Sleep and circadian rhythms in α‐synucleinopathies—Perspectives for disease modification DOI Creative Commons
Dieter Kunz, Henrik Oster, Oliver Rawashdeh

et al.

Acta Physiologica, Journal Year: 2023, Volume and Issue: 238(1)

Published: March 23, 2023

Abstract The global north is facing an unprecedented rise in the prevalence of neurodegenerative diseases. increasing incidence Parkinson's disease being referred to as a pandemic. reason for enormous increase only partly understood. Lifestyle factors are known play role, but they alone cannot account surge. One factor that—although recognized important—has not been explored detail so far influence circadian rhythms. Sleep and rhythm disruption key neurodegeneration, their occurrence during early stages suggests causal role pathogenesis. Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) has identified prodromal state α‐synucleinopathies, such disease, Lewy body dementia, multiple system atrophy offering window insights into development these Even though REM most pronounced, driven modulated by timing system, specific abnormalities have described iRBD. Novel experimental clinical approaches exploiting molecular circuitry underlying timekeeping hold promise disentangle some pathophysiologic mechanisms α‐synucleinopathies. In this review, we summarize current knowledge on disruptions α‐synucleinopathies with emphasis aspects therapeutic potentials. These might contribute our understanding pathogenesis diseases may allow interventions addressing disturbed at stage disease.

Language: Английский

Rhythms of life: circadian disruption and brain disorders across the lifespan DOI Open Access
Ryan W. Logan, Colleen A. McClung

Nature reviews. Neuroscience, Journal Year: 2018, Volume and Issue: 20(1), P. 49 - 65

Published: Nov. 20, 2018

Language: Английский

Citations

532
Circadian rhythms, refractive development, and myopia DOI Open Access
Ranjay Chakraborty, Lisa A. Ostrin, Debora L. Nickla

et al.

Ophthalmic and Physiological Optics, Journal Year: 2018, Volume and Issue: 38(3), P. 217 - 245

Published: April 24, 2018

Abstract Purpose Despite extensive research, mechanisms regulating postnatal eye growth and those responsible for ametropias are poorly understood. With the marked recent increases in myopia prevalence, robust biologically‐based clinical therapies to normalize refractive development childhood needed. Here, we review classic contemporary literature about how circadian biology might provide clues develop a framework improve understanding of etiology, possibly lead rational approaches ameliorate errors developing children. Recent findings Increasing evidence implicates diurnal rhythms error development. In both humans animals, ocular length other anatomical physiological features undergo oscillations. Systemically, such primarily generated by ‘master clock’ surpachiasmatic nucleus, which receives input from intrinsically photosensitive retinal ganglion cells (ip RGC s) through activation photopigment melanopsin. The retina also has an endogenous clock. laboratory animals experimental myopia, oscillations parameters perturbed. Retinal signaling is now believed influence development; dopamine, important neurotransmitter found retina, not only entrains intrinsic light:dark cycle, but it modulates Circadian clocks comprise transcription/translation feedback control mechanism utilizing so‐called clock genes that have been associated with ametropias. Contemporary research reviving ideas first proposed nineteenth century light exposures impact refraction As result, properties ambient lighting being investigated areas medical science, dysregulation thought many non‐ocular disorders, likely because patterns modern artificial exert adverse effects on pacemakers. How, or if, contribute known. Summary premise this could be productive area worthy increased investigation, improved therapeutic interventions.

Language: Английский

Citations

181
Circadian rhythms in neurodegenerative disorders DOI
Malik Nassan, Aleksandar Videnović

Nature Reviews Neurology, Journal Year: 2021, Volume and Issue: 18(1), P. 7 - 24

Published: Nov. 10, 2021

Language: Английский

Citations

162
A method for single-neuron chronic recording from the retina in awake mice DOI Open Access
Guosong Hong, Tian-Ming Fu,

Mu Qiao

et al.

Science, Journal Year: 2018, Volume and Issue: 360(6396), P. 1447 - 1451

Published: June 28, 2018

The retina, which processes visual information and sends it to the brain, is an excellent model for studying neural circuitry. It has been probed extensively ex vivo but refractory chronic in electrophysiology. We report a nonsurgical method achieve chronically stable recordings from single retinal ganglion cells (RGCs) awake mice. developed noncoaxial intravitreal injection scheme injected mesh electronics unrolls inside eye conformally coats highly curved retina without compromising normal functions. allows 16-channel multiple types of RGCs with responses stimuli at least 2 weeks, reveals circadian rhythms RGC over day/night cycles.

Language: Английский

Citations

154
Printing Flexible and Hybrid Electronics for Human Skin and Eye‐Interfaced Health Monitoring Systems DOI
Kyunghun Kim, Bongjoong Kim, Chi Hwan Lee

et al.

Advanced Materials, Journal Year: 2019, Volume and Issue: 32(15)

Published: July 12, 2019

Advances in printing materials and techniques for flexible hybrid electronics the domain of connected healthcare have enabled rapid development innovative body-interfaced health monitoring systems at a tremendous pace. Thin, flexible, stretchable biosensors that are printed on biocompatible soft substrate provide ability to noninvasively unobtrusively integrate with human body continuous early detection diseases other conditions affecting well being. Hybrid integration such extremely well-established silicon-based microcircuit chips offers viable route in-sensor data processing wireless transmission many medical clinical settings. Here, set advanced is summarized, covering diverse aspects ranging from active electronic process capability, their use skin eye-interfaced different levels complexity. Essential components devices, including constituent biomaterials, structural layouts, assembly methods, power configurations, outlined discussed categorized manner tailored specific needs. Perspectives benefits challenges these basic applied biomedical research presented discussed.

