Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes

Molecules, Journal Year: 2023, Volume and Issue: 28(20), P. 7209 - 7209

Published: Oct. 21, 2023

The clinical relationship between diabetes and inflammation is well established. Evidence clearly indicates that disrupting oxidant-antioxidant equilibrium elevated lipid peroxidation could be a potential mechanism for chronic kidney disease associated with type 2 mellitus (T2DM). Under diabetic conditions, hyperglycemia, especially inflammation, increased reactive oxygen species generation are bidirectionally associated. Inflammation, oxidative stress, tissue damage believed to play role in the development of diabetes. Although exact underlying stress its impact on progression remains uncertain, hyperglycemia-inflammation-oxidative interaction plays significant onset vascular disease, hepatic injury, pancreas and, therefore, holds promise as therapeutic target. strongly use multiple antidiabetic medications fails achieve normal range glycated hemoglobin targets, signifying treatment-resistant Antioxidants polyphenols considered useful adjuvant therapy their anti-inflammatory effect antioxidant activity. We aimed analyze current major points reported preclinical, vivo, studies antioxidants prevention or treatment T2DM. Then, we will share our speculative vision future trials.

Language: Английский

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Lycopene: A Potent Antioxidant with Multiple Health Benefits

Journal of Nutrition and Metabolism, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Lycopene is a naturally occurring carotenoid predominantly found in tomatoes and tomato‐based products. Like other phytochemicals, it exhibits health beneficial biological activities that can be exploited when used as dietary supplement. In vitro vivo , lycopene has been demonstrated to mitigate oxidative stress‐induced metabolic dysfunctions diseases including inflammation, obesity, diabetes mellitus. shown alleviate affect the bone, eye, kidney, liver, lungs, heart, nervous system. This review presents state of art regarding lycopene’s benefits its potential applications system delivery. Furthermore, protective effects against toxins, safety use, possible toxicity are explored.

Language: Английский

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Nutritional Benefits of Lycopene and Beta‐Carotene: A Comprehensive Overview

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 8715 - 8741

Published: Oct. 16, 2024

Certain carotene components, such as lycopene and beta-carotene, are found in tomatoes, carrots, sweet potatoes, etc. good for human health. It gives plants their distinctive red color. A class of lipid-soluble natural pigments known carotenoids is the precursor vitamin vital antioxidant defense against peroxides cells tissues. This review provides an overview current state knowledge research on sources, structures, physiochemical properties, absorption metabolism, functional advantages, prevention many diseases associated with beta-carotene. These antioxidants have been linked to a lower risk cardiovascular disease cancer, they also help draw pollinators flowers. Carrots potatoes rich sources which strengthens immune system improves eye The vivid color reproductive organs, including flowers fruits, caused by carotenoid, secondary metabolite that produced plastids. other health advantages attributed lycopene. When ingested through food or supplements, beta-carotene manage prevent number diseases, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, infertility disorders. main point toxicity uncommon, these generally accepted be safe at different doses. Including nutrients your diet can improve general provide illness prevention.

Language: Английский

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Algae-Derived Natural Products in Diabetes and Its Complications—Current Advances and Future Prospects

Life, Journal Year: 2023, Volume and Issue: 13(9), P. 1831 - 1831

Published: Aug. 29, 2023

Diabetes poses a significant global health challenge, necessitating innovative therapeutic strategies. Natural products and their derivatives have emerged as promising candidates for diabetes management due to diverse compositions pharmacological effects. Algae, in particular, garnered attention potential source of bioactive compounds with anti-diabetic properties. This review offers comprehensive overview algae-derived natural management, highlighting recent developments future prospects. It underscores the pivotal role care delves into diversity algae, constituents, underlying mechanisms efficacy. Noteworthy algal substantial are briefly elucidated, along specific contributions addressing distinct aspects diabetes. The challenges limitations inherent utilizing algae interventions examined, accompanied by strategic recommendations optimizing effectiveness. By these considerations, this aims chart course research refining algae-based approaches. Leveraging multifaceted activities chemical components holds promise pursuit novel antidiabetic treatments. Through continued fine-tuning interventions, burden could be mitigated, ultimately leading enhanced patient outcomes.

Language: Английский

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Translational Research on Bee Pollen as a Source of Nutrients: A Scoping Review from Bench to Real World

Nutrients, Journal Year: 2023, Volume and Issue: 15(10), P. 2413 - 2413

Published: May 22, 2023

The emphasis on healthy nutrition is gaining a forefront place in current biomedical sciences. Nutritional deficiencies and imbalances have been widely demonstrated to be involved the genesis development of many world-scale public health burdens, such as metabolic cardiovascular diseases. In recent years, bee pollen emerging scientifically validated candidate, which can help diminish conditions through nutritional interventions. This matrix being extensively studied, has proven very rich well-balanced nutrient pool. this work, we reviewed available evidence interest source. We mainly focused richness nutrients its possible roles main pathophysiological processes that are directly linked imbalances. scoping review analyzed scientific works published last four focusing clearest inferences perspectives translate cumulated experimental preclinical into clinically relevant insights. promising uses for malnutrition, digestive health, disorders, other bioactivities could helpful readjust homeostasis (as it also true case anti-inflammatory or anti-oxidant needs), well benefits diseases, were identified. knowledge gaps identified, along with practical challenges hinder establishment fructification these uses. A complete data collection made major range botanical species allows more robust clinical information.

