Deleted Journal, Journal Year: 2024, Volume and Issue: 29(2), P. 111 - 131
Published: May 1, 2024
Language: Английский
Clinical Nutrition, Journal Year: 2023, Volume and Issue: 42(11), P. 2198 - 2206
Published: Sept. 20, 2023
Vitamin D (VitD) has been shown to be important for the immune response of respiratory system, but preventive and therapeutic effects vitamin supplementation on SARS-CoV-2 infection are controversial. This study aimed determine role in prevention treatment through a meta-analysis randomized controlled trials.The databases PubMed, Cochrane Library, Embase, Web Science Google Scholar were searched systematically from inception April 17,2023 identify trials involving comparison versus non-vitamin or treatment.We retrieved 25 eligible trials, including 8128 participants. Four compared infection, results (RR 0.31; 95%CI 0.07 1.32) inconclusive. Regarding with supplementation, it was found that could significantly reduce rates ICU admission 0.63; 0.44 0.89) mechanical ventilation 0.58; 0.39 0.84), had no statistically significant effect mortality. However, subgroup analyses based patients' specific conditions, reduced mortality patients deficiency 0.76; 0.58 0.98).Vitamin may have some beneficial impact severity illness caused by SARS-CoV-2, particularly VitD deficient patients, further studies still needed.
Language: Английский
Citations
35
Nutrients, Journal Year: 2024, Volume and Issue: 16(10), P. 1402 - 1402
Published: May 7, 2024
Since the beginning of COVID-19 pandemic, vitamin D has attracted interest due to its immunomodulatory properties. Numerous studies show a correlation between levels and cases mortality. Therefore, we conducted meta-analysis in order assess relationship D3 supplementation severity. We included 13 randomized clinical trials that contained analyzed endpoints: length hospitalization, number intensive care unit (ICU) admissions, stay ICU, requiring any supplemental oxygenation, duration overall mortality deaths associated with COVID-19. The relative risk 95% confidence interval (CI) mean difference CI were calculated compare effect. A random effects model was used calculate effect sizes. Our showed positive on ICU admission (RR = 0.73; [0.57; 0.95], p 0.02, I2 19.6%) among patients 0.56; [0.34; 0.91]; 0.02; 0%). Vitamin may potentially reduce death
Language: Английский
Citations
11
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 25, 2024
To analyze the impact of different methods Vitamin D administration on prognosis COVID-19 patients.
Language: Английский
Citations
5
Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271
Published: Nov. 13, 2023
Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity
Language: Английский
Citations
12
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: May 27, 2024
Background The therapeutic effects of vitamin D supplementation on Coronavirus disease 2019 (COVID-19) aggravation remain controversial and inconclusive. To probe into this contentious issue, we performed the present meta-analysis randomized controlled trials (RCTs). Methods Literature published up to June 2023 was retrieved from Cochrane Library, PubMed, Web Science Embase. RCTs assessing mortality, intensive care unit (ICU) admission, mechanical ventilation (MV), length hospitalization (LOH), inflammatory markers containing C-reactive protein (CRP), D-dimer, interleukin-6 (IL-6), lactate dehydrogenase (LDH) were included. 19 involved in analysis conducted subgroup analyses baseline COVID-19 severity administration. Results In subgroup, statistically significant moderate severe group observed ICU admission (OR 0.43, 95% CI 0.23, 0.80; p = 0.008), MV 0.44, 0.27, 0.72; 0.001) LOH (SMD –0.49, –0.92, −0.06; 0.027). administration 0.39, 0.16, 0.97; 0.044), 0.18, 0.07, 0.46; 0.000) –0.50, –0.96, −0.04; 0.034) more pronounced patients supplied with multiple-dose than single-dose. Although result mortality showed no effect, it indicated a reduced trend 0.87, 0.63, 1.12; > 0.05). results reached statistical differences. Conclusion This revealed that multiple doses less apt need have shorter hospital stays.
Language: Английский
Citations
4
Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11
Published: Jan. 7, 2025
Current evidence is inconsistent on whether vitamin D supplementation can prevent COVID-19 infection or improve its clinical outcomes. To better understand and look into the issue, we went through background knowledge of D, searched in Pubmed [by using key words title containing "randomized trial", "COVID-19", "vitamin (25-hydroxyvitamin cholecalciferol, calcidiol, calcifediol) supplementation"] for publications studies D/supplementation patients, especially those about randomized trials (RCTs). After reviewing these papers, did a short review pathophysiology COVID-19, summarized features 25 RCTs text tabulated table some features, commented, compared discussed differences between (for example, change serum 25-hydroxyvitamin concentration from nmol/L to ng/mL, making comparison easier). The take-home question that an important indicator effect correction but may not be reliable predicting outcomes COVID-19.
