Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: April 25, 2022
Coronavirus
disease
2019
(COVID-19)
can
disrupt
the
gut
microbiota
balance,
and
patients
usually
have
intestinal
disorders.
The
intestine
is
largest
immune
organ
of
human
body,
microbes
affect
function
lungs
through
gut-lung
axis.
Many
lines
evidence
support
role
beneficial
bacteria
in
enhancing
immunity,
preventing
pathogen
colonization,
thereby
reducing
incidence
severity
infection.
In
this
article,
we
review
possible
approach
modulating
to
help
prevent
treat
respiratory
tract
infections,
including
COVID-19,
discuss
possibility
using
probiotics
prebiotics
for
purpose.
We
also
mechanism
by
which
micro-flora
regulate
immunity
effects
on
micro-ecological
balance.
Based
understanding,
propose
use
modulate
prevention
or
alleviation
COVID-19
Drug Design Development and Therapy,
Journal Year:
2021,
Volume and Issue:
Volume 15, P. 4503 - 4525
Published: Nov. 1, 2021
Abstract:
Curcumin
is
a
natural
compound
with
great
potential
for
disease
treatment.
A
large
number
of
studies
have
proved
that
curcumin
has
variety
biological
activities,
among
which
anti-inflammatory
effect
significant
feature
it.
Inflammation
complex
and
pervasive
physiological
pathological
process.
The
mechanisms
inflammatory
bowel
disease,
psoriasis,
atherosclerosis,
COVID-19
other
research
focus
diseases
are
not
clear
yet,
they
considered
to
be
related
inflammation.
can
effectively
improve
the
symptoms
these
expected
candidate
drug
treatment
diseases.
This
paper
mainly
reviews
curcumin,
mechanism
diseases,
regulatory
on
these,
latest
results
improvement
pharmacokinetics.
It
beneficial
further
study
provides
new
ideas
insights
development
preparations.
Keywords:
anti-inflammatory,
osteoarthritis,
atherosclerotic,
pharmacokinetics,
prodrug
Antibiotics,
Journal Year:
2022,
Volume and Issue:
11(2), P. 135 - 135
Published: Jan. 20, 2022
Curcumin
(1,7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1,6-diene-3,5-dione)
is
a
natural
lipophilic
polyphenol
that
exhibits
significant
pharmacological
effects
in
vitro
and
vivo
through
various
mechanisms
of
action.
Numerous
studies
have
identified
characterised
the
pharmacokinetic,
pharmacodynamic,
clinical
properties
curcumin.
has
an
anti-inflammatory,
antioxidative,
antinociceptive,
antiparasitic,
antimalarial
effect,
it
used
as
wound-healing
agent.
However,
poor
curcumin
absorption
small
intestine,
fast
metabolism,
systemic
elimination
cause
bioavailability
human
beings.
In
order
to
overcome
these
problems,
number
formulations
been
developed.
The
aim
this
paper
provide
overview
recent
research
biological
pharmaceutical
aspects
curcumin,
methods
sample
preparation
for
its
isolation
(Soxhlet
extraction,
ultrasound
pressurised
fluid
microwave
enzyme-assisted
aided
extraction),
analytical
(FTIR,
NIR,
FT-Raman,
UV-VIS,
NMR,
XRD,
DSC,
TLC,
HPLC,
HPTLC,
LC-MS,
UPLC/Q-TOF-MS)
identification
quantification
different
matrices,
techniques
developing
formulations.
optimal
use
appropriate
method
will
significantly
improve
evaluation
activity
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
9
Published: Jan. 10, 2023
The
yellow
polyphenolic
pigment
known
as
curcumin,
originating
from
the
rhizome
of
turmeric
plant
Curcuma
longa
L.,
has
been
utilized
for
ages
in
ancient
medicine,
well
cooking
and
food
coloring.
Recently,
biological
activities
curcumin
have
thoroughly
investigated.
studies
mainly
focused
on
their
antioxidant,
antitumor,
anti-inflammatory,
neuroprotective,
hepatoprotective,
cardioprotective
impacts.
This
review
seeks
to
provide
an
in-depth,
detailed
discussion
usage
within
processing
industries
its
effect
health
support
disease
prevention.
Curcumin’s
bioavailability,
bio-efficacy,
bio-safety
characteristics,
side
effects
quality
standards,
are
also
discussed.
Finally,
curcumin’s
multifaceted
uses,
appeal
enhancement,
agro-industrial
techniques
counteracting
instability
low
nanotechnology
drug
delivery
systems
increase
prospective
clinical
use
tactics
all
Nutrients,
Journal Year:
2022,
Volume and Issue:
14(2), P. 256 - 256
Published: Jan. 7, 2022
Despite
the
ongoing
vaccination
efforts,
there
is
still
an
urgent
need
for
safe
and
effective
treatments
to
help
curb
debilitating
effects
of
COVID-19
disease.
This
systematic
review
aimed
investigate
efficacy
supplemental
curcumin
treatment
on
clinical
outcomes
inflammation-related
biomarker
profiles
in
patients.
We
searched
PubMed,
Scopus,
Web
Science,
EMBASE,
ProQuest,
Ovid
databases
up
30
June
2021
find
studies
that
assessed
curcumin-related
compounds
mild
severe
Six
were
identified
which
showed
supplementation
led
a
significant
decrease
common
symptoms,
duration
hospitalization
deaths.
In
addition,
all
these
intervention
amelioration
cytokine
storm
thought
be
driving
force
cases.
was
seen
as
(p
<
0.05)
proinflammatory
cytokines
such
IL1β
IL6,
with
concomitant
increase
anti-inflammatory
cytokines,
including
IL-10,
IL-35
TGF-α.
