The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review DOI Creative Commons
Ovais Shafi,

Ghazia Siddiqui,

Hassam A Jaffry

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 10, 2022

Abstract Background: Cardiac Myxoma (CM) is a primary tumor of heart. Its origins, why the occurrence cardiac tumors extremely rare and how it may be related to limited regenerative potential, these aspects are not yet entirely known. This study investigates key genes/TFs signaling pathways advance our understanding important questions. Methods: Databases including PubMed, MEDLINE, Google Scholar were searched for published articles without any date restrictions, involving myxoma, genes/TFs/signaling their roles in cardiogenesis, proliferation, differentiation, interactions tumorigenesis, with focus on cardiomyocytes. Results : The genetic landscape governed by very tight control between proliferation differentiation-related genes/TFs/pathways. myxoma originates possibly as consequence dysregulations gene expression differentiation regulators Tbx5, GATA4, HAND1/2, MYOCD, HOPX, BMPs. Such switch cardiomyocytes into progenitor-like state development dysregulating Isl1, Baf60 complex, Wnt, FGF, Notch, Mef2c others. Nkx2-5 MSX2 contribute both Progenitor Cells (CPCs) serve based microenvironment direction cell circuitry tumorigenesis. limit progression tumorigenesis has massive over CPCs. type-specific programming plays governing role controlling potential. Conclusion have proliferative They survive long periods time tightly maintain genes such GATA4 that interact suppressors (TS) exert TS like effect. total effect exerts responsible benign nature tumors. prevents But this also limits potential develops which revert cells towards state, hallmark CM. CM carney complex signifies cells.

Language: Английский

Vincristine attenuates isoprenaline-induced cardiac hypertrophy in male Wistar rats via suppression of ROS/NO/NF-қB signalling pathways DOI
Jerome Ndudi Asiwe, Abayomi M. Ajayi, Benneth Ben‐Azu

et al.

Microvascular Research, Journal Year: 2024, Volume and Issue: 155, P. 104710 - 104710

Published: June 15, 2024

Language: Английский

Citations

5
Progenitor Cell Function and Cardiovascular Remodelling Induced by SGLT2 Inhibitors DOI Creative Commons
Theodora M. Stougiannou, Konstantinos Christodoulou, Theocharis Koufakis

et al.

Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(4), P. 145 - 145

Published: April 9, 2024

Sodium-glucose cotransporters 2 (SGLT2) are high-capacity, low-affinity transporters, expressed mainly in the early portion of proximal renal tube, mediating up to 90% glucose uptake, while SGLT1 receptors found small intestine, facilitating absorption. SGLT2 inhibitors (SGLT2i) originally emerged as agents for treatment type diabetes mellitus; however, they soon demonstrated remarkable cardio- and renoprotective actions that led their licensed use heart failure chronic kidney disease, regardless diabetic status. Cardiovascular remodelling represents an umbrella term encompasses changes occur cardiovascular system, from molecular cellular level, tissue organs after local injury, stress, or pressure. SGLT modulation has been shown positively affect many these observed during pathological remodelling. Among different pathophysiological mechanisms contribute adverse remodelling, various stem progenitor cells have be involved, through alterations number function. Recent studies examined effects SGLT2i on cell populations more specifically endothelial (EPCs). Although some no significant effect, others showed can modulate morphology function EPCs. These preliminary observations effect EPCs may responsible beneficial gliflozins and, by extension, disease. The purpose this narrative review is critically discuss recent evidence cardioprotective SGLT2is, context cardiac

Language: Английский

Citations

4
Regulatory mechanism of icariin in cardiovascular and neurological diseases DOI Open Access
Yuling Wang, Chang Shang, Yang Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 158, P. 114156 - 114156

Published: Dec. 28, 2022

Cardiovascular diseases (CVDs) and neurological are widespread with substantial rates of morbidity mortality around the world. For past few years, preventive effects Chinese herbal medicine on CVDs have attracted a great deal attention. Icariin (ICA), main constituent Epimedii Herba, is flavonoid. It has been shown to provide neuroprotection, anti-tumor, anti-osteoporosis, cardiovascular protection. The endothelial protection, anti-inflammatory, hypolipidemic, antioxidative stress, anti-apoptosis properties ICA can help stop progression diseases. Therefore, our review summarized known mechanisms related studies in prevention treatment cardio-cerebrovascular (CCVDs), better understand its therapeutic potential.

Language: Английский

Citations

17
Basic science of cardiac contractility modulation therapy: Molecular and electrophysiological mechanisms DOI
Daniele Masarone, M. Kittleson, Antonio D’Onofrio

et al.

Heart Rhythm, Journal Year: 2023, Volume and Issue: 21(1), P. 82 - 88

Published: Sept. 26, 2023

Language: Английский

Citations

10
Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide DOI

Jia‐Hui Hong,

Xichun Pan,

Yalan Xiong

et al.

Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(3)

Published: March 1, 2025

ABSTRACT Cardiac hypertrophy, a maladaptive response to chronic stress, progresses heart failure through mechanisms requiring deeper exploration. While forkhead helix transcription factor P3 (FoxP3) is well‐known as key regulator in CD4 + T cells, its role cardiomyocytes remains unclear. Here, by using isoproterenol (ISO)‐induced cardiac hypertrophy models (40 mg/kg daily for vivo study and 10 μmol/L vitro study), we revealed the protective of FoxP3 hypertrophy. Though modulating expression siRNA or plasmid cardiomyocytes, found that knockdown exacerbated ISO‐induced hypertrophic responses, while overexpression attenuated effects. The function cardiomyocytic was further confirmed infection adeno‐associated virus. Mechanically, decreased nuclear activated cells c3 (NFATc3), hypertrophy‐related genes, suppress including atrial natriuretic peptide, brain peptide β‐myosin heavy chain (β‐MHC), thus ameliorate responses. Besides, immunoprecipitation immunofluorescence determination showed could interact with NFATc3 nucleus form complex, thereby regulating activity NFATc3. Chromatin (ChIP) electrophoretic mobility shift assays (EMSAs) specific binding sequences β‐MHC promoter region, occupancy reduced ISO, suggesting down‐regulate expression. Importantly, identified triptolide (TP), bioactive natural product, potent inducer Both (10 μg/kg daily) μmol/L) studies demonstrated TP significantly reversed upregulating expression, inhibiting NFATc3‐mediated transcription. These findings highlight novel factor, elucidating underlying demonstrating therapeutic potential this process.

Language: Английский

Citations

0
Modeling cardiomyocyte signaling and metabolism predicts genotype-to-phenotype mechanisms in hypertrophic cardiomyopathy DOI
Ali Khalilimeybodi, Jeffrey J. Saucerman, Padmini Rangamani

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 175, P. 108499 - 108499

Published: April 24, 2024

Language: Английский

Citations

3
PLAU is associated with cell migration and invasion and is regulated by transcription factor YY1 in cervical cancer DOI Creative Commons
Yanjun Gao,

Xinmei Ma,

Huanxi Lu

et al.

Oncology Reports, Journal Year: 2022, Volume and Issue: 49(2)

Published: Dec. 13, 2022

Cervical cancer, one of the most common malignancies, has a poor survival rate. The identification more biomarkers for cervical cancer diagnosis and therapy is urgently needed. Plasminogen activator urokinase (PLAU) exerts multiple biological effects in various physiological pathological processes; however role PLAU progression not fully understood. In present study, involvement transcriptional regulation were explored. expression was first analyzed, found to be overexpressed. vitro experiments demonstrated that migration invasion HeLa HT3 cells significantly suppressed by knockdown. Additionally, core promoter confirmed, transcription factor YinYang 1 (YY1) regulate mRNA expression. Overall, study elucidated direct association between suggesting YY1/PLAU axis as potential novel therapeutic target cancer.

Language: Английский

Citations

14
Mesenchymal stem cells may alleviate angiotensin II-induced myocardial fibrosis and hypertrophy by upregulating SFRS3 expression DOI Creative Commons

Ling Gu,

Xin Wan,

Ying Liu

et al.

Revista Portuguesa de Cardiologia, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

The development of cardiac fibrosis (CF) and hypertrophy (CH) can lead to heart failure. Mesenchymal stem cells (MSCs) have shown promise in treating diseases. However, the relationship between MSCs splicing factor arginine/serine rich-3 (SFRS3) remains unclear. In this study, our objectives are investigate effect on SFRS3 expression, their impact CF CH. Additionally, we aim explore function overexpression angiotensin II (Ang II)-treated fibroblasts (CFBs) myocytes (CMCs).

Language: Английский

Citations

2
Transcriptional regulation of macrophages in heart failure DOI Creative Commons
Keyan Wang,

Xiaoqian Sun,

Ying Sun

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: March 30, 2023

Adverse cardiac remodeling after acute myocardial infarction is the most important pathological mechanism of heart failure and remains a major problem in clinical practice. Cardiac macrophages, derived from tissue resident macrophages circulating monocyte, undergo significant phenotypic functional changes following injury play crucial roles inflammatory response repair response. Currently, numerous studies indicate that epigenetic regulatory factors transcription can regulate reparative genes timely conversion into then alleviate remodeling. Accordingly, targeting transcriptional regulation may be promising option for treatment. In this review, we not only summarize origin function but more importantly, describe failure, aiming to provide potential therapeutic target failure.

Language: Английский

Citations

4
The benign nature and rare occurrence of cardiac myxoma as a possible consequence of the limited cardiac proliferative/ regenerative potential: a systematic review DOI Creative Commons
Ovais Shafi,

Ghazia Siddiqui,

Hassam A Jaffry

et al.

BMC Cancer, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 18, 2023

Abstract Background Cardiac Myxoma is a primary tumor of heart. Its origins, rarity the occurrence cardiac tumors and how it may be related to limited regenerative potential, are not yet entirely known. This study investigates key genes/ transcription factors (TFs) signaling pathways understand these important questions. Methods Databases including PubMed, MEDLINE, Google Scholar were searched for published articles without any date restrictions, involving myxoma, genes/TFs/signaling their roles in cardiogenesis, proliferation, differentiation, interactions tumorigenesis, with focus on cardiomyocytes. Results The genetic landscape governed by very tight control between proliferation differentiation-related genes/TFs/pathways. myxoma originates possibly as consequence dysregulations gene expression differentiation regulators Tbx5, GATA4, HAND1/2, MYOCD, HOPX, BMPs. Such switch cardiomyocytes into progenitor-like state development dysregulating Isl1, Baf60 complex, Wnt, FGF, Notch, Mef2c others. Nkx2–5 MSX2 contribute predominantly both Progenitor Cells (CPCs), serve based microenvironment direction cell circuitry tumorigenesis. limit progression tumorigenesis has massive over CPCs. type-specific programming plays governing role controlling potential. Conclusion have proliferative They survive long periods time tightly maintain genes such GATA4 that interact suppressors (TS) exert TS like effect. total effect exerts responsible rare benign nature tumors. prevents But this also limits potential develops which revert cells towards state, hallmark CM. CM carney complex signifies cells.

Language: Английский

Citations

4