Jundishapur Journal of Natural Pharmaceutical Products,
Journal Year:
2023,
Volume and Issue:
18(3)
Published: Oct. 3, 2023
Background:
Studies
have
reported
certain
side
effects
that
occur
with
the
use
of
conventional
antidepressants
limit
their
clinical
use.
Plant
derivatives
such
as
Rhus
coriaria
L.
extract
can
be
used
alternatives
for
depression.
Objectives:
This
study
was
designed
to
investigate
antidepressant-like
R.
in
a
mouse
model
and
role
monoaminergic
system
its
mechanism
action.
Methods:
A
total
174
male
NMRI
mice
were
used.
Thirty
minutes
after
treating
animals
common
(25
-
200
mg/kg),
tail
suspension
test
(TST)
performed.
One
hour
serotonergic,
adrenergic,
dopaminergic
antagonists,
100
mg/kg
administered,
TST
performed
30
minutes.
Potential
synergistic
interactions
between
sub-doses
fluoxetine
(Flx)
imipramine
(Imp)
also
investigated.
Injections
all
administered
intraperitoneally.
Results:
(50
mg/kg)
induced
(P
<
0.001)
without
altering
animal
locomotion
open
field
(OFT;
P
>
0.05).
The
showed
activity
blocked
by
pretreating
above-mentioned
antagonists
0.05
0.01,
respectively).
sub-dose
increased
efficiency
0.001).
Conclusions:
via
antidepressants.
We
suggest
adding
dried
powder
formulation
antidepressant
agents
following
thorough
studies
on
substance.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(13), P. 4969 - 4969
Published: June 24, 2023
Aim.
Drug
abuse
and
addiction
are
major
public
health
concerns,
with
millions
of
people
worldwide
affected
by
the
negative
consequences
drug
use.
To
better
understand
this
complex
issue,
a
review
was
conducted
to
examine
mechanisms
action
effects
drugs
abuse,
including
their
acute
chronic
effects,
symptoms
abstinence
syndrome,
as
well
cardiovascular
impacts.
Methods.
The
analyzed
data
were
obtained
after
surveying
an
electronic
database,
namely
PubMed,
no
time
limit,
grey
literature
sources,
reference
lists
relevant
articles.
Results.
highlights
different
categories
such
opioids,
stimulants,
depressants,
hallucinogens,
cannabis,
discusses
specific
ways
that
each
affects
brain
body.
Additionally,
explores
short-term
long-term
on
body
mind,
changes
in
structure
function,
physical
problems,
mental
issues,
depression
anxiety.
In
addition,
health,
focusing
electrocardiogram
changes.
Moreover,
analysis
also
highlighted
possible
genetic
susceptibility
various
addictions.
Furthermore,
delves
into
withdrawal
occur
when
someone
stops
using
period
Conclusion.
Overall,
provides
comprehensive
overview
current
state
knowledge
addiction.
findings
can
inform
development
evidence-based
prevention
intervention
strategies
address
critical
issue.
Receptors,
Journal Year:
2024,
Volume and Issue:
3(2), P. 155 - 181
Published: April 12, 2024
Understanding
the
intricate
role
of
dopamine
D1–D5
receptors
is
pivotal
in
addressing
challenges
posed
by
aging
global
population,
as
well
social
stress
and
advancing
therapeutic
interventions.
Central
to
diverse
brain
functions
such
movement,
cognition,
motivation,
reward,
are
ubiquitously
distributed
across
various
nuclei.
This
comprehensive
review
explores
nuanced
each
receptor,
D1,
D2,
D3,
D4,
D5,
distinct
regions,
elucidating
alterations
witnessed
several
neurological
psychiatric
disorders.
From
substantia
nigra
ventral
tegmental
area,
crucial
for
motor
control
reward
processing,
limbic
system
influencing
emotional
responses,
cognitive
functions,
nucleus
reveals
a
specific
involvement
receptors.
