From bench to bedside: an interdisciplinary journey through the gut-lung axis with insights into lung cancer and immunotherapy DOI Creative Commons
David Dora, Emőke Szőcs, Ádám Soós

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 5, 2024

This comprehensive review undertakes a multidisciplinary exploration of the gut-lung axis, from foundational aspects anatomy, embryology, and histology, through functional dynamics pathophysiology, to implications for clinical science. The bidirectional communication pathway, is central understanding interconnectedness gastrointestinal- respiratory systems, both which share embryological origins engage in continuous immunological crosstalk maintain homeostasis defend against external noxa. An essential component this axis mucosa-associated lymphoid tissue system (MALT), orchestrates immune responses across these distant sites. delves into role gut microbiome modulating interactions, highlighting how microbial dysbiosis increased permeability ("leaky gut") can precipitate systemic inflammation exacerbate conditions. Moreover, we thoroughly present implication oncological practice, particularly lung cancer development response immunotherapies. Our work seeks not only synthesize current knowledge spectrum science related but also inspire future interdisciplinary research that bridges gaps between basic application. ultimate goal was underscore importance holistic advocating an integrated approach unravel its complexities human health disease.

Language: Английский

Antioxidant Activity and Anti-Inflammatory Effect of Blood Orange By-Products in Treated HT-29 and Caco-2 Colorectal Cancer Cell Lines DOI Creative Commons
Rosa Calvello, Giusy Rita Caponio, Antonia Cianciulli

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 356 - 356

Published: March 18, 2025

Blood orange peel flour (BO-pf)-a by-product of the citrus supply chain-still contains bioactive molecules with known health benefits, such as antiradical scavenging activity or an antiproliferative regarding tumors. In vitro studies have demonstrated that polyphenols showed potential involvement in necroptosis. addition to previous research, we tested BO-pf on two colorectal cancer cell lines. Using HT29 and Caco2 cells, our experiments confirmed regulation inflammasome expression. They provided valuable insights into how influences features (i.e., viability, proliferation, pro- anti-inflammatory activity). Notably, extract is a rich source polyphenolic compounds antioxidant properties. Western blot real-time PCR analyses treatment beneficial effects by influencing expression both pro-inflammatory cytokines (IL-1β, IL-6) through modulation TLR4/NF-kB/NLRP3 signaling. Moreover, results this study demonstrate extracts can enhance cytokines, IL-10 TGFβ, suggesting may represent promising functional ingredient counteract intestinal inflammatory responses involved IBD.

Language: Английский

Citations

0
The relationship between thyroid and human-associated microbiota: A systematic review of reviews DOI Creative Commons
Camilla Virili, Ilaria Stramazzo, Maria Flavia Bagaglini

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2023, Volume and Issue: 25(1), P. 215 - 237

Published: Oct. 12, 2023

Abstract In recent years, a growing number of studies have examined the relationship between thyroid pathophysiology and intestinal microbiota composition. The reciprocal influence these two entities has been proven so extensive that some authors coined term "gut-thyroid axis". However, since paper s reported conflicting results, several aspects this correlation need to be clarified. This systematic review was conceived achieve more robust information about: 1)the characteristics gut composition in patients with common morphological, functional autoimmune disorders thyroid; 2)the microbial on micronutrients are essential for maintenance homeostasis; 3)the effect probiotics, prebiotics synbiotics, most popular over-the-counter products, balance; 4)the opportunity use specific dietary advice. literature evaluation made by three independently. A five steps strategy priori adopted. After duplicates removal, 1106 records were initially found 38 reviews finally included analysis. that: 1) significant variations characterize disorders. geographical clustering prevents drawing definitive conclusions topic; 2) available knowledge about probiotics synbiotics not strong enough suggest routine compounds disorders; 3) elimination nutrition should suggested patients, which, instead checked possible vitamins deficiency, often owed gastrointestinal comorbidities.

Language: Английский

Citations

8
The potential links between human gut microbiota and cardiovascular health and disease - is there a gut-cardiovascular axis? DOI Creative Commons
Cátia Almeida,

J. Guilherme Gonçalves-Nobre,

Diogo Alpuim Costa

et al.

Frontiers in Gastroenterology, Journal Year: 2023, Volume and Issue: 2

Published: Oct. 16, 2023

The gut-heart axis is an emerging concept highlighting the crucial link between gut microbiota and cardiovascular diseases (CVDs). Recent studies have demonstrated that pivotal in regulating host metabolism, inflammation, immune function, critical drivers of CVD pathophysiology. Despite a strong CVDs, this ecosystem’s complexity still needs to be fully understood. short-chain fatty acids, trimethylamine N-oxide, bile polyamines are directly or indirectly involved development prognosis CVDs. This review explores relationship metabolites focusing on atherosclerosis hypertension, analyzes personalized microbiota-based modulation interventions, such as physical activity, diet, probiotics, prebiotics, fecal transplantation, promising strategy for prevention treatment.

Language: Английский

Citations

7
Potential therapeutic options for celiac Disease: An update on Current evidence from Gluten-Free diet to cell therapy DOI
Effat Noori,

Nader Hashemi,

Delsuz Rezaee

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112020 - 112020

Published: April 11, 2024

Language: Английский

Citations

2
From bench to bedside: an interdisciplinary journey through the gut-lung axis with insights into lung cancer and immunotherapy DOI Creative Commons
David Dora, Emőke Szőcs, Ádám Soós

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 5, 2024

This comprehensive review undertakes a multidisciplinary exploration of the gut-lung axis, from foundational aspects anatomy, embryology, and histology, through functional dynamics pathophysiology, to implications for clinical science. The bidirectional communication pathway, is central understanding interconnectedness gastrointestinal- respiratory systems, both which share embryological origins engage in continuous immunological crosstalk maintain homeostasis defend against external noxa. An essential component this axis mucosa-associated lymphoid tissue system (MALT), orchestrates immune responses across these distant sites. delves into role gut microbiome modulating interactions, highlighting how microbial dysbiosis increased permeability ("leaky gut") can precipitate systemic inflammation exacerbate conditions. Moreover, we thoroughly present implication oncological practice, particularly lung cancer development response immunotherapies. Our work seeks not only synthesize current knowledge spectrum science related but also inspire future interdisciplinary research that bridges gaps between basic application. ultimate goal was underscore importance holistic advocating an integrated approach unravel its complexities human health disease.

Language: Английский

Citations

2