World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(48), P. 6222 - 6234
Published: Dec. 27, 2023
Ulcerative colitis (UC) is a chronic gastrointestinal disorder characterized by inflammation and ulceration, representing significant predisposition to colorectal cancer. Recent advances in single-cell RNA sequencing (scRNA-seq) technology offer promising avenue for dissecting the complex cellular inter-actions molecular signatures driving UC pathology.
Language: Английский
Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(5)
Published: May 7, 2024
Abstract Background Tumor growth is closely linked to the activities of various cells in tumor microenvironment (TME), particularly immune cells. During progression, circulating monocytes and macrophages are recruited, altering TME accelerating growth. These adjust their functions response signals from stromal Tumor-associated (TAMs), similar M2 macrophages, key regulators TME. Methods We review origins, characteristics, TAMs within This analysis includes mechanisms through which facilitate evasion promote metastasis. Additionally, we explore potential therapeutic strategies that target TAMs. Results instrumental mediating malignant behaviors. They release cytokines inhibit effector attract additional immunosuppressive primarily T cells, inducing exhaustion directly, influencing activity indirectly cellular interactions, or suppressing checkpoints. directly involved proliferation, angiogenesis, invasion, Summary Developing innovative tumor-targeted therapies immunotherapeutic currently a promising focus oncology. Given pivotal role evasion, several approaches have been devised them. include leveraging epigenetics, metabolic reprogramming, engineering repolarize TAMs, inhibiting recruitment activity, using as drug delivery vehicles. Although some these remain distant clinical application, believe future targeting will offer significant benefits cancer patients.
Language: Английский
Citations
44
iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109979 - 109979
Published: May 15, 2024
This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to counter adaptive integration artificial intelligence for predictive modeling, identification biomarkers personalized treatment. comprehensive exploration these provides a foundation innovative therapeutic approaches, aiming navigate complex landscape enhance patient outcomes.
Language: Английский
Citations
19
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4679 - 4679
Published: April 25, 2024
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) strongly attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. upregulated hypoxia and/or inflammation-induced inflammatory release, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis, migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.
Language: Английский
Citations
15
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: Sept. 2, 2024
Metabolic reprogramming provides tumors with an energy source and biofuel to support their survival in the malignant microenvironment. Extensive research into intrinsic oncogenic mechanisms of tumor microenvironment (TME) has established that cancer-associated fibroblast (CAFs) metabolic regulates progression through numerous biological activities, including immunosuppression, chronic inflammation, ecological niche remodeling. Specifically, immunosuppressive TME formation is promoted mediators released via CAFs multiple immune cells collectively thereby inducing pre-metastatic formation, ultimately driving a vicious cycle proliferation metastasis. This review comprehensively explores process regulation dynamic evolution tumor-adapted TME, particular focus on by which promote Existing findings confirm components act cooperatively accelerate events. The potential applications challenges targeted therapies based clinical setting are further discussed context advancing related CAFs.
Language: Английский
Citations
14
Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1851 - 1851
Published: Aug. 14, 2024
Advances in melanoma research have unveiled critical insights into its genetic and molecular landscape, leading to significant therapeutic innovations. This review explores the intricate interplay between alterations, such as mutations BRAF, NRAS, KIT, pathogenesis. The MAPK PI3K/Akt/mTOR signaling pathways are highlighted for their roles tumor growth resistance mechanisms. Additionally, this delves impact of epigenetic modifications, including DNA methylation histone changes, on progression. microenvironment, characterized by immune cells, stromal soluble factors, plays a pivotal role modulating behavior treatment responses. Emerging technologies like single-cell sequencing, CRISPR-Cas9, AI-driven diagnostics transforming research, offering precise personalized approaches treatment. Immunotherapy, particularly checkpoint inhibitors mRNA vaccines, has revolutionized therapy enhancing body’s response. Despite these advances, mechanisms remain challenge, underscoring need combined therapies ongoing achieve durable comprehensive overview aims highlight current state transformative impacts advancements clinical practice.
