Recent Advances in Bioconjugated Transition Metal Complexes for Cancer Therapy

Applied Sciences, Journal Year: 2023, Volume and Issue: 13(9), P. 5561 - 5561

Published: April 29, 2023

The introduction of biologically relevant organic moieties in the coordination sphere transition metal complexes has recently become a well-established strategy to increase selectivity and biocompatibility metallodrugs. In this review, major advances achieved area research last three years are described detail. Particular attention is given bearing main biomolecules life: carbohydrates, lipids, nucleotides, proteins vitamins. Each paragraph summarizes synthetic employed obtain interest as well most interesting biological results obtained with these potential Moreover, structure–activity relationships observed by different groups discussed, goal suggesting reader ligand/metal centre combinations that provide promising fight against cancer. Some compounds examined review other bioconjugated published recent decades exhibit towards cancer cells over normal ones specific mode action. These latter aspects basis what commonly known anticancer target therapy.

Language: Английский

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Targeting Glucose Metabolism in Cancer Cells as an Approach to Overcoming Drug Resistance

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2610 - 2610

Published: Nov. 10, 2023

The “Warburg effect” consists of a metabolic shift in energy production from oxidative phosphorylation to glycolysis. continuous activation glycolysis cancer cells causes rapid and an increase lactate, leading the acidification tumour microenvironment, chemo- radioresistance, as well poor patient survival. Nevertheless, mitochondrial metabolism can be also involved aggressive characteristics. differences between normal tissues considered Achilles heel cancer, offering strategy for new therapies. One main treatment resistance increased expression efflux pumps, multidrug (MDR) proteins, which are able export chemotherapeutics out cell. Cells expressing MDR proteins require ATP mediate their drug substrates. Thus, inhibition energy-producing pathways cells, not only induces cell death per se, but overcomes resistance. Given that most anticancer drugs do have ability distinguish number delivery systems been developed. These nanodrug provide flexible effective methods overcome by facilitating cellular uptake, increasing accumulation, reducing efflux, improving targeted delivery, co-administering synergistic agents, half-life circulation.

Language: Английский

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Comprehensive Insights into Oral Squamous Cell Carcinoma: Diagnosis, Pathogenesis, and Therapeutic Advances

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 261, P. 155489 - 155489

Published: July 27, 2024

Language: Английский

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The interplay of p38 MAPK signaling and mitochondrial metabolism, a dynamic target in cancer and pathological contexts

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 225, P. 116307 - 116307

Published: May 24, 2024

Language: Английский

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Natural Compounds as Promising Adjuvant Agents in The Treatment of Gliomas

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(6), P. 3360 - 3360

Published: March 20, 2022

In humans, glioblastoma is the most prevalent primary malignant brain tumor. Usually, has specific characteristics, such as aggressive cell proliferation and rapid invasion of surrounding tissue, leading to a poor patient prognosis. The current therapy—which provides multidisciplinary approach with surgery followed by radiotherapy chemotherapy temozolomide—is not very efficient since it faces clinical challenges tumor heterogeneity, invasiveness, chemoresistance. this respect, natural substances in diet, integral components lifestyle medicine approach, can be seen potential chemotherapeutics. There are several epidemiological studies that have shown chemopreventive role dietary compounds cancer progression development. These heterogeneous produce anti-glioblastoma effects through upregulation apoptosis autophagy; allowing promotion cycle arrest; interfering metabolism; permitting proliferation, neuroinflammation, chemoresistance, angiogenesis, metastasis inhibition. Although these beneficial promising, efficacy limited due their bioavailability blood–brain barrier permeability. Thereby, further trials necessary confirm vitro vivo anticancer properties compounds. article, we overview treatment considering overcome future prospects.

