Nanomaterials in tumor immunotherapy: new strategies and challenges

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: June 13, 2023

Abstract Tumor immunotherapy exerts its anti-tumor effects by stimulating and enhancing immune responses of the body. It has become another important modality therapy with significant clinical efficacy advantages compared to chemotherapy, radiotherapy targeted therapy. Although various kinds tumor immunotherapeutic drugs have emerged, challenges faced in delivery these drugs, such as poor permeability low cell uptake rate, had prevented their widespread application. Recently, nanomaterials emerged a means for treatment different diseases due targeting properties, biocompatibility functionalities. Moreover, possess characteristics that overcome defects traditional immunotherapy, large drug loading capacity, precise easy modification, thus leading wide application immunotherapy. There are two main classes novel nanoparticles mentioned this review: organic (polymeric nanomaterials, liposomes lipid nanoparticles) inorganic (non-metallic metallic nanomaterials). Besides, fabrication method nanoparticles, Nanoemulsions, was also introduced. In summary, review article mainly discussed research progress based on past few years offers theoretical basis exploring strategies future.

Language: Английский

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The Role of Silver Nanoparticles in the Diagnosis and Treatment of Cancer: Are There Any Perspectives for the Future?

Life, Journal Year: 2023, Volume and Issue: 13(2), P. 466 - 466

Published: Feb. 7, 2023

Cancer is a fatal disease with complex pathophysiology. Lack of specificity and cytotoxicity, as well the multidrug resistance traditional cancer chemotherapy, are most common limitations that often cause treatment failure. Thus, in recent years, significant efforts have concentrated on development modernistic field called nano-oncology, which provides possibility using nanoparticles (NPs) aim to detect, target, treat diseases. In comparison conventional anticancer strategies, NPs provide targeted approach, preventing undesirable side effects. What more, nanoparticle-based drug delivery systems shown good pharmacokinetics precise targeting, reduced resistance. It has been documented that, cells, promote reactive oxygen species (ROS) production, induce cell cycle arrest apoptosis, activate ER (endoplasmic reticulum) stress, modulate various signaling pathways, etc. Furthermore, their ability inhibit tumor growth vivo also documented. this paper, we reviewed role silver (AgNPs) nanomedicine, discussing numerous mechanisms by they render properties under both vitro conditions, potential diagnosis cancer.

Language: Английский

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Copper and Copper-Based Nanoparticles in Medicine—Perspectives and Challenges

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6687 - 6687

Published: Sept. 18, 2023

Nanotechnology has ushered in a new era of medical innovation, offering unique solutions to longstanding healthcare challenges. Among nanomaterials, copper and oxide nanoparticles stand out as promising candidates for multitude applications. This article aims provide contemporary insights into the perspectives challenges regarding use medicine. It summarises biomedical potential copper-based nanoformulations, including progress early-stage research, evaluate mitigate toxicity nanomaterials. The discussion covers prospects nanomaterials context their successful clinical translation. also addresses safety concerns, emphasizing need assessments nanomedicines. However, attention is needed solve current such biocompatibility controlled release. Ongoing research collaborative efforts overcome these obstacles are discussed. analysis guidance safe effective integration practice, thereby advancing recent literature highlighted multifaceted associated with translation from laboratory clinic. In particular, remains formidable hurdle, requiring innovative ensure seamless human body. Additionally, achieving release therapeutic agents poses complex challenge that requires meticulous engineering precise design.

Language: Английский

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Niosomes: Composition, Formulation Techniques, and Recent Progress as Delivery Systems in Cancer Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 223 - 223

Published: Feb. 4, 2024

Niosomes are vesicular nanocarriers, biodegradable, relatively non-toxic, stable, and inexpensive, that provide an alternative for lipid-solid carriers (e.g., liposomes). may resolve issues related to the instability, fast degradation, bioavailability, insolubility of different drugs or natural compounds. can be very efficient potential systems specific delivery anticancer, antioxidant, anti-inflammatory, antimicrobial, antibacterial molecules. This review aims present overview their composition, most common formulation techniques, as well recent utilizations in cancer therapy.