Language: Английский
Citations
0
Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 599 - 599
Published: Feb. 6, 2025
Clinical trials consistently demonstrate an inverse correlation between serum 25-hydroxyvitamin D [25(OH)D; calcifediol] levels and the risk of symptomatic SARS-CoV-2 disease, complications, mortality. This systematic review (SR), guided by Bradford Hill’s causality criteria, analyzed 294 peer-reviewed manuscripts published December 2019 November 2024, focusing on plausibility, consistency, biological gradient. Evidence confirms that cholecalciferol (D3) calcifediol significantly reduce hospitalizations, mortality, with optimal effects above 50 ng/mL. While vitamin requires 3–4 days to act, shows within 24 h. Among 329 trials, only 11 (3%) showed no benefit due flawed designs. At USD 2/patient, D3 supplementation is far cheaper than hospitalization costs more effective standard interventions. SR establishes a strong relationship 25(OH)D vulnerability, meeting criteria. Vitamin infections, deaths ~50%, outperforming all patented, FDA-approved COVID-19 therapies. With over 300 confirming these findings, waiting for further studies unnecessary before incorporating them into clinical protocols. Health agencies scientific societies must recognize significance results incorporate prophylaxis early treatment protocols similar viral infections. Promoting safe sun exposure adequate communities maintain 40 ng/mL (therapeutic range: 40–80 ng/mL) strengthens immune systems, reduces hospitalizations deaths, lowers healthcare costs. When exceed 70 ng/mL, taking K2 (100 µg/day or 800 µg/week) alongside helps direct any excess calcium bones. The recommended dosage (approximately IU/kg body weight non-obese adult) 50–100 cost-effective disease prevention, ensuring health outcomes.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2550 - 2550
Published: March 12, 2025
Even though in mid-2023 the World Health Organization declared end of public health emergency international concern status for COVID-19, many areas uncertainty about SARS-CoV-2 infection pathophysiology remain. Although last 4 years pharmaceutical industries widely invested development effective antiviral treatments and vaccines, large disparities their availability worldwide still exist, thus fostering investigation nutritional supplements as adjuvant therapeutic approaches disease management, especially resource-limited settings. During COVID-19 pandemic, vitamin D has been used an over-the-counter solution to improve evolution, thanks its known immunomodulatory anti-inflammatory actions. Ecological observational studies support a relationship between hypovitaminosis negative outcomes and, according this evidence, several research groups investigated role supplementation protecting from and/or improving evolution. This narrative review is intended offer insights into existing data on D’s biological effects respiratory infections, COVID-19. Furthermore, it will also brief overview complex interplay vaccine-elicited immune response, with special attention anti-COVID-19 vaccines.
Language: Английский
Citations
0
BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e091903 - e091903
Published: March 1, 2025
Objectives Vitamin D deficiency is prevalent among the population. Previous studies have shown that vitamin supplementation might be useful for treating COVID-19 infection. Therefore, we performed a meta-analysis to explore efficacy in patients with deficiency. Design Systematic review and Data sources PubMed, Cochrane Library, Embase Web of Science. Eligibility criteria Randomised controlled trials exploring extraction synthesis Two independent reviewers employed standardised methods search, screen code included studies. The primary outcomes mortality during follow-up, 28-day mortality, need mechanical ventilation intensive care unit (ICU). secondary outcome length stay hospital ICU. risk bias was assessed using Risk Bias 2 tool. Depending on level heterogeneity, either random-effects model or fixed-effects applied. findings were summarised Grading Recommendations Assessment, Development Evaluation (GRADE) evidence profiles synthesised qualitatively. Results A total nine studies, comprising 870 participants, analysis. pooled results indicated associated lower (risk ratio 0.76; 95% CI 0.60 0.97). However, this apparent benefit not robust when examined through leave-one-out method trial sequential Regarding other outcomes, there no statistically significant difference between terms ICU admission. 0.41 day shorter (mean −0.41; −1.09 0.28) 0.07 −0.07; −0.61 0.46) compared supplementation; however, neither significant. Conclusion Based low moderate quality, reduced rate follow-up it did improve nor reduce admission, hospital. PROSPERO registration number CRD42024573791.
Language: Английский
Citations
0
Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3584 - 3584
Published: Aug. 31, 2022
The coronavirus disease 2019 (COVID-19) has already killed more than 6 million people around the world. A growing body of epidemiological evidence suggests that low 25-hydroxy vitamin D (25-OH-vitamin D) plasma levels are associated with an increased risk developing COVID-19 and -most importantly-with a higher severe dying. On other hand, supplementation during early phases been related to decreased length hospital stay, less frequent need for oxygen, reduced mortality rate in inpatients. This seems be particularly true when high dosages used. In light this evidence, further studies needed define best timing most effective dosage schedule.
Language: Английский
Citations
15