Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(3)
Published: Feb. 18, 2024
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 155, P. 113810 - 113810
Published: Oct. 8, 2022
The human gut microbiota is a complex ecosystem involved in the metabolism, immunity, and health of host. microbiome plays key role development host's innate adaptive immune system, while system orchestrates maintenance host-microbe symbiosis. Lung diseases are usually accompanied by dysbiosis intestinal flora an immune-inflammatory response. its metabolites directly or indirectly regulation host lung disease. However, exact mechanism action gut-lung axis crosstalk remains unclear. This review aimed to summarize latest advances their typical diseases, such as pulmonary hypertension, COPD, cancer. Especially COVID-19, problem troubling world, also discussed it. Moreover, it concentrated on mechanisms between identified specific link among microbiota, metabolites, regulation, which could be used breakthrough find new targets for some without therapeutic drugs clinic. It tool "drug-bacterial interaction" potential applications would provide clear direction future research propose strategy targeting
Language: Английский
Citations
84
Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13
Published: May 31, 2022
Respiratory diseases cause a high incidence and mortality worldwide. As natural immunobiotic, Lactobacillus has excellent immunomodulatory ability. Administration of some species can alleviate the symptoms respiratory such as tract infections, asthma, lung cancer cystic fibrosis in animal studies clinical trials. The beneficial effect on is strain dependent. Moreover, efficacy may be affected by many factors, bacteria dose, timing host background. Here, we summarized administered common with focus mechanism safety regulating immunity.
Language: Английский
Citations
75
Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(8), P. 492 - 506
Published: May 22, 2024
Language: Английский
Citations
27
Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)
Published: March 4, 2024
Language: Английский
Citations
16
BMC Microbiology, Journal Year: 2022, Volume and Issue: 22(1)
Published: Feb. 25, 2022
Abstract Background The microbiome alterations are associated with cancer growth and may influence the immune system response to therapy. Particularly, gut has been recently shown modulate melanoma immunotherapy. However, role of skin not well explored in tumour microenvironment link between investigated progression. Therefore, aim present study was examine associations dysbiosis using MeLiM porcine model progression spontaneous regression. Results Parallel analysis cutaneous microbiota faecal same individuals performed 8 12 weeks old piglets. bacterial composition samples analysed by high throughput sequencing V4-V5 region 16S rRNA gene. A significant difference diversity richness tissue healthy piglets control were observed. Both Principal Coordinate Analysis Non-metric multidimensional scaling revealed dissimilarities different communities. Linear discriminant effect size at genus level determined potential biomarkers multiple Lactobacillus, Clostridium sensu stricto 1 Corynebacterium most discriminately higher genera microbiome, while Fusobacterium, Trueperella, Staphylococcus, Streptococcus Bacteroides abundant microbiome. Bacteroides, Fusobacterium Escherichia-Shigella Potential functional pathways based on KEGG database indicated differences predicted profile metabolisms enriched genes related membrane transports allowing for increase intestinal permeability alteration mucosal barrier. Conclusion as identified. provide promising information further studies local involvement support development new therapeutic approaches.
Language: Английский
Citations
67
Diagnostics, Journal Year: 2022, Volume and Issue: 12(7), P. 1742 - 1742
Published: July 19, 2022
The human microbiome encodes more than three million genes, outnumbering genes by 100 times, while microbial cells in the microbiota outnumber 10 times. Thus, and related constitute a vast source for identifying disease biomarkers therapeutic drug targets. Herein, we review evidence backing exploitation of diagnostic disease. We describe importance health detail use metabolites as potential multiple diseases, including cancer, well inflammatory, neurological, metabolic diseases. has enormous to pave road new era biomarker research purposes. scientific community needs collaborate overcome current challenges concerning lack standardization methods understanding causal relationships between
Language: Английский
Citations
51
The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 120, P. 109416 - 109416
Published: July 12, 2023
Language: Английский
Citations
28
International Journal of Cancer, Journal Year: 2023, Volume and Issue: 154(1), P. 28 - 40
Published: Aug. 24, 2023
Abstract Differences in the average age at cancer diagnosis are observed across countries. We therefore aimed to assess international variation median of common cancers worldwide, after adjusting for differences population structure. used IARC's Cancer Incidence Five Continents (CI5) Volume XI database, comprising diagnoses between 2008 and 2012 from population‐based registries 65 calculated crude ages lung, colon, breast prostate each country, then adjusted using indirect standardization. showed that changed by up 10 years standardization, typically increasing low‐ middle‐income countries (LMICs) decreasing high‐income (HICs), given relatively younger older populations, respectively. After range was 12 lung (median 61‐Bulgaria vs 73‐Bahrain), colon (60‐the Islamic Republic Iran 72‐Peru), female (49‐Algeria, Iran, Korea 59‐USA others) (65‐USA, Lithuania 75‐Philippines). Compared HICs, populations LMICs were diagnosed with but (both p LMICS‐vs‐HICs < 0.001). In higher smoking prevalence, both women men corr Female tended be East Asia, Middle Africa. Our findings suggest worldwide likely reflect population‐level risk factors control measures, including screening.
Language: Английский
Citations
25
Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2304 - 2328
Published: Jan. 1, 2024
The gut microbiota is a crucial component of the intricate microecosystem within human body that engages in interactions with host and influences various physiological processes pathological conditions.In recent years, association between dysbiosis tumorigenesis has garnered increasing attention, as it recognized hallmark cancer scientific community.However, only few microorganisms have been identified potential drivers tumorigenesis, enhancing molecular understanding this process substantial importance clinical relevance for treatment.In review, we delineate impact on treatment multiple types while also analyzing associated mechanisms.Moreover, discuss utility data diagnosis patient stratification.We further outline current research harnessing prospects challenges approach.
Language: Английский
Citations
12
Clinical and Translational Allergy, Journal Year: 2024, Volume and Issue: 14(5)
Published: April 30, 2024
Abstract Background Gut microbiota are closely related to the development and regulation of host immune system by regulating maturation cells resistance pathogens, which affects immunity. Early use antibiotics disrupts homeostasis gut increases risk asthma. actively interact with via gut‐lung axis, a bidirectional communication pathway between lung. The manipulation through probiotics, helminth therapy, fecal transplantation (FMT) combat asthma has become hot research topic. Body This review mainly describes current pathogenesis asthma, role axis in Moreover, potential manipulating its metabolites as treatment strategy for been discussed. Conclusion effect on microecology imbalance contributes bacterial structural components metabolites. Asthma, turn, can also cause intestinal damage inflammation throughout body. FMT inform strategies pathogens.
Language: Английский
Citations
12