Secondary metabolite profiling using HR-LCMS, antioxidant and anticancer activity of Bacillus cereus PSMS6 methanolic extract: In silico and in vitro study

Biotechnology Reports, Journal Year: 2024, Volume and Issue: 42, P. e00842 - e00842

Published: May 2, 2024

Novel anticancer drugs of natural origin have increased tremendously due to the resistance multiple chemotherapeutic in breast cancer therapy and their high toxicity with undesirable side effects. The study investigates bioactivity secondary metabolites derived from Bacillus cereus PSMS6 isolated marine soil sediment Velar estuary, Parangepattai, Cuddalore district, Tamil Nadu, India. Strains were antagonistic activity was screened using agar well diffusion method. B. exhibited potency, its crude extract tested for antioxidant, anticancer, cytotoxic MTT assay potential. methanolic analyzed by mass spectrometry HRLC-MS FT-IR determine bioactive compounds. A drug interaction anti-breast protein HER2 performed molecular docking analysis. Antioxidant activities determined total antioxidant scavenging assay, ABTS DPPH free radical assays. methanol had an IC50 value 28.33±1.01, 29.00±0.28 34.91±0.09. negative ion compound Palmitoylglycerone phosphate a LibDock score 149.487 positive N5-(4-Methoxybenzyl) glutamine 120.116. These compounds show promising activity. current reported that metabolite retains anti-cancer, properties. This is first report production PSMS6.

Language: Английский

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A contemporary review of breast cancer risk factors and the role of artificial intelligence

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 18, 2024

Breast cancer continues to be a significant global health issue, necessitating advancements in prevention and early detection strategies. This review aims assess synthesize research conducted from 2020 the present, focusing on breast risk factors, including genetic, lifestyle, environmental aspects, as well innovative role of artificial intelligence (AI) prediction diagnostics.

Language: Английский

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Unveiling the intratumoral microbiota within cancer landscapes

iScience, Journal Year: 2024, Volume and Issue: 27(6), P. 109893 - 109893

Published: May 3, 2024

Recent advances in cancer research have unveiled a significant yet previously underappreciated aspect of oncology: the presence and role intratumoral microbiota. These microbial residents, encompassing bacteria, fungi, viruses within tumor tissues, been found to exert considerable influence on development, progression, efficacy therapeutic interventions. This review aims synthesize these groundbreaking discoveries, providing an integrated overview identification, characterization, functional roles microbiota biology. We focus elucidating complex interactions between microorganisms microenvironment, highlighting their potential as novel biomarkers targets. The purpose this is offer comprehensive understanding dimension cancer, paving way for innovative approaches diagnosis treatment.

Language: Английский

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Exploring the profound link: Breastfeeding’s impact on alleviating the burden of breast cancer – A review

Medicine, Journal Year: 2024, Volume and Issue: 103(15), P. e37695 - e37695

Published: April 12, 2024

Breastfeeding has emerged as a critical factor in understanding and potentially mitigating the risk of breast cancer among women. This review delves into intricate relationship between breastfeeding cancer, elucidating biological mechanisms, protective effects, broader implications for public health. Epidemiological evidence consistently demonstrates correlation reduced with longer durations lactation showing dose-dependent decrease risk. The nexus involves hormonal changes elimination damaged cells, influencing tissue carcinogenesis. Moreover, appears to impact tumor subtypes aggressiveness, particularly demonstrating associations lower risks hormone receptor-negative certain aggressive subtypes. Recognizing significance reducing profound health implications, necessitating comprehensive support, education, policies encourage facilitate breastfeeding.

Language: Английский

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Canine mammary tumors as a promising adjunct preclinical model for human breast cancer research: similarities, opportunities, and challenges

Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

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Health-Related Quality of Life and Disease Acceptance Among Women with Breast Cancer Pre- and Post-Neoadjuvant Chemotherapy

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 497 - 497

Published: Feb. 2, 2025

Background/Objective: The study aimed to evaluate disease acceptance and quality of life in women with breast cancer before after receiving neoadjuvant chemotherapy. Methods: included 211 diagnosed who underwent treatment. following measures were utilized: the EORTC QLQ-C30 QLQ-BR23 modules for assessment, Acceptance Illness Scale (AIS) questionnaire evaluating acceptance, a proprietary questionnaire. Assessments conducted one week first chemotherapy session three weeks completing Statistical analysis was performed using STATISTICA v. 13. Results: respondents exhibited an average their disease, both (28.2 pts) (25.5 pts). A decline observed nearly 59.2% patients Higher levels associated better life. studied decreased chemotherapy, particularly areas: physical functioning (p = 0.0000), social body image assessment sexual satisfaction nausea vomiting fatigue loss appetite insomnia pain hair side effects systemic treatment 0.0000). Conclusions: Post-neoadjuvant among comparison pre-treatment status. These findings may facilitate creation more tailored care approach during

Language: Английский

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Breast Cancer-the-State-of-the Art in the World and Islamic Development Banks Members Countries (IsDB-MCs)

Published: Jan. 1, 2025

Language: Английский

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Bio-inspired, programmable biomacromolecules based nanostructures driven cancer therapy

Biomaterials Advances, Journal Year: 2025, Volume and Issue: 171, P. 214235 - 214235

Published: Feb. 15, 2025

Language: Английский

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Metformin's Anticancer Odyssey: Revealing Multifaceted Mechanisms Across Diverse Neoplastic Terrains- A Critical Review

Biochimie, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Metformin, initially prescribed as an oral hypoglycemic medication for type 2 diabetes, has recently gained attention its potential anticancer effects. Its history dates to 1918, when guanidine, a component of the traditional European herb Galega officinalis, was found reduce glycemia. This review precisely examines mechanisms underlying Metformin's effects across various neoplastic conditions. investigation explores complex interactions between metformin and major signaling pathways associated with carcinogenesis, including AMP-activated protein kinase (AMPK), mTOR, insulin-like growth factor (IGF) pathways. The emphasizes diverse on angiogenesis, inflammation, apoptosis, cellular metabolism in cancer cells. Additionally, new data metformin's capacity alter tumor microenvironment enhance immune surveillance systems against are examined. underscores repurposing oncology, emphasizing clinical relevance adjuvant therapy cancers. provides insightful information about by combining from preclinical studies. These findings not only broaden our knowledge but also open avenues oncology research treatment developments.

Language: Английский

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Investigating compounds from Basella alba for their antioxidant, anti-inflammatory, and anticancer properties through in vitro and network pharmacology, molecular simulation approach

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: March 28, 2025

Language: Английский

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