Small Methods,
Journal Year:
2023,
Volume and Issue:
8(8)
Published: Dec. 1, 2023
Immune
checkpoint
blockade
(ICB)
therapy
for
tumors
has
arisen
in
growing
interest.
However,
the
low
response
rate
of
to
ICB
is
mainly
attributed
inhibitory
infiltration
immune
cells
tumor
microenvironment
(TME).
Despite
promising
benefits
ICB,
therapeutic
effects
antibodies
are
dependent
on
a
high
dose
and
long-term
usage
clinic,
thereby
leading
immune-related
adverse
effects.
Accordingly,
combined
with
nano-delivery
systems
could
be
used
overcome
T
cell
exhaustion,
which
reduces
side
higher
rates
patients.
In
this
review,
authors
aim
exhaustion
TME
via
modulation
enhanced
immunotherapy.
Several
strategies
summarized
combine
further
enhance
immunotherapy:
a)
expressing
surface
systems;
b)
loading
inhibitors
into
c)
gene-editing
technology
d)
mediated
modulation.
Taken
together,
might
strategy
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(10), P. 1410 - 1410
Published: Oct. 4, 2023
Metal
nanoparticles
(NPs)
have
garnered
considerable
attention,
due
to
their
unique
physicochemical
properties,
that
render
them
promising
candidates
for
various
applications
in
medicine
and
industry.
This
article
offers
a
comprehensive
overview
of
the
most
recent
advancements
manufacturing,
characterization,
biomedical
utilization
metal
NPs,
with
primary
focus
on
silver
gold
NPs.
Their
potential
as
effective
anticancer,
anti-inflammatory,
antimicrobial
agents,
drug
delivery
systems,
imaging
agents
diagnosis
treatment
variety
disorders
is
reviewed.
Moreover,
translation
therapeutic
settings,
issue
inclusion
clinical
trials,
are
assessed
light
over
30
investigations
concentrate
administering
either
or
NPs
conditions
ranging
from
nosocomial
infections
different
types
cancers.
paper
aims
not
only
examine
biocompatibility
nanomaterials
but
also
emphasize
challenges
may
limit
safe
integration
into
healthcare
practices.
More
than
100
nanomedicines
currently
market,
which
justifies
ongoing
study
use
medicine.
Overall,
present
review
highlight
innovative
therapeutics
field
biomedicine,
citing
some
relevant
current
applications.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(6), P. 728 - 728
Published: March 7, 2024
In
seeking
alternative
cancer
treatments,
antimicrobial
peptides
(AMPs),
sourced
from
various
life
forms,
emerge
as
promising
contenders.
These
endogenous
peptides,
also
known
host
defense
(HDPs),
play
crucial
roles
in
immune
defenses
against
infections
and
exhibit
potential
combating
cancers.
With
their
diverse
defensive
functions,
plant-derived
AMPs,
such
thionins
defensins,
offer
a
rich
repertoire
of
properties.
Insects,
amphibians,
animals
contribute
unique
AMPs
like
cecropins,
temporins,
cathelicidins,
showcasing
broad-spectrum
activities
bacteria,
fungi,
viruses.
Understanding
these
natural
holds
significant
for
developing
effective
targeted
therapies
infectious
diseases.
Antimicrobial
(AMPs)
structural
characteristics,
including
α-helical,
β-sheet,
extended,
loop
peptides.
Environmental
conditions
influence
structure,
connecting
to
changes
cell
membrane
hydrophobicity.
AMPs’
actions
involve
direct
killing
regulation,
with
additional
depolarization.
this
review,
we
focus
on
that
act
anticancer
agents
mechanisms
akin
activity.
Buforin
particularly
I
II,
derived
histone
H2A,
demonstrate
antibacterial
potential.
IIb
its
analogs
show
promise,
selectivity
cells.
Despite
the
challenges,
approach
combat
microbial
resistance
treatment.
types,
HeLa,
breast,
lung,
ovarian,
prostate,
liver
cancers,
buforins
inhibitory
effects
apoptosis
induction.
To
address
limitations
stability
bioavailability,
researchers
explore
buforin-containing
bioconjugates,
covalently
linked
nanoparticles
or
liposomes.
Bioconjugation
enhances
specificity-controlled
release
combats
drug
resistance,
presenting
avenue
Clinical
translation
awaits
further
evaluation
through
vivo
studies
future
clinical
trials.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3187 - 3215
Published: April 1, 2024
Abstract:
Green
synthesis
of
silver
(Ag)
and
gold
(Au)
nanoparticles
(NPs)
has
acquired
huge
popularity
owing
to
their
potential
applications
in
various
fields.
