The Sleep-Immune Crosstalk in Health and Disease

Physiological Reviews, Journal Year: 2019, Volume and Issue: 99(3), P. 1325 - 1380

Published: March 28, 2019

Sleep and immunity are bidirectionally linked. Immune system activation alters sleep, sleep in turn affects the innate adaptive arm of our body’s defense system. Stimulation immune by microbial challenges triggers an inflammatory response, which, depending on its magnitude time course, can induce increase duration intensity, but also a disruption sleep. Enhancement during infection is assumed to feedback promote host defense. Indeed, various parameters, associated with reduced risk, improve outcome vaccination responses. The induction hormonal constellation that supports functions one likely mechanism underlying immune-supporting effects In absence infectious challenge, appears homeostasis through several mediators, such as cytokines. This notion supported findings prolonged deficiency (e.g., short duration, disturbance) lead chronic, systemic low-grade inflammation diseases have component, like diabetes, atherosclerosis, neurodegeneration. Here, we review available data this regulatory sleep-immune crosstalk, point out methodological challenges, suggest questions open for future research.

Language: Английский

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Mental health in elite athletes: International Olympic Committee consensus statement (2019)

British Journal of Sports Medicine, Journal Year: 2019, Volume and Issue: 53(11), P. 667 - 699

Published: May 16, 2019

Mental health symptoms and disorders are common among elite athletes, may have sport related manifestations within this population impair performance. cannot be separated from physical health, as evidenced by mental increasing the risk of injury delaying subsequent recovery. There no evidence or consensus based guidelines for diagnosis management in athletes. Diagnosis must differentiate character traits particular to athletes psychosocial maladaptations.Management strategies should address all contributors consider biopsychosocial factors relevant maximise benefit minimise harm. Management involve both treatment affected individual optimising environments which train compete. To advance a more standardised, approach an International Olympic Committee Consensus Work Group critically evaluated current state science provided recommendations.

Language: Английский

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Nutrition, Physical Activity, and Other Lifestyle Factors in the Prevention of Cognitive Decline and Dementia

Nutrients, Journal Year: 2021, Volume and Issue: 13(11), P. 4080 - 4080

Published: Nov. 15, 2021

Multiple factors combined are currently recognized as contributors to cognitive decline. The main independent risk factor for impairment and dementia is advanced age followed by other determinants such genetic, socioeconomic, environmental factors, including nutrition physical activity. In the next decades, a rise in cases expected due largely aging of world population. There no hitherto effective pharmaceutical therapies treat age-associated dementia, which underscores crucial role prevention. A relationship among diet, activity, lifestyle with function has been intensively studied mounting evidence supporting these development decline chief cause disability globally. Several dietary patterns, foods, nutrients have investigated this regard, some encouraging disappointing results. This review presents current effects components, supplements, sleep social engagement on prevention or delay onset age-related dementia.

Language: Английский

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Blood–Brain Barrier Dynamics to Maintain Brain Homeostasis

Trends in Neurosciences, Journal Year: 2021, Volume and Issue: 44(5), P. 393 - 405

Published: Jan. 8, 2021

The blood-brain barrier (BBB) is a dynamic platform for exchange of substances between the blood and brain parenchyma, it an essential functional gatekeeper central nervous system (CNS). While widely recognized that BBB disruption hallmark several neurovascular pathologies, aspect has received somewhat less attention modulation tightness to maintain homeostasis in response extrinsic environmental factors physiological changes. In this review, we summarize how integrity adjusts critical stages along life span, as well permeability can be altered by common stressors derived from nutritional habits, psychological stress.

Language: Английский

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Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease

Biomedicine & Pharmacotherapy, Journal Year: 2020, Volume and Issue: 132, P. 110887 - 110887

Published: Nov. 2, 2020

Alzheimer's disease (AD) is an age-related neurodegenerative with multiple predisposing factors and complicated pathogenesis. Aβ peptide one of the most important pathogenic in etiology AD. Accumulating evidence indicates that imbalance production clearance brain AD patients leads to deposition neurotoxic oligomer formation. Melatonin shows a potent neuroprotective effect can prevent or slow down progression AD, supporting view melatonin potential therapeutic molecule for modulates regulatory network secretase expression affects function secretase, thereby inhibiting amyloidogenic APP processing production. Additionally, ameliorates Aβ-induced neurotoxicity probably promotes through glymphatic-lymphatic drainage, BBB transportation degradation pathways. In this review, we summarize discuss role against Aβ-dependent We explore cellular molecular mechanisms on assembly, clearance, circadian cycle disruption. clinical trials treatment patients, showing has promising improving sleep quality cognitive function. This review aims stimulate further research as agent

