A Systematic Review of the Efficacy and Safety of Mulberry Formulations for Chemotherapy- and/or Radiotherapy-Induced Oral Mucositis DOI Open Access

J. Raghunand Sindhe,

V Asha,

Arvind Muthukrishnan

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 15, 2024

Oral mucositis (OM) is one of the common side effects radiotherapy and chemotherapy. It an extremely painful condition characterized by erythema, edema, ulceration oral mucosa. Many plant-based chemical formulations are used to prevent OM. The aim study evaluate efficacy safety different black mulberry in chemotherapy and/or radiotherapy-induced A systematic search was performed using PubMed, Excerpta Medica database (Embase), Cochrane Library, Web Science databases for articles published until March 2023. We have included studies conducted on people undergoing compared effect any formulation with other interventions. Out 30 retrieved, four a cumulative sample size (N = 297) were review. Mulberry no intervention, grape molasses, chlorhexidine, sodium bicarbonate. articles, three showed significant decrease grade 2 3 OM also better prevention as intervention control groups, article, molasses more preventive occurrence dry mouth. improvement pain score quality life. incidence severity lower group than One article less weight loss, another gradual gain from use mulberries. From this, we conclude that effective treatment shows

Language: Английский

The Impact of Probiotics on Oral Cancer: Mechanistic Insights and Therapeutic Strategies DOI Creative Commons

Lakshmi Nandhana S S,

D. Maheswary,

Sujith Sri Surya Ravi

et al.

Oral Oncology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100715 - 100715

Published: Jan. 1, 2025

Language: Английский

Citations

2
From Pathogenesis to Intervention: The Importance of the Microbiome in Oral Mucositis DOI Open Access
Júlia S. Bruno, Ghanyah Al-Qadami, Alexa M. G. A. Laheij

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8274 - 8274

Published: May 5, 2023

Oral mucositis (OM) is a common and impactful toxicity of standard cancer therapy, affecting up to 80% patients. Its aetiology centres on the initial destruction epithelial cells increase in inflammatory signals. These changes oral mucosa create hostile environment for resident microbes, with infections co-occurring OM, especially at sites ulceration. Increasing evidence suggests that microbiome occur beyond opportunistic infection, growing appreciation potential role OM development severity. This review collects latest articles indexed PubMed electronic database which analyse bacterial shift through 16S rRNA gene sequencing methodology patients under treatment mucositis. The aims are assess whether gut causally contribute or if they simply consequence mucosal injury. Further, we explore emerging patient’s microbial fingerprint prediction. maintenance bacteria via target therapy constant improvement should be considered treatment.

Language: Английский

Citations

25
Probiotics in the Treatment of Radiotherapy-Induced Oral Mucositis: Systematic Review with Meta-Analysis DOI Creative Commons
Giuseppe Minervini, Rocco Franco,

Maria Maddalena Marrapodi

et al.

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(5), P. 654 - 654

Published: April 27, 2023

The inflammatory injury of the mucous membranes lining digestive tract, from mouth to anus, is called mucositis. One intriguing and compelling new therapeutic modalities that has emerged in recent decades due advances our understanding this condition’s pathophysiology probiotics. purpose meta-analysis evaluate efficiency probiotics treatment chemotherapy-induced mucositis for head neck malignancies; a literature search was performed on PubMed, Lilacs, Web Science, articles published 2000 31 January 2023 were considered, according keywords entered. term “Probiotics” combined with “oral mucositis” using Boolean connector AND; at end research, 189 studies identified three engines. Only used draw up present systematic study metanalysis; showed an effective method, analysis results these use promoted decrease severity symptoms.

Language: Английский

Citations

16
Understanding Protective Mechanisms of an Oral Probiotic in Reducing Radiation-Induced Oral Mucositis DOI
Hannah R. Wardill, Paolo Bossi, Stephen T. Sonis

et al.

Journal of Clinical Oncology, Journal Year: 2024, Volume and Issue: 42(12), P. 1436 - 1438

Published: March 1, 2024

Language: Английский

Citations

6
Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta‐analysis DOI Creative Commons
Martina Coppini, Vito Carlo Alberto Caponio, Rodolfo Mauceri

et al.

Oral Diseases, Journal Year: 2024, Volume and Issue: 30(7), P. 4126 - 4144

Published: June 24, 2024

Oral mucositis (OM) is considered one of the most common side effects patients undergoing cancer therapy. OM prevention plays a crucial role in effectiveness treatment and patient's quality life. Different preventive treatments have been proposed clinical trials, however with inconclusive results.

