Gut Microbiota and Vascular Diseases: An Update DOI Creative Commons
Jiaqi Wu, Yuxuan Li,

Peipei Yang

et al.

Cardiovascular Innovations and Applications, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Vascular diseases, including atherosclerosis, aneurysms, and vascular calcification, are a leading cause of morbidity mortality worldwide. In past decades, the gut microbiota has been found to be an indispensable population exerting effects on hosts under physiological pathological conditions. Gut microbiota-derived metabolites, such as trimethylamine-N-oxide short-chain fatty acids, mediate these by regulating cells systematically. Translation research knowledge clinical scenarios led development new therapies dietary interventions metabolite inhibitors. This review describes recent advancements in understanding interplay between dysfunction, potential treatments for diseases.

Language: Английский

Astragalus polysaccharide ameliorated complex factor-induced chronic fatigue syndrome by modulating the gut microbiota and metabolites in mice DOI Open Access

Xin‐Tong Wei,

Jiayun Xin, Wei Chen

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 163, P. 114862 - 114862

Published: May 9, 2023

Chronic fatigue syndrome (CFS) is a debilitating disease with no symptomatic treatment. Astragalus polysaccharide (APS), component derived from the traditional Chinese medicine A. membranaceus, has significant anti-fatigue activity. However, mechanisms underlying potential beneficial effects of APS on CFS remain poorly understood. A model 6-week-old C57BL/6 male mice was established using multiple-factor method. These underwent examinations for behavior, oxidative stress and inflammatory indicators in brain intestinal tissues, ileum histomorphology. 16 S rDNA sequencing analysis indicated that regulated abundance gut microbiota increased production short chain fatty acids (SCFAs) anti-inflammatory bacteria. In addition, reversed abnormal expression Nrf2, NF-κB, their downstream factors brain-gut axis alleviated reduction SCFAs cecal content caused by CFS. Further, modulated changes serum metabolic pathways induced Finally, it verified butyrate exerted antioxidant neuronal cells. conclusion, could increase regulating microbiota, (especially butyrate) can further regulate inflammation brain, thus alleviating This study explored efficacy mechanism perspective gut-brain provides reference to explore role central nervous system.

Language: Английский

Citations

35
Gut microbiota: A magical multifunctional target regulated by medicine food homology species DOI Creative Commons

Wei‐Fang Zuo,

Qiwen Pang,

Lai-Ping Yao

et al.

Journal of Advanced Research, Journal Year: 2023, Volume and Issue: 52, P. 151 - 170

Published: June 2, 2023

The relationship between gut microbiota and human health has gradually been recognized. Increasing studies show that the disorder of is related to occurrence development many diseases. Metabolites produced by are responsible for their extensive regulatory roles. In addition, naturally derived medicine food homology species with low toxicity high efficiency have clearly defined owing outstanding physiological pharmacological properties in disease prevention treatment.Based on supporting evidence, current review summarizes representative work targeting regulate host pathophysiology discusses challenges prospects this field. It aims facilitate understanding among species, microbiota, further stimulate advancement more relevant research.As reveals, from initial practical application mechanism studies, evolved into an irrefutable interaction. On one hand, through affecting population structure, metabolism, function maintain homeostasis intestinal microenvironment microbiota. other also involved bioconversion active ingredients thus influences properties.

Language: Английский

Citations

28
Paeoniflorin confers ferroptosis resistance by regulating the gut microbiota and its metabolites in diabetic cardiomyopathy DOI

Haowei Wu,

Peipei Zhang, Jiedong Zhou

et al.

AJP Cell Physiology, Journal Year: 2024, Volume and Issue: 326(3), P. C724 - C741

Published: Jan. 15, 2024

This study demonstrated for the first time that paeoniflorin (PA) exerts protective effects in diabetic cardiomyopathy mice by alleviating myocardial damage, resisting ferroptosis, and changing community composition structure of intestinal microbiota, 11,12-epoxyeicosatrienoic acid (11,12-EET) may serve as a key contributor its therapeutic efficacy.

Language: Английский

Citations

10
A microbiota pattern associated with cardiovascular events in secondary prevention: the CORDIOPREV study DOI
Javier Arenas‐Montes, Juan F. Alcalá‐Díaz, Helena García-Fernández

et al.

European Heart Journal, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Abstract Background and Aims Preventing new cardiovascular events in patients with established disease (CVD) is a daunting task for clinicians. Intestinal microbiota may help identify at risk, thus improving the strategies of secondary prevention. The aim this study was to evaluate baseline differences between gut from coronary heart (CHD) suffering major adverse (MACEs) following 7 years, compared CHD who did not undergo MACE period, build score associated risk MACE. Methods Within framework CORDIOPREV study, clinical trial that involved 1002 CHD, intestinal examined available faecal samples (n = 679, 132 MACE), through 16S metagenomics on Illumina MiSeq Quiime2 software. Lipopolysaccharide (LPS) measured using limulus amoebocyte lysate test. Results Random survival forest identified 10 bacterial taxa higher predictive power incidence. Receiver operating characteristic curves yielded an area under curve 65.2% (59.1%–71.3%) training set 68.6% (59.3%–77.9%) validation set. incidence hazard ratio 2.01 (95% confidence interval 1.37–3.22). analysis showed greater LPS post-prandial fold change group (P .005). Conclusions These results reinforce relationship CVD suggest profile patients, addition endotoxaemia.

Language: Английский

Citations

1
Ganoderma lucidum polysaccharides improve lipid metabolism against high-fat diet-induced dyslipidemia DOI
Wenshuai Wang,

Yaohan Zhang,

Zhiying Wang

et al.

