The Role of the Brain-Derived Neurotrophic Factor in Chronic Pain: Links to Central Sensitization and Neuroinflammation

Biomolecules, Journal Year: 2024, Volume and Issue: 14(1), P. 71 - 71

Published: Jan. 5, 2024

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS), marked by maladaptive neuroplasticity and neuronal hyperexcitability within pathways. Accumulating evidence suggests that CS also driven neuroinflammation peripheral nervous system. In any chronic disease, search for perpetuating factors crucial identifying therapeutic targets developing primary preventive strategies. The brain-derived neurotrophic factor (BDNF) emerges as a critical regulator synaptic plasticity, serving both neurotransmitter neuromodulator. Mounting supports BDNF’s pro-nociceptive role, spanning from its pain-sensitizing capacity across multiple levels nociceptive pathways to involvement neuroinflammation. Moreover, consistently elevated BDNF are observed various disorders. To comprehensively understand profound impact pain, we delve into key characteristics, focusing on role underlying molecular mechanisms contributing pain. Additionally, explore potential utility an objective biomarker This discussion encompasses emerging approaches aimed at modulating expression, offering insights addressing complexities

Language: Английский

---

Royal Jelly: Biological Action and Health Benefits

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 6023 - 6023

Published: May 30, 2024

Royal jelly (RJ) is a highly nutritious natural product with great potential for use in medicine, cosmetics, and as health-promoting food. This bee mixture of important compounds, such proteins, vitamins, lipids, minerals, hormones, neurotransmitters, flavonoids, polyphenols, that underlie the remarkable biological therapeutic activities RJ. Various bioactive molecules like 10-hydroxy-2-decenoic acid (10-HDA), antibacterial protein, apisin, major royal specific peptides apisimin, royalisin, royalactin, apidaecin, defensin-1, jelleins are characteristic ingredients RJ shows numerous physiological pharmacological properties, including vasodilatory, hypotensive, antihypercholesterolaemic, antidiabetic, immunomodulatory, anti-inflammatory, antioxidant, anti-aging, neuroprotective, antimicrobial, estrogenic, anti-allergic, anti-osteoporotic, anti-tumor effects. Moreover, may reduce menopause symptoms improve health reproductive system, liver, kidneys, promote wound healing. article provides an overview molecular mechanisms underlying beneficial effects various diseases, aging, aging-related complications, special emphasis on components their properties. The data presented should be incentive future clinical studies hopefully will advance our knowledge about facilitate development novel RJ-based opportunities improving human well-being.

Language: Английский

---

Inflammaging and Brain Aging

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10535 - 10535

Published: Sept. 30, 2024

Progress made by the medical community in increasing lifespans comes with costs of incidence and prevalence age-related diseases, neurodegenerative ones included. Aging is associated a series morphological changes at tissue cellular levels brain, as well impairments signaling pathways gene transcription, which lead to synaptic dysfunction cognitive decline. Although we are not able pinpoint exact differences between healthy aging neurodegeneration, research increasingly highlights involvement neuroinflammation chronic systemic inflammation (inflammaging) development age-associated via pathogenic cascades, triggered dysfunctions circadian clock, gut dysbiosis, immunosenescence, or impaired cholinergic signaling. In addition, gender susceptibility course neurodegeneration that appear be mediated glial cells emphasize need for future this area an individualized therapeutic approach. rejuvenation still its very early infancy, accumulated knowledge on various involved promoting senescence opens perspective interfering these preventing delaying senescence.

Language: Английский

---

Pentoxifylline Prevents Neuroinflammation and Modifies PTEN/TrkB Signaling in an LPS-Induced Depression Model

Journal of Neuroimmune Pharmacology, Journal Year: 2025, Volume and Issue: 20(1)

Published: April 3, 2025

Language: Английский

---

IL-8 (CXCL8) Correlations with Psychoneuroimmunological Processes and Neuropsychiatric Conditions

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(5), P. 488 - 488

Published: May 3, 2024

Interleukin-8 (IL-8/CXCL8), an essential CXC chemokine, significantly influences psychoneuroimmunological processes and affects neurological psychiatric health. It exerts a profound effect on immune cell activation brain function, suggesting potential roles in both neuroprotection neuroinflammation. IL-8 production is stimulated by several factors, including reactive oxygen species (ROS) known to promote inflammation disease progression. Additionally, CXCL8 gene polymorphisms can alter production, leading differences susceptibility, progression, severity across populations. levels vary among neuropsychiatric conditions, demonstrating sensitivity psychosocial stressors severity. be detected blood circulation, cerebrospinal fluid (CSF), urine, making it promising candidate for broad-spectrum biomarker. This review highlights the need further research diverse effects of associated implications personalized medicine. A thorough understanding its complex role could lead development more effective treatment strategies conditions.

Language: Английский

---

The relevance of BDNF for neuroprotection and neuroplasticity in multiple sclerosis

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 1, 2024

Neuroplasticity as a mechanism to overcome central nervous system injury resulting from different neurological diseases has gained increasing attention in recent years. However, deficiency of these repair mechanisms leads the accumulation neuronal damage and therefore long-term disability. To date, by which remyelination occurs why extent differs interindividually between multiple sclerosis patients regardless disease course are unclear. A member neurotrophins family, brain-derived neurotrophic factor (BDNF) received particular this context it is thought play role thus neuroplasticity, neuroprotection, memory.