Language: Английский

Citations

6
Next-Generation Probiotics and Chronic Diseases: A Review of Current Research and Future Directions DOI Creative Commons
Ashutosh Tiwari,

Dyah Ika Krisnawati,

Erna Susilowati

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(50), P. 27679 - 27700

Published: Nov. 26, 2024

The burgeoning field of microbiome research has profoundly reshaped our comprehension human health, particularly highlighting the potential probiotics and fecal microbiota transplantation (FMT) as therapeutic interventions. While benefits traditional are well-recognized, efficacy mechanisms remain ambiguous, FMT's long-term effects still being investigated. Recent advancements in high-throughput sequencing have identified gut microbes with significant health benefits, paving way for next-generation (NGPs). These NGPs, engineered through synthetic biology bioinformatics, designed to address specific disease states enhanced stability viability. This review synthesizes current on NGP stability, challenges delivery, their applications preventing treating chronic diseases such diabetes, obesity, cardiovascular diseases. We explore physiological characteristics, safety profiles, action various strains while also addressing opportunities presented by integration into clinical practice. NGPs revolutionize microbiome-based therapies improve outcomes is immense, underscoring need further optimize ensure safety.

Language: Английский

Citations

5
Emerging pharmacotherapy trends in preventing and managing oral mucositis induced by chemoradiotherapy and targeted agents DOI
Margherita Gobbo,

Jamie K. Joy,

Helena Guedes

et al.

Expert Opinion on Pharmacotherapy, Journal Year: 2024, Volume and Issue: 25(6), P. 727 - 742

Published: April 12, 2024

The introduction of targeted therapy and immunotherapy has tremendously changed the clinical outcomes prognosis cancer patients. Despite innovative pharmacological therapies improved radiotherapy (RT) techniques, patients continue to suffer from side effects, which oral mucositis (OM) is still most impactful, especially for quality life. We provide an overview current advances in pharmacotherapy RT, relation their potential cause OM, less explored more recent literature reports related best management OM. have analyzed natural/antioxidant agents, probiotics, mucosal protectants healing coadjuvants, pharmacotherapies, immunomodulatory anticancer photobiomodulation impact technology. discovery precise pathophysiologic mechanisms CT RT-induced OM outlined that a multifactorial origin, including direct oxidative damage, upregulation immunologic factors, effects on flora. A persistent upregulated immune response, associated with factors patients' characteristics, may contribute severe long-lasting goal strategies conjugate individual patient, disease, therapy-related guide prevention or treatment. further high-quality research warranted, issue paramount future strategies.

Language: Английский

Citations

4
Current status and prospect of gut and oral microbiome in pancreatic cancer: Clinical and Translational Perspectives DOI
Pengyu Li, Hanyu Zhang, Menghua Dai

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 604, P. 217274 - 217274

Published: Sept. 21, 2024

Language: Английский

Citations

4
Efficacy and tolerability of probiotics, prebiotics, and symbiotics consumption on oral complications of patients with thyroid and head and neck cancers: a systematic review and meta-analysis DOI Creative Commons
Mohammadreza Shafiei, Shayan Mardi, Soodeh Ghadimi

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 2, 2025

Oral complications following cancer treatment are a challenging issue for oncologists. Several studies have demonstrated the efficacy of biotics in prevention and oral thyroid head neck cancers. Following PRISMA criteria, systematic review meta-analysis included on efficacy, safety, dosage, duration was performed. A total 12 randomized controlled trials 885 individuals were this meta-analysis. Our analysis showed that had slight but insignificant effect incidence mucositis (Risk ratio (RR) = 0.90, 95% CI [0.79, 1.03]), significant impact reducing severity (RR 0.62, [0.48, 0.80]). Biotics also developing xerostomia Head (HNC) patients. Subgroup Bifidobacterium-containing products more effective than other blends. findings safe HNC patients suffering from complications.

Language: Английский

Citations

0
Exploring the Influence of Oral and Gut Microbiota on Ulcerative Mucositis: A Pilot Cohort Study DOI Creative Commons
Valentin Bartha, Sébastien Boutin,

Dorothée L. Schüßler

et al.

Oral Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Comparing oral and gut microbiome profiles between patients with without ulcerative mucositis during allogeneic stem cell transplantation (aSCT). Specimens from mucosa, saliva, stool were collected pre-(T0) post- (T0 +28d ± 14d) aSCT (T1). Microbiome structure differences analyzed by 16S-rRNA-gene sequencing, associations to patients' clinical characteristics investigated. Ten of 25 included developed ulcerations. The α-diversity decreased T0 T1, independent PERMANOVA revealed in beta diversity T1 samples At saliva ulcerations showed an increase Mycoplasma salvarius, while commensals mucosal swabs. both groups overabundance Enterococcus spp., associated inflammatory conditions. Salival older overweight slower, whereas swabs or impaired renal function was a higher decline. Female gender history periodontitis increased changes, self-reported probiotics intake related reduced changes. Ulcerations appeared 40% the patients. Distinct microbial including abundance salivarius commensals, marked those study registered German Register for Clinical Studies (DRKS00032882).

Language: Английский

Citations

0