Language: Английский

Citations

131
Gut Microbiota Profiling and Gut–Brain Crosstalk in Children Affected by Pediatric Acute-Onset Neuropsychiatric Syndrome and Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections DOI Creative Commons
Andrea Quagliariello, Federica Del Chierico, Alessandra Russo

et al.

Frontiers in Microbiology, Journal Year: 2018, Volume and Issue: 9

Published: April 6, 2018

Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Autoimmune Disorder Associated with Streptococcal Infections (PANDAS) are conditions that impair brain normal neurologic function, resulting in the sudden onset of tics, obsessive compulsive disorder, other behavioral symptoms. Recent studies have emphasized crosstalk between gut brain, highlighting how composition can influence behavior functions. Thus, present study investigates relationship PANS/PANDAS microbiota ecology. The a cohort 30 patients was analyzed compared to control subjects using 16S rRNA-based metagenomics. Data were for their α β diversity; differences bacterial distribution detected by Wilcoxon LEfSe tests, while metabolic profile predicted via PICRUSt software. These analyses demonstrate presence an altered community structure respect controls. In particular, ecological analysis revealed two main clusters based on age range. avoid bias, data from controls split into groups: 4 8 years old > 9 old. younger group characterized strong increase Bacteroidetes; Bacteroides, Odoribacter, Oscillospira identified as potential microbial biomarkers this type. Moreover, exhibited several pathways concerning modulation antibody response inflammation within well decrease involved function (i.e. SCFA, D-alanine tyrosine metabolism, dopamine pathway). older displayed less uniform profile, thus impairing identification distinct biomarkers. Finally, Pearsons' bacteria anti-streptolysin O-titer reveled negative correlation genera belonging Firmicutes phylum O positive observed Odoribacter. conclusion, suggests streptococcal infections alter communities leading pro-inflammatory status through selection specific strains associated immune activation. findings highlight possibility studying disorder might led novel therapeutic strategies.

Language: Английский

Citations

106
A Hippocampus‐Inspired Dual‐Gated Organic Artificial Synapse for Simultaneous Sensing of a Neurotransmitter and Light DOI
Hae Rang Lee,

Doyoung Lee,

Joon Hak Oh

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(17)

Published: March 22, 2021

Abstract Organic neuromorphic devices and sensors that mimic the functions of chemical synapses sensory perception in humans have received much attention for next‐generation computing integrated logic circuits. Despite recent advances, organic artificial capable detecting both neurotransmitters liquid environments light are not reported. Herein, inspired by hippocampal synapses, a dual‐gate synaptic transistor platform with photoconductive polymer semiconductor, ferroelectric insulator P(VDF‐TrFE), an extended‐gate electrode functionalized boronic acid is developed to simultaneously detect neurotransmitter dopamine light. The enables memory consolidation upon repetitive exposure polychromatic light, exhibiting effectively modulated postsynaptic currents. This proof‐of‐concept hippocampal‐synapse‐mimetic system combining sensor photosensor opens new possibilities developing low‐power multisensors light‐induced consolidative can also contribute development human–machine interfaces.

Language: Английский

Citations

91
Sleep and circadian rhythms in Parkinson’s disease and preclinical models DOI Creative Commons
Jeremy Hunt, Elizabeth J. Coulson, Rajendram V. Rajnarayanan

et al.

Molecular Neurodegeneration, Journal Year: 2022, Volume and Issue: 17(1)

Published: Jan. 9, 2022

The use of animals as models human physiology is, and has been for many years, an indispensable tool understanding the mechanisms disease. In Parkinson's disease, various mouse form cornerstone these investigations. Early were developed to reflect traditional histological features motor symptoms However, it is important that accurately encompass facets disease allow comprehensive mechanistic translational significance. Circadian rhythm sleep issues are tightly correlated often arise prior presentation typical deficits. It essential used understand dysfunctions in circadian rhythms sleep, both facilitate investigations into interplay between assist development rhythm-facing therapeutic treatments. This review describes extent which genetically- neurotoxically-induced murine abnormalities observed clinic.

Language: Английский

Citations

63
Early-stage visual perception impairment in schizophrenia, bottom-up and back again DOI Creative Commons
Petr Adámek, Veronika Langová, Jiřı́ Horáček

et al.

Schizophrenia, Journal Year: 2022, Volume and Issue: 8(1)

Published: March 21, 2022

Abstract Visual perception is one of the basic tools for exploring world. However, in schizophrenia, this modality disrupted. So far, there has been no clear answer as to whether disruption occurs primarily within brain or precortical areas visual (the retina, pathways, and lateral geniculate nucleus [LGN]). A web-based comprehensive search peer-reviewed journals was conducted based on various keyword combinations including saliency, cognition, LGN. Articles were chosen with respect topic relevance. Searched databases included Google Scholar, PubMed, Web Science. This review describes circuit key changes biochemistry pathophysiology that affect creation characteristics retinal signal well its subsequent modulation processing other parts circuit. Changes misinterpretation stimuli associated them may, a result, contribute development schizophrenic disease.

Language: Английский

Citations

49
The Effects of Light and the Circadian System on Rhythmic Brain Function DOI Open Access
Charlotte von Gall

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2778 - 2778

Published: March 3, 2022

Life on earth has evolved under the influence of regularly recurring changes in environment, such as 24 h light/dark cycle. Consequently, organisms have developed endogenous clocks, generating (circadian) rhythms that serve to anticipate these rhythmic changes. In addition circadian rhythms, which persist constant conditions and can be entrained environmental light drives behavior brain function, especially nocturnal laboratory rodents. recent decades, research made great advances elucidation molecular clockwork perception. This review summarizes role clock with a focus complex interaction between different components mammalian system. Furthermore, chronodisruption consequence at night, genetic manipulation, neurodegenerative diseases is briefly discussed.

Language: Английский

Citations

47