Effect of bisphenol A on the neurological system: a review update

Archives of Toxicology, Journal Year: 2023, Volume and Issue: 98(1), P. 1 - 73

Published: Oct. 19, 2023

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) and one of the most produced synthetic compounds worldwide. BPA can be found in epoxy resins polycarbonate plastics, which are frequently used food storage baby bottles. However, bind mainly to estrogen receptors, interfering with various neurologic functions, its use a topic significant concern. Nonetheless, neurotoxicity has not been fully understood despite numerous investigations on disruptive effects. Therefore, this review aims highlight recent studies implications system. Our findings suggest that exposure impairs structural molecular brain changes, promoting oxidative stress, changing expression levels several crucial genes proteins, destructive effects neurotransmitters, excitotoxicity neuroinflammation, damaged blood-brain barrier function, neuronal damage, apoptosis effects, disruption intracellular Ca

Language: Английский

---

A western dietary pattern during pregnancy is associated with neurodevelopmental disorders in childhood and adolescence

Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

---

Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: March 7, 2024

Introduction Critical phases of neurodevelopment and gut microbiota diversification occur in early life both processes are impacted by genetic environmental factors. Recent studies have shown the presence alterations neurodevelopmental disorders. Here we performed a systematic review intestinal composition function pediatric adult patients affected autism spectrum disorder (ASD), attention-deficit/hyperactivity (ADHD), Rett syndrome (RETT). Methods We searched selected keywords online databases PubMed, Cochrane, OVID (January 1980 to December 2021) with secondary references eligible articles. Two reviewers independently critical appraisals on included articles using Appraisal Skills Program for each study design. Results Our identified 18, 7, 3 original describing profiles ASD, ADHD, RETT, respectively. Decreased Firmicutes increased Bacteroidetes were observed individuals ASD ADHD. Proinflammatory cytokines, short-chain fatty acids neurotransmitter levels altered RETT. Constipation visceral pain related changes Hyperactivity impulsivity negatively correlated Faecalibacterium (phylum Firmicutes) positively Bacteroides sp. Bacteroidetes) ADHD subjects. Five explored microbiota-or diet-targeted interventions Probiotic treatments Lactobacillus fecal transplantation from healthy donors reduced constipation ameliorated symptoms children. Perinatal administration prevented onset Asperger adolescence. Micronutrient supplementation improved disease symptomatology without causing significant communities’ composition. Discussion Several discrepancies found among studies, primarily due sample size, variations dietary practices, high prevalence functional gastrointestinal symptoms. Further employing longitudinal designs, larger sizes multi-omics technologies warranted identify contribution developmental trajectories human brain neurobehavior. Systematic registration https://clinicaltrials.gov/ , CRD42020158734.

Language: Английский

---

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

Neuropsychopharmacology, Journal Year: 2020, Volume and Issue: 45(7), P. 1086 - 1096

Published: Feb. 28, 2020

Abstract The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As genomic technologies have advanced over the past several decades, considerable progress has been made linking disorders genetic underpinnings. Interest and consideration of nongenetic risk factors (e.g., lead exposure schizophrenia) have, in contrast, lagged behind heritable frameworks explanation. Thus, association illness environmental chemical exposure, their potential interactions with susceptibility, are largely unexplored. In this review, we describe emerging approaches for considering impact acting alone concert risk, point role epigenetics mediating effects on transcription genes implicated mental disorders. We highlight recent examples research psychiatric that shared biological mechanisms—synaptic dysfunction, immune alterations, gut–brain interactions. outline new tools resources can be harnessed study These tools, combined experimental evidence, suggest there is a need broadly incorporate exposures research, ultimate goal identifying modifiable informing treatment strategies disease.

Language: Английский

---

Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer’s Disease

Biomolecules, Journal Year: 2021, Volume and Issue: 11(11), P. 1635 - 1635

Published: Nov. 4, 2021

Autism spectrum disorder (ASD) and Alzheimer’s disease (AD) are neurodevelopmental neurodegenerative disorders affecting two opposite ends of life span, i.e., childhood old age. Both pose a cumulative threat to human health, with the rate incidences increasing considerably worldwide. In context recent developments, we aimed review correlated symptoms genetics, overlapping aspects in mechanisms pathogenesis ASD AD. Dementia, insomnia, weak neuromuscular interaction, as well communicative cognitive impairments, shared symptoms. A number genes proteins linked both have been tabulated, including MECP2, ADNP, SCN2A, NLGN, SHANK, PTEN, RELN, FMR1. Theories about role neuron development, processing, connectivity, levels neurotransmitters discussed. Based on literature, roles FMRP (Fragile X mental retardation protein), hnRNPC (heterogeneous ribonucleoprotein-C), IRP (Iron regulatory proteins), miRNAs (MicroRNAs), α-, β0, γ-secretases posttranscriptional regulation cellular synthesis processing APP (amyloid-β precursor protein) elaborated describe parallel routes AD pathogenesis. However, interactive genetic environmental factors, oxidative metal ion stress, mutations associated genes, alterations related pathways development needs further investigation.