Language: Английский

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Naringin Prevents Diabetic-Induced Dysmetabolism in Male Wistar Rats by Modulating GSK-3 Activities and Oxidative Stress-Dependent Pathways

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: July 27, 2024

Language: Английский

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Effect of High-Sucrose Diet on the Occurrence and Progression of Diabetic Retinopathy and Dietary Modification Strategies

Nutrients, Journal Year: 2024, Volume and Issue: 16(9), P. 1393 - 1393

Published: May 5, 2024

As the most serious of many worse new pathological changes caused by diabetes, there are risk factors for occurrence and development diabetic retinopathy (DR). They mainly include hyperglycemia, hypertension, hyperlipidemia so on. Among them, hyperglycemia is critical cause, plays a vital role in DR. High-sucrose diets (HSDs) lead to elevated blood glucose levels vivo, which, through oxidative stress, inflammation, production advanced glycation end products (AGEs) vascular endothelial growth factor (VEGF), cause plenty damages retina ultimately bring about loss vision. The existing therapies DR primarily target terminal stage disease, when irreversible visual impairment has appeared. Therefore, early prevention particularly critical. DR-related vision requires adjustments dietary habits, reducing sugar intake. This article discusses factors, pathophysiological processes molecular mechanisms associated with HSDs. It aims raise awareness crucial diet progression DR, promote timely prevent improve quality life. aim make people aware importance According modification strategies that we give, patients can change their poor eating habits manner avoid theoretically avoidable obtain an excellent prognosis.

Language: Английский

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The Interactive Effects of Fruit Intake Frequency and Serum miR-484 Levels as Biomarkers for Incident Type 2 Diabetes in a Prospective Cohort of the Spanish Adult Population: The [email protected] Study

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 160 - 160

Published: Jan. 10, 2025

Background/Objectives: Although evidence suggests that miR-484 and several fruit components are involved in glucose metabolism insulin resistance metabolic pathways, the relationship between serum levels consumption relation to risk of Type 2 diabetes (T2DM) remains elusive. The aim this study was evaluate possible association intake frequency with T2DM Spanish adult population. Methods: 2234 subjects from [email protected] cohort without at baseline were studied. Socio-demographic, anthropometric clinical data recorded, as well responses a questionnaire on habits, including (daily vs. occasional). diagnosed after 7.5 years follow-up. Baseline measured using real-time qPCR categorized based 25th percentile. Association analyses performed logistic regression models adjusted for potential confounders. Interaction effects evaluated multiplicative additive scales. Results: There no frequency. Categorized inversely independently associated likelihood incident T2DM. Analysis interaction effect presence both positive interactions categories Conclusions: Our demonstrates protective daily high regarding supports nutritional recommendations advocating consumption. This also combined low occasional may increase beyond their independent effects.

Language: Английский

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Pharmacoinformatics and ex vivo studies of carotenoids from green algae Caulerpa racemosa as functional biomolecules to modulate type-2 diabetes markers

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 178, P. 348 - 359

Published: Feb. 6, 2025

Language: Английский

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Antioxidant and Anti-Inflammatory Benefits of Gymnema inodorum Leaf Extract in Human Umbilical Vein Endothelial Cells Under Peroxynitrite Stress

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 427 - 427

Published: April 1, 2025

Endothelial dysfunction driven by oxidative and nitrosative stress is a critical factor in the pathogenesis of diabetes-related vascular complications. This study investigated antioxidant anti-inflammatory effects Gymnema inodorum leaf (GiL) extract its flavonoid constituents, kaempferol quercetin, on human umbilical vein endothelial cells (HUVECs) exposed to peroxynitrite-induced stress. Peroxynitrite exposure significantly reduced mRNA levels enzymes (e.g., catalase, glutathione peroxidase 1, superoxide dismutase 2) while increasing expression pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-10, interleukin-12), ultimately leading cellular damage. Treatment with GiL reversed these enhancing defenses antioxidants through upregulation enzymatic suppressing inflammation via downregulation cytokine gene expression. The constituents were identified as active compounds responsible for protective effects, quercetin exhibiting significant free radical scavenging activity modulation inflammatory signaling pathways. High doses showed greater efficacy restoring homeostasis preventing These findings underscore potential source bioactive managing other stress-related complications diabetes.

Language: Английский

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