A
large
number
research
articles
exist
the
literature
describing
green
Ag
Au
NPs
for
biomedical
applications.
However,
these
findings
are
scattered,
making
it
time-consuming
researchers
locate
promising
advancements
unexplored
Unlike
other
review
articles,
this
systematic
study
not
only
highlights
recent
but
also
explores
The
article
discusses
approaches
highlighting
emerging
developments
novel
strategies.
Then,
reviews
important
synthesized
by
critically
evaluating
expected
advantages.
To
expose
future
direction
field,
describes
NPs.
Finally,
discuss
challenges
limitations
This
will
serve
as
a
valuable
reference
researchers,
working
on
Keywords:
nanoparticles,
environmental-friendly,
applications,
potentials
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 17, 2025
Achyranthes
japonica
(Miq.)
Nakai
(AJN)
and
Melandrium
firmum
(Siebold
Zucc.)
Rohrb.
(MFR)
are
medicinal
plants
recognized
for
their
bioactive
phytochemicals,
including
ecdysteroids,
anthraquinones,
flavonoids.
This
study
investigates
the
anticancer
properties
of
key
constituents
these
plants,
focusing
on
BK002
formulation,
a
novel
combination
AJN
MFR.
Specifically,
research
employs
advanced
molecular
docking
in
silico
analyses
to
assess
interactions
compounds
ecdysterone,
inokosterone,
20-hydroxyecdysone
(20-HE)
with
prostate
cancer-related
network
proteins,
5α-reductase,
CYP17,
DNMT1,
Dicer,
PD-1,
PD-L1.
Molecular
techniques
were
applied
evaluate
binding
affinities
contributions
against
cancer-hub
targets.
The
primary
focus
was
enzymes
like
5α-reductase
which
central
androgen
biosynthesis,
as
well
proteins
such
DNA
methyltransferase
1
(DNMT1),
programmed
death-1
(PD-1),
death
ligand-1
(PD-L1).
Based
data
from
cancer
patients,
target
networks
identified,
followed
by
analysis
components
BK002.In
assessments
conducted
safety
profiles
compounds,
providing
insights
into
therapeutic
potential.
studies
revealed
that
20-hydroxyecdysonec
demonstrated
strong
critical
contributing
potential
reduction
androgenic
activity.
These
also
exhibited
significant
inhibitory
PD-L1,
suggesting
capacity
interfere
oncogenic
immune
evasion
pathways.
Ecdysterone,
have
ability
pathways,
favorable
affinity
further
underscore
agents
cancer.
findings
provide
rationale
preclinical
clinical
investigations,
supporting
integration
regimens
aimed
at
modulating
tumor
progression
responses.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(2), P. 2658 - 2668
Published: Jan. 6, 2023
In
this
study,
vitamin
A
palmitate
(VAP)-loaded
poly(lactic-co-glycolic
acid)
(PLGA)/chitosan-coated
PLGA
nanoparticle
(NP)
systems
were
prepared
by
the
nanoprecipitation
technique.
The
characterized
parameters
such
as
particle
size,
polydispersity
index
(PDI),
ζ-potential,
encapsulation
efficiency,
in
vitro
dissolution,
and
release
kinetic
study.
Then,
cytotoxicity
wound
healing
profiles
of
designed
NP
formulations
HaCaT
(human
keratinocyte
skin
cell
lines)
determined.
size
VAP-loaded
NPs
was
obtained
between
196.33
±
0.65
669.23
5.49
nm.
PDI
data
proved
that
all
high
quality
monodisperse.
While
negative
ζ-potential
values
Blank-NP-1
NP-1
encoded
obtained,
positive
chitosan-coated
NPs.
studies
observed
rapid
dissolution
first
1-6
h,
but
prolonged
VAP
after
dissolution.
As
a
result
culture
activity
studies,
it
determined
NP-7
most
effective.
It
thought
reason
for
coded
formulation
with
smallest
concluded
efficiency
increased
its
structure.
This
study
demonstrated
similar
effects
systems,
particular
NP-7,
which
increases
proliferation
at
lower
concentrations
(10
μg·mL-1)
than
alone
(100
μg·mL-1).
nanocarriers
can
be
used
pharmaceutical
industry
have
been
successfully
produced
results
evaluated
promising
industry.