Language: Английский

---

Decoding microRNAs in autism spectrum disorder

Molecular Therapy — Nucleic Acids, Journal Year: 2022, Volume and Issue: 30, P. 535 - 546

Published: Nov. 7, 2022

Autism spectrum disorder (ASD)-a congenital mental accompanied by social dysfunction and stereotyped behaviors-has attracted a great deal of attention worldwide. A combination genetic environmental factors may determine the pathogenesis ASD. Recent research multiple ASD models indicates that microRNAs (miRNAs) play central role at onset progression repressing translation key mRNAs in neural development functions. As such, miRNAs show potential to serve as biomarkers for diagnosis or prognosis therapeutic targets treatment In this review, we discuss regulatory mechanisms which influence phenotypes through various vivo vitro models, including necropsy specimens, animal cellular and, particular, induced pluripotent stem cells derived from patients with We then miRNA-based strategies currently being evaluated preclinical studies.

Language: Английский

---

The Emerging Role of Flavonoids in Autism Spectrum Disorder: A Systematic Review

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(10), P. 3520 - 3520

Published: May 17, 2023

Although autism spectrum disorder (ASD) is a multifaceted neurodevelopmental syndrome, accumulating evidence indicates that oxidative stress and inflammation are common features of ASD. Flavonoids, one the largest best-investigated classes plant-derived compounds, known to exert antioxidant, anti-inflammatory, neuroprotective effects. This review used systematic search process assess available on effect flavonoids A comprehensive literature was carried out in PubMed, Scopus, Web Science databases following PRISMA guidelines. total 17 preclinical studies 4 clinical investigations met our inclusion criteria were included final review. Most findings from animal suggest treatment with improves parameters, reduces inflammatory mediators, promotes pro-neurogenic These also showed ameliorate core symptoms ASD, such as social deficits, repetitive behavior, learning memory impairments, motor coordination. However, there no randomized placebo-controlled trials support efficacy We only found open-label case reports/series, using two luteolin quercetin. preliminary indicate flavonoid administration may improve specific behavioral Overall, this first systematically report for putative beneficial effects promising results provide rationale future controlled aimed at confirming these outcomes.

Language: Английский

---

Expression, Regulation, and Functions of the Galectin-16 Gene in Human Cells and Tissues

Biomolecules, Journal Year: 2021, Volume and Issue: 11(12), P. 1909 - 1909

Published: Dec. 20, 2021

Galectins comprise a family of soluble β-galactoside-binding proteins, which regulate variety key biological processes including cell growth, differentiation, survival, and death. This paper aims to address the current knowledge on unique properties, regulation, expression galectin-16 gene (LGALS16) in human cells tissues. To date, there are limited studies this galectin, with most focusing its tissue specificity placenta. Here, we report 8-Br-cAMP-induced upregulation LGALS16 two placental lines (BeWo JEG-3) context trophoblastic differentiation. In addition, provide results bioinformatics search for using datasets available at GEO, Human Protein Atlas, prediction tools relevant transcription factors miRNAs. Our findings indicate that is detected by microarrays diverse cells/tissues alters association cancer, diabetes, brain diseases. Molecular mechanisms transcriptional post-transcriptional regulation also discussed based resources.

Language: Английский

---

Evidence for an association of prenatal exposure to particulate matter with clinical severity of Autism Spectrum Disorder

Environmental Research, Journal Year: 2023, Volume and Issue: 228, P. 115795 - 115795

Published: April 5, 2023

Early-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur (SO2) has been suggested contribute the etiology Autism Spectrum Disorder (ASD). In this study, we used quality monitoring data examine whether mothers children with ASD were exposed high levels pollutants during critical periods pregnancy, if higher may lead a clinical severity in their offspring. We public from Portuguese Environment Agency estimate these first, second third trimesters full pregnancy first year life child, for 217 subjects born between 2003 2016. These stratified two subgroups according severity, as defined by Diagnostic Observational Schedule (ADOS). For all time periods, average PM2.5, PM10 NO2 which within admissible European Union. However, fraction showed PM2.5 above threshold. A was associated (p = 0.001), 0.011) 0.041) trimester when compared milder severity. After logistic regression, associations identified 0.002; OR 1.14, 95%CI: 1.05-1.23) 0.04; 1.07, 1.00-1.15) 0.02; 1.01-1.14) trimester. Exposure PM is known elicit neuropathological mechanisms ASD, neuroinflammation, mitochondrial disruptions, oxidative stress epigenetic changes. results offer new insights impact early-life

Language: Английский

---

Chemogenetic induction of CA1 hyperexcitability triggers indistinguishable autistic traits in asymptomatic mice differing in Ambra1 expression and sex

Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 17, 2025

Among the genomic alterations identified as risk factors in mice models of autism spectrum disorders (ASD), heterozygous deletion Ambra1 (Activating Molecule Beclin1-Regulated Autophagy) triggers an ASD phenotype associated with hippocampal hyperexcitability exclusively female sex although protein is comparably expressed hippocampus symptomatic females and asymptomatic males. Given intricate relationship between deficiency etiology ASD, we took advantage including Ambra1+/− males wild-type (Wt) both sexes to investigate whether their non-pathogenic variations levels could underlie a differential susceptibility exhibit ASD-like traits response experimental elevation excitability. Here report that selective activation inhibitory DREADD CA1 parvalbumin-positive interneurons (PV-IN) reduces GABAergic currents onto pyramidal neurons (PN), causes social attentional deficits, augments proportion immature/thin spines PN dendrites same extent Wt sexes. Our findings show substantial pro-autophagic gene product shown by differing mutation and/or do not reactivity chemogenetic induction idiopathic ASD.

Language: Английский

---