In
addition,
genetic
variations
affect
risk
developing
schizophrenia
parkinsonism.
The
further
investigates
physiological
significance
pathogenic
impacts
critical
areas
like
prefrontal
cortex,
hypothalamus,
striatum.
By
unraveling
complexities
receptor
biology,
especially
those
focused
on
different
nuclei,
this
provides
foundation
understanding
their
varied
roles
health
disease,
which
essential
development
targeted
strategies
aimed
at
mitigating
impact
mental
well-being.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: May 23, 2024
Restricted
by
synaptic
plasticity,
dopamine
receptor
(DR)
upregulation
takes
a
long
time
to
work.
Moreover,
the
impact
of
blood-brain
barrier
(BBB)
on
delivery
efficiency
restricts
development
drugs.
Taking
inspiration
from
snuff
bottles,
convenient,
fast-acting,
and
nonaddictive
nasal
drug
system
has
been
developed
rapidly
reshape
balance
transmitters.
This
optical
magnetic
response
called
CFs@DP,
comprised
carbonized
MIL-100
(Fe)
frameworks
(CFs)
domperidone
(DP),
which
can
enter
brain
via
administration.
Under
dual
stimulation
near-infrared
(NIR)
irradiation
catecholamine-induced
complexation,
CFs@DP
disintegrates
release
iron
ions
DP,
causing
type
1
(D
Life,
Journal Year:
2023,
Volume and Issue:
13(4), P. 1043 - 1043
Published: April 19, 2023
Background:
Pramipexole
is
a
dopamine
full
agonist
approved
for
the
treatment
of
Parkinson’s
disease
and
restless
legs
syndrome.
Its
high
affinity
D3
receptor
neuroprotective,
antioxidant,
anti-inflammatory
activity
provides
rationale
depression.
In
this
paper,
we
review
studies
on
effectiveness
safety
antidepressant
pramipexole
augmentation
in
treatment-resistant
Methods:
This
comprehensive
systematic
meta-analysis
observational
pramipexole–antidepressant
included
patients
with
resistant
unipolar
bipolar
The
primary
outcome
measure
was
response,
measured
at
study
endpoint.
Results:
We
identified
8
including
281
overall,
57%
women
39.5%
disorder
60.5%
major
depressive
disorder.
mean
follow-up
duration
27.3
weeks
(range
8–69).
pooled
estimate
response
62.5%,
without
significant
differences
between
Safety
good,
nausea
somnolence
most
frequent
side
effects.
Conclusions:
findings
review,
needing
further
confirmation,
show
that
off-label
use
as
could
be
useful
safe
strategy
International Journal of General Medicine,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 347 - 357
Published: Jan. 1, 2024
Abstract:
Depression
is
a
prevalent
mental
disorder
and
has
profound
impact
on
an
individual's
psychological
physical
well-being.
It
characterized
by
persistently
depressed
mood,
loss
of
interest,
energy
loss,
cognitive
dysfunction.
In
recent
years,
more
people
have
changed
to
diseases,
such
as
depression,
anxiety,
mania
so
on.
the
incidence
covering
all
ages,
but
still
mainly
young
middle-aged
women.
Traditional
treatments
for
depression
rely
medication
psychotherapy,
these
methods
are
not
effective
patients
often
accompanied
certain
side
effects.
Therefore,
finding
safe
alternative
or
adjuvant
become
priority.
Here
we
highlight
research
progress
acupuncture
in
treatment
explore
mechanism
depression.
Acupuncture
ancient
method,
involves
multiple
biological
pathways,
example,
regulating
neurotransmitter
levels,
neuroendocrine
axis,
improving
neuroplasticity,
anti-inflammatory
other
effects,
emotional
state
play
antidepressant
role.
To
provide
evidence
support
widespread
use
clinical
practice.
We
hope
new
ideas
with
even
reduce
Keywords:
acupuncture,
