Food & Function,
Journal Year:
2024,
Volume and Issue:
15(18), P. 9070 - 9084
Published: Jan. 1, 2024
PERK/CHOP
pathway-mediated
excessive
endoplasmic
reticulum
(ER)
stress
is
closely
linked
to
aging-related
cognitive
impairment
(ARCD).
Zerumbone
(ZB),
a
naturally
occurring
sesquiterpene
molecule
obtained
from
dietary
bitter
ginger,
has
garnered
significant
interest
due
its
diverse
range
of
biological
properties.
It
unclear,
though,
if
ZB
can
reduce
ARCD
by
preventing
ER
that
dependent
on
the
pathway.
Here,
PERK-CHOP
pathway
was
main
focus
an
evaluation
effects
and
mechanisms
for
attenuating
in
D-galactose
(D-gal)-induced
aging
mice
SH-SY5Y
cells.
According
our
findings,
not
only
greatly
decreased
neuronal
both
Cells,
Journal Year:
2024,
Volume and Issue:
13(2), P. 123 - 123
Published: Jan. 9, 2024
The
COVID-19
pandemic
has
brought
to
the
forefront
intricate
relationship
between
SARS-CoV-2
and
its
impact
on
neurological
complications,
including
potential
links
neurodegenerative
processes,
characterized
by
a
dysfunction
of
protein
quality
control
systems
ER
stress.
This
review
article
explores
role
systems,
such
as
Unfolded
Protein
Response
(UPR),
Endoplasmic
Reticulum-Associated
Degradation
(ERAD),
Ubiquitin–Proteasome
System
(UPS),
autophagy
molecular
chaperones,
in
infection.
Our
hypothesis
suggests
that
produces
stress
exploits
leading
disruption
proteostasis
cannot
be
solved
host
cell.
culminates
cell
death
may
represent
link
neurodegeneration.
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(3), P. 1400 - 1461
Published: Jan. 17, 2024
Abstract
Neuropsychiatric
disorders
are
anticipated
to
be
a
leading
health
concern
in
the
near
future,
emphasizing
an
outstanding
need
for
development
of
new
effective
therapeutics
treat
them.
Stilbenes,
with
resveratrol
attracting
most
attention,
example
multi‐target
compounds
promising
therapeutic
potential
broad
array
neuropsychiatric
and
neurological
conditions.
This
review
is
comprehensive
summary
current
state
research
on
stilbenes
several
such
as
depression,
anxiety,
schizophrenia,
autism
spectrum
disorders,
epilepsy,
traumatic
brain
injury,
neurodegenerative
disorders.
We
describe
discuss
results
both
vitro
vivo
studies.
The
majority
studies
concentrate
resveratrol,
limited
findings
exploring
other
pterostilbene,
piceatannol,
polydatin,
tetrahydroxystilbene
glucoside,
or
synthetic
derivatives.
Overall,
although
extensive
preclinical
show
benefits
various
central
nervous
system
clinical
evidence
their
efficacy
largely
missing.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(20), P. 15430 - 15430
Published: Oct. 21, 2023
In
the
last
two
decades,
there
has
been
increasing
evidence
supporting
non-neuronal
cells
as
active
contributors
to
neurodegenerative
disorders.
Among
glial
cells,
astrocytes
play
a
pivotal
role
in
driving
amyotrophic
lateral
sclerosis
(ALS)
progression,
leading
scientific
community
focus
on
"astrocytic
signature"
ALS.
Here,
we
summarized
main
pathological
mechanisms
characterizing
astrocyte
contribution
MN
damage
and
ALS
such
neuroinflammation,
mitochondrial
dysfunction,
oxidative
stress,
energy
metabolism
impairment,
miRNAs
extracellular
vesicles
contribution,
autophagy
protein
misfolding,
altered
neurotrophic
factor
release.
Since
glutamate
excitotoxicity
is
one
of
most
relevant
features,
focused
specific
this
aspect,
highlighting
known
or
potential
molecular
by
which
participate
level
and,
conversely,
undergo
toxic
effect
excessive
glutamate.
scenario,
can
behave
"producers"
"targets"
high
levels,
going
through
changes
that
affect
themselves
turn,
neuronal
surrounding
thus
actively
impacting
course.
Moreover,
review
aims
point
out
knowledge
gaps
deserve
further
investigation.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 25, 2024
Neurodegenerative
diseases,
which
are
characterized
by
progressive
neuronal
loss
and
cognitive
decline,
a
significant
concern
for
the
aging
population.
Neuroinflammation,
shared
characteristic
of
these
is
implicated
in
their
pathogenesis.
This
article
briefly
summarizes
role
magnesium,
an
essential
mineral
involved
numerous
enzymatic
reactions
critical
bioactivity,
context
neuroinflammation
decline.
The
potential
neuroprotective
effects
including
mechanisms
neuroprotection
magnesium
through
maintaining
ion
homeostasis,
reducing
inflammation,
preventing
excitotoxicity,
also
described.
Additionally,
we
discuss
impact
inadequate
on
its
as
therapeutic
agent
attenuating
decline
to
improve
neurodegenerative
conditions.
Food & Function,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Nicotinamide
riboside
alleviated
cognitive
impairment
induced
by
sucrose/aspartame,
which
might
be
related
to
neuroinflammation,
pyroptosis,
oxidative
stress,
apoptosis
and
autophagy.
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 2, 2025
Diabetes-associated
neurodegeneration
may
result
from
increased
oxidative
stress
in
the
brain
under
hyperglycemic
conditions,
which
leads
to
neuronal
cell
death.
The
current
study
employs
neuroblastoma
line
SH-SY5Y
and
db/db
mouse
model
of
diabetes
maintained
on
a
high-fat
diet
investigate
neuroprotective
effects
primary
functional
components
mulberry
(Morus
alba
Linn)
leaf
extract
(MLE),
chlorogenic
acid
(CGA),
neochlorogenic
(NCGA).
CGA
NCGA
demonstrated
ability
enhance
activities
antioxidant
enzymes
superoxide
dismutase
glutathione
peroxidase,
attenuate
inflammation
via
regulating
nuclear
factor
erythroid
2-related
2
(Nrf2),
factor-κB
(NFκB),
inflammatory
cytokines,
thereby
protecting
cells
damage
induced
by
palmitic
high
glucose.
were
found
decrease
expression
proinflammatory
proteins
α-synuclein
amyloid-β
(Aβ).
In
addition,
treatments
tyrosine
hydroxylase
(TH)
brain-derived
neurotrophic
(BDNF).
Furthermore,
MLE
supplementation
animal
resulted
decreased
levels
Aβ
concomitant
with
an
elevated
TH.
These
experimental
findings
suggest
that
be
mediated
three
pathways:
reducing
stress,
decreasing
inflammation,
enhancing
BDNF
expression.
npj Systems Biology and Applications,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 17, 2025
A
molecular
systems
architecture
is
presented
for
the
neuromuscular
junction
(NMJ)
in
order
to
provide
a
framework
organizing
complexity
of
biomolecular
interactions
amyotrophic
lateral
sclerosis
(ALS)
using
systematic
literature
review
process.
ALS
fatal
motor
neuron
disease
characterized
by
progressive
degeneration
upper
and
lower
neurons
that
supply
voluntary
muscles.
The
contains
cells
such
as
neurons,
skeletal
muscle
cells,
astrocytes,
microglia,
Schwann
endothelial
which
are
implicated
pathogenesis
ALS.
This
provides
multi-layered
understanding
intra-
inter-cellular
microenvironment,
may
be
utilized
target
identification,
discovery
single
combination
therapeutics,
clinical
strategies
treat