Language: Английский
Citations
7
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8523 - 8523
Published: Aug. 5, 2024
The innate immune system, composed of neutrophils, basophils, eosinophils, myeloid-derived suppressor cells (MDSCs), macrophages, dendritic (DCs), mast (MCs), and lymphoid (ILCs), is the first line defense. Growing evidence demonstrates crucial role immunity in tumor initiation progression. Several studies support idea that immunity, through release pro- and/or anti-inflammatory cytokines growth factors, plays a significant pathogenesis, progression, prognosis cutaneous malignant melanoma (MM). Cutaneous most common skin cancer, with an incidence rapidly increased recent decades. Melanoma highly immunogenic tumor, due to its high mutational burden. metastatic form retains mortality. advent immunotherapy revolutionized therapeutic approach this significantly ameliorated patients' clinical outcome. In review, we will recapitulate multiple roles related implications for immunotherapy.
Language: Английский
Citations
5
Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10
Published: Oct. 16, 2023
Since antiquity, numerous advantages of olive oil and its by-products have been recognized in various domains, including cooking, skincare, healthcare. Extra virgin is a crucial component the Mediterranean diet; several compounds exert antioxidant, anti-proliferative, anti-angiogenic pro-apoptotic effects against variety cancers, also affect cellular metabolism, targeting cancer cells through their metabolic derangements. Numerous tree parts, leaves, can contribute metabolites useful to human health. Olive mill waste water (OMWW), dark pungent liquid residue produced vast amounts during extraction, contains high organic matter concentrations that may seriously contaminate soil surrounding waters if not managed properly. However, OMWW rich source phytochemicals with health benefits. In ancient Rome, farmers would employ what was known as amurca, mulch-like by-product production, for many purposes applications. Several studies investigated chemopreventive activities extracts. The most prevalent polyphenol extracts hydroxytyrosol (HT). Verbascoside oleuperin are abundant. We assessed impact one such extract, A009, on endothelial (HUVEC) cells. A009 vitro assays (growth, migration, adhesion) inhibited angiogenesis vivo , outperforming HT alone. from tumors showed potential cardioprotective mitigating cardiotoxicity induced by chemotherapy drugs, commonly used treatment, reducing up-regulation pro-inflammatory markers cardiomyocytes. Extracts other evaluated biological international research teams. results obtained make them promising candidates further development nutraceutical cosmeceutical agents or dietary supplement, especially prevention even co-treatments anti-cancer drugs. Furthermore, offer benefits opens up avenues application field cardio-oncology.
Language: Английский
Citations
11
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 16, 2025
The dynamic interactions between tumor endothelial cells (TECs) and the immune microenvironment play a critical role in progression of non-small cell lung cancer (NSCLC). In general, exhibit diverse immunomodulatory properties, influencing recruitment, antigen presentation, regulation checkpoint expression. Understanding multifaceted roles TECs as well assigning specific functional hallmarks to various TEC phenotypes offer new avenues for targeted development therapeutic interventions, particularly context advanced immunotherapy anti-angiogenic treatments. This review provides insights into complex interplay system NSCLC including discussion potential optimized opportunities.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 25, 2025
Background Renal cell carcinoma (RCC) is characterized by a high degree of genomic but also functional intratumoral heterogeneity (ITH). Mutations in VHL , chromatin remodeling genes such as SETD2 and that regulate the PI3K/AKT/mTOR pathway have been identified recurrent drivers despite ITH. Whether to what extent these mutations shape ITH including formation spatial niches incompletely understood. Herein, we analyze correlation between mutational their proxies spatially defined manner. Methods A total 23 RCCs were analyzed panel next-generation sequencing followed immunohistochemistry for five key genetic alterations expression CD31, GLUT1, phospho-mTOR S2448, H3K36me3 Ki-67. Antibody stainings scored semiquantitatively tumor periphery center. Results Unexpectedly, presence mutation was not found correlate with its CD31/microvessel density or glucose transporter GLUT1. Likewise, there no activating activated S2448. Furthermore, methyltransferase gene level downstream target H3K36me3. Lastly, proliferation marker Ki-67 number driver mutations. Conclusion This proof-of-concept study adds genotype-phenotype additional layer complexity known RCC.
Language: Английский
Citations
0
Published: March 28, 2024
The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) potently attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. strongly upregulated hypoxia and/or inflammation-induced inflammatory secretion, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.
Language: Английский
Citations
2