Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat

Journal of Psychiatric Research, Journal Year: 2016, Volume and Issue: 82, P. 109 - 118

Published: July 26, 2016

Language: Английский

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The Brain-Gut-Microbiome Axis

Cellular and Molecular Gastroenterology and Hepatology, Journal Year: 2018, Volume and Issue: 6(2), P. 133 - 148

Published: Jan. 1, 2018

Language: Английский

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Human gut microbiota/microbiome in health and diseases: a review

Antonie van Leeuwenhoek, Journal Year: 2020, Volume and Issue: 113(12), P. 2019 - 2040

Published: Nov. 2, 2020

Language: Английский

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The far-reaching scope of neuroinflammation after traumatic brain injury

Nature Reviews Neurology, Journal Year: 2017, Volume and Issue: 13(3), P. 171 - 191

Published: Feb. 10, 2017

Language: Английский

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The Microbiome-Gut-Brain Axis in Health and Disease

Gastroenterology Clinics of North America, Journal Year: 2017, Volume and Issue: 46(1), P. 77 - 89

Published: Jan. 5, 2017

Language: Английский

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Leaky gut: mechanisms, measurement and clinical implications in humans

Gut, Journal Year: 2019, Volume and Issue: 68(8), P. 1516 - 1526

Published: May 10, 2019

The objectives of this review on ‘leaky gut’ for clinicians are to discuss the components intestinal barrier, diverse measurements permeability, their perturbation in non-inflammatory ‘stressed states’ and impact treatment with dietary factors. Information ‘healthy’ or ‘leaky’ gut public domain requires confirmation before endorsing exclusions, replacement non-irritating foods (such as fermented foods) use supplements repair damage. barrier includes surface mucus, epithelial layer immune defences. Epithelial permeability results from increased paracellular transport, apoptosis transcellular permeability. Barrier function can be tested vivo using orally administered probe molecules vitro mucosal biopsies humans, exposing colonic mucosa rats mice cell layers extracts stool human patients. Assessment beyond layer. ‘Stress’ disorders such endurance exercise, non-steroidal anti-inflammatory drugs administration, pregnancy surfactants bile acids factors emulsifiers) increase Dietary reverse leakiness damage ‘stress’ disorders. Whereas inflammatory ulcerating diseases result leaky gut, no disease cured by simply normalising function. It is still unproven that restoring ameliorate clinical manifestations GI systemic diseases. Clinicians should aware potential dysfunction a target future therapy.

Language: Английский

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The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?

Neurochemistry International, Journal Year: 2016, Volume and Issue: 99, P. 110 - 132

Published: June 25, 2016

Language: Английский

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Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Nature reviews. Immunology, Journal Year: 2021, Volume and Issue: 21(11), P. 739 - 751

Published: April 12, 2021

Language: Английский

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Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

The Journal of Physiology, Journal Year: 2016, Volume and Issue: 595(2), P. 489 - 503

Published: Sept. 19, 2016

There is a growing realisation that the gut-brain axis and its regulation by microbiota may play key role in biological physiological basis of neurodevelopmental, age-related neurodegenerative disorders. The routes communication between brain are being unravelled include vagus nerve, gut hormone signalling, immune system, tryptophan metabolism or way microbial metabolites such as short chain fatty acids. importance early life shaping future health outcomes also emerging. Disturbances this composition antibiotic exposure, lack breastfeeding, infection, stress environmental influences coupled with influence host genetics can result long-term effects on physiology behaviour, at least animal models. It worth noting mode delivery birth those born Caesarean section having distinctly different to per vaginum. At other extreme life, ageing associated narrowing diversity healthy correlates diverse microbiome. Recently, has been implicated variety conditions including depression, autism, schizophrenia Parkinson's disease. still considerable debate whether not changes core pathophysiology merely epiphenomenal. plausible neuropsychiatric disorders might be treated targeting either transplantation, antibiotics psychobiotics.

Language: Английский

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Kynurenine pathway metabolism and the microbiota-gut-brain axis

Neuropharmacology, Journal Year: 2016, Volume and Issue: 112, P. 399 - 412

Published: July 6, 2016

Language: Английский

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