Puerarin: a potential natural neuroprotective agent for neurological disorders

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114581 - 114581

Published: March 24, 2023

Puerarin is an isoflavone compound derived from Pueraria lobata in traditional Chinese medicine. Accumulating evidence has indicated that puerarin demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Based on the latest research progress as a neuroprotective agent, its activity, molecular mechanism, therapeutic application were systematically reviewed with emphasis pre-clinical studies. The related information was extracted compiled major scientific databases, including PubMed, ScienceDirect, SpringerLink, National Knowledge Infrastructure, using 'Puerarin', 'Neuroprotection', 'Apoptosis', 'Autophagy', 'Antioxidant', 'Mitochondria', 'Anti-inflammation' keywords. This review complied Preferred Reporting Items Systematic Reviews criteria. Forty-three articles met established inclusion exclusion shown against variety of disorders, ischemic cerebrovascular disease, subarachnoid hemorrhage, epilepsy, cognitive traumatic brain injury, Parkinson's Alzheimer's anxiety, depression, diabetic neuropathy, neuroblastoma/glioblastoma. anti-apoptosis, proinflammatory mediator inhibitory, autophagy regulatory, anti-oxidative stress, mitochondria protection, Ca2+ influx anti-neurodegenerative activities. exerts noticeable models disorders vivo (animal). will contribute to development novel clinical drug candidate However, well-designed, high-quality, large-scale, multicenter randomized studies are needed determine safety utility patients

Language: Английский

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Flavonoids and Alzheimer’s disease: reviewing the evidence for neuroprotective potential

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Language: Английский

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Anti-Inflammatory, Analgesic, Functional Improvement, and Chondroprotective Effects of Erigeron breviscapus (Vant.) Hand.-Mazz. Extract in Osteoarthritis: An In Vivo and In Vitro Study

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 1035 - 1035

Published: April 2, 2024

Osteoarthritis (OA) is a degenerative bone disease characterized by inflammation as primary pathology and currently lacks therapeutic interventions to impede its progression. Erigeron breviscapus (Vant.) Hand.-Mazz. (EB) an east Asian herbal medicine with long history of use wide range confirmed efficacy against cardiovascular central nervous system diseases. The purpose this study evaluate whether EB worthy further investigation treatment for OA based on anti-inflammatory activity. This aims assess the potential OA, focusing properties. Analgesic effects, functional improvements, inhibition cartilage destruction induced were evaluated in acetic acid-induced peripheral pain mice monosodium iodoacetate-induced rat models. Additionally, effect was assessed serum tissue vivo, well lipopolysaccharide-induced RAW 264.7 cells. demonstrated significant alleviation pain, impairment, degradation along notable pro-inflammatory cytokines, including interleukin-1β, interleukin-6, matrix metalloproteinases 13, nitric oxide synthase 2, both vitro dose-dependent manner compared active control. Accordingly, merits exploration disease-modifying drug capable mitigating multifaceted osteoarthritis through Nonetheless, additional validation broader experimental design essential substantiate findings study.

Language: Английский

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Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Neuroprotection/Neuroprotection (Chichester, England. Print), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Background Alzheimer's disease (AD) is a neurodegenerative disorder that affects the central nervous system. Silent information regulator sirtuin 1 (SIRT1) may deacetylate and suppress forkhead box O (FOXO) activities to promote neuronal survival. FOXO1 involved in regulation of metabolism, senescence, stress response, apoptosis. Moreover, endoplasmic reticulum (ERS) mediates cell Therefore, this study aimed determine whether downregulation SIRT1 expression exacerbates cognitive dysfunction by activating acetylation promoting ERS‐mediated apoptosis amyloid precursor protein/presenilin (APP/PS1) transgenic mice. Methods We used APP/PS1 mice construct an vivo AD model. Additionally, we β‐amyloid (Aβ)‐incubated HT22 cells primary neurons (PNs) for vitro analyses. Cognitive function was assessed using novel object recognition, Morris water maze, fear conditioning. Discrepancies between wild‐type (WT) were evaluated unpaired t test. In addition, one‐way analysis variance conducted behavioral assessments other tests involving four distinct groups, followed Tukey's honestly significant difference test post hoc pairwise comparisons. Results The downregulated (in animal experiments, WT vs. mice, n = 3, p 0.002; + Aβ 1–42 , 0.001; 1−42 < 0.001), whereas upregulated both 0.004; 1–42, leading dysfunction, plaque deposition, Quercetin, agonist, reversed these changes (For SIRT1, Quercetin‐treated 0.014; 1− 42 0.003; 0.014. For ac‐FOXO1, cells+ 0.023; 0.003). However, antagonist AS1842856 invalidated positive effects quercetin (ac‐FOXO1: AS1842856‐treated 0.001). Quercetin counteracted contrast, promoted processes vitro. Conclusion Our findings demonstrate

Language: Английский

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Diversity, Composition, and Ecological Function of Endophytic Fungal Communities Associated with Erigeron breviscapus in China

