Pain and Stress Detection Using Wearable Sensors and Devices—A Review

Sensors, Journal Year: 2021, Volume and Issue: 21(4), P. 1030 - 1030

Published: Feb. 3, 2021

Pain is a subjective feeling; it sensation that every human being must have experienced all their life. Yet, its mechanism and the way to immune still question be answered. This review presents correlation of pain stress, assessment detection approach with medical devices wearable sensors. Various physiological signals (i.e., heart activity, brain muscle electrodermal respiratory, blood volume pulse, skin temperature) behavioral are organized for wearables sensors detection. By reviewing used in healthcare domain, we hope find healthcare-monitoring system applied on stress Since leads multiple consequences or symptoms such as tension depression related, there chance new chronic using daily life devices. Then by integrating modern computing techniques, handle management issue.

Language: Английский

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Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Journal of Neuroinflammation, Journal Year: 2023, Volume and Issue: 20(1)

Published: Nov. 27, 2023

As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks premature death other medical conditions for patients. Neuroinflammation is abnormal immune response in brain, its correlation with MDD receiving increasing attention. has been reported to be involved through distinct neurobiological mechanisms, among which dysregulation neurogenesis dentate gyrus (DG) hippocampus (HPC) The DG two niches adult mammalian neurotrophic factors are fundamental regulators this process. cell types mediating neuroinflammation include microglia, astrocytes, oligodendrocytes, meningeal leukocytes, peripheral cells selectively penetrate blood-brain barrier infiltrate into inflammatory regions. This review summarizes functions affected by during progression corresponding influences on memory patients model animals.

Language: Английский

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The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress?

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(4), P. 3640 - 3640

Published: Feb. 18, 2023

The overall burden of cancer is rapidly increasing worldwide, reflecting not only population growth and aging, but also the prevalence spread risk factors. Gastrointestinal (GI) cancers, including stomach, liver, esophageal, pancreatic, colorectal represent more than a quarter all cancers. While smoking alcohol use are factors most commonly associated with development, growing consensus includes dietary habits as relevant for GI Current evidence suggests that socioeconomic development results in several lifestyle modifications, shifts from local traditional diets to less-healthy Western diets. Moreover, recent data indicate increased production consumption processed foods underlies current pandemics obesity related metabolic disorders, which directly or indirectly emergence various chronic noncommunicable conditions However, environmental changes restricted patterns, unhealthy behavioral features should be analyzed holistic view lifestyle. In this review, we discussed epidemiological aspects, gut dysbiosis, cellular molecular characteristics cancers explored impact behaviors, diet, physical activity on developing context progressive societal changes.

Language: Английский

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Long-term effects of chronic stress models in adult mice

Journal of Neural Transmission, Journal Year: 2023, Volume and Issue: 130(9), P. 1133 - 1151

Published: Feb. 14, 2023

Abstract Neuropsychiatric disorders, such as major depression, anxiety and post-traumatic stress disorder, tend to be long-term conditions in whose development maintenance are central pathogenic factors. Translational mouse models widely used neuropsychiatric research, exploiting social non-social stressors investigate the mechanisms underlying their detrimental effects. However, most studies focus on short-term consequences of chronic stress, whereas only a few interested course. This is counterintuitive given human that preclinical designed mimic. In this review, we have summarized limited work date effects mice models. First, different presented definition short- vs. sequelae proposed. On basis, behavioral, endocrine, vegetative addressed before examining data cellular molecular alterations brain. Finally, future directions for research discussed.

Language: Английский

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Health position paper and redox perspectives - Disease burden by transportation noise

Redox Biology, Journal Year: 2023, Volume and Issue: 69, P. 102995 - 102995

Published: Dec. 19, 2023

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic risk factor for ischemic heart disease. contrast, they quality of evidence link other diseases was very low moderate. Since then, several studies on impact various have been published. Also, investigating mechanistic pathways underlying noise-induced health effects are emerging. We review current regarding and related disease-mechanisms. Several high-quality cohort consistently found be associated with higher disease, failure, diabetes, all-cause mortality. Furthermore, recent indicated railway may increase not commonly investigated in an environmental context, including breast cancer, dementia, tinnitus. The harmful activation physiological stress response nighttime sleep disturbance. Oxidative inflammation downstream hormone signaling dysregulated circadian rhythms identified as major disease-relevant pathomechanistic drivers. discuss role reactive oxygen species present results from antioxidant interventions. Lastly, we provide overview oxidative markers adverse redox processes reported noise-exposed animals humans. This position paper summarizes all available epidemiological, clinical, preclinical transportation important public discusses its implications population level.

