The Past and Future of Angiogenesis as a Target for Cancer Therapy and Prevention

Cancer Prevention Research, Journal Year: 2024, Volume and Issue: 17(7), P. 289 - 303

Published: May 7, 2024

Abstract Cancer growth is dependent on angiogenesis, the formation of new blood vessels, which represents a hallmark cancer. After this concept was established in 1970s, inhibition tumor development and metastases by blocking neoangiogenic process has been an important approach to treatment tumors. However, antiangiogenic therapies are often administered when cancer already progressed. The key reducing burden prevention. We noticed 20 years ago that series possible chemopreventive agents showed properties tested experimental models. This article reviews relevant advances understanding rationale for targeting angiogenesis therapy, prevention, interception recently investigated substances with activity may be suitable such strategies. Many compounds, either dietary derivatives or repurposed drugs, tools angioprevention. Such molecules have favorable safety profile likely allow prolonged duration necessary efficient preventive strategy. Recent evidence mechanisms use described here food derivatives, including flavonoids, retinoids, triterpenoids, omega fatty acids, carotenoids from marine microorganisms. As examples, number epigallocatechin, resveratrol, xanthohumol, hydroxytyrosol, curcumin, fenretinide, lycopene, fucoxanthin, as aspirin, β blockers, renin–angiotensin–aldosterone inhibitors, carnitines, biguanides, reviewed.

Language: Английский

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Current View on Major Natural Compounds Endowed with Antibacterial and Antiviral Effects

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 603 - 603

Published: June 28, 2024

Nowadays, infectious diseases of bacterial and viral origins represent a serious medical problem worldwide. In fact, the development antibiotic resistance is responsible for emergence strains that are refractory even to new classes antibiotics. Furthermore, recent COVID-19 pandemic suggests viruses can emerge spread all over world. The increase in depends on multiple factors, including malnutrition, massive migration population from developing industrialized areas, alteration human microbiota. Alternative treatments conventional antibiotics antiviral drugs have intensively been explored. this regard, plants marine organisms an immense source products, such as polyphenols, alkaloids, lanthipeptides, terpenoids, which possess antibacterial activities. Their main mechanisms action involve modifications cell membranes, with formation pores, release cellular content, inhibition adherence host cells, well efflux pump. Natural antivirals interfere replication spreading, protecting enhanced production interferon. Of note, these not free side effects, their administration humans needs more research terms safety. Preclinical natural compounds confirms effects against bacteria viruses, but there still only few clinical trials. Therefore, full exploitation intensive studies next steps be pursued area medicine.

Language: Английский

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Eco-friendly 2D boron nitride membranes with molecular imprinting for sustainable recovery of phenolic compounds

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159570 - 159570

Published: Jan. 1, 2025

Language: Английский

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From Tree to Treatment: Innovative Applications of Olive Products and Byproducts in Culinary, Health, and Environmental Sustainability

Published: Jan. 1, 2025

Language: Английский

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Exploitation of Natural By-Products for the Promotion of Healthy Outcomes in Humans: Special Focus on Antioxidant and Anti-Inflammatory Mechanisms and Modulation of the Gut Microbiota

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 796 - 796

Published: June 29, 2024

Daily, a lot of food is wasted, and vegetables, fruit, cereals as well marine products represent the major sources unwanted by-products. The sustainability, waste recovery, revalorization by-products have been proposed main goals so-called circular economy. In fact, wastes are enriched in endowed with beneficial effects on human health. Grape, olives, rice contain different compounds, such polyphenols, dietary fibers, polysaccharides, vitamins, proteins, which exert antioxidant anti-inflammatory activities, inhibiting pro-oxidant genes Nuclear Factor kappa-light-chain-enhancer activated B cells (NF-kβ) pathway, demonstrated by vitro vivo experiments. Dietary fibers act upon gut microbiota, expanding bacteria, contribute to healthy outcomes. Furthermore, foods, even including microalgae, arthropods, fish, rich carotenoids, polyunsaturated fatty acids, chitooligosaccharides, afford protection. present review will cover derived from wastes, describing mechanisms action involved modulation microbiota. some also explored clinical trials, while others, by-products, need more investigation for their full exploitation bioactive compounds humans.

Language: Английский

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Transgenerational hormesis in healthy aging and antiaging medicine from bench to clinics: Role of food components

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 220, P. 111960 - 111960

Published: July 5, 2024

Language: Английский

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Historical evolution of olive oil production processes focusing on the role of water, the contribution of energy sources, and the by-product management: The case-study of Crete, Greece

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 175861 - 175861

Published: Aug. 30, 2024

Language: Английский

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Effect of a Phytochemical-Rich Olive Derived Extract on Anthropometric, Hematological and Metabolic Parameters