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1080 - 1080

Published: May 6, 2025

Endophytic fungi (EF) play crucial roles in accelerating the accumulation of medicinal components and regulating survival reproduction plants. Erigeron breviscapus is a well-known traditional Chinese plant with effective therapeutic effects wide application, but little known about diversity, community structure, ecological EF this plant. Here, communities associated different tissues E. at two seasons were studied by high-throughput sequencing methods. Furthermore, FUNGuild was performed to predict functions fungi. Didymella found be most dominant genus across all four tissues, followed Plectosphaerella, Filobasidium, Cystofilobasidium, Cladosporium. Notably, unique genera biomarkers different. Interestingly, it that roots had highest fungal richness diversity summer. Moreover, both PCoA plots PERMANOVA analyses indicated tissue season main factors contributing differences breviscapus. prediction revealed pathotroph–saprotroph undefined taxa accounted for high proportion We also some valuable endophytes encouraged deeper investigation. These findings provide theoretical reference further development utilization resources

Language: Английский

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A comprehensive perspective on the disposition, metabolism, and pharmacokinetics of representative multi-components of Dengzhan Shengmai in rats with chronic cerebral hypoperfusion after oral administration

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 307, P. 116212 - 116212

Published: Feb. 3, 2023

Language: Английский

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Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 24, 2023

Colorectal cancer (CRC) is the third most common malignant tumor in world, and it prone to recurrence metastasis during treatment. Aerobic glycolysis one of main characteristics cell metabolism CRC. Tumor cells rely on rapidly consume glucose obtain more lactate intermediate macromolecular products so as maintain growth proliferation. The regulation CRC pathway closely associated with several signal transduction pathways transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, p53. Targeting glycolytic has become key research aspects therapy. Many phytochemicals were shown exert anti-CRC activity by targeting pathway. Here, we review effects mechanisms pathways, providing a new method drug development.

Language: Английский

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Integrated bioinformatics, network pharmacology, molecular docking, and molecular dynamics simulation to explore the potential pharmacological mechanism of Erigeron breviscapus (Vant.) Hand-Mazz regulating ferroptosis for the treatment of Alzheimer's disease

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1314, P. 138698 - 138698

Published: May 21, 2024

Ferroptosis plays a role in Alzheimer's disease (AD) development. Erigeron breviscapus (Vant.) Hand-Mazz (EBHM) shows promising effects treating cognitive impairment-related diseases. However, the mechanisms by which EBHM regulates ferroptosis AD treatment are not fully understood. This study used bioinformatics, network pharmacology, molecular docking, and dynamics simulation to explore how treatment. The results identified four key genes—HSPA8, GSK3B, CTSB, YWHAG—that involved this regulation, constructed multigene diagnostic model for AD. demonstrated moderate accuracy (area under curve [AUC] = 0.636) distinguishing from non-demented (ND) was further validated with external datasets showing good capabilities (AUC values of 0.898, 0.889, 0.746, 0.712). Additionally, CIBERSORT analysis revealed significant correlation between immune cell infiltration these genes, highlighting their potential immunity. Molecular docking studies indicated that 3,4,5-tricaffeoylquinic acid (TCQA) had highest binding affinity HSPA8, suggesting TCQA HSPA8 components core targets EBHM's regulation therapy. simulations confirmed stability strong TCQA-HSPA8 complex. These findings enhance our understanding underlying may offer new avenues developing effective treatments.

Language: Английский

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Induction of RIPK3/MLKL-mediated necroptosis by Erigeron breviscapus injection exhibits potent antitumor effect

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 16, 2023

Colorectal cancer (CRC) is the second leading cause of tumor-related deaths worldwide. Resistance tumor cells to drug-induced apoptosis highlights need for safe and effective antitumor alternatives. Erigeron breviscapus (Dengzhanxixin in China) injection (EBI), extracted from natural herb (Vant.) Hand.-Mazz (EHM), has been widely used clinical practice cardiovascular diseases. Recent studies have suggested that EBI's main active ingredients exhibit potential effects. This study aims explore anti-CRC effect EBI elucidate underlying mechanism. The was evaluated vitro using CCK-8, flow cytometry, transwell analysis, vivo through a xenograft mice model. RNA sequencing utilized compare differentially expressed genes, proposed mechanism verified experiments. Our demonstrates significantly inhibits proliferation three human CRC cell lines effectively suppresses migration invasion SW620 cells. Moreover, model, markedly retards growth lung metastasis. RNA-seq analysis revealed might exert effects by inducing necroptosis Additionally, activates RIPK3/MLKL signaling pathway, classical pathway greatly promotes generation intracellular ROS. Furthermore, on alleviated after pretreatment GW806742X, MLKL inhibitor. findings suggest inducer treatment. Notably, non-apoptotic programmed death can circumvent resistance apoptosis, which provides novel approach overcoming drug resistance.

Language: Английский

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Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma

Planta Medica, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract Glaucoma is a common eye condition characterized by the loss of retinal ganglion cells and their axons, optic nerve damage, visual field defects, which seriously affect patientʼs quality life. The pathogenesis glaucoma still unclear at present. It presents as damage to cells, main treatment primarily reduce intraocular pressure surgery or taking medication. However, even with well-controlled pressure, undergo degeneration, progressive apoptosis, axonal loss. Therefore, protecting inhibiting apoptosis are current hot topic for prevention glaucoma. Recently, Erigeron breviscapus, originating from Yunnan province in China, has been shown be promising herb neuroprotective effects treat traditional usage, botanical characteristics, phytochemical composition E. breviscapus were explored through literature review. Furthermore, we have summarized pharmacological mechanisms its active components cells. These research findings can not only provide guidance recommendations protection but also further explore potential

Language: Английский

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