Role of probiotics in managing various human diseases, from oral pathology to cancer and gastrointestinal diseases

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 5, 2024

The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.

Language: Английский

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Oral probiotic supplementation to alleviate diarrhea induced by fluoropyrimidines or irinotecan-based chemotherapy: a systematic review and meta-analysis

Complementary Therapies in Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 103151 - 103151

Published: Feb. 1, 2025

Fluoropyrimidines and irinotecan cause diarrhea, which can be particularly severe in some cases. Probiotic supplementation is a potential option for managing chemotherapy-induced diarrhea. This study aims to evaluate the efficacy safety of probiotics diarrhea induced by fluoropyrimidine or irinotecan-based chemotherapy cancer patients. A literature search was conducted Cochrane Library, PubMed, ScienceDirect, SciFinder, Scopus August 2023. Observational prospective studies patients receiving 5-fluorouracil, capecitabine, were included. RevMan (version 5.4.1) used statistical analysis. The protocol registered PROSPERO. Of 9400 records, 24 14 included systematic review meta-analysis, respectively. Most provided combination probiotic strains from initiation completion cycles. significantly reduced all grade (RR = 0.40; 95% CI: 0.27, 0.60; P < 0.00001, I2: 0%), nausea vomiting 0.49; CI [0.37, 0.67]; bloating 0.27; [0.11, 0.69]; 0.006, 0%) anorexia 0.62: [0.43, 0.90]; 0.01, 39%) compared controls. Absolute risk reductions (ARR) ranged 22.7% 28.5%, with number needed treat (NNT) value 3 5. Moreover, improved intestinal microbial balance symptom scales quality life. promising manage chemoradiotherapy-induced without serious side effects fluoropyrimidines regimens. Given clinically meaningful ARR favorable NNT values, may have role clinical practice. However, larger trials are standardize strain, dosage, duration, target patient subgroups. PROSPERO database (CRD42023473324).

Language: Английский

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Preventive Effect of Probiotics on Oral Mucositis Induced by Cancer Treatment: A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(21), P. 13268 - 13268

Published: Oct. 31, 2022

Oral mucositis is a common adverse effect of cancer therapy. Probiotics have been shown to exert anti-inflammatory and immunomodulatory effects. We performed meta-analysis randomized controlled trials (RCTs) investigate whether probiotics can prevent therapy–induced oral mucositis. searched PubMed, Embase, Cochrane Library, ClinicalTrials.gov databases for related published before September 2022; no language restrictions were applied. The primary outcome was the incidence severe Secondary outcomes requirement enteral nutrition during treatment, body weight loss, decreased quality life. study has registered in PROSPERO (number: CRD 42022302339). Eight RCTs, including 708 patients, reviewed; however, only seven could be performed. Three using Lactobacilli-based reported that probiotic group significantly low (risk ratio [RR] = 0.84, 95% confidence interval [CI] 0.77–0.93, p 0.0004). Seven (RR 0.65, CI 0.53–0.81, < 0.0001). (odds 0.34, CI: 0.13–0.92, 0.05). This demonstrated effectiveness prevention mitigation recommend use treat

Language: Английский

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Association between oral and fecal microbiome dysbiosis and treatment complications in pediatric patients undergoing allogeneic hematopoietic stem cell transplantation

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 20, 2024

Abstract The oral and gastrointestinal mucosae represent the main targets of toxic effect chemo and/or radiotherapy administered during conditioning regimen before hematopoietic stem cell transplant (HSCT). These harmful consequences immunological complications that may occur after (such as Graft versus Host Disease, G v HD) are responsible for clinical symptoms associated with mucositis aplasia phase, like pain, nausea, vomiting, diarrhea. toxicities could play a critical role in microbiomes post-transplant degree microbial dysbiosis dysregulation among different bacterial species also be crucial intestinal mucosa homeostasis, altering host’s innate adaptive immune responses favoring abnormal occurrence HD. This prospective pediatric study aims to analyze longitudinally gut 17 patients who received allogeneic HSCT malignant non-malignant diseases. was mainly an increased relative abundance Fusobacteria , Prevotella species, while Streptococcus descendants showed negative correlation. fecal microbiome subjects affected by cutaneous acute HD (aG correlated Proteobacteria . Oral mucosal microbiota undergoes changes HSCT, Fusobacteria, they target future therapeutic approaches, revealed increase class ( Alphaproteobacteria Deltaproteobacteria ) correlation Gammaproteobacteria

Language: Английский

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Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review

BMC Oral Health, Journal Year: 2023, Volume and Issue: 23(1)

