Peptides,
Journal Year:
2024,
Volume and Issue:
175, P. 171169 - 171169
Published: Feb. 9, 2024
The
goal
of
the
present
study
is
to
investigate
role
intraamygdaloid
oxytocin
in
learning-related
mechanisms.
Oxytocin
a
neuropeptide
which
involved
social
bonding,
trust,
emotional
responses
and
various
behaviors.
By
conducting
passive
avoidance
Morris
water
maze
tests
on
male
Wistar
rats,
memory
performance
learning
was
investigated.
doses
10
ng
100
were
injected
into
central
nucleus
amygdala.
Our
results
showed
that
significantly
reduced
time
required
locate
platform
during
test
while
increasing
latency
test.
However,
experiment
failed
produce
significant
effect
either
tests.
rats
pretreated
with
20
receptor
antagonist
(L-2540)
administered
amygdala
also
subjected
aforementioned
highlight
receptors
spatial-
learning.
Results
suggest
supports
processing
both
antagonists
can
however
block
effects
substantiate
uses
enhance
performance.
International Journal of Molecular Sciences,
Journal Year:
2021,
Volume and Issue:
22(14), P. 7737 - 7737
Published: July 20, 2021
The
hypothalamic
peptide
oxytocin
and
its
receptor
are
involved
in
a
range
of
physiological
processes,
including
parturition,
lactation,
cell
growth,
wound
healing,
social
behavior.
More
recently,
increasing
evidence
has
established
the
effects
on
food
intake,
energy
expenditure,
peripheral
metabolism.
In
this
review,
we
provide
comprehensive
description
central
oxytocinergic
system
which
acts
to
shape
eating
behavior
Next,
discuss
beneficial
exerts
key
metabolic
organs,
suppression
visceral
adipose
tissue
inflammation,
skeletal
muscle
regeneration,
bone
mineralization.
A
brief
summary
actions
learned
from
animal
models
is
presented,
showing
that
weight
loss
induced
by
chronic
treatment
related
not
only
anorexigenic
effects,
but
also
resulting
increase
expenditure
lipolysis.
Following
an
in-depth
discussion
technical
challenges
endogenous
measurements
humans,
synthesize
data
association
between
levels,
status,
syndrome,
health.
We
then
review
clinical
trials
acute
administration
reduces
attenuates
fMRI
activation
motivation
brain
areas,
increases
self-control
regions.
Further
strengthening
role
appetite
regulation,
conditions
insult
certain
genetic
pathologies
associated
with
depletion
present
hyperphagia,
extreme
gain,
poor
profile.
Intranasal
currently
being
evaluated
human
learn
whether
oxytocin-based
therapeutics
can
be
used
treat
obesity
sequela.
At
end
address
fundamental
remain
translating
line
research
care.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106039 - 106039
Published: Feb. 1, 2025
Social
interactions
are
vital
for
various
taxa
and
species.
Prosocial
affiliative
dynamics
within
a
group
between
individuals
not
only
pleasurable
rewarding,
but
also
appear
to
actively
contribute
well-being,
cognitive
performance,
disease
prevention.
Moreover,
disturbances
in
acting
or
being
prosocial
can
represent
major
burden
an
individual
their
affective
partners.
These
disruptions
evident
across
spectrum
of
neuropsychiatric
conditions,
including
depression
autism
disorders.
Importantly,
interactive
patterns
behavior
vary
with
sex.
The
fact
that
genders
differentially
affected
by
disorders
associated
social
impairment
underscores
the
high
importance
this
research
uncovering
underlying
neural
correlates
mechanisms.
This
review
focuses
on
elucidating
sex-related
differences
behaviors
potential
association
sexually
different
correlates.
Specifically,
we
aim
shed
light
complex
interplay
sex,
behavior,
neurobiology
interaction
patterns.
Psychotherapy and Psychosomatics,
Journal Year:
2022,
Volume and Issue:
91(4), P. 253 - 264
Published: Jan. 1, 2022
<b><i>Introduction:</i></b>
Anxiety
disorders
are
prevalent
mental
conditions
characterized
by
exaggerated
anxious
arousal
and
threat
reactivity.
Animal
human
studies
suggest
an
anxiolytic
potential
of
the
neuropeptide
oxytocin
(OT),
yet,
while
a
clinical
application
will
require
chronic
administration
protocols,
previous
have
exclusively
focused
on
single-dose
(acute)
intranasal
OT
effects.
<b><i>Objective:</i></b>
To
facilitate
translation
mechanism
into
application,
we
determined
whether
effects
maintained
with
repeated
(chronic)
or
influenced
dose
frequency
trait
anxiety.
