Oxidative Stress and Antioxidants in Age-Related Macular Degeneration

Antioxidants, Journal Year: 2023, Volume and Issue: 12(7), P. 1379 - 1379

Published: July 3, 2023

Oxidative stress plays a crucial role in aging-related eye diseases, including age-related macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative capacity decreases, excess levels of reactive oxygen species produce oxidative damage many ocular cell types underling pathologies. In AMD, loss central vision the elderly is caused primarily by retinal pigment epithelium (RPE) dysfunction and/or choroidal neovascularization that trigger malfunction photo-sensing photoreceptor cells. Along with various genetic environmental factors contribute to aging have critical involvement AMD pathogenesis. To this end, dietary intake antioxidants proven way scavenge free radicals prevent or slow progression. This review focuses on highlights pathogenic from both clinical experimental studies. The beneficial roles micronutrients are also summarized.

Language: Английский

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Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.

Language: Английский

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Potential New Target for Dry Eye Disease—Oxidative Stress

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 422 - 422

Published: March 29, 2024

Dry eye disease (DED) is a multifactorial condition affecting the ocular surface. It characterized by loss of tear film homeostasis and accompanied symptoms that may potentially result in damage to surface even vision loss. Unmodifiable risk factors for DED mainly include aging, hormonal changes, lifestyle issues such as reduced sleep duration, increased screen exposure, smoking, ethanol consumption. As its prevalence continues rise, has garnered considerable attention, prompting exploration potential new therapeutic targets. Recent studies have found when production ROS exceeds capacity antioxidant defense system on surface, oxidative stress ensues, leading cellular apoptosis further damage. These events can exacerbate inflammation responses, increasing levels promoting vicious cycle DED. Therefore, given central role reactive oxygen species DED, strategies involving antioxidants emerged novel approach treatment. This review aims enhance our understanding intricate relationship between thereby providing directions explore innovative approaches this complex disorder.

Language: Английский

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A Pivotal Role of Nrf2 in Neurodegenerative Disorders: A New Way for Therapeutic Strategies

Pharmaceuticals, Journal Year: 2022, Volume and Issue: 15(6), P. 692 - 692

Published: May 31, 2022

Clinical and preclinical research indicates that neurodegenerative diseases are characterized by excess levels of oxidative stress (OS) biomarkers lower antioxidant protection in the brain peripheral tissues. Dysregulations oxidant/antioxidant balance known to be a major factor pathogenesis involve mitochondrial dysfunction, protein misfolding, neuroinflammation, all events lead proteostatic collapse neuronal cells their loss. Nuclear factor-E2-related 2 (Nrf2) is short-lived works as transcription related expression many cytoprotective genes involved xenobiotic metabolism responses. A emerging function Nrf2 from studies over past decade its role resistance OS. key regulator OS defense supports protective defending against conditions. This review describes influence on what way regulates for Furthermore, we evaluate recent evidence beneficial potential specific activator compounds therapeutic agents.

Language: Английский

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Novel potential pharmacological applications of dimethyl fumarate—an overview and update

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 7, 2023

Dimethyl fumarate (DMF) is an FDA-approved drug for the treatment of psoriasis and multiple sclerosis. DMF known to stabilize transcription factor Nrf2, which in turn induces expression antioxidant response element genes. It has also been shown that influences autophagy participates transcriptional control inflammatory factors by inhibiting NF-κB its downstream targets. receiving increasing attention potential be repurposed several diseases. This versatile molecule indeed able exert beneficial effects on different medical conditions through a pleiotropic mechanism, virtue antioxidant, immunomodulatory, neuroprotective, anti-inflammatory, anti-proliferative effects. A growing number preclinical clinical studies show may have important therapeutic implications chronic diseases, such as cardiovascular respiratory pathologies, cancer, eye disorders, neurodegenerative conditions, systemic or organ specific immune-mediated comprehensive review summarizes highlights plethora DMF's underlines repurposing opportunities variety conditions.

