Small molecules in the treatment of COVID-19

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Dec. 5, 2022

Abstract The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to societies economies. Until now, effective therapeutics against are in high demand. Along with our improved understanding the structure, function, pathogenic process SARS-CoV-2, many small molecules potential anti-COVID-19 effects have been developed. So far, several antiviral strategies were explored. Besides directly inhibition viral proteins such as RdRp M pro , interference host enzymes including ACE2 proteases, blocking relevant immunoregulatory pathways represented by JAK/STAT, BTK, NF-κB, NLRP3 pathways, regarded feasible drug development. development treat achieved strategies, computer-aided lead compound design screening, natural product discovery, repurposing, combination therapy. Several representative remdesivir paxlovid proved or authorized emergency use countries. And candidates entered clinical-trial stage. Nevertheless, due epidemiological features variability issues it is necessary continue exploring novel COVID-19. This review discusses current findings for treatment. Moreover, their detailed mechanism action, chemical structures, preclinical clinical efficacies discussed.

Language: Английский

---

Bioactive Compounds and Biological Activities of Garlic

Current Food Science and Technology Reports, Journal Year: 2024, Volume and Issue: 2(2), P. 111 - 120

Published: April 1, 2024

Language: Английский

---

Boosting the human antiviral response in conjunction with natural plant products

Frontiers in Natural Products, Journal Year: 2025, Volume and Issue: 3

Published: Jan. 7, 2025

The increasing prevalence of viral infections and the emergence drug-resistant or mutant strains necessitate exploration novel antiviral strategies. Accumulating evidence suggests that natural plant products have significant potential to enhance human response. Various (PNPs) known for their properties been evaluated ability modulate immune responses inhibit infections. Research has focused on understanding mechanisms by which these PNPs interact with system complement existing therapies. control compounds such as alkaloids, flavonoids, terpenoids, polyphenols promote cytokine synthesis, increase T-cell macrophage activity, activate genes. Studies investigated molecular interactions between PNPs, viruses, host cells, exploring combining conventional drugs efficacy. However, several challenges remain, including identifying, characterizing, standardizing PNP extracts, optimizing dosages, improving bioavailability, assessing long-term safety, navigating regulatory approval. promising is being explored develop new, effective, This review outlines a framework an integrative approach connect full in combating health. By treatments, more effective sustainable management diseases can be achieved.

Language: Английский

---

A Review on Mechanistic Insight of Plant Derived Anticancer Bioactive Phytocompounds and Their Structure Activity Relationship

Molecules, Journal Year: 2022, Volume and Issue: 27(9), P. 3036 - 3036

Published: May 9, 2022

Cancer is a disorder that rigorously affects the human population worldwide. There steady demand for new remedies to both treat and prevent this life-threatening sickness due toxicities, drug resistance therapeutic failures in current conventional therapies. Researchers around world are drawing their attention towards compounds of natural origin. For decades, beings have been using flora as source cancer chemotherapeutic agents. Currently, clinically approved anticancer vincristine, vinblastine, taxanes, podophyllotoxin, all which come from sources. With triumph these developed into staple products most therapies, technologies now appearing search novel biomolecules with activities. Ellipticine, camptothecin, combretastatin, curcumin, homoharringtonine others plant derived bioactive phytocompounds potential properties. improved field further through use advanced analytical chemistry computational tools analysis. The investigation strategies administration such nanotechnology may enable development products. These enhanced plant-derived drugs aim site-directed delivery, bioavailability, reduced toxicity. This review discusses mechanistic insights origins structural activity relationships make them targets treatments.

Language: Английский

---

Secondary plant metabolites as potent drug candidates against antimicrobial-resistant pathogens

SN Applied Sciences, Journal Year: 2022, Volume and Issue: 4(8)

Published: July 8, 2022

Abstract Antibiotic resistance is a major public health threat of the twenty-first century and represents an important risk to global economy. Healthcare-associated infections mainly caused by drug-resistant bacteria are wreaking havoc in patient care worldwide. The spread such pathogens limits utility available drugs complicates treatment bacterial diseases. As result, there urgent need for new with mechanisms action capable curbing resistance. Plants synthesize utilize various metabolic compounds deter predators. Utilizing these plant-based metabolites promising option identifying novel bioactive that could be harnessed develop potent antimicrobial treat multidrug-resistant pathogens. purpose this review highlight medicinal plants as sources agents developed help combat

Language: Английский

---

Medicinal plant sources and traditional healthcare practices of forest-dependent communities in and around Chunati Wildlife Sanctuary in southeastern Bangladesh

Environmental Sustainability, Journal Year: 2022, Volume and Issue: 5(2), P. 207 - 241

Published: June 1, 2022

Language: Английский

---

Quercetin: A Functional Food-Flavonoid Incredibly Attenuates Emerging and Re-Emerging Viral Infections through Immunomodulatory Actions