Language: Английский

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Circadian disruption and sleep disorders in neurodegeneration

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Feb. 13, 2023

Abstract Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions diseases. Circadian disruption disorders aggravate neurodegeneration in turn disrupt sleep. Importantly, various increase the risk Thus, harnessing biology findings from preclinical translational research is importance for reducing improving symptoms quality life individuals with via approaches that normalize context precision medicine. In this review, we discuss implications by summarizing both human animal studies, focusing on links prevalent forms neurodegeneration. These provide valuable insights into pathogenesis suggest promising role circadian-based interventions.

Language: Английский

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A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(4), P. 666 - 678

Published: Feb. 15, 2024

Abstract Sleep is thought to be restorative brain energy homeostasis, but it not clear how this achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial oxidation and lipid accumulation dependent on prior wake requires the APOE orthologs NLaz GLaz, which mediate neuron–glia transfer. In turn, full night sleep required for clearance, oxidative recovery maximal neuronal mitophagy. Knockdown causes stress accumulate in neurons, integrity protein, Drp1, accumulation. These data suggest neurons avoid damage during by using mitophagy passing form lipids. propose metabolic between reflects fundamental function relevant homeostasis.

Language: Английский

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Circadian and sleep dysfunction in Alzheimer’s disease

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 60, P. 101046 - 101046

Published: April 16, 2020

Language: Английский

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Dynamic ¹¹C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis

Journal of Nuclear Medicine, Journal Year: 2019, Volume and Issue: 60(10), P. 1452 - 1460

Published: March 8, 2019

Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of brain homeostasis. 11C-Pittsburgh compound B (PiB) PET was recently proposed as a tool for detection CSF alterations Alzheimer disease. The current study investigates the magnitude 11C-PiB signal lateral ventricles independent group mild cognitive impairment subjects. We have also evaluated multiple sclerosis model disease with without amyloid-β tissue accumulation. Methods: A set 11 12 subjects 20 matched controls underwent MRI dynamic PET. Lateral ventricle regions interest were generated manually from data. data analyzed using cerebellum or supervised reference region sets, respectively. calculated area under curve 35 to 80 min SUV ratio (SUVR) 50 70 min. Compartmental modeling analysis performed on separate containing control subjects; this included arterial input function, further understand kinetics ventricular signal. Results: ANOVA revealed significant differences SUVR across Alzheimer, impairment, healthy groups (P = 0.004). Pairwise comparisons significantly lower than < 0.001) 0.029). 0.008). uptake rates blood 0.005) 0.004) out 0.002) controls. Conclusion: These results indicate that can be used observe pathologic changes dynamics. replicated previous work demonstrating deficits associated deposits extended observations include sclerosis.

Language: Английский

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Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology

Brain Pathology, Journal Year: 2021, Volume and Issue: 32(3)

Published: Oct. 20, 2021

Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, psychological symptoms, neurodegeneration. This study aimed evaluate the effects of environmental genetic factors on molecular clock establish a link between circadian rhythm disturbance AD. We investigated pathological chronic sleep deprivation (CSD) APPswe /PS1ΔE9 transgenic mice their wild-type (WT) littermates for 2 months evaluated expression levels genes rhythm-related nuclei. Our results showed that CSD impaired learning memory, further exaggerated progression AD mice. Furthermore, caused abnormal Bmal1, Clock, Cry1 nuclei experimental mice, these changes are more significant Abnormal suggested affected by APP/PS1 mutations. In addition, tau phosphorylation was found retrosplenial cortex, which co-located with alteration BMAL1 protein level. Moreover, level tyrosine hydroxylase locus coeruleus WT significantly increased after CSD. There be potential clock, Aβ pathology, tauopathy, noradrenergic system. The this provided new insights into development

Language: Английский

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