Taken
together,
findings
suggested
exerts
its
beneficial
through
at
least
partial
restoration
pro-inflammatory/anti-inflammatory
balance.
conclusion,
may
offer
efficacious
option
improving
disease
outcomes.
highlight
point
future
should
employ
larger
cohorts
patients
different
settings
standardized
preparations
compounds.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(12), P. 10713 - 10746
Published: March 13, 2023
Curcumin
has
been
credited
with
a
wide
spectrum
of
pharmacological
properties
for
the
prevention
and
treatment
several
chronic
diseases
such
as
arthritis,
autoimmune
diseases,
cancer,
cardiovascular
diabetes,
hemoglobinopathies,
hypertension,
infectious
inflammation,
metabolic
syndrome,
neurological
obesity,
skin
diseases.
However,
due
to
its
weak
solubility
bioavailability,
it
limited
potential
an
oral
medication.
Numerous
factors
including
low
water
solubility,
poor
intestinal
permeability,
instability
at
alkaline
pH,
fast
metabolism
contribute
curcumin's
bioavailability.
In
order
improve
different
formulation
techniques
coadministration
piperine,
incorporation
into
micelles,
micro/nanoemulsions,
nanoparticles,
liposomes,
solid
dispersions,
spray
drying,
noncovalent
complex
formation
galactomannosides
have
investigated
in
vitro
cell
culture
models,
vivo
animal
humans.
current
study,
we
extensively
reviewed
clinical
trials
on
various
generations
curcumin
formulations
their
safety
efficacy
many
We
also
summarized
dose,
duration,
mechanism
action
these
formulations.
critically
advantages
limitations
each
compared
placebo
and/or
available
standard
care
therapies
ailments.
The
highlighted
integrative
concept
embodied
development
next-generation
helps
minimize
bioavailability
issues
least
or
no
adverse
side
effects
provisional
new
dimensions
presented
this
direction
may
add
value
cure
Phytotherapy Research,
Journal Year:
2023,
Volume and Issue:
37(4), P. 1462 - 1487
Published: Jan. 31, 2023
Abstract
Curcumin
is
extracted
from
the
rhizomes
Curcuma
longa
L.
It
known
for
its
anti‐inflammatory
and
anti‐oxidant
activities.
Despite
safety
potential
use
against
various
diseases,
curcumin's
utility
restricted
due
to
low
oral
bioavailability.
Co‐administration
of
curcumin
along
with
piperine
could
potentially
improve
bioavailability
curcumin.
The
present
review
aimed
provide
an
overview
efficacy
curcumin‐piperine
co‐supplementation
in
human
health.
findings
this
comprehensive
show
beneficial
effects
improving
glycemic
indices,
lipid
profile
antioxidant
status
diabetes,
inflammatory
caused
by
obesity
metabolic
syndrome,
reducing
oxidative
stress
depression
chronic
neurological
disorders,
also
respiratory
asthma
COVID‐19.
Further
high‐quality
clinical
trial
studies
are
needed
firmly
establish
supplement.
Biomolecules,
Journal Year:
2022,
Volume and Issue:
12(10), P. 1442 - 1442
Published: Oct. 9, 2022
Infectious
diseases
have
been
a
threat
to
human
health
globally.
The
relentless
efforts
and
research
enabled
us
overcome
most
of
the
through
use
antiviral
antibiotic
agents
discovered
employed.
Unfortunately,
microorganisms
capability
adapt
mutate
over
time
resistance
ensues.
There
are
many
challenges
in
treating
infections
such
as
failure
respond
therapeutic
agents,
which
has
led
more
chronic
infections,
complications,
preventable
loss
life.
Thus,
multidisciplinary
approach
collaboration
is
warranted
create
potent,
effective,
versatile
therapies
prevent
eradicate
old
newly
emerging
diseases.
In
recent
past,
natural
medicine
proven
its
effectiveness
against
various
illnesses.
Most
pharmaceutical
currently
used
can
trace
their
origin
products
one
way,
shape,
or
form.
full
potential
yet
be
realized,
numerous
resources
not
explored
analyzed.
This
merits
continuous
support
analysis
ancient
treatment
systems
explore
employ
them
an
alternative
principal
therapy.
Trials,
Journal Year:
2022,
Volume and Issue:
23(1)
Published: June 6, 2022
Abstract
Background
COVID-19
pandemic
has
made
the
disease
a
major
global
problem
by
creating
significant
burden
on
health,
economic,
and
social
status.
To
date,
there
are
no
effective
approved
medications
for
this
disease.
Curcumin
as
an
anti-inflammatory
agent
can
have
positive
effect
control
of
complications.
This
study
aimed
to
assess
efficacy
curcumin-piperine
supplementation
clinical
symptoms,
duration,
severity,
inflammatory
factors
in
patients
with
COVID-19.
Methods
Forty-six
outpatients
were
randomly
allocated
receive
two
capsules
curcumin-piperine;
each
capsule
contained
500
mg
curcumin
plus
5
piperine
or
placebo
14
days.
Results
Mean
changes
complete
blood
count,
liver
enzymes,
glucose
levels,
lipid
parameters,
kidney
function,
c-reactive
protein
(CRP)
not
significantly
different
between
groups.
There
was
improvement
health
status,
including
dry
cough,
sputum
ague,
sore
throat,
weakness,
muscular
pain,
headache,
dyspnea
at
week
2
both
groups
(
P
value
<
0.05);
however,
weakness
more
group
than
025).
Conclusion
The
present
results
showed
that
co-supplementation
could
reduce
weakness.
However,
study,
affect
other
indices,
biochemical
indices.
Trial
registration
Iranian
Registry
Clinical
Trials
IRCT20121216011763N46
.
2020-10-31