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 309, P. 116321 - 116321

Published: March 1, 2023

Language: Английский

Citations

18
Panax notoginseng-microbiota interactions: From plant cultivation to medicinal application DOI

Yu Xu,

Mengjie Zhu,

Yibin Feng

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 119, P. 154978 - 154978

Published: July 17, 2023

Language: Английский

Citations

14
Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner DOI Creative Commons
Dan Huang, Shuang Shen, Qian Zhuang

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Jan. 24, 2024

Abstract Background Cholesterol gallstone (CG) disease is a worldwide common characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders. However, the role and underlying mechanism of GLP CG formation are still unknown. This study aimed determine ameliorating lithogenic diet (LD)-induced formation. Methods Mice were fed either normal chow diet, LD, or LD supplemented with GLP. Real-time quantitative polymerase chain reaction (RT-qPCR) western blotting used detect expression genes involved bile acid (BA) metabolism. The BA concentrations ileum quantified liquid chromatography-tandem mass spectrometry (LC–MS/MS). microbiota cecal contents using 16S ribosomal RNA (16S rRNA) gene sequencing. Results effectively alleviated induced LD. Specifically, reduced total (TC) levels, increased decreased saturation index (CSI) protective effect was attributed inhibition farnesoid X receptor (FXR) signaling, hepatic synthesis secretion. also altered composition ileum, reducing FXR-agonistic BAs increasing FXR-antagonistic BAs, which may contribute intestinal FXR signaling. Additionally, improved dysbiosis flora serum levels hydrogen sulfide (H 2 S), bacterial metabolite that can induce FXR, thereby inhibiting Moreover, could be reversed both global gut-restricted agonists. Conclusions Taken together, ameliorates regulating metabolism an FXR-dependent manner. Our demonstrates potential strategy for prevention disease.

Language: Английский

Citations

5
The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms DOI Creative Commons

Xuting Hao,

Rui Peng,

Miao Guan

et al.

Food & medicine homology., Journal Year: 2024, Volume and Issue: 1(2), P. 9420003 - 9420003

Published: June 3, 2024

Hyperlipidemia is a kind of lipid metabolism disease, whose pathogenesis complex and diverse, mainly related to abnormal glucose metabolism, as well insulin resistance other characteristics. Because their low toxic side effects along with clear medicinal effects, the food homological resources are widely used in regulation blood lipids recent years. The State Administration for Market Regulation website various databases have been searched use materials functional products, categories frequency resources, lipid-lowering active ingredients mechanisms. results showed that 53 kinds were regulate lipids, which Crataegus pinnatifida Bge., Cassia obtusifolia L., Nelumbo nucifera Gaertn., Morus alba L. Pueraria lobata (Willd.) Ohwi most frequently. main triterpenes glycosides, flavonoids, alkaloids polysaccharides, etc., they regulated levels cholesterol by activating AMPK PPARγ.

Language: Английский

Citations

5
Gentiopicroside modulates glucose homeostasis in high-fat-diet and streptozotocin-induced type 2 diabetic mice DOI Creative Commons
Xing Wang,

Dongmei Long,

Xianghong Hu

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 4, 2023

Gluconeogenesis is closely related to the occurrence and development of type 2 diabetes mellitus (T2DM). Gentiopicroside (GPS) main active secoiridoid glycoside in Gentiana manshurica Kitagawa, which can improve chronic complications associated with regulate glucose metabolism. However, effects potential mechanisms by GPS affects T2DM understudied poorly understood. In this study, we systematically explored pharmacological on induced a high-fat diet (HFD) streptozotocin (STZ) as well its mechanisms. The results showed that supplementation discernibly decreased blood levels, food intake water consumption, ameliorated intolerance, abnormal pyruvate tolerance, insulin resistance dyslipidemia. Furthermore, pathological morphological abnormalities liver pancreas, reduced hepatic steatosis maintain balance between α-cells β-cells pancreas. Moreover, significantly inhibited gluconeogenesis, evidenced suppressed protein expression phosphoenolpyruvate carboxykinase (PEPCK) 6-phosphatase (G6Pase) liver. Additionally, Western blot analysis revealed increased p-PI3K, p-AKT, p-FOXO1 FOXO1 at level immunostaining demonstrated zonula occludens-1 (ZO-1) occludin ileum. Collectively, these indicate may inhibit gluconeogenesis regulating PI3K/AKT/FOXO1 signaling pathway intestinal barrier integrity, ultimately T2DM. Together, findings candidate drug for prevention treatment T2DM, our study will provide experimental basis further exploration possibility therapeutic agent

Language: Английский

Citations

11
Saponins as therapeutic candidates for atherosclerosis DOI

Nuan Lv,

Luming Wang, Miao Zeng

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(3), P. 1651 - 1680

Published: Feb. 1, 2024

Abstract Drug development for atherosclerosis, the underlying pathological state of ischemic cardiovascular diseases, has posed a longstanding challenge. Saponins, classified as steroid or triterpenoid glycosides, have shown promising therapeutic potential in treatment atherosclerosis. Through an exhaustive examination scientific literature spanning from May 2013 to 2023, we identified 82 references evaluating 37 types saponins terms their prospective impacts on These studies suggest that ameliorate atherosclerosis by regulating lipid metabolism, inhibiting inflammation, suppressing apoptosis, reducing oxidative stress, and modulating smooth muscle cell proliferation migration, well gut microbiota, autophagy, endothelial senescence, angiogenesis. Notably, ginsenosides exhibit significant manifest essential pharmacological attributes, including lipid‐lowering, anti‐inflammatory, anti‐apoptotic, anti‐oxidative stress effects. This review provides comprehensive attributes with particular emphasis role regulation metabolism anti‐inflammatory Thus, may warrant further investigation therapy However, due various reasons such low oral bioavailability, clinical application still needs exploration.

Language: Английский

Citations

4