Exploring the Influence of Gut–Brain Axis Modulation on Cognitive Health: A Comprehensive Review of Prebiotics, Probiotics, and Symbiotics
Mónika Fekete,
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Andrea Lehoczki,
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Dávid Major
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et al.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(6), P. 789 - 789
Published: March 10, 2024
Recent
research
exploring
the
relationship
between
gut
and
brain
suggests
that
condition
of
microbiota
can
influence
cognitive
health.
A
well-balanced
may
help
reduce
inflammation,
which
is
linked
to
neurodegenerative
conditions.
Prebiotics,
probiotics,
symbiotics
are
nutritional
supplements
functional
food
components
associated
with
gastrointestinal
well-being.
The
bidirectional
communication
gut–brain
axis
essential
for
maintaining
homeostasis,
pre-,
pro-,
potentially
affecting
various
functions
such
as
attention,
perception,
memory.
Numerous
studies
have
consistently
shown
incorporating
into
a
healthy
diet
lead
improvements
in
mood.
Maintaining
support
optimal
function,
crucial
disease
prevention
our
fast-paced,
Westernized
society.
Our
results
indicate
benefits
older
individuals
probiotic
supplementation
but
not
who
good
adequate
levels
physical
activity.
Additionally,
it
appears
there
patients
mild
impairment
Alzheimer’s
disease,
while
mixed
seem
arise
younger
healthier
individuals.
However,
important
acknowledge
individual
responses
vary,
use
these
dietary
should
be
tailored
each
individual’s
unique
health
circumstances
needs.
Language: Английский
The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature
Alison Warren,
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Yvonne Nyavor,
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Nikkia Zarabian
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et al.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 16, 2024
Importance
Research
is
beginning
to
elucidate
the
sophisticated
mechanisms
underlying
microbiota-gut-brain-immune
interface,
moving
from
primarily
animal
models
human
studies.
Findings
support
dynamic
relationships
between
gut
microbiota
as
an
ecosystem
(microbiome)
within
(host)
and
its
intersection
with
host
immune
nervous
systems.
Adding
this
effects
on
epigenetic
regulation
of
gene
expression
further
complicates
strengthens
response.
At
heart
inflammation,
which
manifests
in
a
variety
pathologies
including
neurodegenerative
diseases
such
Alzheimer’s
disease,
Parkinson’s
Multiple
Sclerosis
(MS).
Observations
Generally,
research
date
limited
has
focused
bacteria,
likely
due
simplicity
cost-effectiveness
16s
rRNA
sequencing,
despite
lower
resolution
inability
determine
functional
ability/alterations.
However,
omits
all
other
fungi,
viruses,
phages,
are
emerging
key
members
microbiome.
Much
been
done
pre-clinical
and/or
small
studies
more
developed
parts
world.
The
observed
promising
but
cannot
be
considered
reliable
or
generalizable
at
time.
Specifically,
causal
determined
currently.
More
followed
by
then
little
MS.
data
for
MS
encouraging
this.
Conclusions
relevance
While
still
nascent,
interface
may
missing
link,
hampered
our
progress
understanding,
let
alone
preventing,
managing,
putting
into
remission
diseases.
Relationships
must
first
established
humans,
have
shown
poorly
translate
complex
physiology
environments,
especially
when
investigating
microbiome
where
often
overly
simplistic.
Only
can
robust
conducted
humans
using
mechanistic
model
Language: Английский
Extended animal cognition
Synthese,
Journal Year:
2024,
Volume and Issue:
203(5)
Published: April 23, 2024
Language: Английский
The Impact of Game-Based Interventions on Adult Cognition: A Systematic Review
International Journal of Human-Computer Interaction,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 36
Published: Feb. 24, 2025
This
10-year
systematic
review
examines
the
impact
of
game-based
interventions
(GBI)
on
adult
cognition,
covering
learning
and
training,
serious
games,
gamification,
exergames.
The
research
followed
PRISMA
guidelines
Cochrane
recommendations
for
bias
assessment.
We
reviewed
1,398
articles
selected
42
studies
(26
randomized
trials,
16
non-randomized).
Our
findings
highlight
influence
contextual
factors
GBI,
such
as
culture
individual
traits.
emphasize
predominance
digital
over
analog
applications,
reflecting
GBI's
connection
to
Human-Computer
Interaction
(HCI).
underscores
interdisciplinary
nature
need
high-quality
standards.
examined
23
outcome
categories
found
positive
effects
in
areas
like
Satisfaction,
Flow,
Learning,
Motivation,
Perception,
though
with
varying
risks.
On
average,
GBI
designs
incorporated
nine
game
elements.
Most
used
Puzzle
Simulation
genres,
were
single-player,
2D,
computer-based.
Innovations
neurophysiological
tools,
movement
monitoring,
virtual
reality
offer
promising
HCI
avenues.
Language: Английский
The Oral–Gut Microbiome–Brain Axis in Cognition
Noorul Ain Adil,
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Christabel Omo-Erigbe,
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Hariom Yadav
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et al.