Language: Английский

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The Potential Role of Major Argan Oil Compounds as Nrf2 Regulators and Their Antioxidant Effects

Antioxidants, Journal Year: 2024, Volume and Issue: 13(3), P. 344 - 344

Published: March 13, 2024

In recent years, research on the discovery of natural compounds with potent antioxidant properties has resulted in growing interest these due to their potential therapeutic applications oxidative-stress-related diseases. Argan oil, derived from kernels a native tree Morocco, Argania spinosa, is renowned for its rich composition bioactive compounds, prominently tocopherols, polyphenols, and fatty acids. Interestingly, large body data shown that several components argan oil activate nuclear factor erythroid 2-related 2 (Nrf2) pathway, playing crucial role cellular defense against oxidative stress. Activation this Nrf2 pathway by leads increased expression downstream target proteins like NAD(P)H quinone oxidoreductase (NQO1), superoxide dismutase (SOD), heme oxygenase 1 (HO-1), catalase (CAT). Such activation accounts health benefits related defense, anti-inflammatory effects, cardiovascular health, neuroprotection organisms. Furthermore, synergistic action enhances pathway. Accordingly, modulation Kelch-like ECH associated protein (Keap1)/Nrf2 signaling highlights protecting cells stress underlines relevance dietetic prevention applications. This review aims provide an overview how major updating our knowledge mechanisms benefits.

Language: Английский

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Phenothiazines: Nrf2 activation and antioxidant effects

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(3)

Published: Feb. 18, 2024

Abstract Phenothiazines (PTZs) are an emerging group of molecules showing effectiveness toward redox signaling and reduction oxidative injury to cells, via the activation on Kelch‐like ECH‐associated protein 1/nuclear factor erythroid 2‐related 2 (Nrf2). Although several electrophilic indirect Nrf2 activators have been reported, risk “off‐target” effect due complexity their molecular mechanisms action, has aroused research interest non‐electrophilic direct modulators pathway, such as PTZs. This review represents first overview roles PTZs activator free radical scavengers, well potential therapeutic effects in stress‐mediated diseases. Here, we provide a collective comprehensive information ability scavenge radicals activate with aim broaden knowledge potentials stimulate innovative ideas.

Language: Английский

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Rutin prevents EqHV-8 induced infection and oxidative stress via Nrf2/HO-1 signaling pathway

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: April 25, 2024

The Nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway has been extensively studied for its role in regulating antioxidant and antiviral responses. Equid herpesvirus type 8 (EqHV-8) poses a significant threat to the equine industry, primarily manifesting as respiratory disease, abortions, neurological disorders horses donkeys. Oxidative stress is considered key associated with pathogenesis of EqHV-8 infection. Unfortunately, there currently dearth therapeutic interventions available effective control EqHV-8. Rutin well documented potential. In current study we focused on evaluation potential agent against

Language: Английский

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Hyperoside inhibits EHV-8 infection via alleviating oxidative stress and IFN production through activating JNK/Keap1/Nrf2/HO-1 signaling pathways

Journal of Virology, Journal Year: 2024, Volume and Issue: 98(4)

Published: March 19, 2024

Equine herpesvirus type 8 (EHV-8) causes abortion and respiratory disease in horses donkeys, leading to serious economic losses the global equine industry. Currently, there is no effective vaccine or drug against EHV-8 infection, underscoring need for a novel antiviral prevent EHV-8-induced latent infection decrease pathogenicity of this virus. The present study demonstrated that hyperoside can exert effects RK-13 (rabbit kidney cells), MDBK (Madin-Darby bovine kidney), NBL-6 cells (E. Derm cells). Mechanistic investigations revealed induces heme oxygenase-1 expression by activating c-Jun N-terminal kinase/nuclear factor erythroid-2-related 2/Kelch-like ECH-associated protein 1 axis, alleviating oxidative stress triggering downstream interferon response. Accordingly, inhibits infection. Meanwhile, also mitigate injury lungs infected mice. These results indicate may serve as agent infection.IMPORTANCEHyperoside has been reported suppress viral infections, including herpesvirus, hepatitis B virus, infectious bronchitis severe acute syndrome coronavirus 2 However, its mechanism action currently unknown. Here, we significantly adsorption internalization susceptible cells. This process HO-1 via axis activation, an findings could be very EHV-8.

Language: Английский

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The Role of the NRF2 Pathway in Maintaining and Improving Cognitive Function

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 2043 - 2043

Published: Aug. 21, 2022

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a redox-sensitive transcription that binds to the antioxidant response element consensus sequence, decreasing reactive oxygen species and regulating of wide array genes, including detoxifying enzymes, genes involved in mitochondrial function biogenesis. Moreover, NRF2 has been shown directly regulate expression anti-inflammatory mediators reducing pro-inflammatory cytokines. In recent years, attention turned role plays brain different diseases such Alzheimer’s disease, Parkinson’s Huntington’s disease others. This review focused on evidence, derived vitro, vivo from clinical trials, supporting for activation maintaining improving cognitive how its can be used elicit neuroprotection lead enhancement. The also brings critical discussion concerning possible prophylactic and/or therapeutic use activators treating impairment-related conditions.

Language: Английский

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