Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 336, P. 118735 - 118735
Published: Aug. 31, 2024
Language: Английский
MedComm, Journal Year: 2023, Volume and Issue: 4(3)
Published: June 1, 2023
Exosomes are extracellular vesicles with diameters of about 100 nm that naturally secreted by cells into body fluids. They derived from endosomes and wrapped in lipid membranes. involved intracellular metabolism intercellular communication. contain nucleic acids, proteins, lipids, metabolites the cell microenvironment cytoplasm. The contents exosomes can reflect their cells' origin allow observation tissue changes states under disease conditions. Naturally have specific biomolecules act as "fingerprint" parent cells, changed pathological conditions be used biomarkers for diagnosis. low immunogenicity, small size, cross blood-brain barrier. These characteristics make unique engineering carriers. incorporate therapeutic drugs achieve targeted drug delivery. carriers therapy still infancy, but exosome provides a new perspective cell-free therapy. This review discussed relationship occurrence treatment some neuropsychiatric diseases. In addition, future applications diagnosis disorders were evaluated this review.
Language: Английский
Citations
32
CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)
Published: May 1, 2024
Stroke is an acute cerebrovascular disease in which brain tissue damaged due to sudden obstruction of blood flow the or rupture vessels brain, can prompt ischemic hemorrhagic stroke. After stroke onset, ischemia, hypoxia, infiltration components into parenchyma, and lysed cell fragments, among other factors, invariably increase blood-brain barrier (BBB) permeability, inflammatory response, edema. These changes lead neuronal death synaptic dysfunction, latter poses a significant challenge treatment.
Language: Английский
Citations
9
International Journal of Sports Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 20, 2025
Abstract Ischemic stroke is an acute cerebrovascular disease that one of the leading causes death and neurological disorders worldwide. Exosomes are a novel class intercellular signaling regulators containing cell-specific proteins, lipids, nucleic acids transmit messages between cells tissues. MicroRNAs regulatory non-coding ribonucleic usually present in exosomes as molecules. Studies have shown exosomal microRNAs can improve prognosis ischemic by inhibiting inflammatory response, reducing apoptosis, improving imbalance oxidative antioxidant systems, regulating cellular autophagy, among other processes. Previous studies exercise training exert neuroprotective effects on promoting release expression microRNAs, which turn regulate multiple pathways. may be key targets for to promote health. Therefore, study exercise-mediated their provide new perspectives exploring mechanism intervention prevention treatment stroke.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2023, Volume and Issue: 13(3), P. 571 - 571
Published: March 21, 2023
Stroke causes varying degrees of neurological deficits, leading to corresponding dysfunctions. There are different therapeutic principles for each stage pathological development. Neuroprotection is the main treatment in acute phase, and functional recovery becomes primary subacute chronic phases. Neuroplasticity considered basis restoration rehabilitation after stroke, including remodeling dendrites dendritic spines, axonal sprouting, myelin regeneration, synapse shaping, neurogenesis. Spatiotemporal development affects spontaneous rewiring neural circuits brain networks. Microglia resident immune cells that contribute homeostasis under physiological conditions. activated immediately phenotypic polarization changes phagocytic function crucial regulating focal global inflammation recovery. We have previously shown neuroplasticity spatiotemporally consistent with microglial activation, suggesting microglia may a profound impact on stroke be key target post-stroke rehabilitation. In this review, we explore as well functions mechanisms polarization, phagocytosis. This followed by summary microglia-targeted rehabilitative interventions influence promote
Language: Английский
Citations
18
Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: June 7, 2024
There is a well-established link between physical activity and brain health. As such, the effectiveness of exercise as therapeutic strategy has been explored in variety neurological contexts. To determine extent to which could be most beneficial under different circumstances, studies are needed uncover underlying mechanisms behind benefits activity. Interest grown understanding how can regulate microglia, resident immune cells central nervous system. Microglia key mediators neuroinflammatory processes play role maintaining homeostasis healthy pathological settings. Here, we explore evidence suggesting that potential microglia various animal models. We emphasize areas where future research contribute uncovering engaging exercise.
Language: Английский
Citations
4
BMC Neuroscience, Journal Year: 2025, Volume and Issue: 26(1)
Published: Feb. 21, 2025
Abstract Background This study aims to investigate the effects of aerobic exercise training on learning and memory (L&M) performance in rats exposed altitude hypoxia its relationship with hippocampal plasticity PKA–CREB–BDNF signaling pathway. Methods Male Sprague–Dawley were 14.2% or without 60 min non-weight-bearing swimming for 8 weeks. The L&M was evaluated using Morris water maze, mRNA expression PSD95, SYP, PKA, CREB, CBP, BDNF hippocampus detected. Results Chronic exposure significantly impaired reduced BDNF. Aerobic effectively reversed these changes by enhancing synaptic through activation Conclusion can alleviate decline caused exposure, possibly
Language: Английский
Citations
0
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract Physical exercise protects against cognitive impairment caused by chronic cerebral hypoperfusion (CCH). However, the mechanisms through which sends signals from periphery to central nervous system remain incompletely understood. This study demonstrated that promotes secretion of muscle‐derived small extracellular vesicles (sEVs), facilitate interorgan communication between muscle and brain. Systematic delivery sEVs enhances synaptic plasticity alleviated in CCH. Notably, miRNA sequencing reveal miR‐17/20a‐5p as key cargos involved exercise‐induced muscle‐brain crosstalk. Muscle‐derived are also identified primary source swimming‐induced circulating sEVs. Mechanistically, binds DEP‐domain containing mTOR‐interacting protein (DEPTOR) activates mammalian target rapamycin (mTOR) pathway hippocampus. Depletion impairs enhancement function. Moreover, overexpression DEPTOR hippocampus attenuates benefits exercise. Conversely, hippocampus‐specific activation mTOR reverses these effects, highlighting crucial role mediating positive effects Collectively, findings identify myokine with potent on brain, emphasizing therapeutic potential managing impairment.
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 6864 - 6892
Published: Feb. 14, 2024
Language: Английский
Citations
3
Translational Neurodegeneration, Journal Year: 2024, Volume and Issue: 13(1)
Published: Dec. 6, 2024
Abstract Extracellular vesicles (EVs) are membrane originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced basic biological research to essential clinical significance. capacity selectively enrich specific subsets biofluids via distinctive surface markers opened new avenues for molecular understandings across various tissues and organs, notably In recent years, brain-derived have been extensively investigated as biomarkers, therapeutic targets, drug-delivery vehicles diseases. review provides a brief overview characteristics physiological functions classes EVs, focusing on mechanisms by which types mediate occurrence development Concurrently, novel approaches challenges use delivery delineated.
Language: Английский
Citations
3
Psychopharmacology, Journal Year: 2024, Volume and Issue: 241(8), P. 1577 - 1594
Published: April 17, 2024
Language: Английский
Citations
2