<b><i>Methods:</i></b>
In
pre-registered
double-blind
randomized
placebo-controlled
pharmaco-fMRI
trial
acute
(single
dose)
as
well
two
different
frequencies
(OT
administered
daily
for
5
days
every
other
day)
emotional
reactivity
were
assessed
in
<i>n</i>
=
147
individuals
high
versus
low
anxiety
(ClinicalTrials.gov
ID:
NCT03085654).
<b><i>Results:</i></b>
produced
valence,
frequency,
anxiety-specific
effects,
such
that
low-frequency
(intermittent)
dosage
specifically
attenuated
neural
increase
amygdala-insula-prefrontal
circuits
observed
placebo-treated
subjects
response
to
threatening
but
not
positive
stimuli.
<b><i>Conclusions:</i></b>
The
present
provides
first
evidence
low-dose
has
alleviate
elevated
levels,
suggesting
treatment
disorders.
Comprehensive Psychoneuroendocrinology,
Journal Year:
2021,
Volume and Issue:
9, P. 100107 - 100107
Published: Dec. 27, 2021
Oxytocin
is
a
peptide
molecule
with
multitude
of
physiological
and
behavioral
functions.
Based
on
its
association
reproduction
-
including
social
bonding,
sexual
behavior,
birth
maternal
behavior
oxytocin
also
has
been
called
"the
love
hormone."
This
essay
specifically
examines
parallels
between
love.
However,
many
myths
gaps
in
knowledge
remain
concerning
both.
A
few
these
are
described
here
we
hypothesize
that
the
potential
benefits
both
may
be
better
understood
light
interactions
more
ancient
systems,
vasopressin
immune
system.
anti-inflammatory
associated
recently
evolved,
solutions
to
variety
challenges
necessary
for
mammalian
survival
reproduction.
The
shared
functions
have
profound
implications
health
longevity,
prevention
treatment
excess
inflammation
related
disorders,
especially
those
occurring
early
life
during
periods
chronic
threat
or
disease.
Neuropsychopharmacology,
Journal Year:
2023,
Volume and Issue:
48(6), P. 946 - 953
Published: March 20, 2023
Abstract
The
amygdala
is
a
key
region
in
current
neurocircuitry
models
of
reactive
aggression
as
it
crucially
involved
detecting
social
threat
and
provocation.
An
increased
reactivity
to
angry
faces
has
been
reported
aggression-prone
individuals
the
neuropeptide
oxytocin
(OT)
could
dampen
anger-related
number
mental
disorders.
One
example
antisocial
personality
disorder
(ASPD)
which
so
far
only
studied
limited
numbers.
To
address
question
whether
OT
can
normalize
hyperreactivity
emotional
faces,
we
conducted
functional
magnetic
resonance
imaging
experiment
with
20
men
18
women
ASPD
male
female
healthy
control
(HC)
participants
double-blind,
randomized,
placebo
(PLC)-controlled
within-subject
design.
Participants
were
exposed
an
emotion
classification
task
(fearful,
angry,
happy
faces)
after
receiving
intranasal
dose
(24
IU)
synthetic
or
PLC.
We
found
attenuate
right
hyperactivity
such
extent
that
intensity
activity
group
condition
decreased
level
PLC
HC
group.
There
was
also
trend
effects
generally
larger
than
men.
These
findings
suggest
differentially
modulates
following
threatening
provoking
cues
dependence
psychopathology
(ASPD
vs.
HC)
sex
(male
female).
Particularly
patients
benefit
from
treatment
aggression.
World Journal of Psychiatry,
Journal Year:
2023,
Volume and Issue:
13(5), P. 144 - 159
Published: May 19, 2023
Resilience
to
psychological
stress
is
defined
as
adaption
challenging
life
experiences
and
not
the
absence
of
adverse
events.
Determinants
resilience
include
personality
traits,
genetic/epigenetic
modifications
genes
involved
in
response,
cognitive
behavioral
flexibility,
secure
attachment
with
a
caregiver,
social
community
support
systems,
nutrition
exercise,
alignment
circadian
rhythm
natural
light/dark
cycle.
Therefore,
dynamic
flexible
process
that
continually
evolves
by
intersection
different
domains
human's
life;
biological,
social,
psychological.
The
objective
this
minireview
summarize
existing
knowledge
about
multitude
factors
molecular
alterations
result
from
response.
Given
multiple
contributing
building
resilience,
we
set
out
goal
identify
which
were
most
supportive
causal
role
current
literature.
We
focused
on
resilience-related
resulting
mind-body
homeostasis
connection
psychosocial
environmental
factors.
conclude
there
no
one
factor
differentiates
resilient
person
vulnerable
one.
Instead,
requires
an
intricate
network
positive
healthy
lifestyle
contribute
balanced
connection.
holistic
approach
must
be
adopted
future
research
response
address
elements
promote
prevent
illnesses
psychopathology
related
allostatic
load.