Published: Aug. 4, 2024

Background: Extra virgin olive oil is a fundamental component of the Mediterranean diet. It contains several molecules that sustain human well-being by modulating cellular metabolism and exerting antioxidant, anti-inflammatory, anti-ageing effects to protect normal tissues can exert anti-angiogenic, pro-apoptotic on cancer cells. Metabolites found in different parts tree, including leaves, also possess properties might help prevention promote wellness aging. Olive mill wastewater (OMWW), liquid residue produced during extraction, represents an environmental issue. However, it enriched phytochemicals with potential beneficial properties. Dietary supplements based OMWW be for nutritional supplementation advantages ecology. Purpose: This work aims measure hematochemical, anthropometric metabolomic parameters volunteers assuming dietary supplement, OliphenoliaⓇ (OMWW-OL). Methods: The OMWW-OL 25 mL twice daily 30 days was tested pilot cohort characteristics close metabolic syndrome. Hematochemical, anthropometric, were analyzed before intervention, at after stopping consumption. Results: 29 enrolled 23 completed study. participants’ baseline measured, then treatment assumption discontinuation. Although derivative, weight body mass index instead increasing slightly decreased, particularly women. Also, hydration increased, especially women, while blood pressure, glycemia insulin decreased. Cholesterol, low-density high-density lipoproteins triglycerides stable vitamin D levels, alongside calcium, sensibly increased. Albumin increased related sarcopenia displayed promising, although not statistically significant, trends toward positive effects. All values support equilibrium no damaging By spectrometry analysis, we favorable changes D/histamine homocysteine/methionine ratios, increase new metabolite unknown formula, D/unknown ratio. Conclusions: Supplementation has detrimental and, limited potency study, imply modulation biological parameters, being potentially valuable people risk Some these could relevant as prevention.

Language: Английский

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Effect of a Phytochemical-Rich Olive-Derived Extract on Anthropometric, Hematological, and Metabolic Parameters

Nutrients, Journal Year: 2024, Volume and Issue: 16(18), P. 3068 - 3068

Published: Sept. 11, 2024

Background: Extra virgin olive oil is a fundamental component of the Mediterranean diet. It contains several molecules that sustain human well-being by modulating cellular metabolism and exerting antioxidant, anti-inflammatory, anti-ageing effects to protect normal tissues, it can exert anti-angiogenic pro-apoptotic on cancer cells. Metabolites found in different parts tree, including leaves, also possess properties might help prevention promote wellness aging. Olive mill wastewater (OMWW), liquid residue produced during extraction, represents an environmental issue. However, rich phytochemicals with potential beneficial properties. Dietary supplements based OMWW be for nutritional supplementation advantages ecology. Purpose: This work aims measure hematochemical, anthropometric, metabolomic parameters volunteers taking dietary supplement, Oliphenolia® (OMWW-OL). Methods: The OMWW-OL 25 mL twice daily 30 days was tested pilot cohort characteristics close metabolic syndrome. Hematochemical, serum biomarkers were analyzed before intervention, at days, after stopping consumption. Results: A total 29 enrolled, 23 completed study. participants’ baseline measured, then treatment assumption discontinuation. Although derivative, their weight did not increase. Their body mass index, instead augmenting, slightly decreased, particularly women. Also, hydration increased, especially women, while blood pressure, glycemia, insulin decreased. Cholesterol, high-density lipoproteins, triglycerides stable, LDL levels vitamin D levels, alongside calcium, perceptibly increased. Albumin All values support equilibrium, no damaging effects. By spectrometry analysis, we favorable changes D/histamine homocysteine/methionine ratios, increase new metabolite unknown formula, D/unknown ratio. Conclusions: Supplementation has detrimental imply modulation biological parameters. this small study, limited potency, preliminarily suggests extract use could potentially valuable people risk Some these relevant supporting healthy ageing prevention.

Language: Английский

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Anticancer Effects of Secoiridoids—A Scoping Review of the Molecular Mechanisms behind the Chemopreventive Effects of the Olive Tree Components Oleocanthal, Oleacein, and Oleuropein

Nutrients, Journal Year: 2024, Volume and Issue: 16(16), P. 2755 - 2755

Published: Aug. 18, 2024

The olive tree (Olea europaea) and oil hold significant cultural historical importance in Europe. health benefits associated with consumption have been well documented. This paper explores the mechanisms of anti-cancer effects leaf, focusing on their key bioactive compounds, namely oleocanthal, oleacein, oleuropein. chemopreventive potential oleuropein is comprehensively examined through this systematic review. We conducted a literature search to identify eligible articles from Scopus, PubMed, Web Science databases published up 10 October 2023. Among 4037 identified articles, there were 88 describing These compounds ability inhibit cell proliferation, induce death (apoptosis, autophagy, necrosis), angiogenesis, suppress tumor metastasis, modulate cancer-associated signalling pathways. Additionally, oleocanthal also reported disrupt redox hemostasis. review provides insights into O. europaea-derived secoiridoids, shedding light role chemoprevention. bioactivities summarized support epidemiological evidence demonstrating negative correlation between cancer risk. Furthermore, mapped secondary pathways may provide information elucidate new synergies other agents complement chemotherapies develop novel nutrition-based approaches.

Language: Английский

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