Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 16, 2024
Oxidative stress has an important role in type 2 diabetes (T2D). balance score (OBS) is emerging assessment of dietary and lifestyle oxidative balance. We aimed to explore the association OBS with cardiovascular disease (CVD) all-cause CVD mortality T2D population through NHANES 1999-2018.
Language: Английский
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: March 13, 2024
Background Metabolic syndrome (MetS) is a global health concern that threatens human well-being. The oxidative balance score (OBS) tool to identify the level of stress correlated with MetS risk. However, association between OBS and its components has not been reported. Methods This cross-sectional study included adult individuals complete data from National Health Nutrition Examination Survey (NHANES) 2011–2018. A weighted logistic regression analysis was conducted total, dietary, lifestyle scores MetS. Subgroup analyses restricted cubic splines were used further explore associations. Results In 10,025 eligible (51.48% males at median age 46 years) included, prevalence 29.98%. fully adjusted model, higher total associated reduced risk (Q3 vs. Q1: odds ratio [OR] = 0.57, 95% confidence interval [CI], 0.46–0.71, p < 0.001; Q4 OR 0.42, CI, 0.33–0.53, P for trend <0.001). Significant differences observed in relationship dietary (continuous OBS: 0.97, 0.96–0.98, continuous 0.61, 0.58–0.64, 0.001), as well negative five (all 0.05). showed marital status modified subgroup (P interaction 0.014). Moreover, nonlinear correlation (including components) found, elucidating associations Restricted demonstrated obviously U-shape (elevated triglyceride blood pressure). Conclusion suggests strong components. Our indicated decreased manner. Hence, may serve an effective marker identifying MetS, indicating predominance more antioxidants.
Language: Английский
Citations
17
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 20, 2025
The oxidative balance score (OBS) is a composite metric highlights pro-oxidants and antioxidants balance, representing the overall burden of stress. This study aims to examine association between OBS hyperuricemia in Chinese population. was based on population-based cross-sectional survey data Fujian province from August 2020 April 2021. determined 10 food lifestyle components. investigated using logistic regression analysis. Subgroup analyses identified sensitive populations. Restricted cubic spline (RCS) performed potential dose-response relationship. A total 9464 participants were included final An inverse observed remained after adjusting for confounders. Each additional unit associated with 4% 7% reduction risk men [OR: 0.96(0.94,0.99)] women 0.93(0.90,0.96)], respectively. Participants highest quartile had 22% 37% lower hypertension compared lowest [0.78(0.62,0.97)] 0.63(0.49,0.79)], There significant interactions gender, hypertension, dyslipidemia (Pinteraction < 0.05), except age, education, diabetes > 0.05). linear relationship (Pnonlinear = 0.7854) observed. as well Increasing antioxidant levels through modification may be an effective way prevent hyperuricemia, especially women. Large prospective cohort studies randomized controlled trials are required verify effect elucidate its causal mechanism.
Language: Английский
Citations
2
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 8, 2024
Background Nonalcoholic fatty liver disease (NAFLD) stands a prevalent chronic condition significantly influenced by oxidative stress. We investigated the unclear relationship between antioxidant-rich diet and lifestyle cardiovascular (CVD) prevalence rate mortality in adult patients with NAFLD. Methods This study utilized data from National Health Nutrition Examination Survey (NHAENS) spanning 1999 to 2018 investigate association adherence an The employed Oxidative Balance Score (OBS) define antioxidant lifestyle. Results Including 8,670 NAFLD, revealed inverse OBS of most CVD conditions. Fully adjusted models demonstrated that each unit increase OBS, overall corresponded 2, 7, 2% reduction all-cause mortality, respectively. In findings Q2 Q3 were linked reduced cancer whereas did not exhibit association. Additionally, Stratified analysis age (<45 years) education level (> high school) CVD. Conclusion These results underscore protective link diminished adults particularly among younger higher-educated populations.
Language: Английский
Citations
12
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 10
Published: Jan. 5, 2024
Background The relationship between oxidative stress and metabolic dysfunction-associated steatotic liver disease (MASLD) has not been studied, which remains inadequately recognized. This is a cross-sectional study in US adult population to explore the MASLD balance scores (OBS), containing integrating dietary nutrition lifestyle factors. Methods We analyzed data from National Health Nutrition Examination Survey during 2017–2018. Multivariate logistic regression, restricted cubic spline curve (RCS) subgroup analysis were used investigate association OBS MASLD. Cox regression was utilized assess all-cause mortality among individuals. Results multivariable-adjusted odds ratio (OR) 95% confidence interval (CI) for highest quartile of (Q4) 0.30 (0.12, 0.77) ( p = 0.012) compared lowest (Q1). RCS indicated an inverted development Q4 group (HR: 0.15, CI: 0.03–0.87; 0.035) exhibited lower risk death than Q1 group. Conclusion statistically significantly negatively correlated with adults. More prospective investigations are required substantiate our findings.