Language: Английский

---

Aspartame-induced cognitive dysfunction: Unveiling role of microglia-mediated neuroinflammation and molecular remediation

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 135, P. 112295 - 112295

Published: May 21, 2024

Language: Английский

---

BDNF Signaling in Vascular Dementia and Its Effects on Cerebrovascular Dysfunction, Synaptic Plasticity, and Cholinergic System Abnormality

Journal of Lipid and Atherosclerosis, Journal Year: 2024, Volume and Issue: 13(2), P. 122 - 122

Published: Jan. 1, 2024

Vascular dementia (VaD) is the second most common type of and characterized by memory impairment, blood-brain barrier disruption, neuronal cell loss, glia activation, impaired synaptic plasticity, cholinergic system abnormalities. To effectively prevent treat VaD a good understanding mechanisms underlying its neuropathology needed. Brain-derived neurotrophic factor (BDNF) an important with multiple functions in systemic circulation central nervous known to regulate survival, formation, cognitive decline. Recent studies indicate that when compared normal subjects, patients have low serum BDNF levels deficiency cerebrospinal fluid indicator VaD. Here, we review current knowledge on role signaling pathology VaD, such as cerebrovascular dysfunction, impairment.

Language: Английский

---

A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 4, 2024

Abstract Background Neuroinflammation is widely acknowledged as a characteristic feature of almost all neurological disorders and specifically in depression- anxiety-like disorders. In recent years, there has been significant attention on natural compounds with potent anti-inflammatory effects due to their potential mitigating neuroinflammation neuroplasticity. Methods the present study, we aimed evaluate neuroprotective oleacein (OC), rare secoiridoid derivative found extra virgin olive oil. Our goal was explore BDNF/TrkB neurotrophic activity OC subsequently assess its for modulating neuroinflammatory response using human neuroblastoma cells (SH-SY5Y cells) an vivo model depression induced by lipopolysaccharide (LPS)-mediated inflammation. Results SH-SY5Y cells, exhibited dose-dependent increase BDNF expression. This enhancement absent when were co-treated inhibitors BDNF's receptor TrkB, well downstream molecules PI3K MEK. Whole-transcriptomics analysis revealed that upregulated cell cycle-related genes under normal conditions, while downregulating inflammation-associated LPS-induced conditions. Furthermore, surface plasmon resonance (SPR) assays demonstrated stronger more stable binding affinity TrkB compared positive control, 7,8-dihydroxyflavone. Importantly, bioluminescence imaging single oral dose significantly increased expression brains Bdnf-IRES-AkaLuc mice. administration at dosage 10 mg/kg body weight days reduced immobility time tail suspension test LPS-treated group. RT-qPCR decreased pro-inflammatory cytokines Tnfα , Il6 Il1β simultaneously enhancing Bdnf expression, both pro mature protein levels mice hippocampus. These changes comparable those control antidepressant drug fluoxetine. Additionally, microarray mouse confirmed could counteract inflammatory biological events. Conclusion Altogether, our study represents first report antineuroinflammatory properties via modulation activity. finding underscores therapeutic agent anxiety-related

Language: Английский

---

Propofol improves sleep deprivation‐induced sleep structural and cognitive deficits via upregulating the BMAL1 expression and suppressing microglial M1 polarization

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Abstract Background Sleep deprivation (SD) is a growing global health problem with many deleterious effects, such as cognitive impairment. Microglia activation‐induced neuroinflammation may be an essential factor in this. Propofol has been shown to clear sleep debt after SD rats. This study aims evaluate the effects of propofol‐induced on ameliorating quality impairment and decline 48 h SD. Methods Almost 8–12‐week‐old rats were placed system for natural or continuous Afterwards, received propofol (20 mg·kg −1 ·h , 6 h) via tail slept naturally. The Morris water maze (MWM) Y‐maze test assessed spatial learning memory abilities. Rat EEG/EMG monitored sleep. expression brain muscle Arnt‐like protein 1 (BMAL1), brain‐derived neurotrophic (BDNF) hippocampus BMAL1 hypothalamus by western blot. Enzyme‐linked immunosorbent assay detected IL‐6, IL‐1β, arginase (Arg1), IL‐10 levels hippocampus. Immunofluorescence was used determine microglia well morphological changes. Results Compared control group, sleep‐deprived showed poor performance both MWM test, accompanied disturbances structure, including increased total time, time spent delta power non‐rapid eye movement In addition, induces abnormal circadian rhythm BMAL1, activates microglia, causes nerve damage. reversed these changes saved Furthermore, treatment significantly reduced hippocampal IL‐1β IL‐6 levels, BDNF, Arg1, switched surface markers from inflammatory M1 type anti‐inflammatory M2 type. Conclusion reduces SD‐induced disruption, possibly lowering neuronal inflammation switching phenotype activated state, thus exerting neuroprotective effects.

Language: Английский

---