Molecules, Journal Year: 2023, Volume and Issue: 28(3), P. 938 - 938

Published: Jan. 17, 2023

Many of the medicinally active molecules in flavonoid class phytochemicals are being researched for their potential antiviral activity against various DNA and RNA viruses. Quercetin is a that can be found variety foods, including fruits vegetables. It has been reported to effective This review, therefore, deciphered mechanistic how works some deadliest viruses, such as influenza A, Hepatitis C, Dengue type 2 Ebola virus, which cause frequent outbreaks worldwide result significant morbidity mortality humans through epidemics or pandemics. All those have an alarming impact on both human health global national economies. The review extended computing Quercetin-contained natural recourse its modes action different experimental approaches leading actions. gap treatment emphasizes necessity search new compounds. shows inhibits it by targeting viral infections at multiple stages. suppression neuraminidase, proteases DNA/RNA polymerases alteration many proteins well immunomodulation main molecular mechanisms Quercetin’s activities. Nonetheless, huge extensive use inadequately approached therapeutic emerging re-emerging infections. Therefore, this enumerated food-functioned source, effects made insights mechanism-based Quercetin.

Language: Английский

---

A REVIEW ON ANTIVIRAL PLANTS EFFECTIVE AGAINST DIFFERENT VIRUS TYPES

Prospects in Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 21(2), P. 1 - 21

Published: April 13, 2023

The treatment of microbial infections has proven challenging for humans in recent years. Synthetic medications, such as antimicrobial agents, are used treating these infections. Antimicrobials derived from natural sources have gained popularity an alternative to manufactured medications due their lack adverse effects. Plants, which play a significant role this setting, historically served reliable defence against several pathogens. In study, studies on plants viral diseases mentioned. Studies viruses that cause disease been compiled the literature. According findings, it reported literature many different plant species effective herpes simplex virus (HSV-1, HSV-2), human immunodeficiency (HIV), influenza (A, B) and parainfluenza, Poliovirus, Astrovirus, Parvovirus, Sindbis (SINV), Feline calicivirus (FCV), Rhinovirus, Echovirus, Rotavirus, Bovine alphaherpesvirus 1 (BoHV-1), Reovirus, Vaccinia (VACV), Cardiovirus A (Encephalomyocarditis virus; EMCV), Coxsackie virus, Semliki forest, Measles Newcastle (NDV), Coronavirus, Adenovirus (ADV-3, ADV-5, ADV-8, ADV -11), Canine distemper (CDV), Lumpy skin (LSDV), Hepatitis A, B, C Enterovirus. To combat viruses, can be considered potentially invaluable resource.

Language: Английский

---

Antiviral Activity of Water–Alcoholic Extract of Cistus incanus L.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 947 - 947

Published: Jan. 23, 2025

Recently, previously known viruses have changed their pathogenicity and encompassed new types of host populations. An example such an infection is that caused by SARS-CoV, belonging to the “well-known” coronavirus family. Another group are great importance human population herpes viruses. Due increasing viral resistance existing antiviral drugs, plant extracts attracting interest due complex composition simultaneous attack different targets. Based on above, we tested potential water–alcoholic extract obtained from a commercial sample Cistus incanus L. against enveloped SvHA1, SvHA2 (ACV resistant) HCoV 229E. The results showed both complete inhibition intracellular stages replication strong effect extracellular virions in three models. In study SvHA 2, calculated selectivity index was over 10. From experiments virucidal effects two viruses, it found titer samples decreased about 4 lg compared control sample. for introduction into practice.

Language: Английский

---

Medicinal Herbs in the Relief of Neurological, Cardiovascular, and Respiratory Symptoms after COVID-19 Infection A Literature Review

Cells, Journal Year: 2022, Volume and Issue: 11(12), P. 1897 - 1897

Published: June 11, 2022

COVID-19 infection causes complications, even in people who have had a mild course of the disease. The most dangerous seem to be neurological ailments: anxiety, depression, mixed anxiety–depressive (MAD) syndromes, and irreversible dementia. These conditions can negatively affect respiratory system, circulatory heart functioning. We believe that phytotherapy helpful all these conditions. Clinical trials confirm this possibility. work presents plant materials (Valeriana officinalis, Melissa Passiflora incarnata, Piper methysticum, Humulus lupulus, Ballota nigra, Hypericum perforatum, Rhodiola rosea, Lavandula Paullinia cupana, Ginkgo biloba, Murraya koenigii, Crataegus monogyna oxyacantha, Hedera helix, Polygala senega, Pelargonium sidoides, Lichen islandicus, Plantago lanceolata) their dominant compounds (valeranon, valtrate, apigenin, citronellal, isovitexin, isoorientin, methysticin, humulone, farnesene, acteoside, hypericin, hyperforin, biapigenin, rosavidin, salidroside, linalool acetate, linalool, caffeine, ginkgolide, bilobalide, mihanimbine, epicatechin, hederacoside C,α-hederine, presegenin, umckalin, 6,7,8-trixydroxybenzopyranone disulfate, fumaroprotocetric acid, protolichesteric aucubin, acteoside) responsible for activity. It also shows possibility reducing post-COVID-19 neurological, respiratory, cardiovascular which functioning nervous system.

Language: Английский

---