neurodegenerative
disorder
and
a
chronic,
progressive
condition.In
current
investigation,
we
used
rotenone
(ROT)-developing
rat
model
PD
to
assess
neuroprotective
efficacy
ethanolic
Withania
somnifera
root
extract
(EWSR)
in
comparison
known
neuroprotectants
i.e.,
Doxycycline
(Doxy),
ellagic
acid
(EA)
individually
combination
(EWSR-Doxy-EA).Male
Wistar
rats
were
given
ROT
at
dose
2.5
mg/kg
body
weight
daily
for
4
weeks
develop
invivo
model.Once
confirmed,
treated
with
individual
next
5
kept
under
observation
7
days
reversal
PD.ROT
administration
has
altered
behavioural
parameters
(Cognitive,
motor
dysfunction,
sniffing,
grooming,
raring,
crossing,
etc.)
neurotransmitter
profile
(Acetylcholine,
epinephrine,
nor-epinephrine,
dopamine,
glutamate
aspartate)
rats.The
ameliorated
deleterious
effects
restored
cognitive
control
by
rectifying
levels
neurotransmitters
which
are
responsible
functions.EWSR
protective
was
significantly
better
that
(Doxy
EA)
EWSR
increased
when
combined
other
neuroprotectants.Based
on
study
observations,
it
can
be
inferred
good
agent
act
as
potential
alternative
therapeutic
approach
or
drugs
treating
diseases.INTRODUCTION:
progressive,
late-onset
condition
marked
development
fibrillar
cytoplasmic
inclusions
containing
α-synuclein
ubiquitin
relatively
selective
nigrostriatal
dopaminergic
loss.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: Oct. 30, 2024
Excess
weight
gain
is
a
growing
concern
worldwide,
fueled
by
increased
consumption
of
calorie-dense
foods
and
more
sedentary
lifestyles.
Obesity
in
China
also
becoming
increasingly
problematic,
developing
into
major
public
health
concern.
not
only
increases
the
risk
associated
disease
but
imposes
burden
on
care
systems,
it
thus
imperative
that
an
effective
intervention
approach
be
identified.
Recent
studies
have
demonstrated
polyphenol-rich
Mediterranean
diet
has
considerable
potential
this
regard.
Polyphenols
can
inhibit
production
adipocytes
reduce
adverse
reactions,
such
as
inflammation,
insulin
resistance,
gut
microflora
imbalance.
In
review,
we
examine
four
polyphenols
(curcumin,
ellagic
acid,
ferulic
quercetin)
terms
their
interventions
targeting
obesity.
The
mechanisms
help
promote
adipocyte
browning,
increase
thermogenic
factors,
thermogenesis,
regulate
differentiation
are
summarized,
key
signaling
pathways,
including
PPARγ,
C/EBP-,
others,
reviewed.
Journal of Complementary and Integrative Medicine,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Abstract
Objectives
The
liver
is
vital
for
metabolism,
detoxification,
storage,
and
secretion.
Cholestasis,
in
which
bile
flow
hindered,
can
cause
serious
harm
to
the
liver.
This
study
examines
potential
of
ellagic
acid
prevent
cholestasis
male
rats
that
has
been
caused
by
alpha-naphthyl
isothiocyanate
(ANIT).
Method
Male
were
divided
into
four
groups
an
8-day
study.
control
group
received
5
%
dimethyl
sulfoxide
(DMSO)
orally
eight
days
maize
oil
(1
mL/kg,
orally)
48
h
before
sacrifice.
ANIT
Group
DMSO
8
days,
(100
mg/kg,
administered
on
6th
day,
low-Dose
Ellagic
Acid
+
was
given
(5
with
prior
high-Dose
(10
Different
biochemical
histopathological
analyses
conducted
assess
protective
effects
ANIT-induced
injury.
Results
significantly
elevated
serum
enzymes.
It
severe
duct
inflammation
reduced
salt
export
pump
(BSEP)
Na+-taurocholate
cotransporting
polypeptide
(NTCP)
expression,
indicating
treatment
mitigated
these
changes,
improving
parameters
reducing
damage.
results
accumulation
due
decreased
BSEP
NTCP
expression
linked
impaired
farnesoid
X
receptor
(FXR)
signaling.
restored
levels
via
FXR
activation,
acids
inflammatory
markers
IL-1β
TNF-α.
also
enhanced
SIRT1
activity,
further
function
homeostasis.
Conclusions
exhibits
against
enhancing
signaling
ntcp
bsep
mitigating
damage
inflammation.
Current Research in Food Science,
Journal Year:
2023,
Volume and Issue:
6, P. 100527 - 100527
Published: Jan. 1, 2023
In
response
to
environmental
challenges,
stress
is
a
common
reaction,
but
dysregulation
of
the
can
lead
neuropsychiatric
disorders,
including
depression
and
cognitive
impairment.
Particularly,
there
ample
evidence
that
overexposure
mental
have
lasting
detrimental
consequences
for
psychological
health,
function,
ultimately
well-being.
fact,
some
individuals
are
resilient
same
stressor.
A
major
benefit
enhancing
resilience
in
at-risk
groups
it
may
help
prevent
onset
stress-induced
health
problems.
potential
therapeutic
strategy
maintaining
healthy
life
address
problems
with
botanicals
or
dietary
supplements
such
as
polyphenols.