Language: Английский

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Correlation between the Warburg effect and progression of triple-negative breast cancer

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 12

Published: Jan. 27, 2023

Triple-negative breast cancer (TNBC) is ineligible for hormonal therapy and Her-2-targeted due to the negative expression of estrogen receptor, progesterone human epidermal growth factor receptor-2. Although targeted immunotherapy have been shown attenuate aggressiveness TNBC partially, few patients benefited from them. The conventional treatment remains chemotherapy. Chemoresistance, however, impedes therapeutic progress over time, chemotherapy toxicity increases burden on patients. Therefore, introducing more advantageous options a necessity. Metabolic reprogramming centered glucose metabolism considered hallmark tumors. It described as tumor cells tend convert lactate even under normoxic conditions, phenomenon known Warburg effect. Similar Darwinian evolution, its emergence attributed selective pressures formed by hypoxic microenvironment pre-malignant lesions. Of note, effect does not disappear with changes in after formation malignant phenotypes. Instead, it forms constitutive mediated mutations or epigenetic modifications, providing robust survival advantage primary metastatic Expanding evidence has demonstrated that mediates multiple invasive behaviors TNBC, including proliferation, metastasis, recurrence, immune escape, multidrug resistance. Moreover, effect-targeted testified be feasible inhibiting progression. However, all TNBCs are sensitive glycolysis inhibitors because flexibly switch their metabolic patterns cope different pressures, namely plasticity. Between medicines actual curative effect, plasticity creates divide must continuously researched bridged.

Language: Английский

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Rewiring of mitochondrial metabolism in therapy-resistant cancers: permanent and plastic adaptations

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Sept. 13, 2023

Deregulation of tumor cell metabolism is widely recognized as a “hallmark cancer.” Many the selective pressures encountered by cells, such exposure to anticancer therapies, navigation metastatic cascade, and communication with microenvironment, can elicit further rewiring metabolism. Furthermore, phenotypic plasticity has been recently appreciated an emerging Mitochondria are dynamic organelles central hubs whose roles in cancers have major focus numerous studies. Importantly, therapeutic approaches targeting mitochondria being developed. Interestingly, both plastic (i.e., reversible) permanent stable) metabolic adaptations observed following therapeutics. Understanding or nature these mechanisms crucial importance for devising initiation, duration, sequential metabolism-targeting therapies. In this review, we compare mitochondrial driving therapy resistance. We also discuss experimental models therapy-induced adaptation, implications states, clinical adaptations. While make effective treatment challenging, understanding behind phenotypes may lead promising interventions that will ultimately better overall care cancer patients.

Language: Английский

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Betulinic acid in the treatment of breast cancer: Application and mechanism progress

Fitoterapia, Journal Year: 2023, Volume and Issue: 169, P. 105617 - 105617

Published: July 19, 2023

Language: Английский

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Glucose Transporter 1-Mediated Transcytosis of Glucosamine-Labeled Liposomal Ceramide Targets Hypoxia Niches and Cancer Stem Cells to Enhance Therapeutic Efficacy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(14), P. 13158 - 13175

Published: July 12, 2023

Tumour hypoxia plays an important role in modulating tumorigenesis, angiogenesis, invasion, immunosuppression, resistance to treatment, and even maintenance of the stemness cancer stem cells (CSCs). Moreover, targeting treatment hypoxic CSCs reduce influence tumor on therapy remains imperative clinical problem that needs be addressed. Since upregulate expression glucose transporter 1 (GLUT1) through Warburg effect, we considered possibility GLUT1-mediated transcytosis developed a hypoxia-targeting nanomedicine. Our experimental results indicate glucosamine-labeled liposomal ceramide can efficiently transported between by GLUT1 transporters substantially accumulated area vitro CSC spheroids vivo xenografts. We also verified effects exogenous hypoxia, including bioactivities such as upregulation p53 retinoblastoma protein (RB), downregulation hypoxia-inducible factor-1 alpha (HIF-1α) expression, disruption OCT4-SOX2 network stemness, inhibition CD47 PD-L1 expression. To achieve ideal therapeutic outcome, combined with paclitaxel carboplatin, found excellent synergistic clearance being noted three-fourths mice. Overall, our findings provide potential strategy for cancer.

Language: Английский

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Targeting hypoxic and acidic tumor microenvironment by nanoparticles: A review

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105660 - 105660

Published: April 12, 2024

Language: Английский

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