Gut microbiome composition changes in obstructive sleep apnoea syndrome also in relation to excessive daytime sleepiness

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111251 - 111251

Published: Feb. 1, 2025

Language: Английский

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Assessment of Exercise-Associated Gastrointestinal Perturbations in Research and Practical Settings: Methodological Concerns and Recommendations for Best Practice

International Journal of Sport Nutrition and Exercise Metabolism, Journal Year: 2022, Volume and Issue: 32(5), P. 387 - 418

Published: Aug. 13, 2022

Strenuous exercise is synonymous with disturbing gastrointestinal integrity and function, subsequently prompting systemic immune responses exercise-associated symptoms, a condition established as "exercise-induced syndrome." When stress aligned exacerbation factors (i.e., extrinsic intrinsic) are of substantial magnitude, these perturbations can cause performance decrements health implications clinical significance. This potentially explains the exponential growth in exploratory, mechanistic, interventional research gastroenterology to understand, accurately measure interpret, prevent or attenuate debilitating consequences exercise-induced syndrome. Considering recent advancement research, it has been highlighted that published literature area consistently affected by experimental limitations may affect accuracy translating study outcomes into practical application/s and/or design future research. perspective methodological review attempts highlight concerns provides guidance improve validity, reliability, robustness next generation These include participant screening description, exertional heat load, dietary control, hydration status, food fluid provisions, circadian variation, biological sex differences, comprehensive assessment markers syndrome, validity symptoms tool, data reporting presentation. Standardized procedures needed for accurate interpretation findings, avoiding misinterpreted (e.g., pathological relevance response magnitude) overstated conclusions intervention outcomes), which will support more translation safe practice guidelines.

Language: Английский

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Molecular Big Data in Sports Sciences: State-of-Art and Future Prospects of OMICS-Based Sports Sciences

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 8

Published: Jan. 11, 2022

Together with environment and experience (that is to say, diet training), the biological genetic make-up of an athlete plays a major role in exercise physiology. Sports genomics has shown, indeed, that some DNA single nucleotide polymorphisms (SNPs) can be associated performance level (such as elite/world-class athletic status), having impact on physical activity behavior, endurance, strength, power, speed, flexibility, energetic expenditure, neuromuscular coordination, metabolic cardio-respiratory fitness, among others, well psychological traits. Athletic phenotype complex depends combination different traits characteristics: such, it requires "complex science," like metadata multi-OMICS profiles. Several projects trials (like ELITE, GAMES, Gene SMART, GENESIS, POWERGENE) are aimed at discovering genomics-based biomarkers adequate predictive power. could enable optimize maximize performance, predict risk sports-related injuries. Exercise profound proteome too. Proteomics assess both from qualitative quantitative point view modifications induced by training. Recently, scholars have assessed epigenetics changes athletes. Summarizing, omics specialties seem converge unique approach, termed sportomics or athlomics defined "holistic top-down," "non-hypothesis-driven research individual's metabolite during sports exercise" (the Athlome Project Consortium Santorini Declaration) Not only includes metabonomics/metabolomics, but relying athlete's passport profile, would systematic study sports-induced effects any (genome, transcriptome, proteome, etc.). However, wealth data so huge massive heterogenous new computational algorithms protocols needed, more power required strategies for properly effectively combining integrating data.

Language: Английский

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Identification of robust and generalizable biomarkers for microbiome-based stratification in lifestyle interventions

Microbiome, Journal Year: 2023, Volume and Issue: 11(1)

Published: Aug. 8, 2023

Abstract Background A growing body of evidence suggests that the gut microbiota is strongly linked to general human health. Microbiome-directed interventions, such as diet and exercise, are acknowledged a viable achievable strategy for preventing disorders improving However, due significant inter-individual diversity between subjects, lifestyle recommendations expected have distinct highly variable impacts microbiome structure. Results Here, through large-scale meta-analysis including 1448 shotgun metagenomics samples obtained longitudinally from 396 individuals during studies, we revealed Bacteroides stercoris , Prevotella copri vulgatus biomarkers microbiota’s resistance structural changes, aromatic non-aromatic amino acid biosynthesis important regulator dynamics. We established criteria distinguishing compositional changes normal fluctuation classified based on their level response. further developed machine learning model predicting “responders” “non-responders” independently type intervention with an area under curve up 0.86 in external validation cohorts different ethnicities. Conclusions propose here microbiome-based stratification possible identifying plastic or resistant microbial structures. Identifying subjects will not respond generalized therapeutic interventions targeting restructuring ensure primary end-points clinical studies reached.

Language: Английский

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Examining the Interaction between Exercise, Gut Microbiota, and Neurodegeneration: Future Research Directions

Biomedicines, Journal Year: 2023, Volume and Issue: 11(8), P. 2267 - 2267

Published: Aug. 14, 2023

Physical activity has been demonstrated to have a significant impact on gut microbial diversity and function. Emerging research revealed certain aspects of the complex interactions between gut, exercise, microbiota, neurodegenerative diseases, suggesting that changes in metabolic function may an onset progression neurological conditions. This study aimed review current literature from several databases until 1 June 2023 (PubMed/MEDLINE, Web Science, Google Scholar) interplay physical neurodegeneration. We summarized roles exercise microbiota neurodegeneration identified ways which these are all connected. The gut–brain axis is multifaceted network gained considerable attention recent years. Research indicates plays vital shifts during physiological or pathophysiological conditions diseases; therefore, they closely related maintaining overall health well-being. Similarly, shown positive effects brain cognitive function, reduce/delay severe disorders. Exercise associated with various neurochemical changes, including alterations cortisol levels, increased production endorphins, endocannabinoids like anandamide, as well higher levels serotonin dopamine. These linked mood improvements, enhanced sleep quality, better motor control, enhancements resulting exercise-induced effects. However, further clinical necessary evaluate bacteria taxa along age- sex-based differences.

Language: Английский

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