Language: Английский

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The Advancing Role of Nanocomposites in Cancer Diagnosis and Treatment

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6099 - 6126

Published: June 1, 2024

Abstract: The relentless pursuit of effective cancer diagnosis and treatment strategies has led to the rapidly expanding field nanotechnology, with a specific focus on nanocomposites. Nanocomposites, combination nanomaterials diverse properties, have emerged as versatile tools in oncology, offering multifunctional platforms for targeted delivery, imaging, therapeutic interventions. Nanocomposites exhibit great potential early detection accurate imaging diagnosis. Integrating various modalities, such magnetic resonance (MRI), computed tomography (CT), fluorescence into nanocomposites enables development contrast agents enhanced sensitivity specificity. Moreover, functionalizing targeting ligands ensures selective accumulation tumor tissues, facilitating precise diagnostic accuracy. On front, revolutionized by overcoming traditional challenges associated drug delivery. controlled release from nanocomposite carriers enhances bioavailability, reduces systemic toxicity, improves overall efficacy. Additionally, integration stimuli-responsive components within site-specific triggered unique microenvironment tumor. Despite remarkable progress field, biocompatibility, scalability, long-term safety profiles remain. This article provides comprehensive overview recent developments, challenges, prospects, emphasizing transformative revolutionizing landscape diagnostics therapeutics. In Conclusion, integrating heralds new era precision medicine. Keywords: nanocomposites, cancer, diagnosis, therapy, nanoparticles, theranostic

Language: Английский

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Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

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Nanomaterials: Breaking through the bottleneck of tumor immunotherapy

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 230, P. 123159 - 123159

Published: Jan. 5, 2023

Language: Английский

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Biogenic Synthesis of Cu-Mn Bimetallic Nanoparticles Using Pumpkin Seeds Extract and Their Characterization and Anticancer Efficacy

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(7), P. 1201 - 1201

Published: March 28, 2023

Cancer is a chronic, heterogeneous illness that progresses through spectrum of devastating clinical manifestations and remains the 2nd leading contributor to global mortality. Current cancer therapeutics display various drawbacks result in inefficient management. The present study intended evaluate anticancer potential Cu-Mn bimetallic NPs (CMBNPs) synthesized from pumpkin seed extract against colon adenocarcinoma cell line (HT-29).The CMBNPs were biosynthesized by continuously stirring an aqueous solution with CuSO4 manganese (II) acetate tetrahydrate until dark green was obtained. characteristic features biogenic assessed UV-visible spectrophotometry (UV-vis), X-ray powder diffraction (XRD), energy-dispersive (EDX), scanning electron microscopy (SEM), transmission (TEM). A battery biological assays, viz. neutral red uptake (NRU) assay, vitro scratch comet performed for efficacy evaluation.The formation spherical monodispersed nanoparticles average size 50 nm recorded using TEM. We observed dose-dependent cytotoxicity HT-29 IC50 dose 115.2 µg/mL. On other hand, did not show significant normal lines (Vero cells). Furthermore, treatment inhibited migration cells caused DNA damage increase tail length.The results showed substantial studied line. However, it advocated current work be expanded different models so vivo validation could carried out most appropriate model.

Language: Английский

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New Frontiers in Colorectal Cancer Treatment Combining Nanotechnology with Photo- and Radiotherapy

Cancers, Journal Year: 2023, Volume and Issue: 15(2), P. 383 - 383

Published: Jan. 6, 2023

Colorectal cancer is the third most common worldwide. Despite recent advances in treatment of this pathology, which include a personalized approach using radio- and chemotherapies combination with advanced surgical techniques, it imperative to enhance performance these treatments decrease their detrimental side effects on patients’ health. Nanomedicine likely pathway towards solving challenge by enhancing both therapeutic diagnostic capabilities. In particular, plasmonic nanoparticles show remarkable potential due dual functionalities as photothermal therapy agents radiosensitizers radiotherapy. Their functionality, high biocompatibility, easy functionalization, targeting capabilities make them for inducing efficient cell death minimal effects. This review aims identify main challenges diagnosis colorectal cancer. The heterogeneous nature also discussed from single-cell point view. relevant works photo- radiotherapy nanotechnology-based therapies are addressed, ranging vitro studies (2D 3D cultures) vivo clinical trials. Although results promising, preliminary showed that possibility combining must be explored improve efficiency.

Language: Английский

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Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 24, 2024

Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, producing anticancer microbial agents situ to suppress growth. Despite the unique advantages of bacteria-based biotherapy, insufficient efficiency limits its application complete ablation malignant tumors. The combination nanomedicine engineered has attracted increasing attention owing their striking synergistic effects treatment. that function as natural vehicles effectively deliver nanomedicines sites. Moreover, provide an opportunity enhance by modulating TME substrates support nanomedicine-mediated reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, catalytic properties, plays important role promoting bacteria-mediated biotherapies. therapy comprehensively summarized this review. Attention is paid not only fabrication nanobiohybrid composites, but also interpromotion mechanism between therapy. Additionally, recent advances bacteria-synergized multimodal therapies highlighted.

Language: Английский

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