Triphala,
also
known
Zhe
Busong
decoction
Tibetan,
well-recognized
Ayurvedic
polyherbal
medicine
comprising
dried
fruits
from
three
different
plant
species.
As
promising
food-sourced
phytotherapy,
triphala
polyphenols
been
used
throughout
history
treat
variety
medical
conditions,
brain
maintenance.
Nevertheless,
comprehensive
review
still
lacking.
Here,
primary
objective
this
article
provide
an
overview
classification,
safety,
pharmacokinetics
polyphenols,
well
recommendations
development
novel
promoting
susceptible
individuals.
Additionally,
we
summarize
recent
advances
demonstrating
beneficial
by
regulating
5-hydroxytryptamine
(5-HT)
brain-derived
neurotrophic
factor
(BDNF)
receptors,
gut
microbiota,
antioxidant-related
signaling
pathways.
Overall,
scientific
exploration
warranted
understand
their
efficacy.
addition
providing
insights
into
mechanisms
resilience,
blood
barrier
(BBB)
permeability
systemic
bioavailability
need
be
improved
research
community.
Moreover,
well-designed
clinical
trials
needed
increase
validity
polyphenols'
effects
preventing
treating
impairment
dysfunction.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 485 - 485
Published: April 18, 2024
Obesity
is
in
epidemic
proportions
many
parts
of
the
world,
contributing
to
increasing
rates
non-alcoholic
fatty
liver
disease
(NAFLD).
NAFLD
represents
a
range
conditions
from
initial
stage
steatohepatitis
(NASH),
which
can
progress
severe
fibrosis,
through
hepatocellular
carcinoma.
There
currently
exists
no
treatment
for
long-term
management
NAFLD/NASH,
however,
dietary
interventions
have
been
investigated
NASH,
including
several
polyphenolic
compounds.
Ellagic
acid
one
such
compound.
Nutraceutical
food
abundant
ellagic
undergoes
hydrolysis
free
within
stomach
and
small
intestine.
The
proposed
mechanism
action
extends
beyond
its
therapeutic
potential,
as
it
further
broken
down
by
gut
microbiome
into
urolithin.
Both
urolithin
found
alleviate
oxidative
stress,
inflammation,
are
associated
with
NAFLD/NASH.
While
has
made
understanding
pharmacological
biological
activity
involvement
yet
be
fully
elucidated.
Thus,
aim
this
review
summarise
available
literature
elucidating
potential
microbial-derived
metabolite
Critical Reviews in Food Science and Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 37
Published: May 24, 2024
Neurodegenerative
diseases
encompass
a
wide
range
of
debilitating
and
incurable
brain
disorders
characterized
by
the
progressive
deterioration
nervous
system's
structure
function.
Isoflavones,
which
are
naturally
occurring
polyphenolic
phytochemicals,
have
been
found
to
regulate
various
cellular
signaling
pathways
associated
with
system.
The
main
objective
this
comprehensive
review
is
explore
neuroprotective
effects
isoflavones,
elucidate
underlying
mechanisms,
assess
their
potential
for
treating
neurodegenerative
disorders.
Relevant
data
regarding
isoflavones
impact
on
were
gathered
from
multiple
library
databases
electronic
sources,
including
PubMed,
Google
Scholar,
Web
Science,
Science
Direct.
Numerous
genistein,
daidzein,
biochanin
A,
formononetin,
exhibited
potent
properties
against
diseases.
These
compounds
modulate
neurotransmitters,
in
turn
contributes
ability
protect
neurodegeneration.
Both
vitro
vivo
experimental
studies
provided
evidence
neuroprotection
involve
interactions
estrogenic
receptors,
antioxidant
effects,
anti-inflammatory
properties,
anti-apoptotic
activity,
modulation
neural
plasticity.
This
aims
provide
current
insights
into
characteristics
shed
light
therapeutic
applications
future
clinical
scenarios.
Sci,
Journal Year:
2024,
Volume and Issue:
6(2), P. 36 - 36
Published: June 13, 2024
Aging
is
a
complex
biological
and
physiological
change
that
leads
to
loss
of
function
in
all
living
organisms.
Although
the
mechanism
behind
aging
process
still
largely
unknown,
scientific
studies
have
shown
oxidative
stress
age-related
low
autophagy,
which
are
associated
with
various
chronic
diseases
such
as
cancer,
diabetes,
cardiovascular
diseases,
neurodegenerative
promote
aging.
Interestingly,
many
medicinal
plants
their
biologically
active
compounds
ability
extend
lifespan
they
can
inhibit
autophagy.
This
review
evaluates
provides
up-to-date
information
on
anti-aging
potential
bioactive
edible
plants.
In
this
study,
seventeen
(17)
from
effects
were
reviewed.
vivo
vitro
showed
these
exhibit
via
mechanisms
activation
increases
antioxidant
enzymes,
reductions
reactive
oxygen
species,
inhibition
inflammatory
markers,
downregulation
senescence
genes.
study
suggests
containing
may
health
lifespan.
However,
exact
mechanisms,
effective
doses,
clinical
trials,
genotoxic
agents
should
be
further
investigated.