Language: Английский
Citations
5
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: April 5, 2024
Background Oxidative Balance Score (OBS) is a tool for assessing the oxidative stress-related exposures of diet and lifestyle. The study aimed to investigate association between OBS low muscle mass. Methods Overall, 6,307 individuals over age 18 were assessed using data from 2011 2018 National Health Nutrition Examination Survey (NHANES). Weighted logistic regression models used, together with adjusted models. Results There was negative relationship mass [odds ratio (OR): 0.96, 95% confidence interval (CI): 0.94–0.97, p < 0.0001] first level as reference. values (all CI) 0.745 (0.527–1.054) second level, 0.650 (0.456–0.927) third 0.326 (0.206–0.514) fourth (P trend <0.0001). Independent links found lifestyle factors. A restricted cubic spline model indicated non-linear risk non-linearity<0.05). In addition, inflection points nonlinear curves 20. Conclusion be significantly negatively correlated. By modulating balance, healthy antioxidant rich could preventive strategy
Language: Английский
Citations
5
International Journal of Women s Health, Journal Year: 2024, Volume and Issue: Volume 16, P. 1293 - 1301
Published: July 1, 2024
Purpose: To investigate the association between oxidative balance score (OBS) and endometriosis. Methods: This cross-sectional study used four cycles of National Health Nutrition Examination Survey (NHANES) (1999– 2000, 2001– 2002, 2003– 2004, 2005– 2006). OBS involved 16 dietary nutrients 4 lifestyle factors, including 5 pro-oxidants 15 anti-oxidants. According to weighted quartiles, was divided into categories: < 12.54, 12.54– 18.70, 18.71– 24.68, > 24.68. Endometriosis diagnosed based on a question from reproductive health questionnaire. Weighted multivariate logistic analysis Subgroup performed menstrual regularity female hormone use. Results: A total 5095 women were included, with 1140 (22.37%), 1232 (24.18%), 1224 (24.02%), 1499 (29.42%) in 24.68 categories, respectively. After adjusting age, race, family poverty-to-income ratio (PIR), education level, uterine fibroids, regularity, oophorectomy, use, hypertension, dyslipidemia, steroid drug, high (> 24.68) found be associated lower odds endometriosis [odds (OR) = 0.70, 95% confidence interval (CI): 0.50– 0.97, P 0.033] compared low (< 12.54). The similar result also irregular menstruation (OR 0.58, CI: 0.37– 0.91, 0.020) use 0.71, 0.52– 0.98, 0.037). Conclusion: endometriosis, especially Keywords: Oxidative score, menstruation, hormones, NHANES
Language: Английский
Citations
4
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: July 30, 2024
The correlation between oxidative stress and female infertility pathogenesis was established, the balance score (OBS) can serve as a measure of overall burden within an individual. Prior reports have not addressed relationship OBS infertility. This study endeavors to investigate association risk in OBS.
Language: Английский
Citations
4
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 23, 2025
Importance Oxidative stress contributes to the progression of non-alcoholic fatty liver disease (NAFLD). Antioxidants from food can reduce NAFLD incidence, and Composite Dietary Antioxidant Index (CDAI) measures total antioxidant capacity (TAC). However, relationship between CDAI in US adult population remains unclear. Objective To assess whether is associated with adults. Design, setting, participants This population-based cross-sectional study used data on adults National Health Nutrition Examination Survey (NHANES) 2005–2016 cycles. Data were analyzed January February 2024. Exposures obtained dietary intake questionnaire. Main outcomes The main outcome was which defined by score (USFLI) ≥30. Sampling weights calculated according NHANES guidelines. Results Among 9,746 included this [mean age, 48.3 years; 4,662 (47.6%) males], 3,324 (33.0%) classified as having using USFLI. In fully adjusted multivariable logistic regression, negatively (odds ratio [OR], 0.95; 95% CI, 0.93–0.98). Furthermore, individuals highest quartile 34% less likely have compared those lowest (OR, 0.66; 0.52–0.85). subgroup analyses, inversely among a BMI <25 0.89; 0.83–0.95) without metabolic syndrome 0.93; 0.91–0.96). interaction tests revealed significant differences these subgroups ( P for = 0.04 0.003 syndrome). Sensitivity analyses confirmed association hepatic steatosis index (HSI) define NAFLD, applying unweighted adjusting physical activity or after excluding non-Hispanic Black participants, medications known their potential hepatotoxic effects. Conclusions relevance based six cycles (2005–2016) NHANES, population. highlights interventions incidence underscores need future research, including clinical trials mechanistic studies, further explore role antioxidants prevention management.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 28, 2025
Background The oxidative balance score (OBS) combines diverse dietary components with lifestyle factors to comprehensively evaluate stress. investigation focuses on the link between OBS and mortality outcomes, including cardiovascular all-cause deaths, in overweight obese individuals. Methods analysis utilized data from National Health Nutrition Examination Survey (NHANES), covering period 1999 2018. Mortality information, categorized into was gathered Death Index (NDI). Kaplan–Meier survival analysis, along multivariate Cox regression restricted cubic spline (RCS) modeling, were explore risks. Subgroup sensitivity used assess robustness of results possible effect modifiers. Mediation identifies pathways through which independent variable affects dependent variable. Results In this study, 26,219 participants or obesity enrolled, an average age 49.8 ± 17.4 years. During a median follow-up duration 115 months, 2,239 (8.5%) died, 837 (3.2%) disease. According highest among lowest quartile (Q1) those (Q4). Participants fourth experienced 21.7% decrease risk all causes 29.5% risk, according fully adjusted results, compared first quartile. These validated subgroup analyses. RCS revealed notable inverse association outcomes. indicates that white blood cell count (WBC) gamma-glutamyl transferase (GGT) serve as significant mediators risk. Conclusion Elevated levels strongly linked reduced potential for both individuals who are obese.
Language: Английский
Citations
0
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12
Published: March 4, 2025
Globally, metabolic dysfunction-associated fatty liver disease (MAFLD), also known as non-alcoholic (NAFLD) or steatotic (MASLD), is a common chronic disease. The progression of MAFLD leads to vicious cycle in which oxidative stress results from the that augmenting de-novo lipid levels and increases steatosis. Most non-enzymatic antioxidants are present food. Therefore, review summarizes findings studies on food-derived presents an stress-related regulatory network MAFLD, offering new ideas for prevention treatment.
Language: Английский
Citations
0