Handbook of clinical neurology, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 229
Published: Jan. 1, 2025
Language: Английский
Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)
Published: Feb. 13, 2023
Abstract Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions diseases. Circadian disruption disorders aggravate neurodegeneration in turn disrupt sleep. Importantly, various increase the risk Thus, harnessing biology findings from preclinical translational research is importance for reducing improving symptoms quality life individuals with via approaches that normalize context precision medicine. In this review, we discuss implications by summarizing both human animal studies, focusing on links prevalent forms neurodegeneration. These provide valuable insights into pathogenesis suggest promising role circadian-based interventions.
Language: Английский
Citations
65
Progress in Retinal and Eye Research, Journal Year: 2024, Volume and Issue: 101, P. 101273 - 101273
Published: May 15, 2024
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of Alzheimer's disease (AD). Studies have identified the pathological hallmarks AD, including amyloid β-protein (Aβ) deposits abnormal tau protein isoforms, in retinas AD patients animal models. Moreover, structural functional vascular abnormalities such as reduced blood flow, Aβ deposition, blood-retinal barrier damage, along with inflammation neurodegeneration, been described mild cognitive impairment dementia. Histological, biochemical, clinical studies demonstrated that nature severity pathologies brain correspond. Proteomics analysis revealed a similar pattern dysregulated proteins biological pathways patients, enhanced inflammatory neurodegenerative processes, impaired oxidative-phosphorylation, mitochondrial dysfunction. Notably, investigational imaging technologies can now detect AD-specific deposits, well vasculopathy neurodegeneration living suggesting alterations at different stages links to pathology. Current exploratory ophthalmic modalities, optical coherence tomography (OCT), OCT-angiography, confocal scanning laser ophthalmoscopy, hyperspectral imaging, may offer promise assessment AD. However, further research needed deepen our understanding AD's impact on its progression. To advance this field, future require replication larger diverse cohorts confirmed biomarkers standardized retinal techniques. This will validate aiding early screening monitoring.
Language: Английский
Citations
25
Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 170, P. 106044 - 106044
Published: Feb. 4, 2025
Language: Английский
Citations
3
Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 3, 2025
Improving sleep in murine Alzheimer's disease (AD) is associated with reduced brain amyloidosis. However, the window of opportunity for successful sleep-targeted interventions, regarding reduction pathological hallmarks and related cognitive performance, remains poorly characterized. Here, we enhanced slow-wave activity (SWA) during via sodium oxybate (SO) oral administration 2 weeks at early (6 months old) or moderately late (11 stages Tg2576 mice evaluated resulting neuropathology behavioral performance. We observed that performance 6-month-old significantly improved upon SO treatment, whereas no change was 11-month-old mice. Histochemical assessment amyloid plaques demonstrated SO-treated had less plaque burden than placebo-treated ones, ELISA insoluble protein fractions from brains indicated lower Aβ-42/Aβ-40 ratio group vs. controls. Altogether, our results suggest SWA-dependent amyloidosis leads to alleviated impairment only if administered course, potentially highlighting key importance sleep-based interventions clinical cohorts.
Language: Английский
Citations
2
Brain Pathology, Journal Year: 2021, Volume and Issue: 32(3)
Published: Oct. 20, 2021
Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to cognitive impairment, psychological symptoms, neurodegeneration. This study aimed evaluate the effects of environmental genetic factors on molecular clock establish a link between circadian rhythm disturbance AD. We investigated pathological chronic sleep deprivation (CSD) APPswe /PS1ΔE9 transgenic mice their wild-type (WT) littermates for 2 months evaluated expression levels genes rhythm-related nuclei. Our results showed that CSD impaired learning memory, further exaggerated progression AD mice. Furthermore, caused abnormal Bmal1, Clock, Cry1 nuclei experimental mice, these changes are more significant Abnormal suggested affected by APP/PS1 mutations. In addition, tau phosphorylation was found retrosplenial cortex, which co-located with alteration BMAL1 protein level. Moreover, level tyrosine hydroxylase locus coeruleus WT significantly increased after CSD. There be potential clock, Aβ pathology, tauopathy, noradrenergic system. The this provided new insights into development
Language: Английский
Citations
94
Aging Cell, Journal Year: 2022, Volume and Issue: 21(10)
Published: Sept. 3, 2022
Abstract With the aging world population, prevalence of aging‐related disorders is on rise. Diseases such as Alzheimer's, type 2 diabetes mellitus (T2DM), Parkinson's, atherosclerosis, hypertension, and osteoarthritis are age‐related, most these diseases comorbidities or risk factors for AD; however, our understandings molecular events that regulate occurrence still not fully understood. Brain muscle Arnt‐like protein‐1 (Bmal1) an irreplaceable clock gene governs multiple important physiological processes. Continuous research Bmal1 in AD associated ongoing, this review picks relevant studies a detailed account its role mechanisms diseases. Oxidative stress inflammation turned out to be common by which deficiency promotes diseases, other Bmal1‐dependent remain identified. Promising therapeutic strategies involved regulation provided, including melatonin, natural compounds, metformin, d‐Ser2‐oxyntomodulin, interventions, exercise, time‐restricted feeding, adiponectin. The establishment signaling pathway network will lead advances comprehension cellular mechanisms, shedding light novel treatments promoting aging‐associated brain health.
Language: Английский
Citations
38
Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
Language: Английский
Citations
1
Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28819 - e28819
Published: April 1, 2024
Sleep deprivation refers to an intentional or unintentional reduction in sleep time, resulting insufficient sleep. It is often caused by disorders, work demands (e.g., night shifts), and study pressure. promotes Aβ deposition tau hyperphosphorylation, which a risk factor for the pathogenesis progression of Alzheimer's disease (AD). Recent research has demonstrated potential involvement both AD through glial cell activation, lymphatic system, orexin circadian rhythm inflammation, gut microbiota. Thus, investigating molecular mechanisms underlying association between crucial, may contribute development preventive therapeutic strategies AD. This review aims analyze impact on AD, exploring pathological that link initiation offers theoretical foundation drugs aimed at preventing treating
Language: Английский
Citations
8
Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 61(9), P. 6628 - 6641
Published: Feb. 8, 2024
Language: Английский
Citations
7
Experimental Gerontology, Journal Year: 2022, Volume and Issue: 172, P. 112076 - 112076
Published: Dec. 24, 2022
The circadian system is an intricate molecular network of coordinating clocks that organize the internal synchrony organism in response to environment. These rhythms are maintained by genetically programmed positive and negative auto-regulated transcriptional translational feedback loops sustain 24-hour oscillations mRNA protein components endogenous clock. Since inter intracellular activity central pacemaker appears reduce with aging, interaction between clock aging continues elude our understanding. In this review article, we discuss at level how adversely affects functioning rodents humans. natural decline melatonin levels strongly contributes dysregulation resulting development neurological anomalies. Additionally, inappropriate environmental conditions such as Artificial Light Night (ALAN) can cause disruption or chronodisruption (CD) which result a variety pathological diseases, including premature aging. Furthermore, summarize recent evidence suggesting CD may also be predisposing factor for age-related neurodegenerative diseases (NDDs) Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), although more investigation required prove link. Finally, certain chrono-enhancement approaches have been offered intervention strategies prevent, alleviate, mitigate impacts CD. This thus aims bring together advancements chronobiology process, well its role NDDs.
Language: Английский
Citations
27