Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(6), P. 1189 - 1190
Published: Sept. 22, 2023
Division
of
Physiology,
School
Medicine,
Universidad
de
Cadiz,
Spain
(Hierro-Bujalance
C,
Garcia-Alloza
M)
Instituto
Investigacion
e
Innovacion
en
Ciencias
Biomedicas
la
Provincia
Cadiz
(INIBICA),
Salus
Infirmorum-Universidad
C)
*Correspondence
to:
Monica
Garcia-Alloza,
PhD,
[email
protected].
This
is
an
open-access
article
distributed
under
the
terms
Creative
Commons
Attribution-Noncommercial-Share
Alike
4.0
Unported,
which
permits
unrestricted
use,
distribution,
and
reproduction
in
any
medium,
provided
original
work
properly
cited.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11272 - 11272
Published: Oct. 19, 2024
Recent
studies
underscore
the
role
of
gut
and
oral
microbiota
in
influencing
neuroinflammation
through
microbiota–gut–brain
axis,
including
Alzheimer’s
disease
(AD).
This
review
aims
to
provide
a
comprehensive
synthesis
recent
findings
on
involvement
neuroinflammatory
processes
associated
with
AD,
emphasizing
novel
insights
therapeutic
implications.
reveals
that
dysbiosis
AD
patients’
is
linked
heightened
peripheral
central
inflammatory
responses.
Specific
bacterial
taxa,
such
as
Bacteroides
Firmicutes
gut,
well
Porphyromonas
gingivalis
cavity,
are
notably
altered
leading
significant
changes
microglial
activation
cytokine
production.
Gut
alterations
increased
intestinal
permeability,
facilitating
translocation
endotoxins
like
lipopolysaccharides
(LPS)
into
bloodstream
exacerbating
by
activating
brain’s
toll-like
receptor
4
(TLR4)
pathways.
Furthermore,
microbiota-derived
metabolites,
short-chain
fatty
acids
(SCFAs)
amyloid
peptides,
can
cross
blood-brain
barrier
modulate
While
microbial
amyloids
may
contribute
amyloid-beta
aggregation
brain,
certain
SCFAs
butyrate
exhibit
anti-inflammatory
properties,
suggesting
potential
avenue
mitigate
neuroinflammation.
not
only
highlights
critical
pathology
but
also
offers
ray
hope
modulating
could
represent
strategy
for
reducing
slowing
progression.
Purpose
of
Review
This
narrative
review
evaluates
the
role
diet
in
relationship
between
depression
and
Alzheimer's
disease
(AD).
Recent
Findings
AD
are
often
comorbid,
appears
to
independently
increase
future
risk
AD.
Evidence
suggests
influences
both
conditions
directly
indirectly.
Diet
impacts
neurochemical
biological
processes
that
may
affect
development
progression
cognitive
dysfunction.
The
dietary
components
offering
greatest
protection
against
yet
be
determined.
Current
evidence
highlights
importance
polyphenolic
compounds,
folate,
B
vitamins,
polyunsaturated
fatty
acids,
along
with
adherence
patterns
like
Mediterranean
diet,
which
includes
multiple
beneficial
factors.
Summary
investigation
factors
prevention
is
a
comparatively
young
field
research.
Comprehensive
highly
characterised
longitudinal
datasets
advanced
analytical
approaches
required
further
examine
complex
depression,
There
critical
need
for
more
research
this
area
develop
effective
preventive
strategies
aimed
at
maintaining
mental
physical
health
advancing
age.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(22), P. 16533 - 16533
Published: Nov. 20, 2023
One
of
the
most
complex
and
challenging
developments
at
beginning
third
millennium
is
alarming
increase
in
demographic
aging,
mainly—but
not
exclusively—affecting
developed
countries.
This
reality
results
one
harsh
medical,
social,
economic
consequences:
continuously
increasing
number
people
with
dementia,
including
Alzheimer’s
disease
(AD),
which
accounts
for
up
to
80%
all
such
types
pathology.
Its
large
progressive
disabling
potential,
eventually
leads
death,
therefore
represents
an
important
public
health
matter,
especially
because
there
no
known
cure
this
disease.
Consequently,
periodic
reappraisals
different
therapeutic
possibilities
are
necessary.
For
purpose,
we
conducted
systematic
literature
review
investigating
nonpharmacological
interventions
AD,
their
currently
cellular
molecular
action
bases.
endeavor
was
based
on
PRISMA
method,
by
selected
116
eligible
articles
published
during
last
year.
Because
unfortunate
lack
effective
treatments
it
necessary
enhance
efforts
toward
identifying
improving
various
rehabilitative
approaches,
as
well
related
prophylactic
measures.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(6), P. 1189 - 1190
Published: Sept. 22, 2023
Division
of
Physiology,
School
Medicine,
Universidad
de
Cadiz,
Spain
(Hierro-Bujalance
C,
Garcia-Alloza
M)
Instituto
Investigacion
e
Innovacion
en
Ciencias
Biomedicas
la
Provincia
Cadiz
(INIBICA),
Salus
Infirmorum-Universidad
C)
*Correspondence
to:
Monica
Garcia-Alloza,
PhD,
[email
protected].
This
is
an
open-access
article
distributed
under
the
terms
Creative
Commons
Attribution-Noncommercial-Share
Alike
4.0
Unported,
which
permits
unrestricted
use,
distribution,
and
reproduction
in
any
medium,
provided
original
work
properly
cited.