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(4), P. 814 - 814
Published: April 3, 2025
Alzheimer’s
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
cognitive
decline
and
neuronal
loss,
affecting
millions
worldwide.
Emerging
evidence
highlights
the
oral
microbiome—a
complex
ecosystem
of
bacteria,
fungi,
viruses,
protozoa
as
significant
factor
in
health.
Dysbiosis
microbiome
contributes
to
systemic
inflammation,
disrupts
blood–brain
barrier,
promotes
neuroinflammation,
processes
increasingly
implicated
pathogenesis
AD.
This
review
examines
mechanisms
linking
dysbiosis
through
oral–brain
oral–gut–brain
axis.
These
interconnected
pathways
enable
bidirectional
communication
between
cavity,
gut,
brain
via
neural,
immune,
endocrine
signaling.
Oral
pathogens,
such
Porphyromonas
gingivalis,
along
with
virulence
factors,
including
lipopolysaccharides
(LPS)
gingipains,
contribute
while
metabolic
byproducts,
short-chain
fatty
acids
(SCFAs)
peptidoglycans,
further
exacerbate
immune
activation.
Additionally,
this
explores
influence
external
diet,
pH
balance,
medication
use,
smoking,
alcohol
consumption,
hygiene,
on
microbial
diversity
stability,
highlighting
their
role
shaping
outcomes.
The
dynamic
interplay
gut
microbiomes
reinforces
importance
homeostasis
preserving
neurological
interventions,
probiotics,
prebiotics,
dietary
modifications,
offer
promising
strategies
support
function
reduce
risk
diseases,
AD,
maintaining
diverse
microbiome.
Future
longitudinal
research
needed
identify
long-term
impact
cognition.
Language: Английский
Embodied Cognition and the Structure of Personality: An Exploratory Study of Longitudinal Pathways From Early Psychomotor Function
Journal of Personality,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
To
explore
the
developmental
pathways
linking
infant
psychomotor
function
with
personality
in
late
adolescence
through
cognitive,
social,
and
self-regulation
skills.
The
broader
research
question,
seen
lens
of
embodied
cognition,
is
whether
cognition
youth
develop
from
basic
sensorimotor
communicative
systems
infancy.
sample
included
9202
participants
a
representative
UK
birth
cohort.
A
structural
equation
model
examined
prospective
associations
between
motor
functions
at
age
9
months,
self-regulation,
prosociality
5
years,
five-factor
17
years.
meta-traits
stability
plasticity
were
also
explored.
Even
after
controlling
for
confounders
correcting
multiple
paths,
there
was
robust
evidence
that
development
significantly
predicts
structure,
indirect
mediated
by
skills
general
or
social
cognitive
middle
childhood.
While
associated
both
meta-traits,
gross
but
not
stability.
Early
may
have
long-term
effects
on
personality,
This
finding
can
inform
socio-educational
interventions
tailored
curricula
early
childhood
education.
Language: Английский
The Emergence of the Slc11 Clade MCbgut: A Parsimonious Hypothesis for the Dawn of Lactobacillales in the Gut of Early Vertebrates
Bacteria,
Journal Year:
2024,
Volume and Issue:
3(3), P. 223 - 255
Published: Aug. 14, 2024
The
Lactobacillales
(LB)
stand
apart
among
bacterial
orders,
using
manganese
(Mn)
instead
of
iron
to
support
their
growth
and
swiftly
ferment
complex
foods
while
acidifying
environment.
present
work
investigates
whether
a
shift
in
the
use
Mn
could
mark
origin
LB.
Transmembrane
carriers
ubiquitous
Slc11
family
play
key
roles
LB
physiology
by
catalyzing
proton-dependent
import.
In
prior
studies,
clade
found
(MntH
Cb,
MCb)
showed
both
remarkable
structural
plasticity
highly
efficient
uptake,
another
clade,
MCg1,
demonstrated
divergent
evolution
coinciding
with
emergence
genera
(e.g.,
Bordetella,
Achromobacter).
Herein,
MCb
is
subdivided
sister
groups:
MCbie
MCbgut.
derives
directly
from
MCa,
pointing
an
intermediate
stage
predominates
marine
Bacillaceae,
more
conserved
than
MCbgut,
lacks
that
typify
MCbgut
carriers,
responds
differently
identical
mutagenesis.
Exchanging
MCbie/MCbgut
amino
acid
residues
at
sites
distinguish
these
clades
conformation-dependent
effects
templates,
3D
location
targeted
carrier
structure
together
suggests
mechanism
open
inner
gate,
release
into
cytoplasm,
differs
between
Building
on
established
phylogeny
for
Enterococcus
revealed
pair
genes
encoding
was
common
ancestor
LB,
as
MCbgu1
MCbgu2
templates
exhibited
distinct
dynamics
properties.
These
data
are
discussed
when
examining
MCbgut+
emerge
upper
gut
early
vertebrates
(ca.
540
mya),
through
genome
contraction
toward
Mn-centrism,
they
specialized
gastric
aids
favoring
stomach
establishment
jawed
bi-directional
communication
host
nervous,
endocrine
immune
systems.
Language: Английский