ROS-generating nanoplatforms as selective and tunable therapeutic weapons against cancer

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 11, 2023

Abstract Reactive species refers to a group of chemicals, mainly reactive oxygen (ROS) and nitrogen (RNS), that are naturally formed by cells as byproduct cell metabolism regulated various internal external factors. Due their highly chemical reactivity, ROS play crucial role in physiological pathological processes which is why studies on regulation for disease treatment show attracted increasing interest. Notably, now studied powerful therapeutic weapon ROS-regulating therapies such ROS-based cytotoxic mediated ROS-increasing agents cancer treatment. Thanks the significant progress nanotechnology, innovative nanoplatforms with activities have been developed look effective ROS-related nanomedicines. In this review, against photodynamic therapy (PDT), sonodynamic (SDT), radiation (RT) chemodynamic (CDT) discussed, focus stimuli-responsive ROS-generating breaking current limits therapies. Finally, we suppose our review developing field will be valuable promoting not only basic research but overall, translational clinical application.

Language: Английский

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Innovative Fluorescent Polymers in Niosomal Carriers: A Novel Approach to Enhancing Cancer Therapy and Imaging

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract Cancer is anticipated to become the pioneer reason of disease‐related deaths worldwide in next two decades, underscoring urgent need for personalized and adaptive treatment strategies. These strategies are crucial due high variability drug efficacy tendency cancer cells develop resistance. This study investigates potential theranostic nanotechnology using three innovative fluorescent polymers (FP‐1, FP‐2, FP‐3) encapsulated niosomal carriers, combining therapy (chemotherapy radiotherapy) with fluorescence imaging. cargoes assessed their cytotoxic effects across cell lines (A549, MCF‐7, HOb), further analysis determine capacity augment radiotherapy a Linear Accelerator (LINAC) at specific doses. Fluorescence microscopy utilized verify uptake localization cancerous versus healthy lines. The results confirmed that these not only improved antiproliferative but also demonstrate practical application vitro dual function underscores importance dose optimization maximize therapeutic benefits while minimizing adverse effects, thereby enhancing overall treatments.

Language: Английский

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Niosomes loaded with gold nanoparticles for enhanced radiation therapy in lung cancer

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(27), P. 2257 - 2270

Published: Sept. 26, 2024

The present investigation aimed to develop niosomes containing gold nanoparticles (Nio-AuNPs) and evaluate the combinational effect of Nio-AuNPs x-ray radiation therapy (XRT) on growth inhibition potential induction apoptosis in A549 cell line.

Language: Английский

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Nanodiamond Effects on Cancer Cell Radiosensitivity: The Interplay between Their Chemical/Physical Characteristics and the Irradiation Energy

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(23), P. 16622 - 16622

Published: Nov. 22, 2023

Nanoparticles are being increasingly studied to enhance radiation effects. Among them, nanodiamonds (NDs) taken into great consideration due their low toxicity, inertness, chemical stability, and the possibility of surface functionalization. The objective this study is explore influence chemical/physical properties NDs on cellular radiosensitivity combined treatments with beams different energies. DAOY, a human radioresistant medulloblastoma cell line was treated NDs—differing for modifications [hydrogenated (H-NDs) oxidized (OX-NDs)], size, concentration—and analysed (i) ND internalization intracellular localization, (ii) clonogenic survival after treatment beam energies (iii) DNA damage apoptosis, nature ND–radiation biological interactions. Results show that characteristics crucial in determining hydrogenated decreasing either viability when administered alone, or radiation, depending size concentration, while OX-NDs do not. Also, irradiation at high energy (γ-rays 1.25 MeV), combination H-NDs, more efficient eliciting radiosensitisation compared lower (X-rays 250 kVp). Finally, molecular mechanisms addressed, demonstrating killing mediated by induction Caspase-3-dependent apoptosis independent damage. Identifying optimal has potential offer promising therapeutic strategy tackling cancers using H-NDs conjunction high-energy radiation.

Language: Английский

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Universality of hydroxyl radical generation in irradiated nanoenhancer suspensions: Vital role of concentration

AIP Advances, Journal Year: 2024, Volume and Issue: 14(5)

Published: May 1, 2024

Concentration plays an essential role in generating hydroxyl radicals irradiated nanoenhancer suspensions. In this paper, we used coumarin-3-carboxylic acid as a radical-specific probe to investigate the radical production of different concentration nanodiamonds (NDs) and CeO2 NPs phosphate-buffered saline under x-ray irradiation. NDs significantly enhanced production, maximum enhancement was observed at 10 µg/ml, with factor 1.398 ± 0.262. can increase scavenge ranges, lowest highest factors 0.623 0.069 1.738 0.264, respectively. We tested hydrodynamic diameter various concentrations explore effect further. found that increasing concentration, there might be factors, such recombination nanoparticle agglomeration, lead changes factor. Based on data from previous present studies, experimental results indicate is for generation suspensions ionizing radiation. also provide possible mechanisms enhancing by nanoenhancers water radiation decrease high nanoenhancers.

Language: Английский

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