Language: Английский

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Neuroscience of cancer: unraveling the complex interplay between the nervous system, the tumor and the tumor immune microenvironment

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 17, 2025

The study of the multifaceted interactions between neuroscience and cancer is an emerging field with significant implications for understanding tumor biology innovation in therapeutic approaches. Increasing evidence suggests that neurological functions are connected tumorigenesis. In particular, peripheral central nervous systems, synapse, neurotransmitters, neurotrophins affect progression metastasis through various regulatory approaches immune microenvironment. this review, we summarized tumorigenesis metastasis, which controlled by systems. We also explored roles neurotransmitters progression. Moreover, examined interplay system have identified drugs target treatment. review present work supporting agent targeting could potential to improve therapy.

Language: Английский

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Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Aug. 31, 2021

Abstract Background Circular RNAs (circRNAs) are widely expressed in human cells and closely associated with cancer development. However, they have rarely been investigated the context of nasopharyngeal carcinoma (NPC). Methods We screened a new circRNA, circRNF13 , NPC using next-generation sequencing mRNA. Reverse transcription polymerase chain reaction RNA fluorescence situ hybridization were used to detect expression 12 non-tumor epithelial (NPE) tissues 36 samples. Cell proliferation was detected MTT flow cytometry assays, colony formation capability assays. migration invasion analyzed wound-healing Transwell respectively. glycolysis Seahorse glycolytic stress test. Glucose transporter type 1 (GLUT1) ubiquitination SUMOylation modifications co-immunoprecipitation western blotting. CircRNF13 Small Ubiquitin-like Modifier 2 (SUMO2) interactions pull-down luciferase reporter Finally, test whether inhibited metastasis vivo, we xenograft nude mouse model generated by means subcutaneous or tail vein injection. Results found that stably at low levels clinical cells. In vitro vivo experiments showed metastasis. Moreover, activated SUMO2 protein binding 3′- Untranslated Region (3′-UTR) gene prolonging half-life Upregulation promotes GLUT1 degradation through GLUT1, which regulates AMPK-mTOR pathway inhibiting glycolysis, ultimately resulting NPC. Conclusions Our results revealed novel plays an important role development -SUMO2-GLUT1 axis. This study implies mediates provides theoretical basis for further elucidating pathogenesis targeted therapy.

Language: Английский

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Nerves in the Tumor Microenvironment: Origin and Effects

Frontiers in Cell and Developmental Biology, Journal Year: 2020, Volume and Issue: 8

Published: Dec. 17, 2020

Studies have reported the vital role of nerves in tumorigenesis and cancer progression. Nerves infiltrate tumor microenvironment thereby enhancing growth metastasis. Perineural invasion, a process by which cells invade surrounding nerves, provides an alternative route for metastasis generation tumor-related pain. Moreover, central sympathetic nervous system dysfunctions psychological stress-induced hormone network disorders may influence malignant progression through multiple mechanisms. This reciprocal interaction between novel insights into cellular molecular bases tumorigenesis. In addition, they point to potential utility anti-neurogenic therapies. review describes evolving cross-talk cells, thus uncovers therapeutic targets cancer.

Language: Английский

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Nanoparticle-based drug delivery systems in cancer: A focus on inflammatory pathways

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 860 - 872

Published: Feb. 1, 2022

Language: Английский

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Stress and cancer: The mechanisms of immune dysregulation and management

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 5, 2022

Advances in the understanding of psychoneuroimmunology past decade have emphasized notion that stress and cancer are interlinked closely. Durable chronic accelerated tumorigenesis progression, which is unfavorable for clinical outcomes patients. Available evidence has provided unprecedented knowledge about role mechanisms carcinogenesis, most well-known one dysfunction hypothalamus-pituitary-adrenal (HPA) axis sympathetic nervous system (SNS). With abnormal activation neuroendocrine system, stress-related hormones contribute to increased oncogenes expression, exacerbated inflammation impaired immunologic function. In addition, accumulating studies demonstrated diverse interventions including pharmacological approaches, physical exercises psychological relaxation been administered assist mental disorders reduction life quality improvement this review, we systematically summarize connection stress-immune-cancer identified by animal studies, as well conclude effectiveness deficiencies existing management strategies.

Language: Английский

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