Veterinary Immunology and Immunopathology, Journal Year: 2022, Volume and Issue: 247, P. 110415 - 110415
Published: March 23, 2022
Language: Английский
Medicinal Research Reviews, Journal Year: 2022, Volume and Issue: 42(4), P. 1545 - 1587
Published: March 11, 2022
Abstract Incomplete autophagy is an impaired self‐eating process of intracellular macromolecules and organelles in which accumulated autophagosomes do not fuse with lysosomes for degradation, resulting the blockage autophagic flux. In this review, we summarized literature over past decade describing incomplete autophagy, found that different from double‐edged sword effect general on promoting cell survival or death, plays a crucial role disrupting cellular homeostasis, promotes only death. What matters closely relevant to pathogenesis progression various human diseases, which, meanwhile, intimately linking pharmacologic toxicologic effects several compounds. Here, comprehensively reviewed latest progress molecular mechanisms signaling pathways. Moreover, implications pharmacotherapy are also discussed, has great relevance our understanding distinctive physiology disease. Consequently, targeting may contribute development novel generation therapeutic agents diverse diseases.
Language: Английский
Citations
35
Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(10)
Published: Oct. 26, 2022
Abstract Mitophagy is a vital process that controls mitochondria quality, dysregulation of which can promote cancer. Oncoprotein mucin 1 (MUC1) targets to attenuate drug-induced apoptosis. However, little known about whether and how MUC1 contributes mitochondrial homeostasis in cancer cells. We identified novel role promoting mitophagy. Increased mitophagy coupled with the translocation mitochondria, where interacts induces degradation ATPase family AAA domain-containing 3A (ATAD3A), resulting protection PTEN-induced kinase (Pink1) from ATAD3A-mediated cleavage. Interestingly, MUC1-induced associated increased oncogenicity Similarly, inhibition significantly suppresses cell activity vitro vivo. Consistently, ATAD3A protein levels present an inverse relationship tumor tissues breast patients. Our data validate MUC1/ATAD3A/Pink1 axis-mediated constitutes mechanism for maintaining malignancy cells, providing therapeutic approach MUC1-positive cancers.
Language: Английский
Citations
35
Aquatic Toxicology, Journal Year: 2022, Volume and Issue: 249, P. 106204 - 106204
Published: May 20, 2022
Language: Английский
Citations
34
Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 15
Published: May 18, 2022
Skeletal muscle is one of the largest organs in body and essential for maintaining quality life. Loss skeletal mass function can lead to a range adverse consequences. The gut microbiota interact with by regulating variety processes that affect host physiology, including inflammatory immunity, protein anabolism, energy, lipids, neuromuscular connectivity, oxidative stress, mitochondrial function, endocrine insulin resistance. It proposed plays role direction work. Even though notion microbiota-muscle axis (gut-muscle axis) has been postulated, its causal link still unknown. impact on described detail this review.
Language: Английский
Citations
33
Biomedicines, Journal Year: 2022, Volume and Issue: 10(7), P. 1596 - 1596
Published: July 5, 2022
Autophagy is an evolutionarily conserved and tightly regulated process that plays important role in maintaining cellular homeostasis. It involves regulation of various genes function to degrade unnecessary or dysfunctional components, recycle metabolic substrates. modulated by many factors, such as nutritional status, energy level, hypoxic conditions, endoplasmic reticulum stress, hormonal stimulation drugs, these factors can regulate autophagy both upstream downstream the pathway. In cancer, acts a double-edged sword depending on tissue type stage tumorigenesis. On one hand, promotes tumor progression advanced stages stimulating growth. other inhibits development early enhancing its suppressor activity. Moreover, drives resistance anticancer therapy, even though some types, activation induces lethal effects cancer cells. this review, we summarize biological mechanisms dual cancer. addition, report current understanding types with markedly high incidence and/or lethality, existing therapeutic strategies targeting for treatment
Language: Английский
Citations
32
Biomolecules, Journal Year: 2022, Volume and Issue: 12(9), P. 1224 - 1224
Published: Sept. 2, 2022
Wilms’ tumor 1-associating protein (WTAP) is required for N6-methyladenosine (m6A) RNA methylation modifications, which regulate biological processes such as splicing, cell proliferation, cycle, and embryonic development. m6A the predominant form of mRNA modification in eukaryotes. WTAP exerts by binding to methyltransferase-like 3 (METTL3) nucleus METTL3-methyltransferase-like 14 (METTL14)-WTAP (MMW) complex, a core component methyltransferase complex (MTC), localizing nuclear patches. Studies have demonstrated that plays critical role various cancers, both dependent independent its methyltransferases. Here, we describe recent findings on structural features WTAP, mechanisms regulates functions, molecular functions cancers. By summarizing latest research, expect provide new directions insights oncology research discover targets cancer treatment.
Language: Английский
Citations
31
Cellular Signalling, Journal Year: 2022, Volume and Issue: 94, P. 110323 - 110323
Published: March 29, 2022
Language: Английский
Citations
30
AJP Renal Physiology, Journal Year: 2023, Volume and Issue: 325(1), P. F1 - F21
Published: May 11, 2023
Autophagy is a ubiquitous intracellular cytoprotective quality control program that maintains cellular homeostasis by recycling superfluous cytoplasmic components (lipid droplets, protein, or glycogen aggregates) and invading pathogens. Mitophagy selective form of autophagy damaged mitochondrial material, which can extracellularly act as damage-associated molecular patterns, prevents their release. mitophagy are indispensable for the maintenance kidney exert crucial functions during both physiological disease conditions. Impaired negatively impact pathophysiological state promote its progression. helps in maintaining structural integrity kidney. Mitophagy-mediated explicitly critical regulating Both attenuate inflammatory responses An accumulating body evidence highlights persistent injury-induced oxidative stress contribute to dysregulated autophagic mitophagic cell death. also communicate with programmed death pathways (apoptosis necroptosis) play important roles survival preventing nutrient deprivation stress. activated after acute injury. However, aberrant hyperactivation be deleterious cause tissue damage. The findings on various models chronic heterogeneous type- context-specific dependent. In this review, we discuss pathological manifestations.
Language: Английский
Citations
19
Aging, Journal Year: 2021, Volume and Issue: 13(17), P. 21251 - 21267
Published: Sept. 12, 2021
Betulinic acid (BA), a pentacyclic triterpenoid isolated from tree bark, exhibits antitumor effects against solid malignancies and triggers autophagy and/or apoptosis in human cancer cells. Nonetheless, the relationship between potential modulatory actions of BA on autophagy-dependent bladder cell death remain unclear. The present study showed that exposure significantly suppressed viability, proliferation, migration EJ T24 These reflected caspase 3-mediated could be attenuated or abolished by inhibiting ROS production with N-acetyl-L-cysteine, chloroquine, silencing ATG7 targeted siRNA. BA-induced was evidenced epifluorescence imaging lentivirus-induced expression mCherry-GFP-LC3B increased two autophagy-related proteins, LC3B-II TEM. Moreover, enhanced AMPK phosphorylation decreased mTOR ULK-1 suggested activates via AMPK/mTOR/ULK1 pathway. Accordingly, to dorsomorphin (Compound C), an inhibitor, AICAR, activator, respectively inhibited stimulated Bmi-1 overexpression vitro BA-treated xenografts nude mice downregulation is underlying mechanism BA-mediated, apoptosis.
Language: Английский
Citations
35
Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 242, P. 113881 - 113881
Published: July 18, 2022
Language: Английский
Citations
27