Published: Jan. 3, 2023

Oral mucositis (OM) is a major side effect of cancer therapy, which associated with significant symptoms, treatment delays and increased costs for the health system. It an important component quality life patients and, until now, there has been no gold standard regarding prevention or this pathology. Notwithstanding paucity guidelines (due to limited evidence from high-quality, rigorous studies), sodium bicarbonate (SB) rinses are one most used agents OM management.A systematic review (2000-2022) was performed in order compare examine different versus preventing treating OM.Eleven randomized controlled trials (RCT) were evaluated: four conducted seven management OM. The risk bias RCTs assessed using revised Cochrane tool trials.According RoB2 evaluation trials, judged be at high bias, two rated as 'problematic', while five deemed low bias.The results revealed that supporting SB prevention.Results showed takes on strategic importance use prevention; indiscriminate could counterproductive because it causes sudden pH increase proper pharmacological treatment.

Language: Английский

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The Effect of Oral Care Intervention in Mucositis Management Among Pediatric Cancer Patients: An Updated Systematic Review

Journal of Multidisciplinary Healthcare, Journal Year: 2024, Volume and Issue: Volume 17, P. 3497 - 3515

Published: July 1, 2024

Background: Chemotherapy-induced mucositis is inflammation that develops in the oral mucosal due to anticancer treatment. Mucositis has negative consequences may lead distress pediatric patients, resulting escalated expenses, diminished quality of life, hindrance cancer therapy, and decreased survival rates. However, despite numerous methods, care protocols are suggested for implementation population a lack high-level evidence studies, particularly regarding which appropriate agents should be administered. Purpose: This systematic review aimed identify effect intervention management among patients. Methods: Studies were published between 2014 2023 from five databases: PubMed, Embase, Medline, ScienceDirect, Scopus. They identified using search strategy relevant studies interventions managing children with cancer. study used Joanna Briggs Institute (JBI) critical appraisal tools assess followed recommended reporting items reviews meta-analyses (PRISMA) guidelines. Results: Eight met inclusion criteria, including seven RCTs one quasi-experimental study. Oral involving tooth brushing, mouthwash, lip performed entirely or partially. The frequency ranges two six times daily, duration 5 days weeks. honey, olive oil, Aloe Vera, Andiroba, salivary enzyme toothpaste beneficial lower severity mucositis, reduce pain, minimize duration, use analgesics, but not significantly improve child's life. Caphosol mouthwash did mucositis. Conclusion: Our highlights effective integratively, vera, toothpaste, essential manage chemotherapy-induced children. Systematic Review Registration: PROSPERO registration number was CRD42023456278. Keywords: children, cancer, chemotherapy, care,

Language: Английский

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Link between dysbiosis and cancer: Contributing mechanisms and factors

International review of cell and molecular biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

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Effect of multi-strain probiotics supplementation on chemotherapy-related side effects among patients with breast cancer: A pilot trial

Pharmacia, Journal Year: 2025, Volume and Issue: 72, P. 1 - 9

Published: March 14, 2025

This study aimed to identify the effect of a 7-strain probiotics formulation on chemotherapy-related side effects, complete blood counts, biochemistry, and Karnofsky performance scores. All patients diagnosed with breast cancer who received chemotherapy at hospital in Surabaya, Indonesia, were considered eligible join study. Before probiotic supplementation, baseline values tested parameters obtained later compared after 21–30 days supplementation. Multi-strain supplementation could alleviate fatigue nausea symptoms our patients. Significant improvements observed before scores (median: 100 versus 90, respectively; p &lt; 0.001) urea nitrogen (11.6 mg/dL 10.05 mg/dL, = 0.008). Non-significant differences found for alanine aminotransferase, serum creatinine. Our findings provide preliminary evidence about potential role multi-strain effects.

Language: Английский

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Evaluation of the efficacy of probiotics in the chemoradiotherapy of colorectal cancer: a meta-analysis of Randomized Controlled Trials

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 29, 2025

Language: Английский

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Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 2, 2025

Oral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in prevention and oral thyroid head neck cancers. Following PRISMA criteria, systematic review meta-analysis included on efficacy, safety, dosage, duration was performed. A total 12 randomized controlled trials 885 individuals were this meta-analysis. Our analysis showed that had slight but insignificant effect incidence mucositis (Risk ratio (RR) = 0.90, 95% CI [0.79, 1.03]), significant impact reducing severity (RR 0.62, [0.48, 0.80]). Biotics also developing xerostomia Head (HNC) patients. Subgroup Bifidobacterium-containing products more effective than other blends. findings safe HNC patients suffering from complications.

Language: Английский

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